Metastases of glioblastoma multiforme to cervical lymph nodes

1973 ◽  
Vol 38 (5) ◽  
pp. 631-634 ◽  
Author(s):  
Sayed El-Gindi ◽  
Mamdouh Salama ◽  
Mokhtar El-Henawy ◽  
Said Farag
Keyword(s):  
Brain Tumor ◽  
Glioblastoma Multiforme ◽  
Lymph Nodes ◽  
Metastatic Lesion ◽  
Cervical Lymph Nodes ◽  
Content Type ◽  
The Brain ◽  
Fine Print

✓ Two cases of occipital glioblastoma multiforme are reported in which a metastatic lesion involving the cervical lymph nodes on the side of the previous craniotomy was verified during life. This suggests to the authors that the brain tumor metastasized via lymphatic channels.

Glioblastoma multiforme at the site of metal splinter injury: a coincidence?

1999 ◽  
Vol 91 (6) ◽  
pp. 1041-1044 ◽  
Author(s):  
Michael Sabel ◽  
Jörg Felsberg ◽  
Martina Messing-Jünger ◽  
Eva Neuen-Jacob ◽  
Jürgen Piek
Keyword(s):  
Brain Tumor ◽  
Glioblastoma Multiforme ◽  
Malignant Glioma ◽  
Causal Relationship ◽  
Propionibacterium Acnes ◽  
Glioma Tissue ◽  
Left Frontal Lobe ◽  
Content Type ◽  
Chronic Abscess ◽  
Fine Print

✓ The authors report the case of a man who had suffered a penetrating metal splinter injury to the left frontal lobe at 18 years of age. Thirty-seven years later the patient developed a left-sided frontal tumor at the precise site of the meningocerebral scar and posttraumatic defect. Histological examination confirmed a glioblastoma multiforme adjacent to the dural scar and metal splinters. In addition, a chronic abscess from which Propionibacterium acnes was isolated was found within the glioma tissue. The temporal and local association of metal splinter injury with chronic abscess, scar formation, and malignant glioma is highly suggestive of a causal relationship between trauma and the development of a malignant brain tumor.

Louise Eisenhardt, M.D.: First editor of the Journal of Neurosurgery (1944–1965)

1994 ◽  
Vol 80 (2) ◽  
pp. 342-346 ◽  
Author(s):  
Lycurgus M. Davey
Keyword(s):  
Brain Tumor ◽  
Tumor Registry ◽  
Content Type ◽  
Harvey Cushing ◽  
Charter Member ◽  
High Standards ◽  
Literary Portrait ◽  
The Brain ◽  
Fine Print

✓ This is a literary portrait of Louise Eisenhardt, M.D., associate of Harvey Cushing, scholar, investigator, editor, teacher, and curator of the Brain Tumor Registry at Yale. She was a Charter Member of the Harvey Cushing Society which she served as President, long-term Secretary-Treasurer, and Historian. She achieved many “firsts” for women in medicine. A figure in the Homeric tradition of observing accurately and reporting honestly, Dr. Eisenhardt set high standards for both colleagues and students as well as for aspiring medical authors. She left a tradition worthy of emulation.

Spontaneous rupture of a metastatic brain tumor into the ventricular system

1971 ◽  
Vol 34 (3) ◽  
pp. 412-416
Author(s):  
Robert H. Wilkins ◽  
Wang-Kuen Wu
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Tumor ◽  
Spontaneous Rupture ◽  
Ventricular System ◽  
Metastatic Brain Tumor ◽  
Content Type ◽  
Surgical Exposure ◽  
First Case ◽  
The Brain ◽  
Fine Print

✓ Two cases are reported in which spontaneous rupture of a metastatic brain tumor occurred into the ventricular system, leading to the dissemination of the tumor contents in the cerebrospinal fluid. The site of rupture was demonstrated by ventriculography in the first case and by surgical exposure in the second. These cases support the assumption that metastatic neoplasms within the brain may rupture into the ventricular system and spread via the cerebrospinal fluid pathways.

Brain metastasis from malignant pancreatic somatostatinoma

1996 ◽  
Vol 85 (4) ◽  
pp. 681-684 ◽  
Author(s):  
Takumi Abe ◽  
Kinya Oshida ◽  
Kiyoshi Matsumoto ◽  
Masataka Iida ◽  
Naoko Sanno
Keyword(s):  
Brain Metastasis ◽  
Lymph Nodes ◽  
Primary Tumor ◽  
Tumor Recurrence ◽  
Brain Lesions ◽  
Endocrine Tumors ◽  
Content Type ◽  
Pancreatic Tail ◽  
The Brain ◽  
Fine Print

✓ Somatostatinomas are rare endocrine tumors that are located primarily in the pancreas. Metastases are seen most frequently in the liver and lymph nodes. The authors present the case of a 63-year-old man who had a malignant somatostatinoma of pancreatic tail origin that metastasized to the brain 10 years after diagnosis of the primary tumor. The metastatic brain lesions were totally removed and the patient is alive without tumor recurrence 12.3 years after the initial diagnosis. To our knowledge, this case represents the first documentation of brain metastasis from a malignant somatostatinoma, as well as the longest survival time of a patient with a somatostatinoma.

Lymph node metastasis as first manifestation of glioblastoma

1974 ◽  
Vol 41 (5) ◽  
pp. 607-609 ◽  
Author(s):  
Clarisse L. Dolman
Keyword(s):  
Brain Tumor ◽  
Lymph Node ◽  
Glioblastoma Multiforme ◽  
Lymph Node Metastasis ◽  
Young Woman ◽  
Tumor Tissue ◽  
Malignant Cells ◽  
Content Type ◽  
Node Metastasis ◽  
Fine Print

✓ An enlarged parotid lymph node excised from a young woman contained malignant cells. Three weeks later she developed signs of a brain tumor and died despite irradiation. Autopsy revealed a large frontal lobe glioblastoma multiforme which had infiltrated the dura. The lymph node, which had been the first manifestation of disease, contained identical tumor tissue.

Brain-tumor imaging using radiopaque perfluorocarbon

1983 ◽  
Vol 58 (5) ◽  
pp. 650-653 ◽  
Author(s):  
Nicholas J. Patronas ◽  
Javad Hekmatpanah ◽  
Kunio Doi
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Contrast Agent ◽  
Contrast Medium ◽  
Computerized Tomography ◽  
Tumor Imaging ◽  
Content Type ◽  
X Ray ◽  
The Brain ◽  
Fine Print

✓ Perfluorocarbon, a new tumor-seeking x-ray contrast agent, was injected into three rats with experimental brain tumors. After 1 to 3 days the rats were sacrificed, and the brains were removed and subjected to x-ray study. All showed dense radiopaque areas which correlated with the size and shape of the corresponding brain tumors. Conversely, none of the radiograms taken of the brain tumor in five rats receiving no perfluorocarbon (control animals) showed similar increased density. These findings suggest that perfluorocarbon may serve a useful role as a contrast medium for computerized tomography studies of brain tumors in man.

Preclinical evaluation of a novel device for delivering brachytherapy to the margins of resected brain tumor cavities

2002 ◽  
Vol 96 (2) ◽  
pp. 335-343 ◽  
Author(s):  
James B. Stubbs ◽  
Roger H. Frankel ◽  
Karl Schultz ◽  
Ian Crocker ◽  
Dirck Dillehay ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Radiation Dose ◽  
Balloon Catheter ◽  
Surgical Trauma ◽  
Mr Images ◽  
Content Type ◽  
Resection Cavity ◽  
Iodine 125 ◽  
The Brain ◽  
Fine Print

Object. The objectives of this study were to evaluate the safety and performance of a new brachytherapy applicator in the treatment of resected brain tumors in a canine model. Methods. The brachytherapy applicator is an inflatable balloon catheter that is implanted in the resection cavity remaining after a brain tumor has been debulked. After implantation the balloon is inflated with Iotrex, a sterile solution containing organically bound iodine-125. The low-energy photons emitted by the iodine-125 deposit a therapeutic radiation dose across short distances from the surface of the balloon. After delivery of a prescribed radiation dose to the targeted volume, the radioactive fluid is retrieved and the catheter removed. Small resections of the right frontal lobe were performed in large dogs. Magnetic resonance (MR) images were obtained and used to assess tissue response and to measure the conformance between the resection cavity wall and the balloon surface. In four animals a dose ranging from 36 to 59 Gy was delivered. Neurological status and histological characteristics of the brain were assessed in all dogs. Implantation and explantation as well as inflation and deflation of the device were easily accomplished and well tolerated. The device was easily visualized on MR images, which demonstrated the expected postsurgical changes. The resection cavity and the balloon were highly conformal (range 93–100%). Histological changes to the cavity margin were consistent with those associated with surgical trauma. Additionally, radiation-related changes were observed at the margins of the resection cavity in dogs in which the brain was irradiated. Conclusions. This balloon catheter and 125I radiotherapy solution system can safely and reliably deliver radiation to the margins of brain cavities created by tumor resection. Results of this study showed that intracranial pressure changes due to balloon inflation and deflation were unremarkable and characteristic of the imaging properties and radiation safety profile of the device prior to its clinical evaluation. Clinically relevant brachytherapy (adequate target volume and total dose) was accomplished in all four animals subjected to treatment.

Functional and phenotypic differences between glioblastoma multiforme—derived and normal human brain endothelial cells

2005 ◽  
Vol 102 (4) ◽  
pp. 699-705 ◽  
Author(s):  
Christiana Charalambous ◽  
Florence M. Hofman ◽  
Thomas C. Chen
Keyword(s):  
Brain Tumor ◽  
Growth Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Boyden Chamber ◽  
Normal Brain ◽  
Vascular Endothelial ◽  
Phenotypic Properties ◽  
Content Type ◽  
The Brain ◽  
Fine Print

Object. Glioblastomas multiforme (GBMs) are hypervascular tumors characterized by endothelial cell (EC) proliferation. There is increasing evidence that ECs that infiltrate systemic tumors are different from normal blood vessel cells; whether this difference is seen in the central nervous system between GBM and normal brain tissue is not known. The goal of this investigation was to characterize and compare the functional and phenotypic properties of GBM-associated ECs and normal brain ECs. Methods. Human ECs were isolated from fresh tissue specimens, purified using flow cytometry, and characterized by immunostaining. Proliferation was measured by determining bromodeoxyuridine incorporation and Ki-67 staining, and by performing the monotetrazolium assay. The migration rate of the cells was determined using the modified Boyden chamber technique. Apoptosis was evaluated by performing the TUNEL assay, cell death enzyme-linked immunosorbent assay (ELISA), and annexin V staining. Growth factor production was analyzed using the ELISA technique. The brain tumor ECs differed from normal brain ECs morphologically and by their expression and distribution of specific markers (that is, vascular endothelial cadherin [VE-cadherin] and CD31). Functional differences between the two cell populations were also evident. The brain tumor ECs proliferated more slowly and underwent less apoptosis than normal brain ECs; however, the tumor ECs migrated faster than the normal ECs. The normal ECs were sensitive to growth factors such as vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1), whereas the tumor ECs were not. In addition, the brain tumor ECs constitutively produced higher levels of ET-1 and VEGF, compared with the normal ECs. Conclusions. The data demonstrated that ECs derived from normal brain and from GBMs have significant phenotypic and functional distinctions. Further characterization of brain tumor ECs is essential for efficient antiangiogenic treatment of gliomas.

Cerebral radiation necrosis simulating a brain tumor

1974 ◽  
Vol 40 (2) ◽  
pp. 267-271 ◽  
Author(s):  
E. Fletcher Eyster ◽  
Surl L. Nielsen ◽  
Glenn E. Sheline ◽  
Charles B. Wilson
Keyword(s):  
Brain Tumor ◽  
Intracranial Pressure ◽  
Frontal Lobe ◽  
Radiation Necrosis ◽  
Increased Intracranial Pressure ◽  
Content Type ◽  
Cerebral Radiation Necrosis ◽  
Tentorial Herniation ◽  
The Brain ◽  
Fine Print

✓ Two years after undergoing irradiation for a malignant ethmoid tumor, a 50-year-old man developed signs of increased intracranial pressure, an expanding right frontal lobe mass, and tentorial herniation. Operation revealed a mass that grossly appeared to be a glioma, but microscopically proved to be radiation necrosis of the brain.

Induction of human autologous cytotoxic T lymphocytes against minced tissues of glioblastoma multiforme

1996 ◽  
Vol 84 (2) ◽  
pp. 258-263 ◽  
Author(s):  
Hideo Tsurushima ◽  
Shu Qin Liu ◽  
Koji Tsuboi ◽  
Yoshihiko Yoshii ◽  
Tadao Nose ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Glioblastoma Multiforme ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
K562 Cells ◽  
Peripheral Blood Lymphocytes ◽  
Autologous Plasma ◽  
Content Type ◽  
Brain Tumor Cells ◽  
The Brain

✓ The authors induced autologous cytotoxic T lymphocytes (CTLs) directly from peripheral blood lymphocytes by preparing a coculture of minced tissue fragments of glioblastoma multiforme (GBM) with interleukins-1, -2, -4, and -6 and interferon-g in RHAMa medium containing 5% autologous plasma for 2 weeks. At the end of this period, the frequencies of CD3+, CD4+, CD8+, and CD16+ lymphocytes were 95% to 99%, 40% to 62%, 37% to 38%, and 0.2%, respectively. The lymphocytes killed 82% to 100% of the GBM cells within 48 hours at an effector-to-target cell ratio of 1.67, whereas in a separate coculture, autologous lymphokine-activated killer (LAK) cells killed only 33% of GBM cells under the same conditions. The lymphocytes showed no cytotoxicity against LAK-sensitive Daudi cells, natural killer—sensitive K562 cells or autologous fibroblasts grown from the brain tumor, although they did show slight cytotoxicities against allogeneic GBM cell lines. These results lead the authors to suggest that the lymphocyte population contains specific CTLs for autologous brain tumor cells and that these CTLs could be effective in adoptive immunotherapy to combat brain tumor.

Sign in / Sign up

Export Citation Format

Share Document