Lymph node metastasis as first manifestation of glioblastoma

1974 ◽  
Vol 41 (5) ◽  
pp. 607-609 ◽  
Author(s):  
Clarisse L. Dolman
Keyword(s):  
Brain Tumor ◽  
Lymph Node ◽  
Glioblastoma Multiforme ◽  
Lymph Node Metastasis ◽  
Young Woman ◽  
Tumor Tissue ◽  
Malignant Cells ◽  
Content Type ◽  
Node Metastasis ◽  
Fine Print

✓ An enlarged parotid lymph node excised from a young woman contained malignant cells. Three weeks later she developed signs of a brain tumor and died despite irradiation. Autopsy revealed a large frontal lobe glioblastoma multiforme which had infiltrated the dura. The lymph node, which had been the first manifestation of disease, contained identical tumor tissue.

Variation in response to CCNU of glioblastoma multiforme in brain and cervical lymph node

1985 ◽  
Vol 62 (6) ◽  
pp. 918-921 ◽  
Author(s):  
Paul Steinbok ◽  
Clarisse L. Dolman ◽  
James H. Goldie
Keyword(s):  
Lymph Node ◽  
Glioblastoma Multiforme ◽  
Lymph Node Metastasis ◽  
Cervical Lymph Node ◽  
Cervical Lymph Node Metastasis ◽  
Content Type ◽  
Node Metastasis ◽  
Fine Print

✓ The case is reported of a patient in whom a cervical lymph node metastasis decreased in size while the primary intracranial glioblastoma continued to grow during chemotherapy with CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea). This is the first such case reported in humans. Possible explanations for this phenomenon are discussed.

Glioblastoma multiforme at the site of metal splinter injury: a coincidence?

1999 ◽  
Vol 91 (6) ◽  
pp. 1041-1044 ◽  
Author(s):  
Michael Sabel ◽  
Jörg Felsberg ◽  
Martina Messing-Jünger ◽  
Eva Neuen-Jacob ◽  
Jürgen Piek
Keyword(s):  
Brain Tumor ◽  
Glioblastoma Multiforme ◽  
Malignant Glioma ◽  
Causal Relationship ◽  
Propionibacterium Acnes ◽  
Glioma Tissue ◽  
Left Frontal Lobe ◽  
Content Type ◽  
Chronic Abscess ◽  
Fine Print

✓ The authors report the case of a man who had suffered a penetrating metal splinter injury to the left frontal lobe at 18 years of age. Thirty-seven years later the patient developed a left-sided frontal tumor at the precise site of the meningocerebral scar and posttraumatic defect. Histological examination confirmed a glioblastoma multiforme adjacent to the dural scar and metal splinters. In addition, a chronic abscess from which Propionibacterium acnes was isolated was found within the glioma tissue. The temporal and local association of metal splinter injury with chronic abscess, scar formation, and malignant glioma is highly suggestive of a causal relationship between trauma and the development of a malignant brain tumor.

Metastases of glioblastoma multiforme to cervical lymph nodes

1973 ◽  
Vol 38 (5) ◽  
pp. 631-634 ◽  
Author(s):  
Sayed El-Gindi ◽  
Mamdouh Salama ◽  
Mokhtar El-Henawy ◽  
Said Farag
Keyword(s):  
Brain Tumor ◽  
Glioblastoma Multiforme ◽  
Lymph Nodes ◽  
Metastatic Lesion ◽  
Cervical Lymph Nodes ◽  
Content Type ◽  
The Brain ◽  
Fine Print

✓ Two cases of occipital glioblastoma multiforme are reported in which a metastatic lesion involving the cervical lymph nodes on the side of the previous craniotomy was verified during life. This suggests to the authors that the brain tumor metastasized via lymphatic channels.

scholarly journals Copy number variations in primary tumor, serum and lymph node metastasis of bladder cancer patients treated with radical cystectomy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Armin Soave ◽  
Lan Kluwe ◽  
Hang Yu ◽  
Michael Rink ◽  
Philipp Gild ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Primary Tumor ◽  
Tumor Suppressor Genes ◽  
Copy Number ◽  
Genomic Dna ◽  
Tumor Tissue ◽  
Disease Recurrence ◽  
Copy Number Variations ◽  
Node Metastasis

AbstractThe aim of the present study was to analyze copy number variations (CNV) of multiple oncogenes and tumor suppressor genes in genomic DNA from primary tumor tissue, lymph node metastasis and cell-free DNA (cfDNA) from serum of 72 urothelial carcinoma of bladder (UCB) patients treated with radical cystectomy (RC), using multiplex ligation-dependent probe amplification (MLPA). We hypothesized that primary tumor and lymph node metastasis show similar CNV profiles, and CNV are more present in lymph node metastasis compared to primary tumor tissue. Samples from 43 (59.7%) patients could be analyzed. In total, 35 (83%), 26 (68%) and 8 (42%) patients had CNV in primary tumor, serum and lymph node metastasis, respectively. MYC, CCND1, ERBB2 and CCNE1 displayed the most frequent amplifications. In particular, CNV in ERBB2 was associated with aggressive tumor characteristics. CNV in both ERBB2 and TOP2A were risk factors for disease recurrence. The current findings show that CNV are present in various oncogenes and tumor suppressor genes in genomic DNA from primary tumor, lymph node metastasis and cfDNA from serum. CNV were more present in genomic DNA from primary tumor tissue compared to cfDNA from serum and genomic DNA from lymph node metastasis. Patients with CNV in ERBB2 and TOP2A are at increased risk for disease recurrence following RC. Further studies are necessary to validate, whether these genes may represent promising candidates for targeted-therapy.

Sign in / Sign up

Export Citation Format

Share Document