Ultrastructural evidence for CSF production by a choroid plexus papilloma

1976 ◽  
Vol 45 (4) ◽  
pp. 409-415 ◽  
Author(s):  
Nitya R. Ghatak ◽  
Joe M. McWhorter
Keyword(s):  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Communicating Hydrocephalus ◽  
Content Type ◽  
Structural Details ◽  
Fluid Production ◽  
Pinocytotic Vesicles ◽  
Fenestrated Endothelium ◽  
Plexus Papilloma ◽  
Tubular Bodies

✓ A choroid plexus papilloma (CPP) removed from a child with communicating hydrocephalus was studied with the electron microscope. In addition to the usual organelles, the neoplastic epithelial cells contained polypoid microvilli, cilia, coated pinocytotic vesicles, and apical tight junctions. The basal surfaces were consistently juxtaposed to large capillaries lined by fenestrated endothelium. The fine structural details of the tumor were essentially the same as those of normal CP and thus appeared ideally suited for an active secretory function. Two additional features in this tumor were tubular bodies in the endothelium and well developed pericytes. The present findings provide strong evidence for cerebrospinal fluid production by CPP, a phenomenon that has long been suggested by clinical observation.

Third ventricular choroid plexus papilloma with psychosis

1997 ◽  
Vol 87 (1) ◽  
pp. 103-105 ◽  
Author(s):  
Benjamin S. Carson ◽  
Jon D. Weingart ◽  
Michael Guarnieri ◽  
Paul G. Fisher
Keyword(s):  
Choroid Plexus ◽  
Behavioral Problems ◽  
Third Ventricle ◽  
Choroid Plexus Papilloma ◽  
Pathological Examination ◽  
Psychiatric Evaluation ◽  
Content Type ◽  
Resected Tumor ◽  
History Of ◽  
Plexus Papilloma

✓ This 9-year-old boy with a history of behavioral problems and worsening psychosis responded initially to treatment with haloperidol. However, a magnetic resonance image obtained as part of his psychiatric evaluation revealed an anterior third ventricle tumor and mild-to-moderate hydrocephalus. The resected tumor was found on pathological examination to be a choroid plexus papilloma. The patient had an uneventful postoperative course and remained free of psychosis or mood disorder at 1-year follow-up examination.

Intrinsic brainstem choroid plexus papilloma

2004 ◽  
Vol 100 (6) ◽  
pp. 1076-1078 ◽  
Author(s):  
Ashok Pillai ◽  
Kariyattil Rajeev ◽  
Sushil Chandi ◽  
Muthukuttiparambil Unnikrishnan
Keyword(s):  
Central Nervous System ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Residual Tumor ◽  
Brainstem Lesion ◽  
Content Type ◽  
The Central Nervous System ◽  
Choroid Plexus Papillomas ◽  
Fine Print ◽  
Plexus Papilloma

✓ The authors report an intrinsic brainstem lesion that was diagnosed initially as a pontine cavernoma, which finally proved to be a choroid plexus papilloma. Choroid plexus papillomas are rare tumors of the central nervous system and are usually intraventricular in location. The occurrence of this tumor in an intraparenchymal location is extremely rare, and its occurrence within the brainstem is previously unreported. The authors also report a trial of chemotherapy with lomustine in the management of the residual tumor.

Malignant choroid plexus papilloma with extraneural metastasis

1980 ◽  
Vol 52 (2) ◽  
pp. 251-255 ◽  
Author(s):  
Joao B. Valladares ◽  
Robert H. Perry ◽  
Ramanand M. Kalbag
Keyword(s):  
Survival Time ◽  
Choroid Plexus ◽  
Lateral Ventricle ◽  
Choroid Plexus Papilloma ◽  
Content Type ◽  
Long Survival ◽  
Extraneural Metastasis ◽  
Fine Print ◽  
Plexus Papilloma

✓ The authors describe and discuss a case of malignant choroid plexus papilloma originating in the lateral ventricle of an 11-month-old child. Unusual features include a long survival time of 9 years and the presence of an extraneural malignant deposit, probably metastatic in origin.

scholarly journals Choroid Plexus Papilloma with Dandy Walker Variant: Co-existence or Association- A Case Report

2019 ◽  
Vol 46 (2) ◽  
pp. 61-65
Author(s):  
Mohammad Hossain ◽  
Nazmin Ahmed ◽  
Narendra Shalike ◽  
Md Rokibul Islam ◽  
Soumen Samadder ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Communicating Hydrocephalus ◽  
Intermediate Form ◽  
Genetic Syndromes ◽  
Who Grade ◽  
Choroid Plexus Tumors ◽  
Well Differentiated ◽  
Central Nervous Sytem ◽  
Plexus Papilloma

Choroid plexus tumors are rare intracranial tumors which account for 0.4-0.6% of all brain tumors. Choroid plexus tumors represent a spectrum of neoplasms derived from papillary epithelium of normal choroid plexus, including well-differentiated papilloma (WHO grade I), intermediate form as atypical Choroid Plexus Papilloma (WHO grade II) and highly aggressive choroid plexus carcinomas (WHO grade III). Though rare, it is responsible for the communicating hydrocephalus in children due to overproduction of cerebrospinal fluid. Due to advances in molecular biology and better understanding of the tumorigenesis of choroid plexus papilloma, now it is established that several genetic syndromes and central nervous sytem abnormalities are associated with this tumor. Here, we reported a case of a 10 months old child who presented with sudden deterioration of consciousness level and after thorough evaluation, diagnosed as a case of Choroid Plexus Papilloma with Dandy Walker Variant. Till date, this is the first reported case of the association/ co-existence of such two conditions which needs further evaluation. Bangladesh Med J. 2017 May; 46 (2): 61-65

Bobble—head doll syndrome and drop attacks in a child with a cystic choroid plexus papilloma of the third ventricle

1995 ◽  
Vol 83 (4) ◽  
pp. 729-732 ◽  
Author(s):  
Ian F. Pollack ◽  
Nina F. Schor ◽  
A. Julio Martinez ◽  
Richard Towbin
Keyword(s):  
Choroid Plexus ◽  
Third Ventricle ◽  
Choroid Plexus Papilloma ◽  
Head Tilt ◽  
Foramen Of Monro ◽  
Drop Attacks ◽  
Content Type ◽  
The Third ◽  
Head Bobbing ◽  
Plexus Papilloma

✓ The authors report an unusual case of a 2-year-old boy with a 3-month history of episodic rightward anterolateral head tilt and large-amplitude positional anteroposterior head bobbing reminiscent of bobble—head doll syndrome. This child experienced a sudden onset of drop attacks and then, within several hours, deep coma. The causative lesion was a contrast-enhancing, partially cystic third ventricular mass, which ultimately obstructed the aqueduct, producing profound obstructive hydrocephalus. An emergency ventriculostomy and endoscopic fenestration of the septum pellucidum was performed. Four days later, the tumor was completely resected by a transcallosal—transforaminal approach. The lesion was freely mobile within the third ventricle and contained a large cyst within its posterior pole; following drainage of the cyst, the lesion was easily delivered through the foramen of Monro. The histopathological diagnosis was choroid plexus papilloma. The child's neurological deficits, head tilt, and head bobbing resolved immediately after operation. To the best of the authors' knowledge, this represents the first well-documented report of bobble—head doll syndrome and drop attacks secondary to a choroid plexus papilloma. The highly mobile nature of the cystic lesion presumably led to its intermittent impaction within the foramen of Monro and/or proximal aqueduct; this produced the intermittent head tilt and bobble-head symptoms and, ultimately, resulted in acute obstruction of the aqueduct, causing the child's precipitous neurological decline.

Diffuse craniospinal seeding from a benign fourth ventricle choroid plexus papilloma

1998 ◽  
Vol 88 (4) ◽  
pp. 757-760 ◽  
Author(s):  
Richard Leblanc ◽  
Sabah Bekhor ◽  
Denis Melanson ◽  
Stirling Carpenter
Keyword(s):  
Choroid Plexus ◽  
Fourth Ventricle ◽  
Obstructive Hydrocephalus ◽  
Choroid Plexus Papilloma ◽  
Blurred Vision ◽  
Content Type ◽  
Biological Potential ◽  
History Of ◽  
Fine Print ◽  
Plexus Papilloma

✓ Choroid plexus papillomas can metastasize to the subarachnoid space, but extensive metastasis has only been reported when the tumors are malignant. The authors report a case of diffuse, extensive metastasis to the craniospinal leptomeninges from a benign fourth ventricular choroid plexus papilloma in an adult. This 19-year-old woman presented with a 2-year history of headache, blurred vision, diplopia, and ataxia. Magnetic resonance imaging of the brain and spinal cord revealed obstructive hydrocephalus caused by a 4-cm, partially calcified, inhomogeneously enhancing tumor of the fourth ventricle that was displacing the pons, medulla oblongata, and cerebellum. Innumerable cystic lesions of varying size were also seen in the cranial and spinal leptomeninges. Histological examination of the resected fourth ventricular tumor and of a few of the leptomeningeal lesions revealed a benign choroid plexus papilloma and leptomeningeal choroid plexus cysts. This singular case of diffuse and extensive metastasis to the craniospinal leptomeninges from a histologically benign fourth ventricular papilloma adds to the available information about the biological potential of these tumors and expands the differential diagnosis of posterior fossa lesions with subarachnoid metastasis.

Unusual case of extradural choroid plexus papilloma of the sacral canal

2002 ◽  
Vol 97 (1) ◽  
pp. 102-105 ◽  
Author(s):  
Özlem Kurtkaya-Yapicier ◽  
Bernd W. Scheithauer ◽  
Karl Peter Van Peteghem ◽  
John E. Sawicki
Keyword(s):  
Mr Imaging ◽  
Choroid Plexus ◽  
Unusual Case ◽  
Choroid Plexus Papilloma ◽  
Cavum Septum Pellucidum ◽  
Content Type ◽  
Contrast Enhanced ◽  
Resected Tumor ◽  
Sacral Canal ◽  
Plexus Papilloma

✓ An unusual case of a sacral, extradural choroid plexus papilloma involving the S1–3 level is described. This 50-year-old woman presented with a 4-month history of pain involving her right buttock, perineum, and leg. Contrast-enhanced magnetic resonance (MR) imaging of the spine revealed a well-defined, mildly enhancing sacral canal mass at the S1–3 level; its appearance was consistent with that of a benign tumor. Intraoperatively, the lesion was found to be extradural in location and was entwined among nerve roots in the sacral canal. Microscopic examination of the gross totally resected tumor revealed typical features of a choroid plexus papilloma. Despite performing a thorough neuroimaging workup (craniospinal contrast-enhanced MR imaging) for an intracranial or spinal primary mass, none was found. The choroid plexus appeared entirely normal; however, both a cavum septum pellucidum and a cavum vergae were noted. Extraneural choroid plexus papilloma, specifically intrasacral, extradural choroid plexus papilloma has not been previously reported. The present example is thought to have arisen either from ectopic choroid plexus tissue or perhaps by metaplasia from ependymal rests.

Radiation therapy of a choroid plexus papilloma of the cerebellopontine angle with bone involvement

1981 ◽  
Vol 54 (2) ◽  
pp. 245-247 ◽  
Author(s):  
Mahmoud G. Naguib ◽  
Shelley N. Chou ◽  
Angeline Mastri
Keyword(s):  
Radiation Therapy ◽  
Choroid Plexus ◽  
Cerebellopontine Angle ◽  
Choroid Plexus Papilloma ◽  
Bone Destruction ◽  
Bone Involvement ◽  
Content Type ◽  
Fine Print ◽  
Plexus Papilloma

✓ A case is reported of cerebellopontine angle choroid plexus papilloma with overlying bone destruction. Its favorable response to radiation therapy following subtotal excision is described.

Segmental myoclonus as the sole manifestation of a choroid plexus papilloma in the posterior fossa

2001 ◽  
Vol 95 (2) ◽  
pp. 338-340
Author(s):  
Elisabeth Chroni ◽  
Christos Paschalis ◽  
Dimitris Konstantinou ◽  
Theodoros Maraziotis ◽  
Michalis Bonas ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Posterior Fossa ◽  
Choroid Plexus Papilloma ◽  
Signs And Symptoms ◽  
Pathophysiological Mechanism ◽  
Increased Intracranial Pressure ◽  
Content Type ◽  
Cranial Nerve Palsies ◽  
Muscle Groups ◽  
Plexus Papilloma

✓ The authors describe the case of a 22-year-old woman with involuntary contractions of the sternocleidomastoid and trapezius muscles that resulted in turning movements of the head. The jerks displayed the clinical and neurophysiological characteristics of segmental myoclonus (SM) restricted to muscles supplied bilaterally by the first four cervical segments. Magnetic resonance imaging disclosed a tumor in the midline above the cisterna magna that was later histologically proven to be a choroid plexus papilloma. The patient's involuntary movements did not extend to other muscle groups or, in particular, to the palate, as one might have expected in the case of brainstem lesions. Myoclonus was the sole clinical manifestation of the tumor in this patient; other signs and symptoms invariably reported in other cases of posterior fossa papilloma, such as increased intracranial pressure or cranial nerve palsies, were absent. Release from suprasegmental control is suggested as a possible pathophysiological mechanism in this case of SM.

Adult choroid plexus papilloma of the posterior fossa mimicking a hemangioblastoma

2000 ◽  
Vol 92 (5) ◽  
pp. 870-872 ◽  
Author(s):  
Roberto García-Valtuille ◽  
Faustino Abascal ◽  
Ana I. García-Valtuille ◽  
J. Ignacio Pinto ◽  
Luis Cerezal ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Choroid Plexus ◽  
Posterior Fossa ◽  
Choroid Plexus Papilloma ◽  
Mr Images ◽  
Content Type ◽  
Tomography Imaging ◽  
Fine Print ◽  
Plexus Papilloma

✓ The authors report a case of cystic choroid plexus papilloma that originated in the posterior fossa. No connection with the ventricular system was found intraoperatively. Magnetic resonance (MR) and computerized tomography imaging did not furnish a diagnosis, but findings of pathological examinations were consistent with those of choroid plexus papilloma. The authors describe the different appearances of the tumor on MR images and discuss the differential diagnosis with other tumors of the posterior fossa.

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