Recurrent subependymal giant-cell astrocytoma in the absence of tuberous sclerosis

✓ A case is described of a subependymal giant-cell astrocytoma that occurred as a mural nodule within a cyst in the parietal lobe. The tumor recurred twice over a period of 47 years despite two extensive surgical resections. Neither the patient nor any of his children suffered tuberous sclerosis, a disease with which this type of astrocytoma is associated.

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Subependymal giant-cell astrocytoma

Journal of Neurosurgery ◽

10.3171/jns.1979.50.2.0240 ◽

1979 ◽

Vol 50 (2) ◽

pp. 240-245 ◽

Cited By ~ 27

Author(s):

Anders A. F. Sima ◽

David M. Robertson

Keyword(s):

Tuberous Sclerosis ◽

Giant Cell ◽

Tumor Cells ◽

Clinical Investigation ◽

Pathological Examination ◽

Subependymal Giant Cell Astrocytoma ◽

Ultrastructural Examination ◽

Content Type ◽

Fine Print ◽

Giant Cell Astrocytoma

✓ A 13-year-old boy presented with an obstructive left lateral intraventricular mass. Pathological examination revealed a subependymal giant-cell astrocytoma. Further clinical investigation confirmed the diagnosis of tuberous sclerosis. Ultrastructural examination confirmed previously reported features of this tumor. Tumor cells containing large dense granulated bodies and dense-core vesicles, not previously described in this tumor, were identified.

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Sequential CT study of subependymal giant-cell astrocytoma associated with tuberous sclerosis

Journal of Neurosurgery ◽

10.3171/jns.1986.65.6.0874 ◽

1986 ◽

Vol 65 (6) ◽

pp. 874-877 ◽

Cited By ~ 56

Author(s):

Kazuyoshi Morimoto ◽

Heitaro Mogami

Keyword(s):

Tuberous Sclerosis ◽

Giant Cell ◽

Computerized Tomography ◽

Growth Pattern ◽

Diagnosis And Treatment ◽

Subependymal Giant Cell Astrocytoma ◽

Pertinent Literature ◽

Content Type ◽

Fine Print ◽

Giant Cell Astrocytoma

✓ The authors describe the growth pattern of a subependymal giant-cell astrocytoma associated with tuberous sclerosis, which was documented by sequential computerized tomography scans over 7 years. The diagnosis and treatment of this tumor are discussed, and the pertinent literature is reviewed.

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Subependymal giant-cell astrocytoma in children

Journal of Neurosurgery ◽

10.3171/jns.1988.68.6.0880 ◽

1988 ◽

Vol 68 (6) ◽

pp. 880-883 ◽

Cited By ~ 34

Author(s):

Chung W. Chow ◽

Geoffrey L. Klug ◽

Elizabeth A. Lewis

Keyword(s):

Giant Cell ◽

Subependymal Giant Cell Astrocytoma ◽

Low Grade ◽

High Grade ◽

Content Type ◽

Large Numbers ◽

Aggressive Tumor ◽

Fine Print ◽

Giant Cell Astrocytoma

✓ The authors describe five cases of subependymal giant-cell astrocytoma in children in which many clinical, histological, immunohistochemical, and ultrastructural features typical of this tumor were present. However, prominent focal necrosis and mitoses, features usually associated with high-grade tumors, were seen in all cases. Despite the presence of necrosis and mitoses, clinical follow-up studies have revealed a lack of aggressive tumor behavior after surgery alone. The discrepancy between the histological and clinical features in these cases is emphasized so that excessive treatment of a basically low-grade tumor may be avoided. Mast cells were seen in all five cases, often in large numbers.

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