Seprafilm superior to Gore-Tex in the prevention of peridural fibrosis

2004 ◽  
Vol 101 (2) ◽  
pp. 295-302 ◽  
Author(s):  
Cahide Topsakal ◽  
Nusret Akpolat ◽  
Fatih Serhat Erol ◽  
Mehmet Faik Ozveren ◽  
Ismail Akdemir ◽  
...  
Keyword(s):  
Dura Mater ◽  
Spinal Surgery ◽  
Histological Study ◽  
Scar Tissue ◽  
Content Type ◽  
Treatment Groups ◽  
Barrier Membranes ◽  
Peridural Fibrosis ◽  
Fine Print ◽  
Better Than

Object. This is an investigation into the effects of two barrier membranes in the prevention of peridural fibrosis in an animal model. Methods. Seprafilm or Gore-Tex was applied to a laminectomy defect overlying the dura mater in rats separated into treatment groups. A third group of rats underwent laminectomy only and served as controls. Two months postoperatively a histological study was performed to compare the amount of scar tissue in each group. The gross dissection demonstrated that both membranes created a controlled dissection plane, facilitated access to the epidural space, and provided a reduction in the amount of tissue adhering to the dura mater. Statistically, Seprafilm was superior to Gore-Tex in preventing peridural fibrosis (p < 0.05). Conclusions. Seprafilm can prevent peridural fibrosis better than Gore-Tex and can be used in humans in spinal surgery.

Technical advantages of an ultrasonic bone curette in spinal surgery

2005 ◽  
Vol 2 (4) ◽  
pp. 431-435 ◽  
Author(s):  
Hiroshi Nakagawa ◽  
Sang-Don Kim ◽  
Junichi Mizuno ◽  
Yukoh Ohara ◽  
Kiyoshi Ito
Keyword(s):  
Dura Mater ◽  
Spinal Surgery ◽  
High Speed ◽  
Neural Tissue ◽  
Foramen Magnum ◽  
Spinal Diseases ◽  
Safety And Efficacy ◽  
Content Type ◽  
Excessive Heat ◽  
Fine Print

Object. The authors discuss the safety and efficacy of an ultrasonic bone curette in various spinal surgeries and report its advantages in clinical application. Methods. Between April 2002 and September 2003, 76 patients with various spinal diseases (29 cervical, five thoracic, 40 lumbosacral, and two foramen magnum regions) were treated microsurgically by using a Sonopet ultrasonic bone curette with longitudinal and torsional tips and lightweight handpieces. The operations were performed successfully and the device was easy to handle. There were no instrument-related complications or -induced damage to any structure even when removing osseous spurs or ossified lesions near the dura mater, nerves, and vessels. Conclusions. The ultrasonic curette is a useful instrument for procedures performed near the dura mater or other neural tissue without excessive heat production or mechanical injury. This device is recommended for various spinal surgeries in addition to high-speed drills or other tools.

Combined PGI2, indomethacin, and heparin improves neurological recovery after spinal trauma in cats

1983 ◽  
Vol 58 (5) ◽  
pp. 749-754 ◽  
Author(s):  
John M. Hallenbeck ◽  
Thomas P. Jacobs ◽  
Alan I. Faden
Keyword(s):  
Drug Therapy ◽  
Spinal Injury ◽  
Combined Treatment ◽  
Spinal Trauma ◽  
Pharmacological Management ◽  
Content Type ◽  
Treatment Groups ◽  
Opiate Antagonists ◽  
Fine Print ◽  
Better Than

✓ Anesthetized cats were subjected to standardized cervical spinal trauma produced by a modification of the Allen weight-dropping method. One hour after injury, animals were randomly allocated to one of three treatment groups, in which they received 1) saline, 2) naloxone, or 3) combined treatment, consisting of indomethacin, heparin, and prostacyclin (PGI2). Treatment was continued for 4 hours. Neurological function was evaluated weekly by a neurologist unaware of the treatment group, and was graded by means of a scale modified from that of Tarlov. Functional recovery in animals receiving combined drug therapy was significantly better than in saline-treated control animals, and was similar to that observed in naloxone-treated animals. The findings are discussed with respect to “blood-damaged tissue interaction” and may have implications both with regard to the pharmacological management of acute spinal injury and to the mechanism of action of opiate antagonists.

Neuroepithelial cyst in the optic nerve

1987 ◽  
Vol 67 (1) ◽  
pp. 137-139 ◽  
Author(s):  
Alberto Isla ◽  
José Palacios ◽  
José M. Roda ◽  
Manuel Gutierrez ◽  
Cesáreo González ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Computerized Tomography ◽  
Cystic Lesion ◽  
Histological Study ◽  
Content Type ◽  
Neuroepithelial Cyst ◽  
Loss Of Vision ◽  
Progressive Loss ◽  
Suprasellar Region ◽  
Fine Print

✓ A 34-year-old woman presented with progressive loss of vision in her left eye of 2 months' evolution. Computerized tomography showed a hypodense lesion in the suprasellar region. At surgery a cystic lesion was found inside the optic nerve. Histological study proved it to be a neuroepithelial cyst. The pathogenesis of a neuroepithelial cyst in such an exceptional site is discussed.

Diagnosis and treatment of Ogilvie's syndrome after lumbar spinal surgery

1992 ◽  
Vol 76 (6) ◽  
pp. 1012-1016 ◽  
Author(s):  
Robert A. Feldman ◽  
Richard C. Karl
Keyword(s):  
Spinal Surgery ◽  
Mechanical Obstruction ◽  
Ogilvie's Syndrome ◽  
Ogilvie’S Syndrome ◽  
Content Type ◽  
Cecal Perforation ◽  
Life Threatening ◽  
Lumbar Spinal Surgery ◽  
Lumbar Spinal ◽  
Fine Print

✓ Three patients who developed Ogilvie's syndrome following lumbar spinal surgery are described. Ogilvie's syndrome, also known as pseudo-obstruction of the colon, is characterized by massive cecal distention without mechanical obstruction. If this condition is not recognized and not promptly treated, it may be complicated by cecal perforation, a life-threatening hazard. The etiology, diagnosis, management, and potential relationship between lumbar spinal surgery and Ogilvie's syndrome are discussed.

No additional neuroprotection provided by barbiturate-induced burst suppression under mild hypothermic conditions in rats subjected to reversible focal ischemia

2000 ◽  
Vol 93 (5) ◽  
pp. 835-844 ◽  
Author(s):  
Thomas Westermaier ◽  
Stefan Zausinger ◽  
Alexander Baethmann ◽  
Hans-Jakob Steiger ◽  
Robert Schmid-Elsaesser
Keyword(s):  
Mild Hypothermia ◽  
Artery Occlusion ◽  
Burst Suppression ◽  
Moderate Hypothermia ◽  
Sprague Dawley ◽  
Doppler Flowmetry ◽  
Content Type ◽  
Treatment Groups ◽  
Cerebral Artery Occlusion ◽  
Fine Print

Object. Mild-to-moderate hypothermia is increasingly used for neuroprotection in humans. However, it is unknown whether administration of barbiturate medications in burst-suppressive doses—the gold standard of neuroprotection during neurovascular procedures—provides an additional protective effect under hypothermic conditions. The authors conducted the present study to answer this question.Methods. Thirty-two Sprague—Dawley rats were subjected to 90 minutes of middle cerebral artery occlusion and randomly assigned to one of four treatment groups: 1) normothermic controls; 2) methohexital treatment (burst suppression); 3) induction of mild hypothermia (33°C); and 4) induction of mild hypothermia plus methohexital treatment (burst suppression). Local cerebral blood flow was continuously monitored using bilateral laser Doppler flowmetry and electroencephalography. Functional deficits were quantified and recorded during daily neurological examinations. Infarct volumes were assessed histologically after 7 days. Methohexital treatment, mild hypothermia, and mild hypothermia plus methohexital treatment reduced infarct volumes by 32%, 71%, and 66%, respectively, compared with normothermic controls. Furthermore, mild hypothermia therapy provided the best functional outcome, which was not improved by additional barbiturate therapy.Conclusions. The results of this study indicate that barbiturate-induced burst suppression is not required to achieve maximum neuroprotection under mild hypothermic conditions. The magnitude of protection afforded by barbiturates alone appears to be modest compared with that provided by mild hypothermia.

Application of frameless stereotaxy to pedicle screw fixation of the spine

1995 ◽  
Vol 83 (4) ◽  
pp. 641-647 ◽  
Author(s):  
Iain H. Kalfas ◽  
Donald W. Kormos ◽  
Michael A. Murphy ◽  
Rick L. McKenzie ◽  
Gene H. Barnett ◽  
...  
Keyword(s):  
Pedicle Screw ◽  
Spinal Surgery ◽  
Screw Fixation ◽  
Ct Images ◽  
Pedicle Screw Fixation ◽  
Lumbosacral Spine ◽  
Frameless Stereotaxy ◽  
Content Type ◽  
Screw Length ◽  
Fine Print

✓ Interactive frameless stereotaxy has been successfully applied to intracranial surgery. It has contributed to the improved localization of deep-seated brain lesions and has demonstrated a potential for reducing both operative time and morbidity. However, it has not been as effectively applied to spinal surgery. The authors describe the application of frameless stereotactic techniques to spinal surgery, specifically pedicle screw fixation of the lumbosacral spine. Preoperative axial computerized tomography (CT) images of the appropriate spinal segments are obtained and loaded onto a high-speed graphics supercomputer workstation. Intraoperatively, these images can be linked to the appropriate spinal anatomy by a sonic localization digitizer device that is interfaced with the computer workstation. This permits the surgeon to place a pointing device (sonic wand) on any exposed spinal bone landmark in the operative field and obtain multiplanar reconstructed CT images projected in near-real time on the workstation screen. The images can be manipulated to assist the surgeon in determining the proper entry point for a pedicle screw as well as defining the appropriate trajectory in the axial and sagittal planes. It can also define the correct screw length and diameter for each pedicle to be instrumented. The authors applied this device to the insertion of 150 screws into the lumbosacral spines of 30 patients. One hundred forty-nine screws were assessed to be satisfactorily placed by postoperative CT and plain film radiography. In this report the authors discuss their use of this device in the clinical setting and review their preliminary results of frameless stereotaxy applied to spinal surgery. On the basis of their findings, the authors conclude that frameless stereotactic technology can be successfully applied to spinal surgery.

The straight sinus

1974 ◽  
Vol 41 (6) ◽  
pp. 724-727 ◽  
Author(s):  
R. C. Saxena ◽  
M. A. Q. Beg ◽  
A. C. Das
Keyword(s):  
Dura Mater ◽  
Posterior Cranial Fossa ◽  
Cerebral Vein ◽  
Content Type ◽  
Straight Sinus ◽  
Sagittal Sinus ◽  
India Ink ◽  
Human Cadavers ◽  
Cranial Fossa ◽  
Fine Print

✓ The dura mater of the posterior cranial fossa of 86 adult human cadavers has been examined grossly after the injection of India ink through the confluence of sinuses in order to visualize the extent, communications, and tributaries of the straight sinus. Variations from the textbook description of formation by the union of the inferior sagittal sinus and the great cerebral vein are described and discussed.

Tumor-associated neurological dysfunction prevented by lazaroids in rats

1991 ◽  
Vol 74 (1) ◽  
pp. 112-115 ◽  
Author(s):  
Wesley A. King ◽  
Keith L. Black ◽  
Kiyonobu Ikezaki ◽  
Scott Conklin ◽  
Donald P. Becker
Keyword(s):  
Vascular Permeability ◽  
Tumor Model ◽  
Neurological Dysfunction ◽  
Control Group ◽  
Content Type ◽  
Brain Tumor Model ◽  
Walker 256 ◽  
Walker 256 Tumors ◽  
Fine Print ◽  
Better Than

✓ The efficacy of U-74006F and U-78517F in the treatment of blood-tumor barrier permeability and tumor-associated neurological dysfunction was evaluated in a brain-tumor model in rats. U-74006F is a 21-aminosteroid and U-78517F is a 2-methylamino chroman. Rats with stereotactically implanted Walker 256 tumors were treated with methylprednisolone, U-74006F, U-78517F, or vehicle (0.05 N HCl) on Days 6 through 10 following implantation. Neurological function and vascular permeability were assessed on Day 10. Methylprednisolone and U-74006F were equally effective at preventing neurological dysfunction compared to the control group (p < 0.01); U-78517F was slightly less effective than U-74006F and methylprednisolone but was significantly better than vehicle in preventing neurological dysfunction. Delivery of methylprednisolone resulted in a significant decrease in tumor vascular permeability (p < 0.006) while U-74006F and U-78517F had no effect on permeability. This suggests that U-74006F and U-78517F prevented tumor-associated neurological dysfunction by a mechanism other than decreasing permeability in tumor capillaries, and that U-74006F or U-78517F could prove useful in the treatment of brain tumors.

Anatomical features of the straight sinus and its tributaries

1976 ◽  
Vol 44 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Jefferson Browder ◽  
Harry A. Kaplan ◽  
Abbott J. Krieger
Keyword(s):  
Dura Mater ◽  
Vein Of Galen ◽  
Main Trunk ◽  
Content Type ◽  
Tentorium Cerebelli ◽  
Anatomical Features ◽  
Straight Sinus ◽  
Sagittal Sinus ◽  
Collateral Pathways ◽  
Fine Print

✓ The authors report a variety of arrangements of the venous channels comprising the straight sinus (sinus rectus) and its connections during a continuing study of the cerebral sinuses and their tributaries. In approximately 85% of 131 specimens of dura mater with enclosed venous sinuses derived from fresh cadavers, the straight sinus was represented by a single midline tentorial channel whereas in the remaining 15%, segments of it were doubled and in a few, tripled. In addition to these aberrations in the development of the main trunk of this sinus, the venous patterns at the junctions of the inferior sagittal sinus, vein of Galen and straight sinus showed comparable developmental inconstancies. Also in no specimens were the patterns of venous channels in the leaves of the tentorium cerebelli alike. The course, size, and connections of all the tributaries of the straight sinus have been studied and consideration given to their potentials as collateral pathways in the event either the vein of Galen or the straight sinus itself were occluded.

Venous aneurysm of the inferior sagittal sinus

1973 ◽  
Vol 39 (4) ◽  
pp. 537-539 ◽  
Author(s):  
Harry A. Kaplan ◽  
Jefferson Browder
Keyword(s):  
Dura Mater ◽  
Venous Aneurysm ◽  
Falx Cerebri ◽  
Content Type ◽  
Sagittal Sinus ◽  
Vascular Connections ◽  
Fine Print

✓ Among 449 specimens of dura mater and enclosed sinuses obtained at autopsy, there was one with a venous sac in the midpart of the falx cerebri. The vascular connections of this cavity indicated that it was an aneurysm of the inferior sagittal sinus without arterial components.

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