Malignant Degeneration of Intracranial Epidermoid Cyst to Squamous Cell Carcinoma: A Case Report and Literature Review

Neurographics ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 59-62
Author(s):  
A.M. Romesberg ◽  
A.A. Roney ◽  
D.E. Lukins
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cerebellopontine Angle ◽  
Rare Complication ◽  
The Body ◽  
Malignant Degeneration ◽  
Epidermoid Cysts ◽  
Surgical Debulking ◽  
Intracranial Epidermoid

Intracranial epidermoid cysts represent a group of relatively common, benign, indolent tumors most frequently encountered at the cerebellopontine angle. Presentation is usually secondary to compressive neurologic symptoms. Treatment is surgical debulking and generally is curative. As with other epidermoid cysts throughout the body, the risk of degeneration into squamous cell carcinoma is a rare complication that is typically fatal within the CNS.

scholarly journals Malignant Transformation Six Months after Removal of Intracranial Epidermoid Cyst: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Fayçal Lakhdar ◽  
El Mehdi Hakkou ◽  
Rachid Gana ◽  
Rachid My Maaqili ◽  
Fouad Bellakhdar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Epidermoid Cyst ◽  
Cerebellopontine Angle ◽  
Histopathological Examination ◽  
Benign Tumors ◽  
Epidermoid Cysts ◽  
Intracranial Epidermoid

Intracranial epidermoid cysts are uncommon benign tumors of developmental origin; malignant transformation of benign epidermoid cysts is rare, and their prognosis remains poor. We report a case of squamous cell carcinoma arising in the cerebellopontine angle. A 52-year-old man presented with left facial paralysis and cerebellar ataxia. He had undergone total removal of a benign epidermoid cyst six months previously. Postoperative magnetic resonance imaging of the brain revealed a heterogeneous and cystic lesion in the left cerebellopontine angle with hydrocephalus. The cyst wall was enhanced by gadolinium. He underwent ventricle-peritoneal shunt and removal again; the histopathological examination revealed a squamous cell carcinoma possibly arising from an underlying epidermoid cyst. This entity is being reported for its rarity. The presence of contrast enhancement at the site of an epidermoid cyst combined with an acute, progressive neurological deficit should alert the neurosurgeon to the possibility of a malignant transformation.

scholarly journals Cutaneous squamous cell carcinoma arising in hidradenitis suppurativa: A case report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1984735 ◽  
Author(s):  
Catherine F Roy ◽  
Simon F Roy ◽  
Feras M Ghazawi ◽  
Erica Patocskai ◽  
Annie Bélisle ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Rare Complication ◽  
Excisional Biopsy ◽  
Necrosis Factor Alpha ◽  
Spindle Cells ◽  
Poorly Differentiated ◽  
Well Differentiated

We present a case of a 64-year-old man who presented with a rapidly growing tumor in the left buttock and intergluteal cleft area, which was affected by hidradenitis suppurativa. The patient was on tumor necrosis factor-alpha inhibitors for hidradenitis suppurativa for 2 years prior to the development of the mass. Initial biopsy of the mass showed a well-differentiated squamous cell carcinoma with spindle cells and positive epithelial immunomarkers. Subsequent excisional biopsy of the tumor showed an infiltrating poorly differentiated squamous cell carcinoma composed of islands of atypical sarcomatoid spindle cells. Squamous cell carcinoma arising in hidradenitis suppurativa is a rare complication which may occur secondary to chronic inflammation and epidermal hyperproliferation in hidradenitis suppurativa–affected areas.

scholarly journals Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1153
Author(s):  
Elysia Racanelli ◽  
Abdulhadi Jfri ◽  
Amnah Gefri ◽  
Elizabeth O’Brien ◽  
Ivan Litvinov ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hidradenitis Suppurativa ◽  
Case Reports ◽  
Rare Complication ◽  
Cox Proportional Hazards ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Statistical Hypothesis ◽  
Statistical Hypothesis Testing

Background: Cutaneous squamous cell carcinoma (cSCC) is a rare complication of hidradenitis suppurativa (HS). Objectives: To conduct a systematic review and an individual patient data (IPD) meta-analysis to describe the clinical characteristics of HS patients developing cSCC and determine predictors of poor outcome. Methods: Medline/PubMed, Embase, and Web of Science were searched for studies reporting cSCC arising in patients with HS from inception to December 2019. A routine descriptive analysis, statistical hypothesis testing, and Kaplan–Meier survival curves/Cox proportional hazards regression models were performed. Results: A total of 34 case reports and series including 138 patients were included in the study. The majority of patients were males (81.6%), White (83.3%), and smokers (n = 22/27 reported) with a mean age of 53.5 years. Most patients had gluteal (87.8%), Hurley stage 3 HS (88.6%). The mean time from the diagnosis of HS to the development of cSCC was 24.7 years. Human papillomavirus was identified in 12/38 patients tested. Almost 50% of individuals had nodal metastasis and 31.3% had distant metastases. Half of the patients succumbed to their disease. Conclusions: cSCC is a rare but life-threatening complication seen in HS patients, mainly occurring in White males who are smokers with severe, long-standing gluteal HS. Regular clinical examination and biopsy of any suspicious lesions in high-risk patients should be considered. The use of HPV vaccination as a preventive and possibly curative method needs to be explored.

scholarly journals Squamous cell carcinoma in mature cystic teratoma of the ovary

2012 ◽  
Vol 65 (9-10) ◽  
pp. 429-431 ◽  
Author(s):  
Jelena Amidzic ◽  
Matilda Djolai ◽  
Mihaela Mocko-Kacanski ◽  
Aleksandar Gluhovic ◽  
Jelena Ilic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Rare Complication ◽  
Cystic Teratoma ◽  
Internal Surface ◽  
Cystic Mass ◽  
Mature Cystic Teratoma ◽  
Well Differentiated

Introduction. Malignant transformation is a rare complication of mature cystic teratoma, with squamous cell carcinoma as the most common malignancy (in 75% of cases). In this article we present a case of a well-differentiated squamous cell carcinoma arising in a mature cystic teratoma and discuss the morphological and clinico-pathological features of malignant transformation in teratoma. Case Report. An 80-year-old woman with symptoms of acute abdomen underwent left salpingo-oophorectomy. Gross examination showed a cystic mass measuring 20 cm in diameter, with papillary formation on its internal surface. Histology revealed a well-differentiated squamous cell carcinoma arising in mature cystic teratoma. Squamous epithelium surrounding the tumor was dysplastic. Conclusion. Squamous cell carcinoma in mature cystic teratoma is a rare pathologic event and in most cases it is an accidental pathohistological finding.

scholarly journals Porokeratosis with an Invasive Squamous Cell Carcinoma: A Case Report and Review of Literature

2014 ◽  
Vol 32 (1) ◽  
pp. 31-36
Author(s):  
M Nessa ◽  
L Khondker ◽  
MA Bari ◽  
MSI Khan ◽  
M Rahman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Granular Layer ◽  
Malignant Degeneration ◽  
Invasive Squamous Cell Carcinoma ◽  
Review Of Literature ◽  
Large Plaque ◽  
Cornoid Lamella ◽  
Multiple Nodules

Porokeratosis is a clonal disorder of epidermal keratinization, which is characterized by hyperkeratotic papules or plaques that are surrounded by a thread-like elevated border. The histopathologic hallmark of porokeratosis is the cornoid lamella, which is a thin column of parakeratosis that overlies a thin or absent granular layer and that corresponds to the raised, hyperkeratotic border. Porokeratosis has five clinical types and malignant degeneration has been described in all forms of porokeratosis. We report a forty five year old farmer with a large plaque in chest for 30 years and multiple nodules within the large plaque for 2 years. A section of skin from margin of the plaque reveals histopathological features of porokeratosis and section from nodules reveals an invasive squamous cell carcinoma. To the best of our knowledge, this is the first reported case of porokeratosis transformed to squamous cell carcinoma on Bangladesh. DOI: http://dx.doi.org/10.3329/jbcps.v32i1.21035 J Bangladesh Coll Phys Surg 2014; 32: 31-36

scholarly journals Cystic cervical metastasis: A diagnostic dilemma

2021 ◽  
Vol 4 (2) ◽  
pp. 75-78
Author(s):  
Manish Gupta ◽  
Anshul Singh ◽  
Cynthia Kaur ◽  
Akanksha Gupta
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Benign Lesion ◽  
Tongue Base ◽  
Malignant Degeneration ◽  
Neck Swelling ◽  
Cervical Metastasis ◽  
Diagnostic Dilemma ◽  
Branchial Cleft

Metastasis of head neck squamous cell carcinoma to regional deep cervical nodes is a common and usually are bony hard, solid. But sometimes they may present as a cystic mass which makes it a diagnostic challenge, in absence of evident primary, for the treating doctor. Previously they have been labeled as cancers of branchial cleft cysts which have undergone malignant degeneration. With the advancement in understanding of tumor pathophysiology most researchers now have concluded that these are tumors from tissue of waldeyer’s ring which have the potential of producing cystic cervical metastasis. : A 57-year-old male presented to our department with a right side slow growing neck swelling for 2 years. The rest of ear, nose, throat examination was normal. The fine needle aspiration cytology revealed clear fluid. The diagnosis of branchial cleft cyst was made and patient counselled for surgery for benign lesion. After a period of one month the patient presented with change in voice, difficulty in swallowing and another swelling on left side of the neck. FNAC from the left side swelling revealed metastatic squamous cell carcinoma and PET-CT revealed a tongue base growth. Patient underwent an excision of growth from tongue base and neck dissection on both sides. Even for cystic neck swelling in an adult over 40 years of age, the possibility of malignancy should be kept, until proven otherwise.

scholarly journals Malignant squamous cell carcinoma arising in a previously resected cerebellopontine angle epidermoid

2017 ◽  
Vol 8 (1) ◽  
pp. 186 ◽  
Author(s):  
Annika Mascarenhas ◽  
Alyssa Parsons ◽  
Caroline Smith ◽  
Cindy Molloy ◽  
Alistair Jukes
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cerebellopontine Angle
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