Changes of Renin Isoelectric Heterogeneity after Acute and Chronic Stimulation of Renin Secretion

1986 ◽  
Vol 182 (2) ◽  
pp. 258-262 ◽  
Author(s):  
F. M. Sessler ◽  
S. H. Kim ◽  
R. L. Malvin
Keyword(s):  
Renin Secretion ◽  
Chronic Stimulation ◽  
Stimulation Of

Deep brain stimulation modulates hypothalamic-brainstem fibers in cluster headache: case report

2020 ◽  
Vol 132 (3) ◽  
pp. 717-720 ◽  
Author(s):  
Sérgio A. F. Dantas ◽  
Eduardo J. L. Alho ◽  
Juliano J. da Silva ◽  
Nilson N. Mendes Neto ◽  
Erich Talamoni Fonoff ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Cluster Headache ◽  
Brain Stimulation ◽  
Clinical Effects ◽  
Chronic Stimulation ◽  
Mammillary Bodies ◽  
Fiber Tracts ◽  
White Matter Region ◽  
Deep Brain ◽  
Stimulation Of

Hypothalamic deep brain stimulation (DBS) has been used for more than a decade to treat cluster headache (CH) but its mechanisms remain poorly understood. The authors have successfully treated a patient with CH using hypothalamic DBS and found that the contact used for chronic stimulation was located in a white matter region posterior to the mammillary bodies. Fiber tracts crossing that region were the medial forebrain bundle and those interconnecting the hypothalamus and brainstem, including the dorsal longitudinal fasciculus. Because the stimulation of axons is an important mechanism of DBS, some of its clinical effects in CH may be related to the stimulation of fibers interconnecting the hypothalamus and brainstem.

scholarly journals Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mayura V. Wagle ◽  
Stephin J. Vervoort ◽  
Madison J. Kelly ◽  
Willem Van Der Byl ◽  
Timothy J. Peters ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
Cd8 T Cell ◽  
Chronic Stimulation ◽  
Epigenetic State ◽  
Multiple Differentiation ◽  
Cell Stability ◽  
Substantial Interest ◽  
Transcriptional State ◽  
Stimulation Of

AbstractChronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhausted cells exist in multiple differentiation states, from stem-like progenitors that are the key mediators of the response to checkpoint blockade, through to terminally exhausted cells. Due to its clinical relevance, there is substantial interest in defining the pathways that control differentiation and maintenance of these subsets. Here, we show that chronic antigen induces the anergy-associated transcription factor EGR2 selectively within progenitor exhausted cells in both chronic LCMV and tumours. EGR2 enables terminal exhaustion and stabilizes the exhausted transcriptional state by both direct EGR2-dependent control of key exhaustion-associated genes, and indirect maintenance of the exhausted epigenetic state. We show that EGR2 is a regulator of exhaustion that epigenetically and transcriptionally maintains the differentiation competency of progenitor exhausted cells.

scholarly journals Ca-ATPase isozyme expression in sarcoplasmic reticulum is altered by chronic stimulation of skeletal muscle

FEBS Letters ◽  
1990 ◽  
Vol 259 (2) ◽  
pp. 269-272 ◽  
Author(s):  
F.Norman Briggs ◽  
K.Francis Lee ◽  
Joseph J. Feher ◽  
Andrew S. Wechsler ◽  
Kay Ohiendieck ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Chronic Stimulation ◽  
Stimulation Of

Dyskinesias and grip control in Parkinson's disease are normalized by chronic stimulation of the subthalamic nucleus

2002 ◽  
Vol 52 (2) ◽  
pp. 240-243 ◽  
Author(s):  
Roland Wenzelburger ◽  
Bao-Rong Zhang ◽  
Meike Poepping ◽  
Bettina Schrader ◽  
Dieter Müller ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Chronic Stimulation ◽  
Stimulation Of

Mechanism of captopril-induced drinking

1982 ◽  
Vol 242 (1) ◽  
pp. R136-R140 ◽  
Author(s):  
E. L. Schiffrin ◽  
J. Genest
Keyword(s):  
Ace Inhibitor ◽  
Produced Water ◽  
Oral Treatment ◽  
Renin Secretion ◽  
Ang Ii ◽  
Angiotensin I ◽  
Angiotensin I Converting Enzyme ◽  
Orally Active ◽  
The Brain ◽  
Stimulation Of

Captopril (SQ 14,225), an orally active angiotensin I-converting enzyme (ACE) inhibitor, increased drinking and produced water diuresis in rats when given orally at a dose of 100 mg.kg-1.day-1. Chronic intraperitoneal infusion of angiotensin (ANG) II or the ANG II antagonist [Sar1, Ile8]ANG II abolished this response. Intracerebroventricular (icv) captopril infused chronically reduced the dipsogenic response to oral captopril. [Sar1, Ile8]ANG II (icv) was without effect on captopril-induced drinking. These results suggest that drinking produced by chronic oral treatment of rats with captopril may be caused by the effects of the elevated ANG I concentrations achieved after blockade of ACE and stimulation of renin secretion by captopril. Systemic ANG II may reduce this response by decreasing renin secretion. Systemic [Sar1, Ile8]ANG II presumably blocks brain ANG receptors for blood-borne ANG. Since icv [Sar1, Ile8]ANG II is ineffective, the receptors for systemic and icv ANG appear to be distinct. Orally administered captopril does not diffuse into the brain.

Central Stimulation of Renin Secretion through Serotonergic, Noncardiovascular Mechanisms

1994 ◽  
Vol 60 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Peter A. Rittenhouse ◽  
Erica A. Bakkum ◽  
Andrew D. Levy ◽  
Qian Li ◽  
Joseph M. Yracheta ◽  
...  
Keyword(s):  
Renin Secretion ◽  
Central Stimulation ◽  
Stimulation Of
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