Facile synthesis of amide and amine derivatives of 2,2,3,3-tetramethylcyclopropanecarboxylic acid

2009 ◽  
Vol 2009 (8) ◽  
pp. 508-510
Author(s):  
Hui-Long Wang ◽  
Wen-Feng Jiang ◽  
Zhe-Qi Li
Keyword(s):  
Thionyl Chloride ◽  
Facile Synthesis ◽  
One Pot ◽  
Amide Derivatives ◽  
Derivatives Of

An efficient one-pot procedure for the synthesis of amide derivatives of 2,2,3,3-tetramethylpropanecarboxylic acid (TMCA) that involves the treating of TMCA in N,N-dimethylacetamide (DMAC) with thionyl chloride and stoichiometric amounts of reactant amines has been developed. The combined reagent TiCl4/NaBH4 was found to be effective for the reduction of the amide derivatives of TMCA to the corresponding amines.

scholarly journals A Facile Synthesis of Amide Derivatives of [1,2,4]Triazolo[4,3-a]pyridine

2017 ◽  
Vol 29 (9) ◽  
pp. 1920-1924 ◽  
Author(s):  
N. Murthy Gandikota ◽  
R. Sekhar Bolla ◽  
I.V. Kasi Viswanath ◽  
Sridharreddy Bethi
Keyword(s):  
Facile Synthesis ◽  
Amide Derivatives ◽  
Derivatives Of

scholarly journals Facile Synthesis of 1-(4-Bromophenyl)-1H-Tetrazol-5-Amine and Related Amide Derivatives

2017 ◽  
Vol 41 (10) ◽  
pp. 581-585 ◽  
Author(s):  
Hao Yang ◽  
Yifan Ouyang ◽  
Yutong Sun ◽  
Zhe Wang ◽  
Xuanli Zhu ◽  
...  
Keyword(s):  
Starting Material ◽  
High Yield ◽  
Facile Synthesis ◽  
One Pot ◽  
Acyl Chlorides ◽  
One Pot Synthesis ◽  
Amide Derivatives

An efficient one-pot synthesis of 1-(4-bromophenyl)-1 H-tetrazol-5-amine was performed using 4-bromoaniline as the starting material. A novel and widely applicable amidation procedure was then employed, whereby 1-(4-bromophenyl)-1 H-tetrazol-5-amine was acylated with different acyl chlorides in the presence of lithium bis(trimethylsilyl)amide as catalyst, for the high-yield synthesis of [1-(4-bromophenyl)-1 H-tetrazol-5-yl]amide derivatives.

One-Pot, Three-Component Synthesis of Dialkyl 1,2-Dihydroquinoline-2,3-dicarboxylates from Triphenylphosphine, Acetylenic Esters, and Amide Derivatives of 2-Aminobenzaldehyde in Aqueous Acetone

ChemInform ◽  
2006 ◽  
Vol 37 (11) ◽  
Author(s):  
Ali Ramazani ◽  
Ebrahim Ahmadi ◽  
Ali Reza Kazemizadeh ◽  
Leila Dolatyari ◽  
Nader Noshiranzadeh ◽  
...  
Keyword(s):  
Aqueous Acetone ◽  
Acetylenic Esters ◽  
One Pot ◽  
Amide Derivatives ◽  
Derivatives Of

A Facile Synthesis of 2-Aminopropane-1,2,3-tricarboxylic Acid and Its Symmetrical Dimethyl Ester

Synthesis ◽  
2021 ◽  
Author(s):  
Alexey V. Nizovtsev ◽  
Nicolai V. Bovin
Keyword(s):  
Thionyl Chloride ◽  
Hippuric Acid ◽  
Dimethyl Ester ◽  
Tricarboxylic Acid ◽  
Synthetic Route ◽  
Facile Synthesis ◽  
One Pot ◽  
Two Stages

AbstractA new convenient synthetic route to 2-aminopropane-1,2,3-tricarboxylic acid is described. The first two stages of the three-step synthesis are performed in a one-pot procedure and include the cyclization of hippuric acid with DCC followed by treatment with methyl bromoacetate to yield an alkylated oxazolone. Its hydrolysis with HCl provides 2-aminopropane-1,2,3-tricarboxylic acid as its HCl salt. Esterification of the resulting acid with methanol in the presence of thionyl chloride leads selectively to its symmetrical diester.

One-pot Synthesis of the derivatives of 2-cyclopent-2-en-1-one by SOCl2/EtOH

2007 ◽  
Vol 2007 (8) ◽  
pp. 461-463 ◽  
Author(s):  
Zhiguo Hu ◽  
Zhibing Dong
Keyword(s):  
Thionyl Chloride ◽  
Efficient Method ◽  
Aromatic Aldehydes ◽  
Anhydrous Ethanol ◽  
One Pot ◽  
One Pot Synthesis ◽  
Aliphatic Ketones ◽  
One Step ◽  
Derivatives Of

A simple and efficient method for the synthesis of derivatives of cyclopent-2-en-1-one is presented. Aromatic aldehydes reacted with aliphatic ketones in the presence of thionyl chloride in anhydrous ethanol to give seven derivatives of 2-cyclopenten-1-one in one step with reasonable yields. The structures of the products were established.

Synthesis and Biological Activity of 28-Amide Derivatives of 23-Hydroxy Betulinic Acid as Antitumor Agent Candidates

2013 ◽  
Vol 9 (7) ◽  
pp. 920-925 ◽  
Author(s):  
Yi Bi ◽  
Jinyi Xu ◽  
Fei Sun ◽  
Xiaoming Wu ◽  
Wencai Ye ◽  
...  
Keyword(s):  
Biological Activity ◽  
Betulinic Acid ◽  
Antitumor Agent ◽  
Amide Derivatives ◽  
Derivatives Of
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