A Facile Synthesis of 2-Aminopropane-1,2,3-tricarboxylic Acid and Its Symmetrical Dimethyl Ester

Synthesis ◽  
2021 ◽  
Author(s):  
Alexey V. Nizovtsev ◽  
Nicolai V. Bovin
Keyword(s):  
Thionyl Chloride ◽  
Hippuric Acid ◽  
Dimethyl Ester ◽  
Tricarboxylic Acid ◽  
Synthetic Route ◽  
Facile Synthesis ◽  
One Pot ◽  
Two Stages

AbstractA new convenient synthetic route to 2-aminopropane-1,2,3-tricarboxylic acid is described. The first two stages of the three-step synthesis are performed in a one-pot procedure and include the cyclization of hippuric acid with DCC followed by treatment with methyl bromoacetate to yield an alkylated oxazolone. Its hydrolysis with HCl provides 2-aminopropane-1,2,3-tricarboxylic acid as its HCl salt. Esterification of the resulting acid with methanol in the presence of thionyl chloride leads selectively to its symmetrical diester.

Facile synthesis of amide and amine derivatives of 2,2,3,3-tetramethylcyclopropanecarboxylic acid

2009 ◽  
Vol 2009 (8) ◽  
pp. 508-510
Author(s):  
Hui-Long Wang ◽  
Wen-Feng Jiang ◽  
Zhe-Qi Li
Keyword(s):  
Thionyl Chloride ◽  
Facile Synthesis ◽  
One Pot ◽  
Amide Derivatives ◽  
Derivatives Of

An efficient one-pot procedure for the synthesis of amide derivatives of 2,2,3,3-tetramethylpropanecarboxylic acid (TMCA) that involves the treating of TMCA in N,N-dimethylacetamide (DMAC) with thionyl chloride and stoichiometric amounts of reactant amines has been developed. The combined reagent TiCl4/NaBH4 was found to be effective for the reduction of the amide derivatives of TMCA to the corresponding amines.

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

Facile Synthesis of Nitrogen-Doped [(6.)m8]nCyclacene Carbon Nanobelts by a One-Pot Self-Condensation Reaction

2021 ◽  
Vol 143 (7) ◽  
pp. 2716-2721
Author(s):  
Jun Zhu ◽  
Yi Han ◽  
Yong Ni ◽  
Guangwu Li ◽  
Jishan Wu
Keyword(s):  
Condensation Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Nitrogen Doped

A green synthetic route for the surface-passivation of carbon dots as an effective multifunctional fluorescent sensor for the recognition and detection of toxic metal ions from aqueous solution

2019 ◽  
Vol 11 (4) ◽  
pp. 490-506 ◽  
Author(s):  
K. Radhakrishnan ◽  
P. Panneerselvam ◽  
M. Marieeswaran
Keyword(s):  
Aqueous Solution ◽  
Quantum Dots ◽  
Carbon Dots ◽  
Surface Passivation ◽  
Fluorescent Sensor ◽  
Toxic Metal ◽  
Carbon Quantum Dots ◽  
Synthetic Route ◽  
One Pot ◽  
Hydrothermal Methods

In this work, a green synthetic route was used to create a number of surface passivated fluorescent carbon quantum dots, which are explored as promising sensing probes, via facile one-pot hydrothermal methods.

ChemInform Abstract: Facile Synthesis of Multifunctional Pyrrole[2,1-a]isoquinolin-3(2H)-ones via Sulfa-Michael-Triggered One-Pot Reactions.

ChemInform ◽  
2016 ◽  
Vol 47 (25) ◽  
Author(s):  
Tian-You Qin ◽  
Lu Cheng ◽  
Ho-Chol Jang ◽  
Sean Xiao-An Zhang ◽  
Wei-Wei Liao
Keyword(s):  
Facile Synthesis ◽  
One Pot

Facile synthesis of GalNAc monomers and block polycations for hepatocyte gene delivery

2021 ◽  
Author(s):  
Matthew R. Bockman ◽  
Rishad J. Dalal ◽  
Ramya Kumar ◽  
Theresa M. Reineke
Keyword(s):  
Gene Delivery ◽  
Synthetic Route ◽  
Facile Synthesis ◽  
Low Toxicity ◽  
Delivery Vehicles

Here, we present a facile synthetic route for a monomer displaying N-acetyl-d-galactosamine and subsequent copolymerization in a block format with cationic subunits readily accessing liver-targeted polymeric pDNA delivery vehicles with low toxicity.

One-pot, facile synthesis of well-defined molecular brush copolymers by a tandem RAFT and ROMP, “Grafting-through” strategy

2012 ◽  
Vol 50 (9) ◽  
pp. 1681-1688 ◽  
Author(s):  
Ang Li ◽  
Jun Ma ◽  
Guorong Sun ◽  
Zhou Li ◽  
Sangho Cho ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
One Pot ◽  
Grafting Through
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