scholarly journals Increased Mean Platelet Volume (MPV) in Patients with ST Elevation Myocardial Infarction (STEMI) Compared to Non-ST Elevation Myocardial Infarction (NSTEMI) Patients

2020 ◽  
Vol 6 (2) ◽  
pp. 145
Author(s):  
Tri Ratnaningsih ◽  
Istiqomah Istiqomah
Keyword(s):  
Myocardial Infarction ◽  
Risk Factor ◽  
Mean Platelet Volume ◽  
Acute Coronary Syndromes ◽  
St Elevation Myocardial Infarction ◽  
Platelet Volume ◽  
Cross Sectional ◽  
Coronary Syndromes ◽  
St Elevation ◽  
Vascular Mortality

Platelets are known to have a role major in the pathogenesis of atherothrombosis. More giant and hyperreactive platelets accelerate the formation of an intracoronary thrombus. An increased MPV as an indicator of larger and more reactive platelets represents a risk factor for overall vascular mortality, including myocardial infarction. This study aimed to identify the increase of Mean Platelet Volume in Patients with Acute Coronary Syndromes, especially in ST-elevation myocardial infarction and Non-ST-elevation myocardial infarction. Thus this parameter can be used as consideration for diagnosis and treatment decisions. This research is an analytic observational with a cross-sectional method. The subjects were patients with STEMI and NSTEMI who were hospitalized in ICCU Dr.Sardjito Hospital Yogyakarta. Thirty-four subjects STEMI and NSTEMI patients at Dr. Sardjito Hospital, consisting of 28 males (82,35%) and six women (17,65%) with a mean age of 55,5 ± 10,3 years. The results showed that MPV in AMI was higher in patients with STEMI than NSTEMI, but this difference is not significant (p = 0,091). This study concludes that MPV to be higher in patients with STEMI compared to NSTEMI. MPV may be used as a marker of myocardial infarction in clinically appropriate situations.

scholarly journals Study of the Relationship Between Mean Platelet Volume and LAD as a Culprit Vessel in NSTEMI

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Ahmad Separham ◽  
Alireza Shahsavani ◽  
Ali Heidari Sarvestani
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Complete Blood Count ◽  
St Elevation Myocardial Infarction ◽  
Platelet Volume ◽  
Good Tool ◽  
Cross Sectional ◽  
Significant Difference ◽  
St Elevation

Background: Among acute coronary patients, the ratio of non ST-elevation myocardial infarction (NSTEMI) is increasing and according to recent studies, less than 30% of myocardial infarctions (MIs) are due to ST-elevation myocardial infarction (STEMI). Unlike STEMI, in NSTEMI the ECG is not able to identify the culprit vessel. Objectives: In this study, we aimed to evaluate the association of mean platelet volume (MPV) and NSTEMI due to left anterior descending lesion. Methods: In this cross sectional study 349 patients with NSTEMI were included. Major cardiac risk factors (cigarette, diabetes mellitus (DM), hypertension (HTN), hyperlipidemia (HLP), angiographic findings, and drug history of patients were extracted from patients’ medical files. Then the MPV in complete blood count results and angiography findings were analyzed for any association. According to culprit lesions patients were divided into left anterior descending (LAD) and non-LAD groups. Results: There was a significant difference between the two groups (LAD vs. non-LAD) according to platelet count (P = 0.014), MPV (P = 0.001), HLP (0.024) and DM (0.048). Multivariate regression model has shown the MPV (OR = 0.46, 95%CI = 0.27 - 0.78) and DM (OR = 0.18, 95%CI = 0.06 - 0.54) as independent risk factors for NSTEMI due to LAD lesion. The significant positive correlation was also seen between MPV and left ventricle ejection fraction (LVEF) (r = 0.22, P = 0.006). The area under the curve (AUC) of MPV for predicting LAD culprit lesion was calculated as 69% (P < 0.0001). At cut off point of 9.15, has sensitivity and specificity of MPV for predicting LAD as culprit vessel was 100% and 30% respectively. Conclusions: In NSTEMI patients MPV might be a good tool to differentiate patients with LAD as culprit vessel.

Changes in Hemoglobin and Hematocrit May Predict Mortality in Patients with Acute Coronary Syndromes.

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 3171-3171
Author(s):  
Zaid Alirhayim ◽  
Waqas Qureshi ◽  
Vijaya Donthireddy ◽  
Syed Hassan ◽  
Fatima Khalid
Keyword(s):  
Myocardial Infarction ◽  
Plasma Volume ◽  
Acute Coronary Syndromes ◽  
St Elevation Myocardial Infarction ◽  
Receiver Operating Curve ◽  
Mortality Data ◽  
Volume Changes ◽  
Social Security Death Index ◽  
Coronary Syndromes ◽  
St Elevation

Abstract Abstract 3171 Introduction: Changes in plasma volume, the intravascular portion of the extracellular fluid volume, can be estimated by measuring changes in the levels of hemoglobin and hematocrit in the blood. In addition to hemoglobin & hematocrit levels, we are also able to use standard dilution techniques with radiolabeled albumin to accurately measure plasma volume changes. It is not known if plasma volume changes influence outcomes in patients with acute coronary syndromes. The aim of this study was to evaluate the effects of plasma volume changes in patients presenting with the acute coronary syndromes. Methods: Consecutive patients presenting to a single tertiary care center from January 2001 to December 2010 with non ST elevation myocardial infarction (NSTEMI) or ST elevation myocardial infarction (STEMI) were enrolled. Admission hemoglobin (Hbpre) & hematocrit (Hctpre) and discharge hemoglobin (Hbpost) and hematocrit levels (Hctpost) were obtained. Plasma volume changes were measured and a validated formula (ΔPV = ((Hbpre/Hbpost) × (100-Hctpost/100-Hctpre)-1) × 100%) was used to calculate the changes in plasma volumes. A detailed chart review was performed to collect information about baseline variables such as age, gender, hypertension, diabetes, hyperlipidemia, smoking status, and congestive heart failure. The Framingham Risk score was also calculated for each individual. Survival analysis was carried out for plasma volume changes of -20% - 0%, 0 – 20%, and ≥20%. Mortality data was collected from the social security death index for the first 60 days post-discharge. Results: A total of 9770 patients with confirmed NSTEMI or STEMI (mean age 61.8 ± 4.8 years, 48.8% women) were included in the final analysis. Mean pre admission hemoglobin (Hbpre) was 10.2 ± 1.4 g/dl and post admission hemoglobin (Hbpost) was 10.4 ± 1.3 g/dl. Change in plasma volume, ΔPV, was categorized into one of four categories, with 131 (1.3%) ≤20%, 6126 (62.7%) -20% - 0%, 3393 (34.7%) 0 – 20%, and 120 (1.2%) ≥20%. There were 509 deaths within 60 days of discharge. Change in plasma volume was found to be an independent predictor of mortality (HR 5.71; 95% CI 4.75 – 6.86, p = 0.0001) in a Cox proportional hazard model. Most of the deaths occurred during the first thirty days as demonstrated by the Kaplan – Meier's survival curve (Figure 1). Receiver operating curve showed an area under the curve of 0.876 for changes in plasma volume. Conclusion: This study shows that hemoglobin and hematocrit, although simple tests, can provide important prognostic information strongly predictive of short term mortality in patients with acute coronary syndromes. Further studies are required to see if monitoring of plasma volume and correction with pharmacological agents such as diuretics may lead to better outcomes. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Re: Relationship between mean platelet volume and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction

2012 ◽  
Vol 35 (2) ◽  
pp. 46
Author(s):  
Savaş Acikgoz ◽  
Meltem R Ege ◽  
Yesim Guray
Keyword(s):  
Myocardial Infarction ◽  
Metabolic Syndrome ◽  
Mean Platelet Volume ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
St Elevation Myocardial Infarction ◽  
Platelet Volume ◽  
Ventricular Systolic Function ◽  
St Elevation

We have read with great interest the recently published report of Yazici et al. [1], which investigates the relationship between mean platelet volume (MPV) and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction. The authors demonstrated that increased MPV on admission can be associated with the degree of left ventricle systolic depression in these patients. It has been reported that MPV, a measure of platelet size, reflects platelet function and activity...

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