Study of the Relationship Between Mean Platelet Volume and LAD as a Culprit Vessel in NSTEMI

Background: Among acute coronary patients, the ratio of non ST-elevation myocardial infarction (NSTEMI) is increasing and according to recent studies, less than 30% of myocardial infarctions (MIs) are due to ST-elevation myocardial infarction (STEMI). Unlike STEMI, in NSTEMI the ECG is not able to identify the culprit vessel. Objectives: In this study, we aimed to evaluate the association of mean platelet volume (MPV) and NSTEMI due to left anterior descending lesion. Methods: In this cross sectional study 349 patients with NSTEMI were included. Major cardiac risk factors (cigarette, diabetes mellitus (DM), hypertension (HTN), hyperlipidemia (HLP), angiographic findings, and drug history of patients were extracted from patients’ medical files. Then the MPV in complete blood count results and angiography findings were analyzed for any association. According to culprit lesions patients were divided into left anterior descending (LAD) and non-LAD groups. Results: There was a significant difference between the two groups (LAD vs. non-LAD) according to platelet count (P = 0.014), MPV (P = 0.001), HLP (0.024) and DM (0.048). Multivariate regression model has shown the MPV (OR = 0.46, 95%CI = 0.27 - 0.78) and DM (OR = 0.18, 95%CI = 0.06 - 0.54) as independent risk factors for NSTEMI due to LAD lesion. The significant positive correlation was also seen between MPV and left ventricle ejection fraction (LVEF) (r = 0.22, P = 0.006). The area under the curve (AUC) of MPV for predicting LAD culprit lesion was calculated as 69% (P < 0.0001). At cut off point of 9.15, has sensitivity and specificity of MPV for predicting LAD as culprit vessel was 100% and 30% respectively. Conclusions: In NSTEMI patients MPV might be a good tool to differentiate patients with LAD as culprit vessel.

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Increased Mean Platelet Volume (MPV) in Patients with ST Elevation Myocardial Infarction (STEMI) Compared to Non-ST Elevation Myocardial Infarction (NSTEMI) Patients

Medical Laboratory Technology Journal ◽

10.31964/mltj.v6i2.320 ◽

2020 ◽

Vol 6 (2) ◽

pp. 145

Author(s):

Tri Ratnaningsih ◽

Istiqomah Istiqomah

Keyword(s):

Myocardial Infarction ◽

Risk Factor ◽

Mean Platelet Volume ◽

Acute Coronary Syndromes ◽

St Elevation Myocardial Infarction ◽

Platelet Volume ◽

Cross Sectional ◽

Coronary Syndromes ◽

St Elevation ◽

Vascular Mortality

Platelets are known to have a role major in the pathogenesis of atherothrombosis. More giant and hyperreactive platelets accelerate the formation of an intracoronary thrombus. An increased MPV as an indicator of larger and more reactive platelets represents a risk factor for overall vascular mortality, including myocardial infarction. This study aimed to identify the increase of Mean Platelet Volume in Patients with Acute Coronary Syndromes, especially in ST-elevation myocardial infarction and Non-ST-elevation myocardial infarction. Thus this parameter can be used as consideration for diagnosis and treatment decisions. This research is an analytic observational with a cross-sectional method. The subjects were patients with STEMI and NSTEMI who were hospitalized in ICCU Dr.Sardjito Hospital Yogyakarta. Thirty-four subjects STEMI and NSTEMI patients at Dr. Sardjito Hospital, consisting of 28 males (82,35%) and six women (17,65%) with a mean age of 55,5 ± 10,3 years. The results showed that MPV in AMI was higher in patients with STEMI than NSTEMI, but this difference is not significant (p = 0,091). This study concludes that MPV to be higher in patients with STEMI compared to NSTEMI. MPV may be used as a marker of myocardial infarction in clinically appropriate situations.

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Mean platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction

Platelets ◽

10.3109/09537100903487599 ◽

2010 ◽

Vol 21 (2) ◽

pp. 117-121 ◽

Cited By ~ 30

Author(s):

David Pereg ◽

Tatiana Berlin ◽

Morris Mosseri

Keyword(s):

Myocardial Infarction ◽

Mean Platelet Volume ◽

St Elevation Myocardial Infarction ◽

Platelet Volume ◽

St Elevation

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Re: Relationship between mean platelet volume and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction

Clinical & Investigative Medicine ◽

10.25011/cim.v35i2.16287 ◽

2012 ◽

Vol 35 (2) ◽

pp. 46

Author(s):

Savaş Acikgoz ◽

Meltem R Ege ◽

Yesim Guray

Keyword(s):

Myocardial Infarction ◽

Metabolic Syndrome ◽

Mean Platelet Volume ◽

Systolic Function ◽

Left Ventricular Systolic Function ◽

Left Ventricular ◽

St Elevation Myocardial Infarction ◽

Platelet Volume ◽

Ventricular Systolic Function ◽

St Elevation

We have read with great interest the recently published report of Yazici et al. [1], which investigates the relationship between mean platelet volume (MPV) and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction. The authors demonstrated that increased MPV on admission can be associated with the degree of left ventricle systolic depression in these patients. It has been reported that MPV, a measure of platelet size, reflects platelet function and activity...

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Mean platelet volume may not have a role in the prediction of adverse events after percutaneous coronary intervention in patients with ST elevation myocardial infarction

Atherosclerosis ◽

10.1016/j.atherosclerosis.2018.06.875 ◽

2018 ◽

Vol 276 ◽

pp. 204-205 ◽

Cited By ~ 1

Author(s):

Cengiz Beyan ◽

Esin Beyan

Keyword(s):

Myocardial Infarction ◽

Percutaneous Coronary Intervention ◽

Adverse Events ◽

Mean Platelet Volume ◽

Coronary Intervention ◽

St Elevation Myocardial Infarction ◽

Platelet Volume ◽

Percutaneous Coronary ◽

St Elevation

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PROGNOSTIC SIGNIFICANCE OF MEAN PLATELET VOLUME IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2016/675 ◽

2016 ◽

Vol 3 (58) ◽

pp. 3102-3105

Author(s):

Muralidharan Azhakesan ◽

John Christopher Ponnaian ◽

Indhuja Vaikundarajan ◽

Clemmency Baus

Keyword(s):

Myocardial Infarction ◽

Mean Platelet Volume ◽

Prognostic Significance ◽

St Elevation Myocardial Infarction ◽

Platelet Volume ◽

St Elevation

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Gambaran kelainan katup jantung pada pasien infark miokard di RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari 2015-31 Desember 2015

e-CliniC ◽

10.35790/ecl.4.2.2016.14715 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Mawarni I.S. Tumbel ◽

Agnes L. Panda ◽

Janry Pangemanan

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Retrospective Study ◽

Heart Valve ◽

St Elevation Myocardial Infarction ◽

Papillary Muscles ◽

Age Group ◽

Cross Sectional ◽

St Elevation ◽

Cross Sectional Design

Abstract: Myocardial infarction is divided into STEMI (ST elevation myocardial infarction) and NSTEMI (Non ST elevation myocardial Infarction). According to location, infarction consists of inferior, lateral, and aortal. Inferior infarction often causes mitral valve and aortal abnormality due to papillary muscles rupture. This study was aimed to obtain the description of heart valve abnormality in myocardial infarction patients at Prof. Dr. R. D Kandou Hospital Manado from January 2015 to December 2015. This was a retrospective study with a cross sectional design. The results showed that there were 20 cases (90.9%) of NSTEMI and 2 cases (9.1%) of STEMI. The most location of infarction was inferior accounted for 10 cases (45.5%). The most heart valve abnormalities were combination abnormality accounted for 16 cases (72.7%); most were mild MR (5 cases; 55.6%), mild PR (5 cases; 55.6%), and mild TR (3 cases; 33.3%) in NSTEMI cases dominated by male cases (54.5%) and age group 56-66 years (40.9%), and combination of 4 major risk factors (59.1%).Keywords: description, heart valve abnormality, myocardial infarction Abstrak: Infark miokard terbagi menjadi STEMI (ST elevation myocardial infarction) dan NSTEMI (Non ST elevation myocardial infarction). Infark berdasarkan lokasi terdiri atas inferior, lateral, anterior dan aorta. Infark inferior sering menyebabkan kelainan katup mitral dan aorta akibat ruptur muskulus papilaris. Penelitian ini bertujuan untuk mengetahui gambaran kelainan katup jantung pada pasien infark miokard di RSUP Prof. Dr. R. D. Kandou Manado periode 1 Januari 2015 - 31 Desember 2015. Jenis penelitian ialah retrospektif dengan desain potong lintang. Hasil penelitian mendapatkan 20 kasus (90,9%) NSTEMI dan 2 kasus (9,1%) STEMI. Lokasi infark terbanyak yaitu inferior sebanyak 10 kasus (45,5%), didapati kelainan katup terbanyak yaitu kombinasi sebanyak 16 kasus (72,7%), dengan derajat terbanyak yaitu MR mild 5 kasus (55,6%), PR mild 5 kasus (55,6%) dan TR mild sebanyak 3 kasus (33,3%) pada pasien NSTEMI, yang didominasi oleh pasien laki-laki (54,5%), usia 56 – 66 tahun (40,9%), yang memiliki 4 faktor resiko mayor (59,1%). Kata kunci: gambaran, kelainan katup, infark miokard.

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Pattern of Dyslipidemia in different type of Myocardial Infarction

Bangladesh Critical Care Journal ◽

10.3329/bccj.v5i2.34388 ◽

2017 ◽

Vol 5 (2) ◽

pp. 106-109

Author(s):

Md Zahid Alam ◽

Aparna Rahman ◽

Shabnam Jahan Hoque ◽

SM Rezaul Irfan ◽

Md Babul Miah ◽

...

Keyword(s):

Risk Factors ◽

Myocardial Infarction ◽

Prognostic Significance ◽

Density Lipoprotein ◽

St Elevation Myocardial Infarction ◽

Coronary Risk Factors ◽

Cross Sectional ◽

Coronary Syndrome ◽

Lipid Status ◽

St Elevation

Background: Dyslipidemia is one of the main risk factors with prognostic significance in relation to coronary heart disease. Aggressive treatment has been recommended in acute coronary syndrome (ACS). We examined pattern of dyslipidemia in ST Elevation myocardial infarction (STEMI) and Non- ST elevation myocardial infarction (NSTEMI). We also compare the lipid status in between two types of myocardial infarction (MI).Methods: This cross sectional observational study was carried out enrolling 100 subjects with ST elevation and Non ST elevation Myocardial Infarction, in the Department of Cardiology, BIRDEM General Hospital, Shahbag, Dhaka, over a period of six months from January 2012 to June 2012. Fasting lipid profile was done in next morning of admission in both type of MI.Results: Mean age and gender difference was significant between STEMI and NSTEMI. Mean Cholesterol (chol), Triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) were not statistically significant between male and female groups. All mean cholesterol, TG, HDL, LDL were significantly high in older age group. The Mean cholesterol (220.7±28.1Vs208.4±20.9), triglyceride (182.8±34.4 Vs 147.4±28.9), HDL (35.14±5.7 Vs 41.65±3.8) and LDL (160.7±26.2 Vs148.3±16.8)were also statistically significant between STEMI and NSTEMI groups (p<0.05).Conclusion: Dyslipidemia is the dominating coronary risk factors. It could be concluded that significant differences are observed between two types of MI. Lipid status is relatively more uncontrolled in ST elevated MI and must be managed with all possible therapeutic modules to minimize further complications.Bangladesh Crit Care J September 2017; 5(2): 106-109

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