Evaluation of Vitamin D-levels and Bone Mineral Density in Lymphoma and Solid Tumors of Childhood after Treatment

As the survival rate of childhood cancers increases, late effects of the treatment are becoming significantly more critical. The aim of this study is to evaluate serum 25 Hydroxy Vitamin D levels and bone mineral density (BMD) of patients with lymphoma and solid tumors. In this study, we included patients diagnosed with cancer in our pediatric oncology department between 2004 and 2013. These patients were all in remission and completed their treatment. Patient data were collected from corresponding medical files. Vitamin D levels, BMD measurements and other laboratory tests were performed prospectively. The study group consisted of 105 patients who completed treatment at least one year ago. Overall, 59.6 % of the subjects were found to have vitamin D levels less than 20 ng/mL. When the factors affecting vitamin D deficiency were evaluated, there were not any factor related to vitamin D deficiency. However, a positive correlation was observed in the blood sampling time, namely test results taken in summer months (April-September) were higher. In our study, bone mineralization disorder (low BMD) was found in 44.4% of the patients. In addition, we observed that bone health was significantly affected in children who recovered from cancer. 59.6 % of the vitamin D deficiency rate was found to be higher than the similar age group in our country. To our knowledge, this is also the lowest vitamin D levels in children with cancer compared to previously published studies. The rate of low BMD was determined as 44.4%, similar to earlier studies.

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Screening for Vitamin D Deficiency in Black Americans: Comparison of Total, Free, Bioavailable 25 Hydroxy Vitamin D Levels with Parathyroid Hormone Levels and Bone Mineral Density

The journal of nutrition health & aging ◽

10.1007/s12603-018-1080-y ◽

2018 ◽

Vol 22 (9) ◽

pp. 1045-1050 ◽

Cited By ~ 2

Author(s):

Alexis McKee ◽

S. M. Lima Ribeiro ◽

T. K. Malmstrom ◽

H. M. Perry ◽

D. K. Miller ◽

...

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Parathyroid Hormone ◽

Vitamin D Deficiency ◽

Bone Mineral ◽

Black Americans ◽

Mineral Density ◽

Hormone Levels ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

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25-hydroxy vitamin D levels in healthy premenopausal women: Association with bone turnover markers and bone mineral density

Bone ◽

10.1016/j.bone.2009.05.012 ◽

2009 ◽

Vol 45 (3) ◽

pp. 423-426 ◽

Cited By ~ 48

Author(s):

Silvano Adami ◽

Francesco Bertoldo ◽

Vania Braga ◽

Elena Fracassi ◽

Davide Gatti ◽

...

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Bone Turnover ◽

Bone Mineral ◽

Bone Turnover Markers ◽

Premenopausal Women ◽

Mineral Density ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D ◽

Turnover Markers

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Calcium and vitamin D supplementation in children with frequently relapsing and steroid-dependent nephrotic syndrome

Paediatrica Indonesiana ◽

10.14238/pi52.1.2012.16-21 ◽

2012 ◽

Vol 52 (1) ◽

pp. 16

Author(s):

Ayi Dilla Septarini ◽

Taralan Tambunan ◽

Pustika Amalia

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Bone Mineral ◽

Vitamin D Supplementation ◽

Ionized Calcium ◽

Mineral Density ◽

Vitamin D Levels ◽

Before And After ◽

25 Hydroxy Vitamin D ◽

Serum Ionized Calcium

Background Children with frequently relapsing and steroiddependentnephrotic syndrome (FRNS/SDNS) are at riskfor osteoporosis due to impaired metabolism of calcium andvitamin D.Objective To determine the effect of calcium and vitamin Dsupplementation on bone mineral density, serum ionized calciumlevels and serum 25-hydroxy-vitamin D levels in children withFRNS and SDNS.Methods A clinical trial with a before and after design wasperformed. Subjects were SDNS or FRNS pediatric patients 2: 5years of age. Subjects received 800 mg elemental calcium and 400IU vitamin D supplementation for 8 weeks. Serum ionized calcium,serum 25-hydroxy-vitamin D [25(0H)D], and bone mineral density(BMD) were determined before and after the supplementation.Results Of the 30 subjects, 28 completed the study. However,only 20 subjects underwent BMD determination before and aftersupplementation. Of the 28 subjects, 22 had hypocalcemia and 26had low vitamin D levels. Osteopenia was found in 14/20 subjects andosteoporosis was in 2/20 subjects. After 8 weeks of supplementation,mean serum ionized calcium increased from low [1.15 mmol/L (SDO.oJ)] to normal [1.18 mmol/L (SD 0.04)] (P< 0.001) levels, butmean serum 25(0H)D only increased from vitamin D deficiencycategory [20 ng/mL (SD 7 .7)] to vitamin D insufficiency category[25.5 ng/mL (7.7)] (P=0.010). Mean z-score BMD increased from-1.1 (SD 0.9) to -0.7 (SD 0.2) after supplementation (P<0.001).Conclusion Calcium vitamin D supplementation effectively increasedserum ionized calcium, serum 25 (OH)D, and BMD in subjectswith FRNS and SDNS. [Paediatr lndones. 2012;52:16-21].

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Juvenile lupus and serum vitamin D levels: A cross-sectional study

Lupus ◽

10.1177/0961203320957721 ◽

2020 ◽

Vol 29 (13) ◽

pp. 1752-1758

Author(s):

Samar abd Alhamed Tabra ◽

Hend Hassan Abdelnabi ◽

Nivine Fathi Mahmoud Darwish ◽

Amal Mohammed El-Barbary ◽

Muhammad Tarek AbdelGhafar ◽

...

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Disease Activity ◽

Vitamin D Deficiency ◽

Bone Mineral ◽

Healthy Children ◽

Z Score ◽

Mineral Density ◽

Vitamin D Levels ◽

Significant Difference

Background Juvenile systemic lupus erythematosus (JSLE) is usually associated with vitamin D deficiency and low bone mineral density. Objectives To evaluate serum levels of 25-OH vitamin D in JSLE patients and to correlate these findings with disease activity and bone density. Methods This study was conducted on 100 patients with JSLE and 100 healthy children as controls. Disease duration and SLEDAI for disease activity were evaluated. CBC, anti-dsDNA, C3,C4,24hr urinary proteins, creatinine, estimated glomerular filtration rate(e-GFR),Ca,P,PTH, 25 (OH) D levels, and bone mineral density(BMD)Z score were measured. Results There were significant differences in mean 25(OH)D concentration between patients group (19.37 ± 9.72 ng/ml) and controls 35.90 ± 9.66 ng/ml(p < 0.05), with significant difference between active and inactive patients (p < 0.05).There were significant negative correlations between serum 25(OH)D and SLEDAI (r-0.545, p 0.001), steroid dose (r-0.561, p 0.001), anti-dsDNA (r-0.685, p 0.006), 24 hr-proteinuria (r-0.738, p 0.001) and PTH (r-0.335, p 0.001), significant positive correlations between 25(OH)D and C3 (r0.617, p 0.001),C4 (r0.544, p 0.001) serum Ca (r0.424, p 0.001) and Z score (r0.561, p 0.001),with non-significant correlations between 25(OH)D and serum P and both disease & steroid duration, (p > 0.05). Conclusion Vitamin D deficiency is common in JSLE, it’s correlated significantly with disease activity and bone mineral density.

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Serum 25-hydroxy Vitamin D levels as an Indicator of Bone Mineral Density in Osteoporosis

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2018/35447.11919 ◽

2018 ◽

Author(s):

P Modagan ◽

Santhi Silambanan ◽

Gopinath Menon ◽

P Arunalatha

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Bone Mineral ◽

Mineral Density ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

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Vitamin D Deficiency and Osteoporosis In Hemophilia: An Underappreciated Risk

Blood ◽

10.1182/blood.v122.21.3593.3593 ◽

2013 ◽

Vol 122 (21) ◽

pp. 3593-3593 ◽

Cited By ~ 4

Author(s):

Mindy L. Simpson ◽

Leonard A. Valentino

Keyword(s):

Bone Mineral Density ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Board Of Directors ◽

Bone Mineral ◽

Thyroid Function Tests ◽

Mineral Density ◽

Advisory Committees ◽

Vitamin D Levels ◽

History Of

Abstract Background Several predisposing risk factors exist for decreased bone mineral density in patients with hemophilia increasing the likelihood of osteopenia and osteoporosis in this population. We report the findings of a study evaluating the association of vitamin D deficiency, osteoporosis and hemophilia. Objective Describe the findings of a prospective study evaluating vitamin D levels and bone mineral density in patients with hemophilia. We hypothesize that males with hemophilia have decreased vitamin D levels increasing their risk of osteoporosis along with arthropathy and periods of immobility resulting in reduced bone loading. Design/Method Males with hemophilia, age 1-66 years, were eligible for a 3 part study including: 1) data collection on basic health; 2) laboratory measurement of 25-OH Vitamin D, liver enzymes, ionized calcium, magnesium, phosphorus, parathyroid hormone (PTH), and thyroid function tests; and 3) DEXA scan. Results 86 male subjects, age 2-64 years (mean: 19.9, median: 15.0) including 69 (80%) with hemophilia A and 17 (20%) with hemophilia B were enrolled along with 9 (10%) with history of an inhibitor. Vitamin D levels were reduced in 51 (65%) subjects, including 23 (30%) who were vitamin D insufficient (20-29 ng/mL) and 28 (36%) who were vitamin D deficient (<20 ng/mL). Of the 8 enrolled subjects with history of inhibitor who have had vitamin D levels tested, 7 (88%) are abnormally low with range 17-30 ng/mL for all 8. Among the 61 DEXA scans completed, 8 (13%) were abnormal resulting in a diagnosis of osteoporosis – 6 adults and 2 children (age range 12-56 years). The 2 children with abnormal DEXA scans have a history of inhibitor; the 6 adults are all infected with HIV and/or HCV. 7 of the 8 subjects with osteoporosis had vitamin D levels drawn, where 3 (43%) were abnormally low, with a range of only 10-33 ng/mL among all 7. Conclusion Among hemophilia patients enrolled in this study, 65% have abnormally low vitamin D levels which may predispose to decreased bone mineral density over their lifetime. Patients with a history of inhibitor appear to have an increased risk of reduced vitamin D levels. Vitamin D and calcium supplementation may be a simple and inexpensive intervention to address this complication and warrants further investigation in this population. 13% of enrolled subjects had osteoporosis on DEXA where a history of inhibitor or coinfection with HIV and/or HCV is prevalent. High risk subjects may deserve routine screening to allow for earlier intervention. Funding:CSL Behring Foundation grant Disclosures: Valentino: Baxter: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Bayer: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Biogen Idec: Consultancy, Membership on an entity’s Board of Directors or advisory committees; GTC Biotherapeutics: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Inspiration: Consultancy, Membership on an entity’s Board of Directors or advisory committees; Novo Nordisk: Consultancy, Membership on an entity’s Board of Directors or advisory committees.

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