Implicating Dendritic Cells In The Pathogenesis Of Anterior Uveitis 

2018 ◽  
Author(s):  
Michéal O'Rourke
Keyword(s):  
Dendritic Cells ◽  
Anterior Uveitis

The role of dendritic cells in non-infectious anterior uveitis

2015 ◽  
Vol 93 ◽  
pp. n/a-n/a
Author(s):  
M. O'Rourke ◽  
M. Canavan ◽  
C. Sweeney ◽  
J. Fletcher ◽  
U. Fearon ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Anterior Uveitis

The pathogenic role of dendritic cells in non-infectious anterior uveitis

2018 ◽  
Vol 173 ◽  
pp. 121-128 ◽  
Author(s):  
M. O'Rourke ◽  
U. Fearon ◽  
C.M. Sweeney ◽  
S.A. Basdeo ◽  
J.M. Fletcher ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Anterior Uveitis ◽  
Pathogenic Role

scholarly journals Intra-ocular dendritic cells are increased in HLA-B27 associated acute anterior uveitis

2021 ◽  
Author(s):  
Maren Kasper ◽  
Michael Heming ◽  
David Schafflick ◽  
Xiaolin Li ◽  
Tobias Lautwein ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Anterior Uveitis ◽  
Plasma Cells ◽  
Cell Communication ◽  
Hla B27 ◽  
Acute Anterior Uveitis ◽  
Single Cell Rna Sequencing ◽  
Infectious Endophthalmitis ◽  
Local Cell

AbstractUveitis describes a heterogeneous group of inflammatory eye diseases characterized by infiltration of leukocytes into the uveal tissues. HLA-B27-associated uveitis is a common subtype of uveitis and a prototypical ocular autoimmune disease. Local immune mechanisms driving human uveitis are poorly characterized mainly due to the limited available biomaterial and subsequent technical limitations.Here, we provide the first high-resolution characterization of intraocular leukocytes in HLA-B27 positive and negative anterior uveitis and an infectious endophthalmitis control by combining single cell RNA-sequencing (scRNA-seq) with flow cytometry and low-input proteomics. Ocular cell infiltrates consisted primarily of lymphocytes in uveitis and of myeloid cells in infectious endophthalmitis. HLA-B27 positive uveitis exclusively featured an plasmacytoid and classical dendritic cells (cDC) infiltrate, and of plasma cells. Moreover, cDCs were central in predicted local cell-cell communication.The data suggests a unique pattern of ocular leukocyte infiltration in HLA-B27 positive uveitis with relevance of particular dendritic cells.

Dendritic cells of the human epidermis: immuno-electron microscopic studies of la antigen reactivity

1978 ◽  
Vol 36 (2) ◽  
pp. 644-645
Author(s):  
G. Rowden ◽  
M. G. Lewis ◽  
T. M. Phillips
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Cell Types ◽  
Cell Type ◽  
Electron Microscopic ◽  
La Antigen ◽  
Microscopic Studies ◽  
A Cell ◽  
C3 Receptors ◽  
Antigen Reactivity

Langerhans cells of mammalian stratified squamous epithelial have proven to be an enigma since their discovery in 1868. These dendritic suprabasal cells have been considered as related to melanocytes either as effete cells, or as post divisional products. Although grafting experiments seemed to demonstrate the independence of the cell types, much confusion still exists. The presence in the epidermis of a cell type with morphological features seemingly shared by melanocytes and Langerhans cells has been especially troublesome. This so called "indeterminate", or " -dendritic cell" lacks both Langerhans cells granules and melanosomes, yet it is clearly not a keratinocyte. Suggestions have been made that it is related to either Langerhans cells or melanocyte. Recent studies have unequivocally demonstrated that Langerhans cells are independent cells with immune function. They display Fc and C3 receptors on their surface as well as la (immune region associated) antigens.

Human PMNs are phagocytosed by dendritic cells and interfere with DCs maturation: a new link between innate and acquired immunity

2010 ◽  
Vol 34 (8) ◽  
pp. S72-S72
Author(s):  
Qi Xu ◽  
Xiumin Ma ◽  
Yuejie Zhu ◽  
Fengsen Li ◽  
Jianbing Ding
Keyword(s):  
Dendritic Cells ◽  
Acquired Immunity ◽  
Human Pmns

Generation of functionally mature dendritic cells from the multipotential stem cell line FDCP-mix

2000 ◽  
Vol 111 (3) ◽  
pp. 890-897 ◽  
Author(s):  
Timm Schroeder ◽  
Claudia Lange ◽  
John Strehl ◽  
Ursula Just
Keyword(s):  
Dendritic Cells ◽  
Stem Cell ◽  
Cell Line ◽  
Stem Cell Line

In situ demonstration of migration of dendritic cells released from rat small intestine to mesenteric lymph nodes

2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Small Intestine ◽  
Lymph Nodes ◽  
Rat Small Intestine ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph
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