scholarly journals Effect of Powdered Beverages Containing Pu-erh Tea Extract on Postprandial Blood Glucose Levels

2019 ◽  
Vol 9 (8) ◽  
pp. 532
Author(s):  
Ryuji Takeda ◽  
Yumiko Furuno ◽  
Shigeru Imai ◽  
Yumiko Ide ◽  
Danyong Wu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Area Under The Curve ◽  
Postprandial Blood Glucose ◽  
Lower Blood Glucose ◽  
Glucose Levels ◽  
Cooked Rice ◽  
Blood Glucose Levels ◽  
Lower Blood ◽  
Tea Extract

Objective: The current study aimed to examine the effect of a single ingestion of a beveragecontaining Pu-erh tea extract (Pu-erh tea polyphenol 32.48mg, eq. gallic acid) on postprandialblood glucose levels through a comparison using a crossover test.Method: A total of 20 participants, of which 10 were men and 10 were women, aged between 29 and 64 years were instructed to ingest beverages containing Pu-erh tea extract or placebo beverages at the same time as load food (in addition to cooked rice). Their blood glucose levels were measured before and 30, 60, 90, and 120 min after ingestion.Results: In phases I and II of the trial, three participants who had large differences in the quantity of the ingested food on the day before the trial were removed from the study. Finally, the analysis was conducted on 17 participants. Result showed that the group who ingested the beverage containing Pu-erh tea extract had significantly lower blood glucose levels than the group who consumed the placebo beverage 60, 90, and 120 min after ingestion. In terms of the amount of variation before ingestion, the group who ingested beverages with Pu-erh tea extracts had significantly lower blood glucose levels than the group who consumed the placebo beverage 60, 90, and 120 min after ingestion. In terms of area under the curve (AUC) and increase in the area under the curve (IAUC) for blood glucose levels with some variations, the time it took for the participants to consume the trial beverage compared with the placebo beverage was significantl lower.Conclusion: Beverages containing Pu-erh tea extract were found to be effective in suppressingthe increase in postprandial blood glucose levels after being loaded with cooked rice.Keywords: Pu-erh tea, postprandial blood glucose, cooked rice, type 2 diabetes

scholarly journals EFFECT OF AEROBIC EXERCISES AND RESISTANCE TRAINING ON GLUCOSE LEVELS IN TYPE 2 DIABETIC SUBJECTS.

2017 ◽  
Vol 10 (7) ◽  
pp. 360
Author(s):  
Aishwarya Pramod Benkar ◽  
Smita Bhimrao Kanase
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Resistance Training ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Postprandial Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

Objective: Diabetes mellitus is a leading cause of death and disability in the world and its prevalence is predicted to rise to 10% by 2030. Hence, this study is conducted with objectives to find out the effect of aerobic exercises and resisted exercises on blood glucose levels in type 2 diabetes mellitus (T2DM) subjects and to compare the effect of both exercises on blood glucose level.Method: The comparative study was conducted at Krishna Institute of Medical Sciences Deemed University, Physiotherapy department, Karad. 30 participants with age group between 30 and 65 years were taken. Subjects were selected as per inclusion and exclusion criteria. Group A (15) participants were given aerobic exercise on static bicycle, and Group B (15) participants were given resistance training using dumbbells and weight cuffs for 5 days/week for 4 weeks. Diet recommendations were given to every participant.Results: Statistical analysis was performed using paired and unpaired t-test. Analysis showed statistically extremely significant difference in fasting blood glucose level and postprandial blood glucose level in both the groups (p≤0.0001).Conclusion: Thus, this study concludes that both aerobic exercises and resistance training prove to be beneficial in controlling blood glucose levels in T2DM subjects.

scholarly journals Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2330 ◽  
Author(s):  
Ari ◽  
Murdun ◽  
Koutnik ◽  
Goldhagen ◽  
Rogers ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Rodent Models ◽  
Lower Blood Glucose ◽  
Post Exercise ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lower Blood Glucose Level ◽  
Lower Blood

Diseases involving inflammation and oxidative stress can be exacerbated by high blood glucose levels. Due to tight metabolic regulation, safely reducing blood glucose can prove difficult. The ketogenic diet (KD) reduces absolute glucose and insulin, while increasing fatty acid oxidation, ketogenesis, and circulating levels of β-hydroxybutyrate (βHB), acetoacetate (AcAc), and acetone. Compliance to KD can be difficult, so alternative therapies that help reduce glucose levels are needed. Exogenous ketones provide an alternative method to elevate blood ketone levels without strict dietary requirements. In this study, we tested the changes in blood glucose and ketone (βHB) levels in response to acute, sub-chronic, and chronic administration of various ketogenic compounds in either a post-exercise or rested state. WAG/Rij (WR) rats, a rodent model of human absence epilepsy, GLUT1 deficiency syndrome mice (GLUT1D), and wild type Sprague Dawley rats (SPD) were assessed. Non-pathological animals were also assessed across different age ranges. Experimental groups included KD, standard diet (SD) supplemented with water (Control, C) or with exogenous ketones: 1, 3-butanediol (BD), βHB mineral salt (KS), KS with medium chain triglyceride/MCT (KSMCT), BD acetoacetate diester (KE), KE with MCT (KEMCT), and KE with KS (KEKS). In rested WR rats, the KE, KS, KSMCT groups had lower blood glucose level after 1 h of treatment, and in KE and KSMCT groups after 24 h. After exercise, the KE, KSMCT, KEKS, and KEMCT groups had lowered glucose levels after 1 h, and in the KEKS and KEMCT groups after 7 days, compared to control. In GLUT1D mice without exercise, only KE resulted in significantly lower glucose levels at week 2 and week 6 during a 10 weeks long chronic feeding study. In 4-month and 1-year-old SPD rats in the post-exercise trials, blood glucose was significantly lower in KD and KE, and in KEMCT groups, respectively. After seven days, the KSMCT group had the most significantly reduced blood glucose levels, compared to control. These results indicate that exogenous ketones were efficacious in reducing blood glucose levels within and outside the context of exercise in various rodent models of different ages, with and without pathology.

scholarly journals Protective effect of cyanidin-3-O-glucoside on neonatal porcine islets

2017 ◽  
Vol 235 (3) ◽  
pp. 237-249 ◽  
Author(s):  
Chao Li ◽  
Bin Yang ◽  
Zhihao Xu ◽  
Eric Boivin ◽  
Mazzen Black ◽  
...  
Keyword(s):  
Drinking Water ◽  
Blood Glucose ◽  
Related Factor ◽  
Post Transplantation ◽  
Lower Blood Glucose ◽  
Glucose Levels ◽  
Porcine Islets ◽  
Blood Glucose Levels ◽  
Lower Blood ◽  
Neonatal Porcine Islets

Oxidative stress is a major cause of islet injury and dysfunction during isolation and transplantation procedures. Cyanidin-3-O-glucoside (C3G), which is present in various fruits and vegetables especially in Chinese bayberry, shows a potent antioxidant property. In this study, we determined whether C3G could protect neonatal porcine islets (NPI) from reactive oxygen species (H2O2)-induced injury in vitro and promote the function of NPI in diabetic mice. We found that C3G had no deleterious effect on NPI and that C3G protected NPI from damage induced by H2O2. Significantly higher hemeoxygenase-1 (HO1) gene expression was detected in C3G-treated NPI compared to untreated islets before and after transplantation (P < 0.05). Western blot analysis showed a significant increase in the levels of phosphorylated extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol 3-kinase (PI3K/Akt) proteins in C3G-treated NPI compared to untreated islets. C3G induced the nuclear translocation of nuclear erythroid 2-related factor 2 (NRF2) and the significant elevation of HO1 protein. Recipients of C3G-treated NPI with or without C3G-supplemented drinking water achieved normoglycemia earlier compared to recipients of untreated islets. Mice that received C3G-treated islets with or without C3G-supplemented water displayed significantly lower blood glucose levels at 5–10 weeks post-transplantation compared to mice that received untreated islets. Mice that received C3G-treated NPI and C3G-supplemented drinking water had significantly (P < 0.05) lower blood glucose levels at 7 and 8 weeks post-transplantation compared to mice that received C3G-treated islets. These findings suggest that C3G has a beneficial effect on NPI through the activation of ERK1/2- and PI3K/AKT-induced NRF2-mediated HO1 signaling pathway.

Higher blood glucose impairs cardiac autonomic modulation in fasting and after carbohydrate overload in adults

2020 ◽  
Author(s):  
Caroline Maria Oliveira ◽  
Ana Carolina Ghezzi ◽  
Lucieli Teresa Cambri
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Area Under The Curve ◽  
Abdominal Circumference ◽  
Autonomic Modulation ◽  
Cardiac Autonomic Modulation ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lower Blood ◽  
Glucose Group

This study aimed to assess whether the blood glucose levels influence cardiac autonomic modulation under fasting and after carbohydrate overload conditions. Participants (n=108) were separated into lower blood glucose and higher blood glucose groups, based on the median (90.5 mg•dL-1) of fasting glucose assessed. The SD2, SDNN, LF indices, and LF/HF increased, and HF decreased after dextrose overload compared to fasting (p<0.05). Body mass (78.9 vs 69.7 kg), abdominal circumference (90.2 vs 82.2 cm), systolic (113 vs 108 mmHg) and diastolic (72 vs 67 mmHg) blood pressure were higher (p < 0.05) in the higher blood glucose group. Heart rate variability (HRV) indices (SD1: 21.0 vs 26.5; SD2: 76.8: vs 86.1; RMSSD: 28.7 vs 37.5; SDNN: 56.1 vs 62.5 ms; pNN50: 10.6 vs 18.9%, HF: 328.4 vs 506.0; LF: 982.8 vs 1259.0 ms2), and the area under the curve of these indices after dextrose overload were lower in the higher blood glucose group (p < 0.05). Additionally, glycemia after dextrose overload was correlated with HRV indices (Rho = – 0.216 to – 0.273, p < 0.05). Individuals with higher blood glucose, even in the normality range, showed impairment in the cardiac autonomic modulation both at fasting and after carbohydrate overload. Novelty: - Higher fasting blood glucose impairs cardiac autonomic modulation - Carbohydrate overload impairs cardiac autonomic modulation

Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets

2021 ◽  
Author(s):  
Okka Scholz ◽  
Silke Otter ◽  
Alena Welters ◽  
Laura Wörmeyer ◽  
Jurij Dolenšek ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Pancreatic Islets ◽  
Lower Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lower Blood

scholarly journals REVIEW ON MANAGEMENT PREVENTION AND TREATMENT OF DIABETES MELLITUS

2019 ◽  
Vol 7 (2) ◽  
pp. 56-62
Author(s):  
Nagoba Shivappa N ◽  
Sugave Ramling V ◽  
Ningule Ganesh M ◽  
Patil Pooja Y
Keyword(s):  
Diabetes Mellitus ◽  
Developed Countries ◽  
Lower Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lower Blood ◽  
Treatment Of Diabetes ◽  
Toxicity Of Drugs ◽  
Oral Hypoglycemic Drugs

Diabetes mellitus is the third leading cause of death (after heart disease and cancer) in many developed countries it affect about 6-8% of general population. The complication occurs in diabetes mellitus affect the eye, kidney and nervous system. Diabetes is major cause of blindness, renal failure and heart attack. And another is diabetes insipidus. India is the diabetes capital of the world. In India 50 million peoples suffering from type-2 diabetes. This country has major challenge & burden of economic condition to face. Because diabetes mellitus insulin therapy have higher cost & demand is more. But medical experts that timely detection and right management can go a long way in helping patients lead a normal life. That required to more demanding new drug that have need to develop more bioavailability and less toxicity of drugs. Oral hypoglycemic drugs these drugs lower blood glucose levels and are effective orally. Some natural antidiabetic drugs used in treatment of diabetes mellitus, gymnema, pterocarpus, Jamun, bitter guard etc.  

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