scholarly journals REVIEW ON MANAGEMENT PREVENTION AND TREATMENT OF DIABETES MELLITUS

2019 ◽  
Vol 7 (2) ◽  
pp. 56-62
Author(s):  
Nagoba Shivappa N ◽  
Sugave Ramling V ◽  
Ningule Ganesh M ◽  
Patil Pooja Y
Keyword(s):  
Diabetes Mellitus ◽  
Developed Countries ◽  
Lower Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lower Blood ◽  
Treatment Of Diabetes ◽  
Toxicity Of Drugs ◽  
Oral Hypoglycemic Drugs

Diabetes mellitus is the third leading cause of death (after heart disease and cancer) in many developed countries it affect about 6-8% of general population. The complication occurs in diabetes mellitus affect the eye, kidney and nervous system. Diabetes is major cause of blindness, renal failure and heart attack. And another is diabetes insipidus. India is the diabetes capital of the world. In India 50 million peoples suffering from type-2 diabetes. This country has major challenge & burden of economic condition to face. Because diabetes mellitus insulin therapy have higher cost & demand is more. But medical experts that timely detection and right management can go a long way in helping patients lead a normal life. That required to more demanding new drug that have need to develop more bioavailability and less toxicity of drugs. Oral hypoglycemic drugs these drugs lower blood glucose levels and are effective orally. Some natural antidiabetic drugs used in treatment of diabetes mellitus, gymnema, pterocarpus, Jamun, bitter guard etc.  

scholarly journals Canagliflozin: from glycemic control to improvement of cardiovascular and renal prognosis in patients with type 2 diabetes mellitus. Resolution of Advisory Board

2022 ◽  
Vol 24 (5) ◽  
pp. 479-486
Author(s):  
M. V. Shestakova ◽  
A. S. Ametov ◽  
M. B. Antsiferov ◽  
T. P. Bardymova ◽  
F. V. Valeeva ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Maximum Efficiency ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Sodium Glucose Cotransporter ◽  
Lower Blood ◽  
Renal Prognosis

Inhibitors of the sodium-glucose cotransporter type 2 (SGLT2i) are a modern class of antihyperglycemic drugs with an insulin-independent mechanism of action. Due to its ability to effectively lower blood glucose levels, improve a number of other cardiometabolic parameters (body weight, blood pressure, uric acid), as well as reduce cardiovascular and renal risks, SGLT2i have become drugs of choice for many of patients with type 2 diabetes mellitus (T2DM). Meanwhile, along with the generally recognized classes-effects of this group of drugs, there are intragroup features, including those associated with their different selectivity in sodium-glucose cotransporters of types 1 and 2 (SGLT1 and SGLT 2). For example, one of the most studied SGLT2i, canagliflozin, in addition to its inhibitory activity against SGLT2, can also moderately block SGLT1 in the intestine and kidneys that could give a maximum efficiency in the control glycemia and others cardiometabolic parameters. In addition, canagliflozin improves not only cardiovascular, but also renal prognosis in patients with T2DM, which is reflected in the corresponding indications in the summary of product characteristics of the drug. This document summarize the established and new data regarding the efficacy and safety of canagliflozin, as well as its place in the treatment of T2DM.

scholarly journals Effect of Powdered Beverages Containing Pu-erh Tea Extract on Postprandial Blood Glucose Levels

2019 ◽  
Vol 9 (8) ◽  
pp. 532
Author(s):  
Ryuji Takeda ◽  
Yumiko Furuno ◽  
Shigeru Imai ◽  
Yumiko Ide ◽  
Danyong Wu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Area Under The Curve ◽  
Postprandial Blood Glucose ◽  
Lower Blood Glucose ◽  
Glucose Levels ◽  
Cooked Rice ◽  
Blood Glucose Levels ◽  
Lower Blood ◽  
Tea Extract

Objective: The current study aimed to examine the effect of a single ingestion of a beveragecontaining Pu-erh tea extract (Pu-erh tea polyphenol 32.48mg, eq. gallic acid) on postprandialblood glucose levels through a comparison using a crossover test.Method: A total of 20 participants, of which 10 were men and 10 were women, aged between 29 and 64 years were instructed to ingest beverages containing Pu-erh tea extract or placebo beverages at the same time as load food (in addition to cooked rice). Their blood glucose levels were measured before and 30, 60, 90, and 120 min after ingestion.Results: In phases I and II of the trial, three participants who had large differences in the quantity of the ingested food on the day before the trial were removed from the study. Finally, the analysis was conducted on 17 participants. Result showed that the group who ingested the beverage containing Pu-erh tea extract had significantly lower blood glucose levels than the group who consumed the placebo beverage 60, 90, and 120 min after ingestion. In terms of the amount of variation before ingestion, the group who ingested beverages with Pu-erh tea extracts had significantly lower blood glucose levels than the group who consumed the placebo beverage 60, 90, and 120 min after ingestion. In terms of area under the curve (AUC) and increase in the area under the curve (IAUC) for blood glucose levels with some variations, the time it took for the participants to consume the trial beverage compared with the placebo beverage was significantl lower.Conclusion: Beverages containing Pu-erh tea extract were found to be effective in suppressingthe increase in postprandial blood glucose levels after being loaded with cooked rice.Keywords: Pu-erh tea, postprandial blood glucose, cooked rice, type 2 diabetes

scholarly journals KOMPARASI EFEK PEMBERIAN MINYAK JINTAN HITAM (Nigella sativa) DENGAN MINYAK ZAITUN (Olea europea) TERHADAP PENURUNAN GLUKOSA DARAH PADA MENCIT (Mus musculus) STRAIN Balb/c

2017 ◽  
Vol 1 (1) ◽  
pp. 36 ◽  
Author(s):  
Setyo Dwi Santoso ◽  
Imam Suryanto
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Olive Oil ◽  
T Test ◽  
Lower Blood Glucose ◽  
Female Mice ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Lower Blood ◽  
Significant Difference

Diabetes mellitus is a disease in humans characterized by an increase in blood glucose levels exceeds the normal limits. Cumin oil and olive oil is an alternative drug to a decrease in blood glucose levels for people with diabetes mellitus. Cumin oil and olive oil has several compounds that can lower blood glucose levels in excess. This study was conducted in January 2015 for 3 weeks in PUSVETMA Surabaya. Animals used in the study were female mice 2-3 months old with an average weight of 20-25 grams of a much as 30 individuals. At a dosage of dextrose 40% is 0.4 cc/ head/ day and the dosage of cumin oil and olive oil is 0.7 cc/ head/ day. This a study conducted of mice that had been induced dextrose 40% by using a sample of a much as 30 female mice. The results of statistical independent t-test, there was no difference or both of the test sample may lower blood glucose levels among female mice were treated with cumin oil and treated with olive oil. While the results of the data was tested using SPSS statistical Paired t-test showed that effectively lower blood glucose levels are olive oil, because there is a significant difference between before and after administration of olive oil after 7 days of dosing.

Efeitos dos Programas de Treinamento Aeróbio, de Força e Combinado na Glicose Sanguínea em Diabéticos do Tipo 2: uma Revisão Sistemática/ Effects of Aerobic, Strength and Combined Programs Training on Blood Glucose in Type 2 Diabetic: a Systematic Review.

1970 ◽  
Vol 5 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Alexandre de Souza E Silva ◽  
Maria Paula Gonçalves Mota
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Training Program ◽  
Aerobic Training ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pubmed Database

O trabalho tem como objetivo analisar os estudos que avaliaram os efeitos dos programas de treinamento aeróbio, força e combinado nos níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Foi utilizado o método de revisão sistemática, sendo utilizada a base de dados PubMed. As palavras chaves utilizadas para pesquisa foram training and diabetes. Foram identificados 484 artigos originais. Apenas 17 estudos respeitaram os critérios de inclusão. Os resultados evidenciam que os programas de treinamento aeróbio diminuíram os níveis de glicose. O programa de treinamento de força também foi favorável à diminuição dos níveis de glicose sanguínea. Já o programa de treinamento combinado não demonstrou efeitos favoráveis no controle da glicose sanguínea. Conclui-se que o programa de treinamento aeróbio e de força ajudam a controlar os níveis de glicose sanguínea em indivíduos com diabetes do tipo 2. Palavras-chave: diabetes mellitus, treinamento, glicose.ABSTRACTThe study aims to analyze the studies that evaluated the effects of aerobic, strength and combined programs training in blood glucose levels in people with type 2 diabetes. We used a systematic review method and is used to PubMed database. The key words used for searching were training and diabetes. We identified 484 original articles. Only 17 studies complied with the inclusion criteria. The results show that aerobic training programs decreased glucose levels. The strength training program was also favorable to decrease in blood glucose levels. But the combined training program has not shown favorable effects on blood glucose control. We conclude that the aerobic training and strength helps control blood glucose levels in individuals with type 2 diabetes. Keywords: diabetes mellitus, training, glucose.

scholarly journals Pharmaceutical hit of anti type 2 Diabetes mellitus on the phenolic extract of Malaka (Phyllanthus emblica L.) flesh

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Musri Musman ◽  
Mauli Zakia ◽  
Ratu Fazlia Inda Rahmayani ◽  
Erlidawati Erlidawati ◽  
Safrida Safrida
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Phyllanthus Emblica ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Phenolic Extract

Abstract Background Ethnobotany knowledge in a community has shaped local wisdom in utilizing plants to treat diseases, such as the use of Malaka (Phyllanthus emblica) flesh to treat type 2 diabetes. This study presented evidence that the phenolic extract of the Malaka flesh could reduce blood sugar levels in the diabetic induced rats. Methods The phenolic extract of the P. emblica was administrated to the glucose-induced rats of the Wistar strain Rattus norvegicus for 14 days of treatment where the Metformin was used as a positive control. The data generated were analyzed by the two-way ANOVA Software related to the blood glucose level and by SAS Software related to the histopathological studies at a significant 95% confidence. Results The phenolic extract with concentrations of 100 and 200 mg/kg body weight could reduce blood glucose levels in diabetic rats. The post hoc Dunnet test showed that the administration of the extract to the rats with a concentration of 100 mg/kg body weight demonstrated a very significant decrease in blood glucose levels and repaired damaged cells better than administering the extract at a concentration of 200 mg/kg weight body. Conclusion The evidence indicated that the phenolic extract of the Malaka flesh can be utilized as anti type 2 Diabetes mellitus without damaging other organs.

scholarly journals Study on the prevalence of dyslipidemia in type 2 diabetes mellitus

2019 ◽  
Vol 6 (3) ◽  
pp. 786
Author(s):  
Eda Dayakar ◽  
C. Sathya Sree ◽  
E. Sanjay
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Type 2 Diabetic

Background: Diabetes mellitus is a common health problem globally. Dyslipidaemia is a major risk factor to develop cardiovascular disease in diabetics. They present study was undertaken to find out the prevalence of dyslipidaemia in type 2 diabetic patients.Methods: The present study was a cross sectional study consisting of 46 (23 male and 23 female) known type 2 diabetes mellitus patients. Age, gender, duration of diabetes, body mass index (BMI) was recorder in all the diabetic patients.  Fasting blood glucose levels, total cholesterol, triglycerides, HDL, LDL, VLDL levels were measured using standard methods and recorded.Results: The average total cholesterol, triglycerides, LDL, HDL and VLDL were 200±42mg/dl, 169.62±89.79mg/dl, 132.45±36.38mg/dl,39.1±16.6mg/dl and 35.85±17.09mg/dl respectively. The incidence of occurrence of hypercholesterolemia was 58.6% and hypertriglyceridemia 36.9%. Increased levels of LDL were observed in 30 (65.2%) patients and reduced HDL was observed in 43 (93.4%) patients. The incidence rate of dyslipidaemia was higher in female diabetic patients when compared to male diabetic patients.Conclusions: Awareness on the dyslipidaemia and its risk factors should be provided to the type 2 diabetic patients as they are more prone to get cardiovascular disease and lipid profile also should be monitored regularly along with blood glucose levels.

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