Lipocalin 2 could predict circulating MMP9 levels in patients with breast cancer

2021 ◽  
pp. 1-3
Author(s):  
Uleng Bahrun ◽  
Wildana Wildana ◽  
Hegaria Rahmawati ◽  
Liong Boy Kurniawan ◽  
William Hamdani
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Lipocalin 2 ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Patients ◽  
The Relationship ◽  
Metalloproteinase 9

OBJECTIVES: Breast cancer is the most prevalent carcinoma found in Indonesian women, and its incidence remains high worldwide. Lipocalin 2 has been linked with the progression of breast cancer. Matrix metalloproteinase 9 (MMP9) is an enzyme that has an important role in angiogenesis. We investigated the relationship between lipocalin 2 and MMP9 and the ability of lipocalin 2 for predicting MMP9 levels in female patients with breast cancer. METHOD: A total of 55 female patients with breast cancer were enrolled in this cross-sectional study. Lipocalin 2 and MMP9 were measured by enzyme-linked immunosorbent assay. RESULTS: Lipocalin 2 was significantly correlated with MMP9 levels (r = 0.756, p < 0.001). Lipocalin 2 levels could describe the MMP9 levels (𝛽 = 0.76, p < 0.001, R2 = 56.9%). CONCLUSION: Higher lipocalin 2 levels in female patients with breast cancer indicate higher MMP9 levels. Lipocalin 2 can be used to predict MMP9 levels.

scholarly journals Association between vitamin D, oestradiol and interferon-gamma in female patients with inactive systemic lupus erythematosus: A cross-sectional study

2017 ◽  
Vol 46 (3) ◽  
pp. 1162-1171 ◽  
Author(s):  
Visnja Kokic ◽  
Dusanka Martinovic Kaliterna ◽  
Mislav Radic ◽  
Leida Tandara ◽  
Dijana Perkovic
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sectional Study ◽  
Systemic Lupus ◽  
Cross Sectional ◽  
Female Patients ◽  
Hydroxyvitamin D

Objectives To investigate possible associations between 25-hydroxyvitamin D3 (25(OH)D3), oestradiol (E2) and IFN-gamma (IFNγ) in female patients with inactive systemic lupus erythematosus (SLE). Methods Female patients with inactive SLE and age-matched healthy controls were recruited into this cross-sectional study. Serum concentrations of 25(OH)D3, E2 and IFNγ were measured by radioimmunoassay with gamma-counters and enzyme-linked immunosorbent assay. Results 36 patients and 37 controls were enrolled. In patients with SLE, the concentration of 25(OH)D3 was lower and E2 was higher compared with controls. In vitamin D deficient (i.e., 25(OH)D3≤20 ng/ml) patients, IFNγ was 150% higher compared with patients with 25(OH)D3>20 ng/ml and controls. The concentration of E2 was higher in all patients compared with controls independently of the vitamin D level. A difference was found between patients and controls in the correlation of 25(OH)D3 with E2 and a positive correlation was found between E2 and IFNγ in all participants. Conclusions Our results suggest that E2 may have a strong modulating effect on vitamin D function which is significant only at low concentration of E2.

scholarly journals Impact of mastectomy on quality of life in female patients with breast cancer in the Gaza Strip: a cross-sectional study

The Lancet ◽  
2019 ◽  
Vol 393 ◽  
pp. S5
Author(s):  
Enas Alaloul ◽  
Mohamedraed Elshami ◽  
Esraa Khader ◽  
Huda Abu Nemer ◽  
Alaa Alhelu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Gaza Strip ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Patients ◽  
The Gaza Strip

scholarly journals Association of tear matrix metalloproteinase 9 immunoassay with signs and symptoms of dry eye disease: A cross-sectional study using qualitative, semiquantitative, and quantitative strategies

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258203
Author(s):  
You Hyun Lee ◽  
Seung-Pil Bang ◽  
Kyu-Young Shim ◽  
Myung-Jin Son ◽  
Harim Kim ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Matrix Metalloproteinase 9 ◽  
Sectional Study ◽  
Cross Sectional ◽  
Staining Score ◽  
Corneal Staining ◽  
Metalloproteinase 9

Purpose This study aimed to analyze the association of tear matrix metalloproteinase 9 (MMP-9) immunoassay with the severity of dry eye (DE) signs and symptoms through qualitative, semiquantitative, and quantitative evaluations of immunoassay band. Materials and methods This cross-sectional study enrolled 320 eyes of 320 patients. The clinical signs of DE were assessed using the Ocular Surface Disorder Index (OSDI) score, visual analogue scale (VAS), tear breakup time (tBUT), tear volume evaluation by tear meniscometry, and staining scores of the cornea and conjunctiva by the Oxford grading scheme. The tear MMP-9 immunoassay results were interpreted using qualitative (positive or negative), semi-quantitative (reagent band density on a four-point scale: 0 = negative; 1 = weakly positive; 2 = moderately positive; 3 = strongly positive), and quantitative (ratio of reagent band density to control band density) indicators. Results Positive MMP-9 immunoassay results were significantly related to shorter tBUT, tBUT ≤3 seconds, higher corneal staining score, corneal staining score ≥2, and conjunctival staining score ≥2. The semi-quantitative results of the MMP-9 immunoassay were positively correlated with higher corneal staining score (r = 0.122, p = 0.029) and negatively correlated with tBUT (r = -0.125, p = 0.025). However, in the quantitative analysis, none of the DE signs or symptoms were correlated to the band density of the MMP-9 immunoassay. Conclusions The positive MMP-9 immunoassay results were related to the severity of ocular signs of DE. However, using quantitative measures of the MMP-9 immunoassay to assess the clinical severity of DE requires further investigation.

scholarly journals Association of Tear Matrix Metalloproteinase 9 Immunoassay With Signs and Symptoms of Dry Eye Disease: A Cross-Sectional Study Using Qualitative, Semiquantitative, and Quantitative Strategies

2020 ◽  
Author(s):  
You Hyun Lee ◽  
Seung-Pil Bang ◽  
Kyu-Young Shim ◽  
Myung-Jin Son ◽  
Harim Kim ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Dry Eye ◽  
Signs And Symptoms ◽  
Cross Sectional Study ◽  
Clinical Severity ◽  
Sectional Study ◽  
Cross Sectional ◽  
Staining Score ◽  
Corneal Staining ◽  
Metalloproteinase 9

Abstract This study aimed to analyze the association of tear matrix metalloproteinase 9 (MMP-9) immunoassay with the severity of dry eye (DE) signs and symptoms through qualitative, semiquantitative, and quantitative evaluations of immunoassay band. This cross-sectional study enrolled 320 eyes of 320 patients. The clinical signs of DE were assessed using the Ocular Surface Disorder Index (OSDI) score, visual analogue scale (VAS), tear breakup time (tBUT), tear volume evaluation by tear meniscometry, and staining scores of the cornea and conjunctiva by the Oxford grading scheme. Positive MMP-9 immunoassay results were significantly related to shorter tBUT, tBUT ≤3 seconds, higher corneal staining score, corneal staining score ≥2, and conjunctival staining score ≥2. The semiquantitative results of the MMP-9 immunoassay were positively correlated with higher corneal staining score and negatively correlated with tBUT. However, in the quantitative analysis, none of the DE signs or symptoms were correlated to the band density of the MMP-9 immunoassay. In conclusion, The qualitatively and semiquantitatively evaluated MMP-9 immunoassay results are related to the clinical severity of DE. However, the quantitatively evaluated MMP-9 immunoassay results did not represent the clinical severity of DE disease.

scholarly journals Pattern of Presentation of Patients With Breast Cancer in Iraq in 2018: A Cross-Sectional Study

2019 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed Tareq Mutar ◽  
Mohammed Saleh Goyani ◽  
Ali Mohammed Had ◽  
Aqeel Shakir Mahmood
Keyword(s):  
Breast Cancer ◽  
Ductal Carcinoma ◽  
Lobular Carcinoma ◽  
Stage Iv ◽  
Tumor Stage ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Tubular Carcinoma ◽  
Female Patients

PURPOSE This study aims to describe the pattern of presentation of Iraqi female patients with breast cancer by assessing the grades and stages of their cancers at the time of presentation, to identify patients’ main complaints, and to discover whether there is any difference in presentation between patients in Iraq and those in other countries. PATIENTS AND METHODS This is a retrospective cross-sectional study that was performed in the National Center of Cancer in 2018. The target population was female patients with breast cancer who came to the Center for treatment and follow-up. A sample of 171 patients was drawn from this population. Self-evaluation forms were used in interviews with the patients to collect personal and sociodemographic data; clinical and histologic characteristics of the patients’ tumors were obtained from their medical records. Ethical approval was obtained. RESULTS Forty-five percent of the patients were younger than age 50 years, and 25% were younger than age 45 years. In all, 42.9% of the patients were diagnosed with stage III and 25% with stage IV cancer, and metastasis was diagnosed in 24.1%. In our study population, 53.4% of the tumors were found in the right breast, and 3.9% of patients had bilateral breast tumors. The most common histopathologic type was invasive ductal carcinoma (81.4%) followed by invasive lobular carcinoma (6.9%) and tubular carcinoma (5.9%). The patients’ most common complaints were breast lump (71.3%) and pain (18.9%). No correlation was found between tumor stage and breast self-examination, family history, education, occupation, histopathology, or grade. CONCLUSION Most of the patients are diagnosed at a late stage when treatment is less effective.

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