Abstract
The effect of O-(β-hydroxyethyl)-rutoside (HR) on human erythrocyte and platelet functions is reported. Only high concentrations of the compound distinctly inhibited red cell and platelet aggregation induced by ADP and epinephrine. Lower concentrations of HR inhibit [14C8]adenosine incorporation into red cells as well as into platelets. Inhibition occurs at both 0°C and 37°C, presumably because diffusion of [14C8]adenosine is hindered. Phosphorylation of [14C8] adenosine by the platelets is not inhibited by HR. The inhibition of red cell aggregation is reversed by washing the cells with plasma. Collectively, these findings indicate an effect of the compound at the site of the membrane, independent of cellular metabolism