scholarly journals Why individuals with cerebral palsy are at higher risk for respiratory complications from COVID-19

2020 ◽  
Vol 13 (3) ◽  
pp. 317-327
Author(s):  
Joline E. Brandenburg ◽  
Matthew J. Fogarty ◽  
Gary C. Sieck
Keyword(s):  
Cerebral Palsy ◽  
Basic Science ◽  
Respiratory Function ◽  
Science Research ◽  
Clinical Work ◽  
Diaphragm Muscle ◽  
Respiratory Complications ◽  
Respiratory Dysfunction ◽  
Potential Risks ◽  
And Function

Respiratory dysfunction is a leading cause of morbidity and mortality in individuals with cerebral palsy (CP). In children and adults with CP, movement and physical function is always affected. Yet, many clinicians overlook potential for impaired movement and function of the diaphragm muscle (DIAm) in individuals with CP. Since individuals with pre-existing respiratory disorders are at greater risk for respiratory complications if they contract COVID-19, understanding potential risks to individuals with CP is important. In this review we present research on respiratory function and DIAm force generation in children with CP. We compare this clinical work to basic science research investigating phrenic motor neuron and DIAm motor unit dysfunction in an animal model with CP symptoms, the spa mouse. Finally, we integrate the clinical and basic science work in respiratory function in CP, discussing potential for individuals with CP to have severe respiratory symptoms from COVID-19.

scholarly journals Pulmonary function test correlation with subclinical respiratory dysfunction in chronic cervical cord compression

2021 ◽  
Vol 12 (10) ◽  
pp. 64-68
Author(s):  
Manpreet Singh Banga ◽  
Sandeep BV ◽  
Anantha Kishan ◽  
Rajesh Babu Devabhakthuni ◽  
Arun MA ◽  
...  
Keyword(s):  
Respiratory Function ◽  
Clinical Signs ◽  
Posterior Longitudinal Ligament ◽  
Cervical Disc ◽  
Cervical Cord ◽  
Respiratory Complications ◽  
Respiratory Dysfunction ◽  
Male Predominance ◽  
Post Operative Period ◽  
Ossified Posterior Longitudinal Ligament

Background: To assess respiratory function in cervical chronic compressive myelopathy (CCM) patients in pre-operative period, post-operative period and to compare pre-operative status with post-operative status. Aims and Objectives: 1. To assess respiratory function in cervical CCM patients in pre-operative period. 2. To assess respiratory function in cervical CCM patients in post-operative period, following relief of compression. 3. To compare, pre-operative status with post-operative status. Materials and Methods: A prospective study was done in 50 patients with cervical CCM due to either cervical disc disease or ossified posterior longitudinal ligament (OPLL) who were operated. None of the patients included in the study had any clinical signs & symptoms of respiratory dysfunction. Spirometry was performed in pre-operative and postoperative period after 3 months and results were analyzed. Forced vital capacity (FVC), forced expiratory volume in first second (FEV1), ratio of mean FEV1 to FVC (FEVI: FVC%) and peak expiratory flow rate (PEFR) were calculated. Results: Majority of the patients were in their fourth decade of life with male predominance. Thirty-six patients (72%) presented with prolapsed intervertebral disc and 14 patients (28%) had ossified posterior longitudinal ligament (OPLL). Patients were operated depending upon the pathology. The present study showed that there was significant reduction in preoperative FVC, FEV1, PEFR values as compared with predicted values and they showed significant improvement in post-operative period after surgical relief of compression. Conclusion: Significant yet occult respiratory dysfunction in form of impairment of various lung capacities exists in patients with cervical CCM. An objective evaluation of this occult respiratory dysfunction is essential to prognosticate, prevent respiratory complications and to improve post-operative respiratory rehabilitation. Institution of incentive spirometry as a routine in all cervical CCM cases will be of benefit in preventing respiratory complications.

A Perspective On The Impact of COVID-19 Pandemic in Basic Science Research and its Future implications

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Yam Nath Paudel ◽  
Efthalia Angelopoulou ◽  
Bhupendra Raj Giri ◽  
Christina Piperi ◽  
Iekhsan Othman ◽  
...  
Keyword(s):  
Basic Science ◽  
Large Scale ◽  
Preventive Measure ◽  
Science Research ◽  
Research Institutes ◽  
Basic Science Research ◽  
Long Term Consequences ◽  
Long Term Impact ◽  
The Impact

: COVID-19 has emerged as a devastating pandemic of the century that the current generations have ever experienced. The COVID-19 pandemic has infected more than 12 million people around the globe and 0.5 million people have succumbed to death. Due to the lack of effective vaccines against the COVID-19, several nations throughout the globe has imposed a lock-down as a preventive measure to lower the spread of COVID-19 infection. As a result of lock-down most of the universities and research institutes has witnessed a long pause in basic science research ever. Much has been talked about the long-term impact of COVID-19 in economy, tourism, public health, small and large-scale business of several kind. However, the long-term implication of these research lab shutdown and its impact in the basic science research has not been much focused. Herein, we provide a perspective that portrays a common problem of all the basic science researchers throughout the globe and its long-term consequences.

Respiratory function changes after chemotherapy: an additional risk for postoperative respiratory complications?

2004 ◽  
Vol 77 (1) ◽  
pp. 260-265 ◽  
Author(s):  
Francesco Leo ◽  
Piergiorgio Solli ◽  
Lorenzo Spaggiari ◽  
Giulia Veronesi ◽  
Filippo de Braud ◽  
...  
Keyword(s):  
Respiratory Function ◽  
Respiratory Complications ◽  
Additional Risk ◽  
Postoperative Respiratory Complications

Setting Up for Success: Strategies to Foster Surgeons’ Pursuit of Basic Science Research

2021 ◽  
Vol 268 ◽  
pp. 71-78
Author(s):  
Devon Livingston-Rosanoff ◽  
Keon Young Park ◽  
Esra Alagoz ◽  
Susan Thibeault ◽  
Angela Gibson
Keyword(s):  
Basic Science ◽  
Science Research ◽  
Success Strategies ◽  
Basic Science Research

scholarly journals Research Productivity and Citation Impact of Indian institutes of Science Education and Research

2021 ◽  
Vol 41 (6) ◽  
pp. 455-462
Author(s):  
Jyotshna Sahoo ◽  
Sudam Charan Sahu ◽  
Basudev Mohanty
Keyword(s):  
Science Education ◽  
Research Productivity ◽  
Basic Science ◽  
Research Output ◽  
Citation Impact ◽  
Science Research ◽  
Publication Patterns ◽  
Research Outcomes ◽  
Basic Science Research ◽  
Research Publications

The paper’s main objective is to investigate the trends of basic science research in India using a combination of qualitative and quantitative approaches. It examines the publication patterns and impact of research productivity of five basic science institutions, i.e., “Indian Institutes of Science Education and Research” (IISER), namely IISER Kolkata, IISER Pune, IISER Mohali, IISER Bhopal, and IISER Thiruvananthapuram. The research output indexed in the SCOPUS bibliographic database of these five established IISERs was obtained from 2015 to 2019. A total number of 7329 research publications were analysed using various scientometric dimensions. This paper makes a concerted effort to present a comprehensive picture of the assessment of research outcomes at the five older IISERs, which are ostensibly India’s most active and prominent basic science research institutions. The findings reveal that these institutions are accountable for important research outcomes, such as a high number of citations, preferences towards open access (OA) publications, a rise in research publication year over year, a strong author network, a high degree of collaboration, and a high impact in terms of other scientometrics indicators. This paper discusses the findings of the research publications on the position of IISERs in basic sciences research and draws some conclusions about their effects.

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