scholarly journals Rationale of method of analysis of evidence-based data on the pharmacological activity of succinic acid and its combinations drugs

2018 ◽  
pp. 97-102
Author(s):  
M. V. Leleka ◽  
O. M. Zalis′ka
Keyword(s):  
Clinical Trials ◽  
Succinic Acid ◽  
Pharmacological Activity ◽  
Retrieval System ◽  
Dosage Forms ◽  
New Drugs ◽  
Cochrane Library ◽  
Evidence Based ◽  
Search Results ◽  
The Cochrane Library

Succinic acid as endogenous metabolite has a wide range of applications in medical practice in Ukraine and abroad. We research a new medicines, based on succinic acid, ascorbic acid and rutin for the prevention and treatment of influenza. Analysis of the data evidence-based medicine necessary for the implementation of quality assessment study feasibility of adding succinic acid in the various dosage forms and determine their pharmacological activity. It was studied international databases and registers of clinical trials MEDLINE®, EMBASE®, Scopus, Cochrane Library for the period from 1966 to June 2015. In the search for key phrases search engine electronic library «The Cochrane Library» found 872 913 publications, including 71 in the section «Trials». Of these, only 23 were devoted to review the results of clinical trials of medications that contain in their composition succinic acid. In the analysis of papers revealed that all 12 Trials of the search engine PubMed are present in search results «The Cochrane Library». Therefore, for further analysis we selected directory search results Trials «The Cochrane Library» and 3 Review of retrieval system PubMed. We analyzed Trials in terms of pharmacological activity and dynamics of publications. For pharmacological properties and relevance RCTs grouped as follows: antihypoxic action confirm 7 RCT (2003–2013 years), improve of iron absorption in the gastrointestinal tract – 6 RCT (1966–1974 years), hepatoprotective – 4 RCT (2013–2014 years). One RCT has effectiveness succinic acid for use in gastroenterology (in combination with omeprazole, 2012), depression (2013), the transplant (1993) during menopause (2008), renal failure (2013) for fever during surgery (2007). We can call such medicines containing succinic acid and have proven clinical efficacy: Remaksol, Tsytoflavin, Vecam (Omeprazole + succinic acid). We analyzed the Review of reviews of retrieval system PubMed. Analysis reviews MedLine (Review) opens new prospects for the use of succinic acid in the treatment of hypoxia and viral hepatitis. The results of clinical trials confirm the feasibility of developing new drugs with succinic acid. We conducted a review of evidence data about the inclusion of succinic acid in the various dosage forms. Succinic acid is the part of the drugs with different pharmacological effect. The results of clinical trials confirm the feasibility of developing of new drugs with succinic acid.

Evidence-Based Podiatric Medicine

2009 ◽  
Vol 99 (3) ◽  
pp. 260-266 ◽  
Author(s):  
Fiona Hawke ◽  
Joshua Burns ◽  
Karl B. Landorf
Keyword(s):  
Systematic Reviews ◽  
Medical Literature ◽  
Cochrane Collaboration ◽  
The United States ◽  
Evidence Base ◽  
Cochrane Library ◽  
Free Access ◽  
Evidence Based ◽  
User Friendliness ◽  
The Cochrane Library

Due to the exponential increase in the quantity and quality of podiatric medicine–related research during the past decade, podiatric physicians are inundated with an insurmountable volume of research relevant to clinical practice. Systematic reviews can refine this literature by using explicit, rigorous, and reproducible methods to identify, critically appraise, and synthesize the best evidence from all clinical trials to answer clearly defined clinical questions. The Cochrane Collaboration is an international not-for-profit organization created to improve the user-friendliness and accessibility of medical literature mainly through preparing and maintaining systematic reviews of health-care interventions. The Cochrane Library currently contains more than 50 podiatric medicine–relevant systematic reviews summarizing and synthesizing evidence from many hundreds of randomized controlled trials evaluating interventions for foot problems. Although more than 60 countries worldwide have open online access to The Cochrane Library, in the United States, only the state of Wyoming has free access to full-text reviews. In an era demanding an evidence-based approach for every clinical intervention, high-quality systematic reviews streamline podiatric medical literature by reducing the time, cost, and training necessary to establish a solid evidence base for practice. (J Am Podiatr Med Assoc 99(3): 260–266, 2009)

scholarly journals Cerumen Management: An Updated Clinical Review and Evidence-Based Approach for Primary Care Physicians

2020 ◽  
Vol 11 ◽  
pp. 215013272090418 ◽  
Author(s):  
Garret A. Horton ◽  
Matthew T. W. Simpson ◽  
Michael M. Beyea ◽  
Jason A. Beyea
Keyword(s):  
Primary Care ◽  
Primary Care Physicians ◽  
English Language ◽  
Family Physicians ◽  
Neck Surgery ◽  
Adverse Outcomes ◽  
Cochrane Library ◽  
Evidence Based ◽  
The Cochrane Library ◽  
Cerumen Removal

Objective: To provide family physicians with a practical, evidence-based approach to managing patients with cerumen impaction. Methods: MEDLINE, The Cochrane Library, and the Turning Research Into Practice (TRIP) database were searched for English-language cerumen impaction guidelines and reviews. All such articles published between 1992 and 2018 were reviewed, with most providing level II and III evidence. Results: Cerumen impaction is a common presentation seen in primary care and cerumen removal is one of the most common otolaryngologic procedures performed in general practice. Cerumen impaction is often harmless but can be accompanied by more serious symptoms. Cerumenolytics and irrigation of the ear canal are reasonable first-line therapies and can be used in conjunction or isolation. If irrigation and cerumenolytics are contraindicated, manual removal is appropriate, but the tools necessary are not commonplace in primary care clinics and specialized training may be required to prevent adverse outcomes. Conclusion: Family physicians play a key role in the assessment and management of cerumen impaction and are well equipped to do so. Knowledge of the available techniques for cerumen removal as well as their contraindications ensures that cerumen is removed safely and effectively. When cerumen removal cannot be removed safely in a primary care setting, referral to Otolaryngology-Head and Neck Surgery is appropriate.

Evidence-based urology in practice: the cochrane library

2009 ◽  
Vol 104 (8) ◽  
pp. 1048-1049 ◽  
Author(s):  
Sakineh Hajebrahimi ◽  
Philipp Dahm ◽  
Jeanette Buckingham
Keyword(s):  
Cochrane Library ◽  
Evidence Based ◽  
The Cochrane Library

All I want for coagulation

2011 ◽  
Vol 56 (4) ◽  
pp. 183-187 ◽  
Author(s):  
K P Nunn ◽  
M R Bridgett ◽  
M R Walters ◽  
I Walker
Keyword(s):  
Deep Vein Thrombosis ◽  
Cochrane Library ◽  
Evidence Based ◽  
Compression Stockings ◽  
Vein Thrombosis ◽  
Dvt Prophylaxis ◽  
Clinical Encounters ◽  
Santa Claus ◽  
The Cochrane Library ◽  
Deep Vein

Evidence-based medicine underpins modern practice of medicine. This paper describes a fictional consultation between Santa Claus and a doctor regarding deep vein thrombosis (DVT) prophylaxis, giving a review of the evidence for DVT prophylaxis in travellers while exposing the difficulty in applying evidence to atypical clinical encounters. Medline and the Cochrane Library were searched, and guidelines reviewed. Keywords used were DVT, thromboembolism, deep vein thrombosis and air travel-related venous thromboembolism. All relevant studies found, have been included in this review, with additional studies identified from the references in these articles. In conclusion, compression stockings, with or without a one-off dose of either aspirin or heparin, are the most evidence-based approaches for prophylaxis in someone with established risk factors for DVT prior to a long-haul flight. Simple exercises should also be encouraged.

scholarly journals Awareness and the use of evidence-based medicine resources among physicians

2019 ◽  
Vol 6 (10) ◽  
pp. 4612-4614
Author(s):  
Amjad Alhelo ◽  
Bashar Samara
Keyword(s):  
Evidence Based Medicine ◽  
Best Practice ◽  
Response Rate ◽  
Cross Sectional Study ◽  
Cochrane Library ◽  
Evidence Based ◽  
Cross Sectional ◽  
Evidenced Based ◽  
The Cochrane Library ◽  
Based Medicine

Aim: to evaluate awareness and the use of evidence-based medicine resources among physicians in Jordan.  Method: A cross-sectional study by internet was performed among 517 doctors who were responsive from a total of 717 doctors, a total of 72.1% response rate. Doctors from all specialties were contacted from a Facebook group called doctors café in Jordan. A questionnaire was given to each one of them to measure their awareness and use of Evidence based database.   Result: From 517 physicians 377 they are using evidenced based resources frequently, and 91 using resources but not frequently and 49 not using evidence-based resources. The resource that was mostly used by the doctors was PubMed, followed by other resources such as Up to date, National Guideline Clearinghouse, Medscape, BMJ best practice, e-books and other online journals for published papers. The Cochrane Library was surprisingly not so familiar amongst physicians. Conclusion: There is good awareness about EBM among physicians in Jordan, and that benefits health care in Jordan.

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