Proliferative Inflammatory Atrophy

ABSTRACT: Gene expression of ErbB1 and ErbB2, and immunostaining of EGFR (Her1) and Her2 (c-erbB-2) were evaluated in this study to ascertain whether these receptors are involved in the evolution of canine premalignant and malignant prostatic lesions, as proliferative inflammatory atrophy (PIA) and prostatic carcinoma (PC). With regards to the intensity of EGFR immunostaining, there was no difference between normal prostatic tissue and tissues with PIA or PC. In relation to Her2 immunostaining, there were differences between normal prostatic tissue and those with PIA and PC, as also differences between prostates with PIA and PC. There was no correlation between EGFR and Her2 immunostaining. ErbB1 gene product was detected in two normal tissue samples, in one with PIA, and in all samples with PC. ErbB2 mRNA was recorded in two canine samples with PIA, in all with PC, but was not detected in normal prostatic tissue. It was concluded that EGFR and Her2 play roles in canine PIA and PC, suggesting that those receptors may be involved in canine prostatic carcinogenesis.

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Clinical Significance of Proliferative Inflammatory Atrophy in Negative Prostatic Biopsies

The Prostate ◽

10.1002/pros.23234 ◽

2016 ◽

Vol 76 (16) ◽

pp. 1501-1506 ◽

Cited By ~ 11

Author(s):

Pol Servian ◽

Ana Celma ◽

Jacques Planas ◽

José Placer ◽

Inés M. de Torres ◽

...

Keyword(s):

Clinical Significance ◽

Proliferative Inflammatory Atrophy

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Consequences of interleukin 1β‐triggered chronic inflammation in the mouse prostate gland: Altered architecture associated with prolonged CD4+infiltration mimics human proliferative inflammatory atrophy

The Prostate ◽

10.1002/pros.23784 ◽

2019 ◽

Vol 79 (7) ◽

pp. 732-745 ◽

Cited By ~ 11

Author(s):

Arya Ashok ◽

Rebecca Keener ◽

Michael Rubenstein ◽

Stephanie Stookey ◽

Sagar Bajpai ◽

...

Keyword(s):

Chronic Inflammation ◽

Prostate Gland ◽

Interleukin 1Β ◽

Proliferative Inflammatory Atrophy ◽

Mouse Prostate

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Abstract 5260: Genomic gains in prostatic carcinoma and proliferative inflammatory atrophy in dogs

10.1158/1538-7445.am2012-5260 ◽

2012 ◽

Cited By ~ 2

Author(s):

Carlos E. Fonseca Alves ◽

Ariane F. Busso ◽

Sara M. Silveira ◽

Silvia R. Rogatto ◽

Renee Laufer Amorim

Keyword(s):

Prostatic Carcinoma ◽

Proliferative Inflammatory Atrophy

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p16 Is upregulated in proliferative inflammatory atrophy of the prostate

The Prostate ◽

10.1002/pros.20258 ◽

2005 ◽

Vol 65 (1) ◽

pp. 73-82 ◽

Cited By ~ 22

Author(s):

Dennis Faith ◽

Steven Han ◽

Daniel K. Lee ◽

Andreas Friedl ◽

Jessica L. Hicks ◽

...

Keyword(s):

Proliferative Inflammatory Atrophy

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Meta-analysis of impact of circumcision and vitamin D on occurrence of prostate cancer: Could they act by suppressing anaerobes colonizing areas of prostatic proliferative inflammatory atrophy?

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.5_suppl.259 ◽

2012 ◽

Vol 30 (5_suppl) ◽

pp. 259-259

Author(s):

R. Oliver

Keyword(s):

Prostate Cancer ◽

Vitamin D ◽

Prostate Biopsy ◽

Meta Analysis ◽

Bacterial Flora ◽

Sun Exposure ◽

Life Time ◽

Significant Excess ◽

Hydroxyvitamin D ◽

Proliferative Inflammatory Atrophy

259 Background: There is evidence that some false positive PSA tests can reflect prostatic inflammation that leads to Proliferative Inflammatory atrophy (PIA) that promotes malignant change. Report from circumcision trials in Africa suggest that dominant bacterial flora in un-circumcised men was anaerobes. As circumcised men have a lower incidence of PC this presentation reviews the literature on lack of circumcision and that on Vitamin D deficiency and as a cause of diminished host surveillance that could have potential to synergise as causes of PC. Methods: Three papers reporting incidence of PC in Jewish and non-Jewish men undergoing prostate biopsy for prostate symptoms and 7 series reporting case controlled studies published between 1952 and 2001 have provided data on circumcision and PC risk. There were 10 papers referred to in the IARC 2008 report on plasma 25-hydroxyvitamin D and PC. These have been reviewed together with 8 more published from 2008-10 and 3 that have examined impact of an index of life-time sun exposure on PC risk. Results: The 2 of 3 series of prostate biopsy reported 1951-65 demonstrated significant excess and 1 a non-significant excess of PC in the non-Jewish population. Of the 7 case controlled reported from 1971-2001, only 1 reported significant (OR 1.38) and 1 non-significant (OR 1.15) excess of lack of circumcision in those with prostate cancer, the remaining 6 studies having an excess cancer in those who have been circumcised (OR 0.50 – 0.82 pooled risk 0.70). Only 1 of the 18 plasma 25-OH Vit D series showed significant reduction of PC overall (6 did have reduction in prognostic subsets though 2 had higher incidence in the same sub-groups. In contrast all 3 series that have examined an index of life-time sun exposure showed significant reduction of PC (OR 0.18, 0.32 and 0.52 n= 850). Conclusions: The inconsistencies in the circumcision data suggest that it is not the surgery alone but the confounding variable of the hygiene rules that at least contribute to the reduced PC in Jewish men, and mirrors the similar differences seen in the protective value against AIDS of circumcision in Xhosa African and Asian Muslim men.

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