scholarly journals Radix Angelicae Sinensis/Radix Astragali Herbal Supplement

2020 ◽  
Author(s):  
Keyword(s):  
Radix Astragali ◽  
Herbal Supplement ◽  
Radix Angelicae Sinensis ◽  
Angelicae Sinensis

An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis

2009 ◽  
Vol 124 (1) ◽  
pp. 87-97 ◽  
Author(s):  
Mo Yang ◽  
Godfrey C.F. Chan ◽  
Ruixia Deng ◽  
Margaret H. Ng ◽  
Sau Wan Cheng ◽  
...  
Keyword(s):  
Radix Astragali ◽  
Radix Angelicae Sinensis ◽  
Herbal Decoction ◽  
Angelicae Sinensis

scholarly journals The combination of Radix Astragali and Radix Angelicae Sinensis attenuates the IFN-γ-induced immune destruction of hematopoiesis in bone marrow cells

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Juan Liu ◽  
Jie Wei ◽  
Changzhi Wang ◽  
Xiaoying Meng ◽  
Hening Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Cell Immune Response ◽  
Ionization Mass ◽  
Radix Astragali ◽  
Hematopoietic Stem ◽  
Radix Angelicae Sinensis ◽  
Ifn Γ ◽  
Immune Destruction ◽  
Angelicae Sinensis

Abstract Background Radix Astragali and Radix Angelicae Sinensis are two herbs that compose Danggui Buxue Tang (an herbal formula for treatment of anemia diseases). In this study, we explored the molecular mechanism and effective targets to immune destruction of bone marrow (BM) cells treated with Radix Astragali, Radix Angelicae Sinensis or a combination of two agents. The potential synergic advantages of two herbs should also be explored. Methods The constituents of Radix Astragali and Radix Angelicae Sinensis were analyzed by high performance liquid chromatography-electrospray ionization/mass spectrometer system BM cells were separated from limbs of BALB/c mice, and immune destruction was induced with IFN-γ. The percentages of hematopoietic stem cells (HSCs) and CD3+ T cells were detected by flow cytometry. The distribution of T-bet and changes in the combination of SAP and SLAM in BM cells were observed by immunofluorescence. Western blotting was used to assay the expression of key molecules of the eIF2 signaling pathway in BM cells. Results Seven constituents of Radix Astragali and six constituents of Radix Angelicae Sinensis were identified. The percentages of HSCs increased significantly after treatment with Radix Angelicae Sinensis, especially at high concentrations. The percentages of CD3+ T cells were significantly decreased after Radix Astragali and Radix Angelicae Sinensis treatment. However, the synergistic function of two-herb combinations was superior to that of the individual herbs alone. The distribution of T-bet in BM cells was decreased significantly after Radix Angelicae Sinensis treatment. The number of SLAM/SAP double-stained cells was increased significantly after Radix Astragali treatment at low concentrations. The phosphorylation levels of eIF2α were also reduced after Radix Astragali and Radix Angelicae Sinensis treatment. Conclusions Radix Astragali and Radix Angelicae Sinensis could intervene in the immunologic balance of T lymphocytes, inhibit the apoptosis of BM cells induced by immune attack, restore the balance of the T cell immune response network and recover the hematopoietic function of HSCs. The synergistic effects of Radix Astragali and Radix Angelicae Sinensis were superior to those of each herb alone.

scholarly journals Chinese Herbal Formula, Modified Danggui Buxue Tang, Attenuates Apoptosis of Hematopoietic Stem Cells in Immune-Mediated Aplastic Anemia Mouse Model

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Jingwei Zhou ◽  
Xue Li ◽  
Peiying Deng ◽  
Yi Wei ◽  
Juan Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Herbal Formula ◽  
Radix Astragali ◽  
Hematopoietic Stem ◽  
Danggui Buxue Tang ◽  
Chinese Herbal Formula ◽  
Radix Angelicae Sinensis ◽  
Chinese Herbal ◽  
Immune Mediated ◽  
Angelicae Sinensis

A derivative formula, DGBX, which is composed of three herbs (Radix astragali,Radix Angelicae sinensis, andCoptis chinensisFranch), is derived from a famous Chinese herbal formula, Danggui Buxue Tang (DBT) (Radix astragaliandRadix Angelicae sinensis). We aimed to investigate the effects of DGBX on the regulation of the balance between proliferation and apoptosis of hematopoietic stem cells (HSCs) due to the aberrant immune response in a mouse model of aplastic anemia (AA). Cyclosporine (CsA), an immunosuppressor, was used as the positive control. Our results indicated that DGBX could downregulate the production of IFNγin bone marrow cells by interfering with the binding between SLAM and SAP and the expressions of Fyn and T-bet. This herbal formula can also inhibit the activation of Fas-mediated apoptosis, interferon regulatory factor-1-induced JAK/Stat, and eukaryotic initiation factor 2 signaling pathways and thereby induce proliferation and attenuate apoptosis of HSCs. In conclusion, DGBX can relieve the immune-mediated destruction of HSCs, repair hematopoietic failure, and recover the hematopoietic function of HSCs in hematogenesis. Therefore, DGBX can be used in traditional medicine against AA as a complementary and alternative immunosuppressive therapeutic formula.

scholarly journals Perimenopause Amelioration of a TCM Recipe Composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii: AnIn VivoStudy on Natural Aging Rat Model

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Ji-Yan Su ◽  
Qing-Feng Xie ◽  
Wei-Jin Liu ◽  
Ping Lai ◽  
Dan-Dan Liu ◽  
...  
Keyword(s):  
Rat Model ◽  
Lumbar Vertebrae ◽  
Natural Aging ◽  
Female Rats ◽  
Potential Candidate ◽  
Radix Astragali ◽  
Astragali Radix ◽  
Radix Angelicae Sinensis ◽  
Aging Rat ◽  
Angelicae Sinensis

Traditional Chinese medicine (TCM) has been extensively applied as preferable herbal remedy for menopausal symptoms. In the present work, the potential of a TCM recipe named RRF, composed of Radix Astragali, Radix Angelicae Sinensis, and Folium Epimedii, was investigated on a natural aging rat model. After administration of RRF (141, 282, and 564 mg/kg/d), the circulated estradiol (E2) level increased accompanied by a reduction of serum follicle stimulating hormone (FSH). But no significant impact on serum lutenizing hormone (LH) level was observed. As a result of the E2-FSH-LH adjustment, the histomorphology degenerations of ovary, uterus, and vagina of the 11.5-month female rats were alleviated. And lumbar vertebrae trabecular microstructure was also restored under RRF exposure by means of increasing the trabecular area and area rate. Moreover, levels of hypothalamic dopamine (DA) and norepinephrine (NE) rallied significantly after RRF treatment. Results from our studies suggest that RRF possesses a positive regulation on the estrogen imbalance and neurotransmitter disorder, thereby restoring reproductive organ degeneration and skeleton deterioration. The above-mentioned benefits of RRF on the menopause syndromes recommend RRF as a potential candidate for the treatment of perimenopausal syndrome.

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