scholarly journals Rosai-Dorfman Disease Presenting as Recurrent Nasal Polyposis

2014 ◽  
Vol 29 (2) ◽  
pp. 22-23
Author(s):  
Neil Louis L. Apale ◽  
Joel A. Romualdez ◽  
Rodolfo E. Rivera
Keyword(s):  
Nasal Polyposis ◽  
Private Hospital ◽  
Clinical Presentation ◽  
Sinus Surgery ◽  
Radiologic Findings ◽  
Rosai Dorfman Disease ◽  
S 100 ◽  
History Of ◽  
Histopathologic Findings ◽  
Recurrent Nasal Polyposis

Objective: To present a case of Rosai-Dorfman disease in an individual with a 14-year history of recurrent nasal polyposis, and discuss its clinical presentation, physical examination, radiologic findings, histopathologic characteristics, and available treatment. Methods:             Design: Case Report             Setting: Tertiary Private Hospital             Patient: One Result:  A 26-year-old Filipino diagnosed and repeatedly treated medically and surgically for recurrent nasal polyposis underwent repeat endoscopic sinus surgery. A histopathologic impression of Rosai-Dorfman disease was confirmed by positive S-100 and CD1a negative immunochemistry in conjunction with the morphologic findings. Conclusion: Rosai-Dorfman disease is a rare entity which should be considered when dealing with recurrent nasal polyposis that is intractable to initial medical and surgical therapies. Histopathologic findings of emperipolesis and immunohistochemical S-100 stains play a key role in the diagnosis, but there is yet no definite treatment for this disease. Keywords: recurrent nasal polyposis, Rosai-Dorfman disease, emperipolesis, S-100 stain

scholarly journals Paraspinal gossybipoma: A case report and review of the literature

2010 ◽  
Vol 01 (02) ◽  
pp. 102-104 ◽  
Author(s):  
Baris Kucukyuruk ◽  
Huseyin Biceroglu ◽  
Bashar Abuzayed ◽  
Mustafa O Ulu ◽  
Ali M Kafadar
Keyword(s):  
Clinical Presentation ◽  
Review Of The Literature ◽  
Disk Herniation ◽  
Serous Fluid ◽  
Lumbar Disk Herniation ◽  
Radiologic Findings ◽  
Initial Surgery ◽  
History Of ◽  
Retained Surgical Sponges ◽  
Operation Wound

ABSTRACTSpinal or paraspinal retained surgical sponges (gossybipoma or textiloma) are rare incidents and mostly asymptomatic in chronic cases, but can be confused with other masses such as a hematoma, an abscess or a tumor. In chronic cases, the presentation can be as late as decades after the initial surgery; however, some gossybipomas cause infection or abscess formation in the early stages. The authors report a 40-year-old woman with a history of operation for lumbar disk herniation before 8 months, and got admitted with a complaint of serous fluid leakage from the operation wound. In this report, the authors discuss the clinical presentation, the radiologic findings and the differential diagnosis of gossybipoma.

scholarly journals Sinonasal Plasmablastic Lymphoma Arising in the Setting of Recurrent Nasal Polyposis in an Immunocompetent Individual

2022 ◽  
pp. 014556132110708
Author(s):  
Marco DiBlasi ◽  
Christopher Jayne ◽  
Reilly McNamara ◽  
Catherine Iasiello ◽  
Daryl Colden
Keyword(s):  
Nasal Polyposis ◽  
B Cell Lymphoma ◽  
Sinonasal Tract ◽  
Plasmablastic Lymphoma ◽  
Sinus Surgery ◽  
Diagnostic Process ◽  
First Case ◽  
Sinonasal Mass ◽  
High Index Of Suspicion ◽  
Recurrent Nasal Polyposis

Plasmablastic lymphoma (PBL) is an aggressive, rare variant of B-cell lymphoma typically associated with human immunodeficiency virus and other immunocompromised populations. Most commonly found in the oral cavity, PBL can occasionally originate in the sinonasal tract. Diagnosis of PBL is difficult due to overlapping features with other malignancies; however, early detection and treatment are imperative given its aggressive clinical course. When in the sinonasal tract, the diagnostic process can be further complicated if the patient has a history of recurrent nasal polyposis. Described is the case of a 57-year-old immunocompetent male who initially presented with benign nasal polyposis, only to return a year after sinus surgery with a unilateral sinonasal mass consistent with PBL. As literature has yet to characterize this phenomenon, this article presents the first case reported of sinonasal PBL arising in the setting of recurrent nasal polyposis. This case emphasizes the importance of investigating sinonasal masses showing laterality, maintaining a high index of suspicion for malignancy, and keeping close surveillance of the patient after treatment of PBL.

Adult-onset Woakes’ syndrome: a rare entity

2021 ◽  
Vol 14 (1) ◽  
pp. e236894
Author(s):  
Pedro Salvador ◽  
Francisco Moreira da Silva ◽  
Rui Fonseca
Keyword(s):  
Ct Scan ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyposis ◽  
Sinus Surgery ◽  
Nasal Dorsum ◽  
Rare Entity ◽  
Adult Onset ◽  
Aspirin Exacerbated Respiratory Disease ◽  
Nasal Pyramid ◽  
Recurrent Nasal Polyposis

Woakes’ syndrome (WS) is a rare entity, defined as severe recalcitrant nasal polyposis with consecutive deformity of the nasal pyramid. WS occurs mainly in childhood and its aetiology remains unclear. We report a case of a 68-year old woman, with aspirin-exacerbated respiratory disease, who presented with recurrent nasal polyposis and progressive broadening of the nasal dorsum. CT scan revealed extensive bilateral nasal polyposis and diffuse osteitis, with anterior ethmoidal calcified lesions. The patient underwent revision endoscopic sinus surgery and nasal pyramid deformity was successfully managed without osteotomies.

Meticulous endoscopic sinus surgery to prevent recurrence of massive nasal polyposis

2012 ◽  
Vol 126 (8) ◽  
pp. 789-794 ◽  
Author(s):  
S M S Hoseini ◽  
B Saedi ◽  
K Aghazadeh
Keyword(s):  
Endoscopic Surgery ◽  
Endoscopic Sinus Surgery ◽  
Nasal Polyposis ◽  
Demographic Data ◽  
Effective Means ◽  
Sinus Surgery ◽  
Previous Surgery ◽  
Endoscopic Findings ◽  
History Of

AbstractObjective:To evaluate the effect of meticulous endoscopic surgery, including opening of all involved sinus cells, on the subsequent symptoms and endoscopic findings of patients with massive nasal polyposis.Study design and method:One hundred patients with massive nasal polyposis resistant to medical treatment were selected. We documented each patient's demographic data, associated diseases, endoscopic findings, Lund–Mackay score and Sino-Nasal Outcome Test 22 (SNOT22) symptom score. All patients were followed up for at least two years to evaluate any recurrence.Results:Of the 100 patients, 20 per cent had a history of asthma and 27 per cent had undergone previous surgery. All underwent endoscopic sinus surgery. After two years of follow up, 8 per cent had recurrence requiring surgery. Recurrence was significantly associated with a history of asthma (p < 0.001) and the histopathological presence of eosinophilia (p = 0.014).Conclusion:Meticulous endoscopic opening of all involved sinus cells can be a safe and effective means of controlling massive nasal polyposis, with an acceptable recurrence rate.

Allergic Mucin Sinusitis without Fungus

1997 ◽  
Vol 11 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Hassan H. Ramadan ◽  
Huma A. Quraishi
Keyword(s):  
Clinical Picture ◽  
Nasal Polyposis ◽  
Clinical Presentation ◽  
Fungal Sinusitis ◽  
Asthma Treatment ◽  
Allergic Fungal Sinusitis ◽  
Fungal Hyphae ◽  
History Of ◽  
Allergic Mucin

Allergic fungal sinusitis (AFS) is a distinct clinical pathologic entity that has been recognized for over a decade. The hallmark of this process is eosinophilic allergic mucin with fungal hyphae on histopathology. We have identified a subset of patients who present with a clinical picture similar to that of AFS patients in which fungus could not be demonstrated pathologically or on culture. We present four cases of allergic mucin sinusitis without fungus. A comparison of the clinical presentation of this group of patients with those with AFS will be discussed. Both groups had nasal polyposis and a history of multiple sinonasal procedures. By contrast, the patients with allergic mucin sinusitis were older than the AFS group. All of the patients with allergic mucin sinusitis also had asthma. Treatment was the same for both groups of patients.

scholarly journals Grafting to denuded nasal cavity for prevention of recurrent nasal polyposis by endoscopic sinus surgery

2018 ◽  
Vol 4 (5) ◽  
pp. 1135
Author(s):  
Hany Amin ◽  
Yasser Mohammed Hassan Mandour ◽  
Ahmed Elrefai
Keyword(s):  
Nasal Cavity ◽  
Nasal Obstruction ◽  
Nasal Mucosa ◽  
Endoscopic Sinus Surgery ◽  
Nasal Septum ◽  
Nasal Polyposis ◽  
Inferior Turbinate ◽  
Sinus Surgery ◽  
Nasal Polypi ◽  
Recurrent Nasal Polyposis

<p class="abstract"><strong>Background:</strong> The objective of the study was to avoid nasal polyposis occurrence after recurrent FEES.</p><p class="abstract"><strong>Methods:</strong> 87 patients undergoing recurrent FESS due to recurrent nasal polyposis, after completing all steps of FESS the placement of normal nasal mucosa from inferior turbinate or nasal septum instead of the mucosa of the fovea ethmoidalis and lamina papyracea was done.  </p><p class="abstract"><strong>Results:</strong> There were nasal obstruction improvement in 79 patients (90.8%), but there were 8 patients (9.2%) had recurrent nasal polypi causing nasal obstruction. There was smell improvement in 38 patients (71.7%) out of 15 patients (28.3%).</p><p class="abstract"><strong>Conclusions:</strong> The nasal cavity grafting in FESS of recurrent nasal polyposis with nasal septal or inferior turbinate mucosa had promising results in prevention of nasal polyposis recurrence. These results made a recommendation of nasal cavity grafting during primary FESS of nasal polyposis.</p>

Primary Intracranial Melanocytic Tumor Simulating Pituitary Macroadenoma: Case Report and Review of the Literature

Neurosurgery ◽  
2005 ◽  
Vol 57 (2) ◽  
pp. E369-E369 ◽  
Author(s):  
Audrey Rousseau ◽  
Michèle Bernier ◽  
Michèle Kujas ◽  
Pascale Varlet
Keyword(s):  
Clinical Presentation ◽  
Careful Consideration ◽  
Caucasian Woman ◽  
Subtotal Resection ◽  
Pituitary Macroadenoma ◽  
Melanocytic Tumors ◽  
Melanocytic Tumor ◽  
S 100 ◽  
History Of

ABSTRACT OBJECTIVE AND IMPORTANCE: Primary intracranial melanocytic tumors are rare lesions, sellar ones being even more exceptional. So far, six melanomas and two melanocytomas have been described in an intrasellar and/or suprasellar location. CLINICAL PRESENTATION: We report on the case of a 25-year-old Caucasian woman presenting with a 4-year history of amenorrhea and an intrasellar mass with suprasellar extension suggestive of a pituitary macroadenoma. INTERVENTION: A gross subtotal resection of a hemorrhagic tumor was performed. Histological examination revealed melanin-laden pleomorphic tumor cells that tested positive for HMB-45 and S-100 and negative for cytokeratins, thus demonstrating that the tumor was a melanocytic neoplasm. An extensive workup failed to find evidence of any other primary site. The patient received no further treatment and is alive and well after 24 months of follow-up. CONCLUSION: Primary sellar melanocytic neoplasms are extremely rare lesions and present with few differential diagnoses. Deciding whether the tumor is best classified as a melanocytoma or a melanoma may prove difficult. Wide histological variations in both melanocytomas and melanomas render careful consideration of the clinical, radiological, and gross features essential in distinguishing one from the other.

scholarly journals Rosai-Dorfman Disease of Bone and Soft Tissue

2021 ◽  
Vol 146 (1) ◽  
pp. 40-46
Author(s):  
Roberto A. Garcia ◽  
Edward F. DiCarlo
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Clinical Presentation ◽  
Clinical Manifestations ◽  
Imaging Findings ◽  
Imaging Characteristics ◽  
Rosai Dorfman Disease ◽  
S 100 ◽  
Systemic Manifestations ◽  
Variable Clinical Presentation

Context.— Rosai-Dorfman disease is a rare histiocytic proliferative disorder of unknown pathogenesis that may be diagnostically difficult in extranodal sites. It is commonly an unsuspected diagnosis when arising in bone and soft tissue, especially when it presents without associated lymphadenopathy. Its variable clinical presentation and nonspecific imaging findings make the diagnosis quite challenging, particularly in small biopsies. The problem is compounded by its less-characteristic histomorphologic features in comparison with nodal disease. Awareness of the potential diagnostic pitfalls in Rosai-Dorfman disease of bone and soft tissue should raise the degree of diagnostic accuracy. Objective.— To review the clinical manifestations, imaging characteristics, and histomorphologic features of Rosai-Dorfman disease of bone and soft tissue along with a brief discussion of its differential diagnosis, pathogenesis, and current management. Data Sources.— Thorough review of the literature with focus on clinical manifestations, imaging findings, key histomorphologic features, pathogenesis, and treatment. Conclusions.— The diagnosis of Rosai-Dorfman disease of bone and soft tissue may be quite challenging because of its variable clinical presentation and nonspecific imaging findings. It may be asymptomatic without systemic manifestations or associated lymphadenopathy. The definitive diagnosis relies on histopathologic identification of the characteristic S-100–positive histiocytes demonstrating emperipolesis. Bone and soft tissue lesions tend to have lower numbers of characteristic histiocytes and less conspicuous emperipolesis and often demonstrate areas of fibrosis or storiform spindle cell areas resembling fibrohistiocytic lesions. Awareness of these unusual features is necessary in order to consider Rosai-Dorfman disease in the differential diagnosis when confronting these rare and often misleading lesions.

A Retrospective Analysis of Treatment Outcomes and Time to Relapse after Intensive Medical Treatment for Chronic Sinusitis

2002 ◽  
Vol 16 (6) ◽  
pp. 303-312 ◽  
Author(s):  
Hamsa N. Subramanian ◽  
Kenneth B. Schechtman ◽  
Daniel L. Hamilos
Keyword(s):  
Medical Treatment ◽  
Medical Therapy ◽  
Nasal Polyposis ◽  
Chronic Sinusitis ◽  
Sinus Surgery ◽  
Early Relapse ◽  
Symptom Scores ◽  
Oral Steroids ◽  
History Of ◽  
Time To Relapse

Background Despite the high prevalence of chronic sinusitis, there are few published studies assessing its response to medical treatment. We analyzed, retrospectively, 40 patients seen in our center who were treated for chronic sinusitis with a protocol of intensive medical therapy. Both symptomatic and radiographic improvements were assessed as well as factors associated with early relapse. Methods Intensive medical treatment consisted of 1 month of antibiotics, a short course of oral steroids, and adjunctive therapy (e.g., nasal irrigations plus intranasal steroids). After intensive medical therapy, adjunctive medical therapy was continued. A sinus computed tomography was performed at baseline and 6–8 weeks later and scored for extent of disease. Pre- and posttreatment symptom scores also were assessed. Time to relapse was defined as the time interval after antibiotic treatment at which a recurrence of symptoms necessitated reinstitution of antibiotics and/or oral steroids. Results Thirty-six of the 40 patients improved either symptomatically, radiographically, or both following the medical regimen. Twenty-six patients had sustained symptomatic benefit beyond 8 weeks after initial treatment. A statistically significant correlation was found between the change in pre- to posttreatment symptom scores and computed tomography scores. Using a log-rank test to compare rates of sinusitis relapse, nasal polyposis and a history of sinus surgery were significantly associated with earlier relapse (p = 0.006 and 0.018, respectively). In contrast, atopy, asthma, and persistent obstruction of the ostiomeatal unit were not associated with early relapse. Conclusion Intensive medical treatment resulted in symptomatic and radiographic improvement in chronic sinusitis, and the majority of patients remained free of a relapse for >8 weeks. A history of nasal polyposis or previous sinus surgery was associated with earlier relapse of sinusitis symptoms. In contrast, the presence of atopy, a history of asthma, or persistent OMU obstruction was not associated with earlier relapse. Although long-term benefits have not been established, a prospective study of treatment outcomes from intensive medical treatment appears to be warranted.

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