COMPARATIVE EFFICACY OF INTERMITTENT AND DAILY DOXAZOSIN   THERAPY    FOR   LUTS   ASSOCIATED    WITH   BPH

Objective: To investigate the efficacy of intermittent doxazosin therapy on LUTS associated BPH. Material & Method: This study was performed between January to April 2010 enrolling 20 patients with LUTS associated BPH. Study subjects were randomly allocated to 2 therapeutic groups. The first group was assigned daily doxazosin therapy (11 patients), while the second group was assigned intermittent doxazosin therapy (9 patients). Initially all subjects were given doxazosin 2 mg daily for 2 weeks. Subsequently group I received doxazosin 2 mg daily therapy, while group II received doxazosin 2 mg every other day. All medications were taken up to 12 weeks. Outcomes were evaluated prior to therapy, and after 2, 4, 8, and 12 weeks of therapy. Efficacy of doxazosin therapy was measured by International Prostate Symptom Score (IPSS), peak urinary flow rate (Q max), and residual urine volume. Statistical analysis was performed to evaluate difference in efficacy between the treatment groups. Results: Daily doxazosin therapy for 2 weeks resulted in significant improvement of Q max and IPSS. After 4, 8, and 12 weeks significant improvement was maintained in both daily and intermittent groups, as measured by Q max, residual urine volume and IPSS. There were no significant differences in Q max, residual urine volume, and IPSS between the daily and intermittent groups at 4, 8, and 12 groups. Conclusion: There were significant improvements of Q max, residual urine and IPSS at 2 to 12 weeks in daily as well as intermittent doxazosin therapy groups. There were no significant differences in efficacy between daily and intermittent therapy groups

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Constitutional, organopathic and combined homeopathic treatment of benign prostatic hypertrophy: a clinical trial

Homeopathy ◽

10.1016/j.homp.2012.08.005 ◽

2012 ◽

Vol 101 (04) ◽

pp. 217-223 ◽

Cited By ~ 8

Author(s):

A.K. Hati ◽

B. Paital ◽

K.N. Naik ◽

A.K. Mishra ◽

G.B.N. Chainy ◽

...

Keyword(s):

Specific Antigen ◽

Urine Volume ◽

Benign Prostatic Hypertrophy ◽

Prostatic Hypertrophy ◽

Intermittent Flow ◽

Urinary Flow ◽

Residual Urine Volume ◽

Homeopathic Treatment ◽

Presenting Symptoms ◽

Residual Urine

Background: Benign Prostatic Hypertrophy (BPH) is common in older men. This study compared homeopathic treatment strategies using constitutional medicines (CM) or organopathic medicines (OM) alone or in combination (BCOM) in patients suffering from BPH.Methods: 220 men aged 30–90 years were recruited in Odisha, India. Patients presenting symptoms of prostatism, with or without evidence of bladder outflow obstruction were included in the study. Patients with serum prostate specific antigen (PSA)> 4 nmol/mL, malignancy, complete urine retention, stone formation and gross bilateral hydronephrosis were excluded. Patients were sequentially allocated to OM, CM or BCOM. The main outcome measure was the International Prostate Symptom Score (IPSS).Results: 73, 70 and 77 patients respectively were sequentially allocated to OM, CM or BCOM. 180 patients (60 per group) completed treatment and were included in the final analysis. Overall 85% of patients showed improvement of subjective symptoms such as frequency, urgency, hesitancy, intermittent flow, unsatisfactory urination, feeble stream, diminution of residual urine volume but there was no reduction in prostate size. Treatment response was highest with BCOM (38.24%) compared to OM (31.62%) and CM (30.15%). Effect sizes were highest for the decrease in IPSS, residual urine volume and urinary flow rate.

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A Comparative Study Between Standard Monopolar Versus Bipolar Saline Turp: Our Experience in Armed Forces Hospital

Bangladesh Journal of Urology ◽

10.3329/bju.v21i2.49858 ◽

2020 ◽

Vol 21 (2) ◽

pp. 66-70

Author(s):

MS Islam ◽

SM Waheed ◽

MA Rakib ◽

A Chowdhury ◽

MN Amin

Keyword(s):

Postoperative Bleeding ◽

Operating Time ◽

Urine Volume ◽

Armed Forces ◽

Similar Efficacy ◽

Urinary Flow ◽

Residual Urine Volume ◽

Treatment Groups ◽

Transfusion Requirements ◽

Maximum Urinary Flow

Objective: To-evaluate the outcome of bipolar Versus conventional monopolar transurethral resection of the prostate (TURP) on urinary function. Material and Methods: A total of 300 patients with benign prostatic hyperplasia (BPH) were randomized to bipolar or monopolar conventional TURP treatment groups. Operative and early postoperative variables and complications were recorded and all patients were re-evaluated at 1, 3, 6 and 12 months after surgery using the International Prostate Symptom Score (IPSS), uroflowmetry, post-void residual urine volume (PVR). Results: The operating time was shorter in the monopolar TURP group. Postoperative bleeding and blood transfusion requirements did not significantly differ between the two groups. Sodium levels were significantly lower in the monopolar group than in the bipolar group. Transuretheral resection syndrome developed in two (1.4%) patients in the monopolar group. Both groups had similar and significantly improved IPSS values, maximum urinary flow rate values and PVRmeasurement. Conclusion: Bipolar TURP is a safe and effective procedure that is associated with a relatively longer operating time, a smaller reduction in serum sodium levels and a similar efficacy compared with conventional monopolar TURP. Bangladesh Journal of Urology, Vol. 21, No. 2, July 2018 p 66-70

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Safety and efficacy of photoselective vaporization of the prostate using the 180-W GreenLight XPS laser system in patients taking oral anticoagulants

Journal of International Medical Research ◽

10.1177/0300060517747489 ◽

2018 ◽

Vol 46 (3) ◽

pp. 1230-1237 ◽

Cited By ~ 3

Author(s):

Alper Eken ◽

Bülent Soyupak

Keyword(s):

Benign Prostatic Hyperplasia ◽

International Prostate Symptom Score ◽

Oral Anticoagulants ◽

Laser System ◽

Urine Volume ◽

Prostatic Hyperplasia ◽

Urinary Flow ◽

Residual Urine Volume ◽

Photoselective Vaporization ◽

Maximum Urinary Flow

Objective To evaluate the safety and efficacy of the 180-W GreenLight XPS laser system for the treatment of benign prostatic hyperplasia in patients taking oral anticoagulants. Methods All consecutive patients admitted for lower urinary tract symptoms associated with benign prostatic hyperplasia from November 2012 to October 2016 and who underwent photoselective vaporization of the prostate with the 180-W GreenLight XPS laser were included in the study. The perioperative outcomes examined were the operating time, laser time, energy usage, and duration of postoperative catheterization. Functional parameters (International Prostate Symptom Score, maximum urinary flow rate, and post-void residual urine volume), prostate volume, and serum prostate-specific antigen concentration were examined at baseline and 3 months. Perioperative complications, if any, were noted. Results All functional parameters (International Prostate Symptom Score, maximum urinary flow rate, and post-void residual urine volume) significantly improved from baseline to 3 months. A small number of patients experienced at least one minor adverse event. There was no difference in the rate of adverse events between patients who were and were not taking anticoagulants. Conclusions Photoselective vaporization with a 180-W laser is an efficacious and safe treatment for benign prostatic hyperplasia, even in patients taking anticoagulant medications.

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The International Prostate Symptom Score in a community-based sample of men between 55 and 74 years of age: prevalence and correlation of symptoms with age, prostate volume, flow rate and residual urine volume

British Journal of Urology ◽

10.1111/j.1464-410x.1995.tb07421.x ◽

1995 ◽

Vol 75 (5) ◽

pp. 622-630 ◽

Cited By ~ 169

Author(s):

J.L.H.R. Bosch ◽

W.C.J. Hop ◽

W.J. Kirkels ◽

F.H. Schröder

Keyword(s):

Symptom Score ◽

Flow Rate ◽

International Prostate Symptom Score ◽

Prostate Volume ◽

Volume Flow Rate ◽

Urine Volume ◽

Volume Flow ◽

Residual Urine Volume ◽

Community Based ◽

Residual Urine

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Should Measurement of Maximum Urinary Flow Rate and Residual Urine Volume be a Part of a "Minimal Care" Assessment Programme in Female Incontinence?

Scandinavian Journal of Urology and Nephrology ◽

10.1080/003655902753679418 ◽

2002 ◽

Vol 36 (2) ◽

pp. 124-127 ◽

Cited By ~ 7

Author(s):

P. Sander ◽

L. Mouritsen ◽

J. Thorup Andersen ◽

W. Fischer-Rasmussen

Keyword(s):

Flow Rate ◽

Urine Volume ◽

Urinary Flow Rate ◽

Urinary Flow ◽

Residual Urine Volume ◽

Female Incontinence ◽

Assessment Programme ◽

Residual Urine ◽

Care Assessment ◽

Maximum Urinary Flow

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Comparative randomized study on the efficaciousness of endoscopic bipolar prostate resection versus monopolar resection technique. 3 year follow-up

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2013.2.86 ◽

2013 ◽

Vol 85 (2) ◽

pp. 86 ◽

Cited By ~ 13

Author(s):

Roberto Giulianelli ◽

Luca Albanesi ◽

Francesco Attisani ◽

Barbara Cristina Gentile ◽

Giorgio Vincenti ◽

...

Keyword(s):

Hospital Stay ◽

Transurethral Resection ◽

Randomized Study ◽

Transrectal Ultrasound ◽

Urine Volume ◽

Isotonic Saline ◽

Urinary Flow ◽

Residual Urine Volume ◽

Residual Urine

Objective: Transurethral resection of the prostate (TURP) is the current optimal thera- py for the relief of bladder outflow obstruction, with subjective and objective success rate of 85 to 90%. Aim of this study was to evaluate efficacy and safety of Plasmakinetic ener- gy (Gyrus electro surgical system), which produces vaporization of tissue immersed in isotonic saline against standard monopolar transurethral resection of the prostate. Methods: From January 2002 to April 2002, 160 consecutive patients, who had low urinary tract symptoms (LUTS) of benign prostatic hyperplasia (BPH) were enrolled in this study. Patients were randomised to undergo bipolar TURP (80 patients) or monopolar TURP (80 patients). Preoperative work-up was assessed by administering IPSS, IIEF-5 and Qol questionnaires. All patients were submitted to uroflowmetry, transrectal ultrasound (TRUS), post-voidal residual urine measurement and PSA determination. In the two groups, IPSS, IIEF-5 and Qol, uroflowme- try, TRUS, post-voidal residual urine measurement, PSA determination and number of reopera- tions were evaluated at 1, 3, 6, 12, 18, 24, 30 and 36 months follow up, and then every year. Furthermore, in both groups operative time, resected tissue weight and perioperative complica- tions were analysed. Total postoperative catheter time, total post-operative hospital stay, haemo- globin loss were also recorded in the two groups. Results: Comparative data on IPSS symptom score, IIEF-5, Qol, PSA, peak urinary flow rate and post-void residual urine volume were similar in the two groups but showed a significant improve- ment respect to baseline values. The postoperative haemoglobin levels, postoperative catheteri- zation time, hospital stay and 3-year overall surgical re-treatment-free rate were significantly better in the bipolar group. Conclusions: Bipolar TURP has a comparable outcome to standard monopolar TURP at short and medium term regard to subjective and objective outcome measurements. Its impact on blad- der outlet function is also similar to that of monopolar TURP. Improvement in IPSS, Qol index, IIEF-5, Qmax and post-void residual urine volume were comparable in both group denoting sim- ilar efficacy of the techniques.

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