Development of reference materials with the composition of propyl and isopropyl alcohol solutions

2020 ◽  
pp. 66-72
Author(s):  
Irina A. Piterskikh ◽  
Svetlana V. Vikhrova ◽  
Nina G. Kovaleva ◽  
Tatyana O. Barynskaya
Keyword(s):  
Reference Materials ◽  
Measurement Errors ◽  
Isopropyl Alcohol ◽  
Certified Reference Materials ◽  
Toxic Substances ◽  
Biological Objects ◽  
Margin Of Error ◽  
Measurement Results ◽  
And Control ◽  
Characteristic Mass

Certified reference materials (CRM) composed of propyl (11383-2019) and isopropyl (11384-2019) alcohols solutions were created for validation of measurement procedures and control of measurement errors of measurement results of mass concentrations of toxic substances (alcohol) in biological objects (urine, blood) and water. Two ways of establishing the value of the certified characteristic – mass consentration of propanol-1 or propanol-2 have been studied. The results obtained by the preparation procedure and comparison with the standard are the same within the margin of error.

Development of certified reference materials set for opened porosity of solid substances and materials

2021 ◽  
pp. 58-66
Author(s):  
Egor P. Sobina ◽  
Ilya P. Aronov
Keyword(s):  
Reference Materials ◽  
Open Porosity ◽  
Certified Reference Materials ◽  
Measurement Techniques ◽  
Measuring Instruments ◽  
Measurement Results ◽  
And Control ◽  
Porosity Measurements ◽  
Calibration Laboratories ◽  
Certified Values

The article deals with data of research for development of certified reference materials set for opened porosity of solid substances and materials (imitators) (OPGP SO UNIIM set) GSO 11116-2018/GSO 11119-2018. The certified values of open porosity are determined using a gas pycnometer. Certified reference materials are intended for certification of measurement techniques and control of the accuracy of open porosity measurement results for petrophysical studies of core. Certified reference materials can be used for calibration, verification of open porosity measurements of rock and for testing of measuring instruments. A complete budget of the CRM uncertainty is presented, taking into account changes in ambient temperature when it used in testing and calibration laboratories.

Certified Reference Materials and Metrological Traceability for Mycotoxin Analysis

2019 ◽  
Vol 102 (6) ◽  
pp. 1695-1707
Author(s):  
Zhen Guo ◽  
Xianjiang Li ◽  
Hongmei Li
Keyword(s):  
Reference Materials ◽  
Certified Reference Materials ◽  
Mutual Recognition ◽  
Metrological Traceability ◽  
International Standards ◽  
Great Effort ◽  
Legal Metrology ◽  
International Laboratory Accreditation Cooperation ◽  
Weights And Measures ◽  
Measurement Results

Abstract In the past decade, with the signing of the joint declaration by the International Bureau of Weights and Measures (BIPM), the International Organisation of Legal Metrology, the International Laboratory Accreditation Cooperation, and the International Organization for Standardization, and the issuing of new international standards such as ISO/IEC 17025 and ISO 13528, metrological traceability has become more and more important for the mutual recognition of measurement results. It is found that the important factors for ensuring the accuracy of results are not only relevant to calibrants but also to the analysis procedure. This paper focuses on the analysis of key factors that affect measurement results, such as analytical methods, reference materials (RMs), and proficiency testing of mycotoxins. The Capacity Building and Knowledge Transfer Programme for mycotoxins, led by the BIPM, which aims to establish a global measurement system traced to the Système International d’Unités (SI), is well illustrated. Furthermore, this paper suggests to stakeholders that great effort is needed to promote the effective use of certified RM resources that are traced to the SI and globally recognized by the International Committee for Weights and Measures to finally realize “one measurement, global recognition.”

Analysis of Natural Toxins by Liquid Chromatography-Chemiluminescence Nitrogen Detection and Application to the Preparation of Certified Reference Materials

2016 ◽  
Vol 99 (5) ◽  
pp. 1173-1184 ◽  
Author(s):  
Krista Thomas ◽  
Dominik Wechsler ◽  
Yi-Min Chen ◽  
Sheila Crain ◽  
Michael A Quilliam
Keyword(s):  
Reference Materials ◽  
Limit Of Detection ◽  
Certified Reference Materials ◽  
National Research Council ◽  
Complementary Method ◽  
Routine Monitoring ◽  
Wide Range ◽  
Measurement Results ◽  
Calibration Solution

Abstract The implementation of instrumental analytical methods such as LC-MS for routine monitoring of toxins requires the availability of accurate calibration standards. This is a challenge because many toxins are rare, expensive, dangerous to handle, and/or unstable, and simple gravimetric procedures are not reliable for establishing accurate concentrations in solution. NMR has served as one method of qualitative and quantitative characterization of toxin calibration solution Certified Reference Materials (CRMs). LC with chemiluminescence N detection (LC-CLND) was selected as a complementary method for comprehensive characterization of CRMs because it provides a molar response to N. Here we report on our investigation of LC-CLND as a method suitable for quantitative analysis of nitrogenous toxins. It was demonstrated that a wide range of toxins could be analyzed quantitatively by LC-CLND. Furthermore, equimolar responses among diverse structures were established and it was shown that a single high-purity standard such as caffeine could be used for instrument calibration. The limit of detection was approximately 0.6 ng N. Measurement of several of Canada's National Research Council toxin CRMs with caffeine as the calibrant showed precision averaging 2% RSD and accuracy ranging from 97 to 102%. Application of LC-CLND to the production of calibration solution CRMs and the establishment of traceability of measurement results are presented.

scholarly journals 30 years of IRMM-1027 reference materials for fissile material accountancy and control: development, production and characterisation

2021 ◽  
Author(s):  
Rožle Jakopič ◽  
Kalman Toth ◽  
Jeroen Bauwens ◽  
Renata Buják ◽  
Carmel Hennessy ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Isotopic Composition ◽  
Reference Materials ◽  
Isotope Dilution ◽  
Organic Substance ◽  
Certified Reference Materials ◽  
Isotope Dilution Mass Spectrometry ◽  
Fissile Material ◽  
High Quality ◽  
And Control

AbstractThe IRMM-1027 Large-sized dried (LSD) spikes are certified reference materials applied to measure the uranium and plutonium content of dissolved fuel solutions using isotope dilution mass spectrometry. High quality starting metals of uranium and plutonium are dissolved to produce a stock solution, which is dispensed into individual vials and dried down. The present spikes are mixtures of typically 50 mg 20% enriched U and 2 mg enriched 239Pu as dried nitrates, conditioned in an organic substance for stability. Each vial of an IRMM-1027 LSD spike comes with certified masses of uranium (235U and 238U) and 239Pu and isotopic composition with associated uncertainty. This article will discuss major developments since the production of the first batch of LSD spikes and will reflect on the current preparation and certification approaches.

Certified Reference Materials and Metrological Traceability for Mycotoxin Analysis

2019 ◽  
Vol 102 (6) ◽  
pp. 1695-1707
Author(s):  
Zhen Guo ◽  
Xianjiang Li ◽  
Hongmei Li
Keyword(s):  
Reference Materials ◽  
Certified Reference Materials ◽  
Mutual Recognition ◽  
Metrological Traceability ◽  
International Standards ◽  
Great Effort ◽  
Legal Metrology ◽  
International Laboratory Accreditation Cooperation ◽  
Weights And Measures ◽  
Measurement Results

In the past decade, with the signing of the joint declaration by the International Bureau of Weights and Measures (BIPM), the International Organisation of Legal Metrology, the International Laboratory Accreditation Cooperation, and the International Organization for Standardization, and the issuing of new international standards such as ISO/IEC 17025 and ISO 13528, metrological traceability has become more and more important for the mutual recognition of measurement results. It is found that the important factors for ensuring the accuracy of results are not only relevant to calibrants but also to the analysis procedure. This paper focuses on the analysis of key factors that affect measurement results, such as analytical methods, reference materials (RMs), and proficiency testing of mycotoxins. The Capacity Building and Knowledge Transfer Programme for mycotoxins, led by the BIPM, which aims to establish a global measurement system traced to the Système International d’Unités (SI), is well illustrated. Furthermore, this paper suggests to stakeholders that great effort is needed to promote the effective use of certified RM resources that are traced to the SI and globally recognized by the International Committee for Weights and Measures to finally realize “one measurement, global recognition.”

scholarly journals Certified reference materials of antibacterial substances: principle of development

2021 ◽  
Vol 16 (4) ◽  
pp. 27-38
Author(s):  
A. Yu. Gulyaeva ◽  
I. V. Kis ◽  
S. V. Kolyachkina ◽  
A. Y. Khrushchev
Keyword(s):  
Reference Materials ◽  
Certified Reference Materials ◽  
Antibiotic Sensitivity ◽  
Measuring Instruments ◽  
Pharmaceutical Drugs ◽  
Accuracy Control ◽  
Basic Principles ◽  
Measurement Results ◽  
Active Substances

The authors of the publication have described the basic principles of the procedure of defining metrological characteristics of certified reference materials (hereinafter referred to as CRMs) of antibacterial substances that are being developed. CRMs of antibacterial substances are intended for certification of measurement procedures and accuracy control of measurement results. CRMs can be used for graduation, calibration of measuring instruments if their metrological and technical characteristics comply with the procedures of graduation and calibration of measuring instruments, as well as determination of antibiotic sensitivity of pathogenic microorganisms and authenticity of active substances in pharmaceutical drugs.

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