scholarly journals TO STUDY THE USE OF DISULFIRAM IN ALCOHOL DEPENDENCE SYNDROME (ICD 10/DSM IV CRITERIA) AT SECONDARY CARE SETTING

Author(s):  
Anita Thakur ◽  
Shallu Dhiman ◽  
Jyoti Sharma

Background: Disulfiram blocks the enzyme aldehyde dehydrogenase (ALDH). If alcohol is present, acetaldehyde accumulates usually resulting in an unpleasant reaction, the disulfiram-ethanol reaction (DER), consisting primarily of tachycardia, flushing, nausea, and vomiting. Methods: A consecutive sampling method was used (meeting inclusion criteria and willing to participate in  study) twelve -month follow-up study was conducted in which 75 patients visiting Outpatient department in secondary care setting  with diagnosis Alcohol dependence Syndrome (ICD 10/DSM IV criteria) received 250 mg disulfiram after consent from both patient and caregiver. Results: Out of 75 patients 13(17.4%) patients completed one year of supervised disulfiram treatment and remained abstinent. Out of 62 remained abstinent, 22(29.4%) of remained abstinent and on regular treatment for 6 months. 19 (25.4%) patients relapsed after 3 months of treatment. 17  (22.4%)patients relapsed within  2 week to 2 months of treatment. Unwanted effects due to disulfiram and no response at 500 mg  in one patient led to stopping of treatment in 4(5.4%) patients. Conclusion: The study concludes with the role of disulfiram in the present day and long-term pharmacotherapy of alcohol dependence along with future research needs in this area. Keywords: Disulfiram; Alcohol Dependence; Alcohol; Deterrent; Pharmacotherapy.

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hissei Imai ◽  
Toko Takamatsu ◽  
Hideaki Mitsuya ◽  
Hajime Yoshizawa ◽  
Hidehiko Mitsuya ◽  
...  

2021 ◽  
Vol 27 (12) ◽  
pp. S23-S24
Author(s):  
Maryam Batool ◽  
Beenish Khan ◽  
Muhammad Zaka-Ul Haq ◽  
Muhammad Raza-Ul Haq

2020 ◽  
Vol 73 ◽  
pp. S764
Author(s):  
Mohsan Subhani ◽  
Peuish Sugathan ◽  
Guruprasad Aithal ◽  
Emilie Wilkes ◽  
Naaventhan Palaniyappan

2019 ◽  
Vol 16 (3) ◽  
pp. 27-33
Author(s):  
Sanjeev Chandra Gautam ◽  
Yash Bhattarai

Use of alcohol has been one of the major source of recreation and stress relievers to date and it is one of the most abused substances in the world due to its free availability. The cost that a spouses incur in terms of economic hardships, social isolation and physical strain can be referred to as Spouse Burden. Spouses play an important role inpatient’s support and treatment and with a study like this there might be a better understanding of the problem. A descriptive, cross-Sectional hospital based study was done in 62 patients who met the diagnostic criteria for Alcohol Dependence Syndrome (ICD-10 DCR) and consents were taken from required personnel. Most of the patients examined were in the age group 40 to 60 years of age (72.6%) followed by the age group up to 40 (22.6%). 72.5% of the spouses were up to 40 years of age, followed by spouses of the age group 40-60 (27.5%).Males were the primary alcohol abusers(87%).51.6% of the patients were unemployed and the rest 48.4% was still employed whereas 51.6%of the spouses were employed and the rest48.4% unemployed. 51.6% of the patients were illiterate whereas majority of the spouses were literate(67.7%). There is a significant severity of burden of alcohol dependence syndrome in spouses and these verity of dependence is positively correlated with spouse burden. Financial, spouse routine, spouse interaction, physical and mental health of other members of the family were significantly affected with increase in dependence.


2001 ◽  
Vol 29 (3) ◽  
pp. 379-383 ◽  
Author(s):  
Enrique Echeburúa ◽  
Javier Fernández-Montalvo ◽  
Concepción Báez

The aim of this paper was to determine the features of pathological gamblers who dropped out of the treatment or relapsed within a one year follow-up period. The sample consisted of 69 patients selected according to DSM-IV criteria. Results indicated that the only difference between the patients who dropped out of treatment and the ones who completed was the level of state-anxiety. The former were more anxious than the latter. Predictive variables for the therapeutic failure were the dissatisfaction with the treatment, the high level of alcohol consumption, and the neuroticism as a personality variable. Implications of the study for clinical practice and future research in this field are commented upon.


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