scholarly journals A REVIEW ON CONTROLLED RELEASE MATRIX TABLET

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Sandeep Kumar ◽  
Vijay Sharma ◽  
D.S. Rathore
Keyword(s):  
Controlled Release ◽  
Evaluation Studies ◽  
Porous Matrix ◽  
Oral Route ◽  
The Body ◽  
Oral Dosage ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Short Period ◽  
Oral Dosage Forms

Oral route is the most convenient route of drug administration. So far so many oral dosage forms have been developed to improve the patient compliance. The drugs with less half life are eliminated from the body with in short period of time. Different types of extended release matrix tablet have been explained briefly along with the various formulation which mainly by wet granulation or direct compression method or by dispersion of solid particle within a porous matrix formed by using different polymers. This review highlights the types of matrices, mechanisms involved and evaluation studies.  Keywords: Controlled release, matrix tablet, Polymer, Diffusion

scholarly journals Recent Patents on Modified Release Oral Dosage Forms

2021 ◽  
Vol 11 (4-S) ◽  
pp. 195-211
Author(s):  
Atul Pund ◽  
Atishkumar Mundada ◽  
Manoj Magar ◽  
Abhijeet Kadam
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Extended Release ◽  
Dosage Forms ◽  
Delivery Systems ◽  
The Body ◽  
Oral Dosage ◽  
Modified Release ◽  
Delayed Release ◽  
Oral Dosage Forms

Background: Conventional oral dosage forms have limited bioavailability and frequent dosing of the drug is needed to maintain the effective therapeutic concentration in the body. This results in poor patient compliance and fluctuations in the plasma drug levels, especially in the chronic diseases and disorders. Objective: To overcome such problems and to enhance the efficiency and bioavailability of the drug, modified drug delivery systems such as extended release delivery systems (controlled release; sustained release) and delayed release delivery systems are developed which can prolong the release and hence action of the drug in the body. Methods: Through this review, we throw the light on recent patents and patent applications on modified release systems pertaining to oral dosage forms.  The various free patent search databases were used to collect and analyze the information on modified release delivery systems. Results: Modified release systems such as extended release and delayed release delivery systems have been found to be of great significance due to their advantages over immediate release dosage forms. These systems are formulated using various approaches, different types of release controlling polymers such as natural, semisynthetic and synthetic polymers and found to avoid the limitations of conventional oral dosage forms. Conclusion: Modified drug release systems have potential especially, in case of the chronic diseases, mental health disorders and lifestyle diseases and disorders. These systems have unique commercial advantages which will sustain the interest of both the researchers and the pharmaceutical companies. Keywords: Modified release systems, extended release systems, controlled release systems, sustained release systems, delayed release systems, oral dosage forms, multilayer dosage form, multilayered tablets

scholarly journals A COMPREHENSIVE REVIEW ON SUSTAINED RELEASE MATRIX TABLETS: A PROMISING DOSAGE FORM

2019 ◽  
Author(s):  
Agarwal Prakhar ◽  
Akhtar Semimul
Keyword(s):  
Drug Delivery ◽  
Dosage Form ◽  
Extended Release ◽  
Evaluation Studies ◽  
Porous Matrix ◽  
Matrix Tablets ◽  
Wet Granulation ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Hydrophobic Polymers

Oral ingestion is most convenient and commonly employed route of drug delivery due to its ease of administration, least aseptic and flexibility in the design of dosage form. The objective of the study was to explore the necessity, advantages and various techniques of extended release matrix tablet to get a constant drug delivery rate and reproducible kinetics for advance delivery. Different types of extended release matrix tablet have been explained briefly along with the various formulation which mainly by wet granulation or direct compression method or by dispersion of solid particle within a porous matrix formed by using different polymers. Matrix controls the free rate of drug. Matrix tablets can be formulated by either direct compression or wet granulation method by using a variety of hydrophilic or hydrophobic polymers. The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.

scholarly journals Indomethacin Controlled Release Matrix Tablet Prepared by Wet Granulation Procedure.

1997 ◽  
Vol 45 (1) ◽  
pp. 214-216 ◽  
Author(s):  
Guojie XU ◽  
Hisakazu SUNADA ◽  
Ruhua ZHANG
Keyword(s):  
Controlled Release ◽  
Wet Granulation ◽  
Matrix Tablet

scholarly journals THE ROLE OF MATRIX TABLET IN DRUG DELIVERY SYSTEM

2018 ◽  
Vol 10 (1) ◽  
pp. 1 ◽  
Author(s):  
Nita Mondal
Keyword(s):  
Controlled Release ◽  
Safety Margin ◽  
Oral Route ◽  
Dosage Forms ◽  
Matrix Tablets ◽  
Release Mechanism ◽  
Matrix Tablet ◽  
The Matrix ◽  
Potent Drug ◽  
Materials Used

Matrix tablet is an important tool for controlled and sustained release dosage forms. The oral route remains the most common route for the administration of drugs. Tablets offer the lowest cost approach to sustained and controlled release dosage forms. The hydrophilic polymer matrix is widely used in this dosage form. The use of different polymers in controlling the release of drugs has become the most important tool in the formulation of matrix tablets. The drug releases by both dissolution-controlled as well as diffusion-controlled mechanisms from the matrix. The development of oral controlled release systems has been a challenge to formulation scientists due to their inability to restrain and localize the system at targeted areas of the gastrointestinal tract. There are several advantages of matrix devices including improved patient compliance due to less frequent drug administration, reduction of fluctuation in steady-state drug levels, maximum utilization of the drug, increased safety margin of a potent drug. This review aims on the discussion of different materials used to prepare matrix tablets, different types of matrix tablets and the drug release mechanism from the matrices.

Oral Soluble Films: Attributes of the Polymeric Material and Critical Process Parameters for Designing Good Quality Films

2020 ◽  
Vol 3 (3) ◽  
pp. 167-188
Author(s):  
Suhani Sinha ◽  
Rohit Dutt
Keyword(s):  
Drug Delivery ◽  
Process Parameters ◽  
Oral Route ◽  
The Body ◽  
Market Potential ◽  
Oral Dosage ◽  
Systemic Absorption ◽  
Printing Technology ◽  
Critical Process Parameters ◽  
Critical Process

Background:: Soluble films prepared using polymeric matrices have gained prominence in drug delivery because of its multifarious merits. They are emerging as a momentous technology for designing precision medicines using printing technology, wherein the drugs, proteins/peptides and hormones in printing ink solution can be printed on placebo films targeted for specific age group dosage administration. Advances made in 3D printing technology in biomanufacturing for sophisticated tailor-made scaffolds of bone and tissue have further given impetus to digitally-controlled depositing of materials to create freeform geometries in the field of dosage form development. Objective: The patent expiry of a significant number of existing chemical entities is an encouraging factor for the possible market potential of these films as a novel drug delivery system through the oral route, topical route and ocular route. Most prominent amongst them is the oral route simply because of its substantial advantages over other pre-existing oral dosage forms. Method: Oral soluble films can be tailored for both local action in the buccal cavity as well as for systemic action to other parts of the body by direct absorption into the systemic circulation through the buccal mucosa. Depending upon the material attributes of its polymeric components, they can be targeted for buccal, sublingual, ocular or topical administration and can also be loaded inside hard gelatin capsule shells for administration into the gastrointestinal tract. Polymeric oral film technology has been exploited to address gaps in varied therapeutic segments including pain and inflammation management to provide instant relief, anti-emesis following chemotherapy, central nervous system disorders due to ease of administration to the caregivers and patient compliance, cardiovascular diseases due to faster onset of action, cancer therapy with enhanced safety and efficacy due to direct systemic absorption bypassing the first pass metabolism effect. Conclusion: This review summarizes the research works done to address gaps in varied therapeutic areas with an emphasis on critical material attributes of its polymeric components and the critical process parameters to be considered for manufacturing robust good quality medicinal films.

scholarly journals Fast dissolving tablets: waterless patient compliance dosage forms

2019 ◽  
Vol 9 (1) ◽  
pp. 303-317
Author(s):  
SANTOSH KUMAR RADA ◽  
Annu Kumari
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Oral Route ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Oral Drug ◽  
Self Medication ◽  
Existing Problems ◽  
Solid Dosage ◽  
Oral Dosage Forms

Drug delivery by the oral route is the most prescribable and acceptable route in terms of patient’s compliance. Improvement of patient’s compliance has always a challenge towards the development of oral drug delivery system. In the market different types of oral dosage forms are available in which tablets, capsules, syrups, suspensions are preferred ones. Oral solid drug delivery faces drawback in case of swallowing especially with paediatrics and geriatric psychotic patients. Therefore scientists attracted towards fast mouth dissolving drug delivery systems to encounter existing problems with unique property of palatability and rapid disintegration. The concept of fast dissolving tablet came into existence in late 1970 and further improvements are still going on in connection with its preparation and methodology. Fast dissolving tablets have faster disintegration and dissolution rate and releases within 30 seconds as they come in contact with saliva. These systems also obviate the requirement of carry water during drug administration. This facilitate drug delivery to the patients of dysphasic, psychic, paediatrics, geriatric and bed-ridden, unconscious population. As fast dissolving tablets falls under desired expectation of safer, convenient and economical solid dosage forms, several techniques have been developed to improve disintegration quality in the recent past years. This article mainly focuses on formulation and evaluation technologies with recent advancement made so far in the field of fast dissolving tablets. Keywords: Fast disintegration; Dysphasia; Mouth dissolving; Self-medication.

Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques

2012 ◽  
Vol 47 (3) ◽  
pp. 615-623 ◽  
Author(s):  
Natalja Genina ◽  
Daniela Fors ◽  
Hossein Vakili ◽  
Petri Ihalainen ◽  
Leena Pohjala ◽  
...  
Keyword(s):  
Controlled Release ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Flexographic Printing ◽  
Oral Dosage Forms ◽  
Printing Techniques
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