scholarly journals Brain Atrophy and Physical and Cognitive Disability in Multiple Sclerosis

2021 ◽  
Author(s):  
Ignacio Casanova ◽  
◽  
Carlos Lopez De Silanes ◽  
Laura De Torres ◽  
Miriam Eimil ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Practice ◽  
Brain Atrophy ◽  
Physical Disability ◽  
Cognitive Status ◽  
Practice Setting ◽  
Cognitive Domains ◽  
Primary Progressive ◽  
Clinical Practice Setting ◽  
The Relationship

Introduction: brain atrophy is associated with physical disability in multiple sclerosis (MS), but there is a great variability between different studies and methodologies, and its use is still limited to research projects. Objective: to analyze the relationship between several volumetric measurements and physical disability and cognitive functioning in MS patients in a clinical practice setting. Material and methods: cross-sectional study. 41 patinets (31 relapsing-remitting MS, 6 secondary-progressive MS and 4 primary-progressive MS). Whole brain volume (WBV), Gray Matter Volume (GMV) and T2 lesion load (T2L) were obtained using Icometrix ® software. Physical disability was measured with the Expanded Disability Status Scale (EDSS), and cognitive status was evaluated with the Brief Repeatble Battery of neuropsychological tests (BRB-N). The relationship between brain volumes and EDSS was analyzed through lineal multivariate regression. The association between volumetry measurements and the number of affected cognitive domains was studied with negative binomial regression. Results: GMV was associated with age (b=-1.7; p=0,014) and with EDSS (b= -7.55; p=0.013). T2L was associated with EDSS (b= 2.29; p=0.032). The number of affected cognitive domains was associated with clinical phenotype, worse in primary progressive MS (PPMS). There was not correlations between cognitive impairment and cerebral volumes. Conclusions: Brain atrophy measurement is feasible in clinical practice setting, and it is helpful in monitoring the EDSS progression. Primary progressive phenotype is associated with greater risk of cognitive dysfunction.

Fingolimod Use for the Treatment of Multiple Sclerosis in a Clinical Practice Setting in Madrid

2016 ◽  
pp. 1 ◽  
Author(s):  
Victoria Galán Sánchez-Seco ◽  
Ignacio Casanova-Peño ◽  
Roberto Álvarez-Lafuente ◽  
Mónica Sánchez-Jiménez ◽  
Ángel García-Martínez ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Practice ◽  
Practice Setting ◽  
Clinical Practice Setting

scholarly journals The Relationship Between Nursing Students’ Perceived Sense of Belongingness and Their Willingness to Self-Report Medication Errors in the Clinical Practice Setting: A Feasibility Study

2021 ◽  
Author(s):  
Anda Botezatu
Keyword(s):  
Clinical Practice ◽  
Nursing Students ◽  
Medication Errors ◽  
Nursing Student ◽  
Well Being ◽  
High Response Rate ◽  
Self Report ◽  
Practice Setting ◽  
Clinical Practice Setting ◽  
The Relationship

Medication errors threaten the physical and emotional well-being of the Canadian population (Mayo & Duncan, 2004). There is a paucity of published studies examining medication errors in the nursing student population. The purpose of this pilot study was determining the feasibility of conducting a larger scale study examining the relationship between nursing students’ perceived sense of belongingness and their willingness to self-report medication errors in the clinical practice setting. Thirty fourth year nursing students completed the study instruments. The study’s conceptual framework guided the development of objectives and interpretation of results. Overall, there was a high response rate, the study protocol was appropriate, and study instruments were valid and reliable. Results indicated a negative nonsignificant inverse relationship between the two main variables. Implications related to nursing practice, education, theory, and results are offered, with a specific focus on the need to replicate the study using a larger sample.

scholarly journals The Relationship Between Nursing Students’ Perceived Sense of Belongingness and Their Willingness to Self-Report Medication Errors in the Clinical Practice Setting: A Feasibility Study

2021 ◽  
Author(s):  
Anda Botezatu
Keyword(s):  
Clinical Practice ◽  
Nursing Students ◽  
Medication Errors ◽  
Nursing Student ◽  
Well Being ◽  
High Response Rate ◽  
Self Report ◽  
Practice Setting ◽  
Clinical Practice Setting ◽  
The Relationship

Medication errors threaten the physical and emotional well-being of the Canadian population (Mayo & Duncan, 2004). There is a paucity of published studies examining medication errors in the nursing student population. The purpose of this pilot study was determining the feasibility of conducting a larger scale study examining the relationship between nursing students’ perceived sense of belongingness and their willingness to self-report medication errors in the clinical practice setting. Thirty fourth year nursing students completed the study instruments. The study’s conceptual framework guided the development of objectives and interpretation of results. Overall, there was a high response rate, the study protocol was appropriate, and study instruments were valid and reliable. Results indicated a negative nonsignificant inverse relationship between the two main variables. Implications related to nursing practice, education, theory, and results are offered, with a specific focus on the need to replicate the study using a larger sample.

Association of apolipoprotein E and myeloperoxidase genotypes to clinical course of familial and sporadic multiple sclerosis

2004 ◽  
Vol 10 (3) ◽  
pp. 266-271 ◽  
Author(s):  
B Zakrzewska-Pniewska ◽  
M Styczynska ◽  
A Podlecka ◽  
R Samocka ◽  
B Peplonska ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Apolipoprotein E ◽  
Brain Atrophy ◽  
Genetic Factors ◽  
Clinical Course ◽  
Progression Rate ◽  
Disease Course ◽  
Familial Cases ◽  
Sporadic Cases ◽  
The Relationship

The importance of apolipoprotein E (ApoE) and myeloperoxidase (MPO) genotypes in the clinical characteristics of multiple sclerosis (MS) has been recently emphasized. In a large group of Polish patients we have tested the hypothesis that polymorphism in ApoE and MPO genes may influence the course of the disease. G enotypes were determined in 117 MS patients (74 females and 43 males; 99 sporadic and 18 familial cases) with mean EDSS of 3.6, mean age of 44.1 years, mean duration of the disease 12.8 years and mean onset of MS at 31.2 years, and in 100 healthy controls. The relationship between ApoE and MPO genes’ polymorphism and the MS activity as well as the defect of remyelination (diffuse demyelination) and brain atrophy on MRI were analysed. The ApoE o4 allele was not related to the disease course or the ApoE o2 to the intensity of demyelination on MRI. The genotype MPO G/G was found in all familial MS and in 57% (56/99) of sporadic cases. This genotype was also related to more pronounced brain atrophy on MRI. The MPO G/G subpopulation was characterized by a significantly higher proportion of patients with secondary progressive MS (PB- 0.05) and by a higher value of EDSS. A ccording to our results the MPO G allele is frequently found (in 96% of cases) among Polish patients with MS. More severe nervous tissue damage in the MPO G/G form can be explained by the mechanism of accelerated oxidative stress. It seems that MPO G/G genotype may be one of the genetic factors influencing the progression rate of disability in MS patients.

scholarly journals Subcortical ischemic vascular disease and cognition: A systematic review

2008 ◽  
Vol 2 (2) ◽  
pp. 82-90 ◽  
Author(s):  
Gilberto Sousa Alves ◽  
Carlos Eduardo de Oliveira Alves ◽  
Maria Elisa Lanna ◽  
Denise Madeira Moreira ◽  
Eliasz Engelhardt ◽  
...  
Keyword(s):  
Vascular Disease ◽  
Memory Retrieval ◽  
White Matter Lesions ◽  
Case Control ◽  
Cognitive Status ◽  
Independent Factor ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Cognitive Domains ◽  
The Relationship

Abstract Subcortical Ischemic Vascular Disease (SIVD) is underdiagnosed. This review investigates the relationship among SIVD severity, cognitive status and neuroimaging markers. Methods: Cohort, cross-sectional and case control studies were searched on ISI, Medline, Scielo, PsychoInfo and LILACS databases published between 1995 and 2006. Results: The most impaired cognitive domains were executive, attentional and memory retrieval mechanisms. These cognitive features were frequently associated to White Matter Lesions (WML). Conclusions: WML is an independent factor in cognitive decline. However, the threshold for this impact is not yet clearly established.

scholarly journals Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting

2014 ◽  
Vol 15 (14) ◽  
pp. 1739-1747 ◽  
Author(s):  
Otito F Iwuchukwu ◽  
QiPing Feng ◽  
Wei-Qi Wei ◽  
Lan Jiang ◽  
Min Jiang ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Clinical Practice ◽  
Practice Setting ◽  
Clinical Practice Setting
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