scholarly journals The Subcutaneous Injection of Organophosphate: A Case Report

2021 ◽  
Vol 11 (4) ◽  
pp. 34343-34343
Author(s):  
Shafeajafar Zoofaghari ◽  
◽  
Afshar Fazeli Dehkordi ◽  
Kourosh Nemati ◽  
Mozhdeh Hashemzadeh ◽  
...  
Keyword(s):  
Developing Countries ◽  
Case Report ◽  
Clinical Response ◽  
Subcutaneous Injection ◽  
Nausea And Vomiting ◽  
Response To Treatment ◽  
Good Clinical Response ◽  
Current Case ◽  
Parenteral Route ◽  
Successful Recovery

Organophosphate (OP) poisoning is prevalent in developing countries. Toxicity occurs by voluntary injection, inhalation, and absorption. Self-injection is rare. The current case report describes a 61-y/o male with subcutaneous self-injected one cc OP poisoning presenting with delayed drowsiness, nausea, and vomiting. He was treated and presented a good clinical response to treatment with pralidoxime and had a successful recovery. Diagnosis of OP compound toxicity by the parenteral route is a challenge. By observing patients, the dose, and the time between poisoning until the time to start treatment, we can conclude different presentations and outcomes of OP poisoning.

Systemic Steroids Suppress Antimelanocyte Antibodies in Vitiligo

1997 ◽  
Vol 1 (4) ◽  
pp. 193-195 ◽  
Author(s):  
Seung-Kyung Hann ◽  
Dunlu Chen ◽  
Jean-Claude Bystryn
Keyword(s):  
Clinical Response ◽  
Steroid Treatment ◽  
Response To Therapy ◽  
Response To Treatment ◽  
Systemic Steroid ◽  
Good Clinical Response ◽  
Systemic Steroid Therapy ◽  
Initiation Of Therapy ◽  
Antibody Levels

Background: Vitiligo is associated with autoantibodies to melanocytes. The role of these antibodies in the pathogenesis of the disease is still unknown. Objective: The purpose of this study was to examine the role of vitiligo antibodies in the pathogenesis of the disease by studying whether or not there is a correlation between changes in their level and response to therapy with systemic steroid. Methods: Antibodies to the 40 to 45 kD, 75 kD, and 90 kD vitiligo antigens were measured prior to and following systemic steroid therapy in 10 patients with active vitiligo. Results: Four months following initiation of therapy, seven (78%) of nine patients with good clinical response to steroid treatment had a significant decrease in the level of vitiligo antibodies. By contrast, one patient who had no response to treatment had a slight increase in antibody levels. Conclusion: These findings suggest that one mechanism by which corticosteroids can cause repigmentation in vitiligo is by decreasing the level of vitiligo antibodies, and support the notion that vitiligo antibodies are involved in the pathogenesis of this disease.

scholarly journals Urinary tract infection by Acinetobacter dijkshoorniae and good clinical response to treatment

2020 ◽  
Vol 33 (4) ◽  
pp. 281-282
Author(s):  
María Isabel Casanovas Moreno-Torres ◽  
Fanny Rodríguez-Campos ◽  
Miguel Gutiérrez-Soto ◽  
José María Navarro-Marí ◽  
José Gutiérrez-Fernández
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Clinical Response ◽  
Response To Treatment ◽  
Good Clinical Response

scholarly journals Necrotizing fasciitis complicated with multiple organ dysfunction syndrome after breast augmentation with fat from the waist and lower extremities: a case report

2020 ◽  
Vol 48 (7) ◽  
pp. 030006052093762
Author(s):  
Mingjun Zhang ◽  
Longjin Chen ◽  
Kai Chi ◽  
Liyan Xu ◽  
Yonglin Li
Keyword(s):  
Case Report ◽  
Mortality Rate ◽  
Necrotizing Fasciitis ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Lower Limb ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Current Case ◽  
Successful Recovery

Necrotizing fasciitis (NF) is a rapidly progressing soft tissue infection with a mortality rate as high as 30% to 50%. However, the incidence rate of NF after liposuction is extremely low. In the current case report, we describe a woman with NF who developed multiple organ dysfunction syndrome (MODS) after fat acquisition. The aim of this paper is to summarize the management of these patients. After debridement and drainage, correction of multiple organ failure, and plastic surgery, the patient’s organ and lower limb functions improved to a normal level. Early diagnosis, early operative treatment, and correction of systemic abnormalities are the keys to successful recovery of patients with NF complicated with MODS after liposuction.

Concentrations of doxycycline and penicillin G in sera and cerebrospinal fluid of patients treated for neuroborreliosis.

1996 ◽  
Vol 40 (5) ◽  
pp. 1104-1107 ◽  
Author(s):  
M Karlsson ◽  
S Hammers ◽  
I Nilsson-Ehle ◽  
A S Malmborg ◽  
B Wretlind
Keyword(s):  
Cerebrospinal Fluid ◽  
Borrelia Burgdorferi ◽  
Treatment Failure ◽  
Clinical Response ◽  
Drug Administration ◽  
Drug Concentration ◽  
Response To Treatment ◽  
Penicillin G ◽  
Good Clinical Response

Concentrations of doxycycline and penicillin G in serum and cerebrospinal fluid (CSF) were analyzed in 46 patients during treatment for neuroborreliosis. Twenty patients were treated intravenously with penicillin G at 3 g every 6 h (q6h), and 26 patients were treated orally with doxycycline at 200 mg q24h. All samples were collected on day 13 of treatment. The median concentrations of penicillin G in serum were 0.5, 37, and 5.6 micrograms/ml before and 1 and 3 h after drug administration, and that in CSF was 0.5 (range, 0.3 to 1.6) microgram/ml after 2 to 3 h. The median concentrations of doxycycline in serum were 2.1, 6.1, and 4.7 micrograms/ml before and 2 and 6 h after drug administration, and that in CSF was 0.6 (range, 0.4 to 2.5) microgram/ml after 4 h. All patients had concentrations of penicillin G or doxycycline in CSF above the lowest reported MICs of penicillin G (0.003 microgram/ml) and doxycycline (0.12 microgram/ml) for Borrelia burgdorferi. However, no patients had a drug concentration in CSF above the highest reported MIC of penicillin G (8 micrograms/ml), and only one had a drug concentration in CSF above the highest reported MIC of doxycycline (2 micrograms/ml), despite good clinical response to treatment. No treatment failure or relapse was observed during a 1-year follow-up, although one patient treated with penicillin G and one treated with doxycycline were retreated because of residual pain. The chosen dosages of penicillin G and doxycycline seem to give sufficient concentrations in serum and CSF for the treatment of neuroborreliosis.

Refractory Hyperlactatemia After a Septic Shock in a Patient With Carnitine Deficiency: A Case Report

2018 ◽  
Vol 33 (1) ◽  
pp. 113-116 ◽  
Author(s):  
Philippe Hogan ◽  
Roxane Plourde ◽  
Maude Fortier ◽  
Dave Brindamour ◽  
Colin Lagrenade-Verdant ◽  
...  
Keyword(s):  
Septic Shock ◽  
Valproic Acid ◽  
Case Report ◽  
Clinical Response ◽  
Carnitine Deficiency ◽  
Response To Treatment ◽  
Carnitine Supplementation

A 56-year-old woman with septic shock presented with persistent hyperlactatemia, despite an adequate clinical response to treatment. Carnitine deficiency was suspected, as the patient was malnourished and chronically taking valproic acid. No other plausible cause of hyperlactatemia was found. Carnitine supplementation resulted in rapid normalization of lactatemia.

scholarly journals Eosinophilic Granulomatosis with Polyangiitis Relapse after COVID-19 Vaccination: A Case Report

Vaccines ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 13
Author(s):  
Giulia Costanzo ◽  
Andrea Giovanni Ledda ◽  
Alessandra Ghisu ◽  
Matteo Vacca ◽  
Davide Firinu ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Case Report ◽  
Clinical Response ◽  
Granulomatosis With Polyangiitis ◽  
Caucasian Woman ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Good Clinical Response ◽  
Eosinophilic Granulomatosis

Background: We here describe the case of a 71-year-old Caucasian woman previously diagnosed with Eosinophilic Granulomatosis with Polyangiitis (EGPA) that had been treated with Mepolizumab, an anti-IL5 monoclonal antibody, since 2019 with a good clinical response. Methods: She had a mild COVID-19 in December 2020 and she tested negative for SARS-CoV-2 infection in only late January 2021. In April 2021 she received the first dose of mRNA BNT162b2 vaccine. Ten days later she developed myalgia, dyspnea and numbness of the limbs due to a relapse of EGPA that occurred during Mepolizumab treatment.

scholarly journals Subcutaneous injection of organophosphate: a case report of unusual poisoning

2021 ◽  
Author(s):  
shafeajafar Zoofaghari ◽  
Afshar Fazeli Dehkordi ◽  
Kourosh Nemati ◽  
Mozhdeh Hashemzadeh ◽  
Arman Otroshi
Keyword(s):  
Case Report ◽  
Subcutaneous Injection ◽  
Organophosphate Poisoning ◽  
Current Case

Organophosphate poisoning by self-injection is rare. Current case report describes a man with subcutaneous self-injected OP. poisoning presenting with delayed. He was treated with pralidoxime. Through the observation, dose and the time between poisoning until time to start treatment we can conclude different presentations and outcomes of OP poisoning.

scholarly journals Bexarotene-Induced Hypertriglyceridemia: A Case Report

2018 ◽  
Vol 11 (1) ◽  
pp. 234-238 ◽  
Author(s):  
Chris Maminakis ◽  
Arin C. Whitman ◽  
Nahida Islam
Keyword(s):  
Case Report ◽  
T Cell ◽  
Clinical Response ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Good Clinical Response ◽  
Therapy Management ◽  
High Incidence ◽  
Management Recommendations

We present a case of a patient with cutaneous T-cell lymphoma started on bexarotene 300 mg/m2 due to progressing disease. The patient experienced good clinical response, but unfortunately, she developed rapid and profound hypertriglyceridemia. Although hypertriglyceridemia occurs in high incidence with bexarotene therapy, management recommendations are scarce. Due to the rise in triglycerides, atorvastatin 10 mg daily was initiated in combination with fenofibrate 120 mg daily. Triglycerides continued to increase, so the patient was instructed to take atorvastatin 40 mg, fenofibrate 120 mg, and to hold bexarotene for 2 weeks. After the 2-week break, bexarotene was restarted at 150 mg/m2.

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