scholarly journals Anesthetic management of a parturient with Eisenmenger’s syndrome: A case report

2021 ◽  
pp. 327-329
Author(s):  
Anshul Singh ◽  
Nishant Patel
Keyword(s):  
Congenital Abnormalities ◽  
Anesthetic Management ◽  
Volume Overload ◽  
Pulmonary Vasculature ◽  
Healthy Male ◽  
Vaginal Route ◽  
Drug Deposition ◽  
Eisenmenger’S Syndrome ◽  
Maternal And Neonatal Outcomes ◽  
Labor Epidural

Eisenmenger’s syndrome results from certain uncorrected congenital abnormalities of the heart facilitating left to right shunt and chronic volume overload of the pulmonary vasculature, leading to irreversible changes in the pulmonary vasculature. Pregnancy in the patients of this syndrome is associated with a high risk of cardiovascular decompensation, thromboembolic complications, and sudden cardiac death. We present the case of a 25-year-old pregnant woman with Eisenmenger’s syndrome who delivered through the vaginal route at 37 weeks of gestation, under labor epidural anesthesia. A healthy male baby was delivered within 40 min of drug deposition in the epidural space. The postpartum period was essentially uneventful with successful maternal and neonatal outcomes.

Anesthetic Management of Ovarian Bleeding with Eisenmenger's Syndrome: A case report

2001 ◽  
Vol 41 (2) ◽  
pp. 252
Author(s):  
Hong Bum Kim ◽  
Seung Young Park ◽  
Tae Yop Kim ◽  
In Kyu Kim ◽  
Myoung Keun Shin ◽  
...  
Keyword(s):  
Case Report ◽  
Anesthetic Management ◽  
Eisenmenger’S Syndrome

scholarly journals Role of nasal casts for in vitro evaluation of nasal drug delivery and quantitative evaluation of various nasal casts

2020 ◽  
Vol 11 (8) ◽  
pp. 485-495
Author(s):  
Per G Djupesland ◽  
John C Messina ◽  
Ramy A Mahmoud
Keyword(s):  
Computed Tomography ◽  
Drug Delivery ◽  
Quantitative Evaluation ◽  
Healthy Male ◽  
Nasal Drug Delivery ◽  
Normal Range ◽  
Cross Sectional ◽  
Drug Deposition

Background: Nasal casts may characterize intranasal drug deposition. Methodology: The Koken cast, described as ‘anatomically correct’, and the Optinose cast, derived from MRI of a healthy male during velum closure, were dimensionally compared and assessed for deposition assessment suitability. Results: Smallest vertical cross-sectional areas (valve region) for Koken and Optinose right/left: 2.55/2.75 and 1.18/1.18 cm2, respectively, versus a ‘normative’ mean (range) of 0.85 cm2 (0.2–1.6 cm2). Intranasal volumes differed (computed tomography/water fill): Koken, 35.8/38.6 cm3 and Optinose, 24.1/25.0 cm3, versus a ‘normative’ mean (range) of 26.4 cm3 (20.9–31.1 cm3). Conclusion: Koken cast dimensions are larger than the normal range and the Optinose cast. The validity of casts for regulatory drug deposition studies is suspect.

scholarly journals Image-based modelling of inhaler deposition during respiratory exacerbation

2020 ◽  
Author(s):  
Josh Williams ◽  
Jari Kolehmainen ◽  
Steve Cunningham ◽  
Ali Ozel ◽  
Uwe Wolfram
Keyword(s):  
Respiratory Diseases ◽  
Upper Airway ◽  
Patient Specific ◽  
Computational Studies ◽  
Healthy Male ◽  
Drug Deposition ◽  
Lower Airways ◽  
The One ◽  
The Impact ◽  
Female Lung Cancer

AbstractFor many of the one billion sufferers of respiratory diseases worldwide, managing their disease with inhalers improves their ability to breathe. Poor disease management and rising pollution can trigger exacerbations which require urgent relief. Higher drug deposition in the throat instead of the lungs limit the impact on patient’s symptoms. To optimise delivery to the lung, patient-specific computational studies of aerosol inhalation can be used. However in many studies, inhalation modelling does not represent an exacerbation, where the patient’s breath is much faster and shorter. Here we compare differences in deposition of inhaler particles in the airways of a healthy male, female lung cancer and child cystic fibrosis patient. We aimed to evaluate deposition differences during an exacerbation with image-based healthy and diseased patient models. We found that during an exacerbation, particles progressing to the lower airways were distributed similarly to those inhaled during healthy breathing, but fewer in quantity. Throat deposits were halved in the healthy patient compared to the diseased patients under extreme inhalation, due to changes in the detailed shape of the throat. Our results identify that the modelled upper airway must be patient-specific, and an exacerbating profile tested for optimal measurement of reliever inhaler deposition.

Successful term pregnancy after selective embolization of a large postmolar uterine arteriovenous malformation

2006 ◽  
Vol 16 (Suppl 1) ◽  
pp. 439-441 ◽  
Author(s):  
C. C. Tsai ◽  
Y. F. Cheng ◽  
C. C. Changchien ◽  
H. Lin
Keyword(s):  
Vaginal Bleeding ◽  
Uterine Bleeding ◽  
Healthy Male ◽  
Vaginal Route ◽  
Term Pregnancy ◽  
Selective Embolization ◽  
Male Baby ◽  
Uterine Arteriovenous Malformation ◽  
History Of ◽  
Reproductive Capability

Uterine arteriovenous malformations (AVM) are very uncommon disorders. Successful conservative treatment with subsequently conceived is rarely reported. We describe a 31-year-old woman with a complex and large postmolar AVM; she was successfully treated with transarterial selective embolization for a long history of repeated excessive vaginal bleeding and anemia. She resumed normal menstrual periods soon after treatment, and she subsequently conceived about 2 years later. A healthy male baby was delivered at 39 weeks of gestation via vaginal route. Selective embolization of a complex and large uterine AVM seems to be feasible for the treatment of uterine bleeding and preservation of reproductive capability.

scholarly journals Anesthetic management for emergent craniotomy in a patient with Eisenmenger's syndrome - A case report -

2009 ◽  
Vol 57 (5) ◽  
pp. 666 ◽  
Author(s):  
Kum Hee Chung ◽  
Seung Ho Kim ◽  
Duk Hee Chun ◽  
Jong Yun Lee ◽  
Seong Cheol Park ◽  
...  
Keyword(s):  
Case Report ◽  
Anesthetic Management ◽  
Eisenmenger’S Syndrome

Ventricular Septal Defect with Aortic Valve Insufficiency in a New Zealand White RabbitS

2011 ◽  
Vol 47 (4) ◽  
pp. e42-e49 ◽  
Author(s):  
Károly Vörös ◽  
Frauke Seehusen ◽  
Stephan Hungerbühler ◽  
Andrea Meyer-Lindenberg ◽  
Nina von der Hoeh
Keyword(s):  
New Zealand ◽  
Aortic Valve ◽  
Ventricular Septal Defect ◽  
Septal Defect ◽  
Normal Sinus Rhythm ◽  
Zealand White Rabbit ◽  
Volume Overload ◽  
Pulmonary Vasculature ◽  
Valve Insufficiency ◽  
The Right

A heart murmur was detected in a 10 mo old, female New Zealand White rabbit. Auscultation revealed cardiac murmurs both at the left and right hemithorax. Phonocardiography confirmed the systolic–diastolic nature of the left-sided and the systolic character of the right-sided murmur. Electrocardiography showed normal sinus rhythm; tall R waves and large T waves in lead II; and deep S waves in leads II, III, and aVF. Thoracic radiography demonstrated generalized cardiomegaly with prominent pulmonary vasculature. Echocardiography revealed a perimembraneous ventricular septal defect with aortic insufficiency. Signs of biventricular volume overload, relative pulmonic stenosis, and pulmonary valve insufficiency were also seen as consequences of the defect. Necropsy demonstrated a ventricular septal defect just below the aortic valve, a dilated pulmonary trunk, dilated and hypertrophied ventricles, dilated atria, and rightward displacement of the aortic root. Cardiac histopathology showed ventricular cardiomyocyte degeneration (swelling and hypereosinophilia of the cytoplasm with a loss of cross striation, and nuclear hyperchromasia), cartilaginous metaplasia of the aorta, and subendocardial fibrosis of the right ventricular flow tract.

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