scholarly journals Effect of Vitamin D3 Supplementation on Levator Ani Muscle Strength in Primipara Pregnancy with Post-partum Vitamin D3 Deficiency

2020 ◽  
pp. 231-236
Author(s):  
Rizkar A. Sukarsa ◽  
Devi N. Anti ◽  
Benny H. Purwara ◽  
R.M Sonny Sasotya
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Vitamin D3 ◽  
Post Partum ◽  
Serum Vitamin ◽  
Levator Ani ◽  
P Value ◽  
Levator Ani Muscle ◽  
Basal Tone ◽  
Vitamin D3 Supplementation

Objective: To determine the benefi ts of post-partum vitamin D supplementation on striated muscle strength. Methods: This is a pre-post quasi-experimental study on postpartum vitamin D3 supplement provision in primiparous women with vitamin D3 defi ciency. The effect of vitamin D3 supplement was assessed through the measurement of pelvic floor muscle strength before and after 3 months of vitamin D3 supplementation. Thirty-three primiparous postpartum women with spontaneous vaginal delivery who met inclusion criteria participated in this study. Serum vitamin D3 level, basal tone, and maximum levator ani contraction were measured by perimetry prior to and after vitamin D3 supplementation. This study was conducted in the Obstetric Clinic and Clinical Serology Laboratory of Clinical Pathology Department, Dr. Hasan Sadikin General Hospital/ Faculty of Medicine, Universitas Padjadjaran from March 1 to May 31, 2018.Results: Data analysis using the Wilcoxon test showed an increase in serum vitamin D3 level and a basal tone strength after vitamin D3 supplementation with a P-value of <0.001. However, the maximum strength of levator ani muscle contraction did not increase (P-value <0.829).Conclusions: Vitamin D3 supplementation increases basal tone strength.Keywords: basal tone, maximum levator ani muscle contraction, perimetry, primiparous vitamin D3 defi ciency, vitamin D. Abstrak Tujuan: Untuk mengetahui manfaat pemberian suplementasi vitamin D pascasalin terhadap kekuatan otot lurik.Metode: Tipe penelitian ini adalah penelitian eksperimental quasi dengan rancangan sebelum dan sesudah pemberian vitamin D3 pada ibu primipara pascasalin yang mengalami defisiensi vitamin D3, dengan mengukur kekuatan otot dasar panggul sebelum dan sesudah pemberian 3 bulan vitamin D3. Subjek penelitian adalah primipara pasca persalinan spontan yang memenuhi kriteria inklusi penelitian (n=33). Dilakukan pemeriksaan kadar vitamin D serum dan pengukuran tonus basal dan kontraksi maksimal levator ani dengan menggunakan perimetri sebelum dan sesudah pemberian suplementasi vitamin D3. Penelitian dilakukan di Poliklinik obstetri FKUP/RSHS dan Laboratorium serologi Klinik Patologi Klinik FKUP/RSHS pada bulan 1 Maret- 31 Mei 2018.Hasil: Hasil penelitian ini dengan menggunakan uji wilcoxon didapatkan peningkatan kadar serum vitamin D3 dan peningkatan kekuatan tonus basal setelah pemberian suplementasi vitamin D3 dengan nilai P<0,001. Sedangkan kekuatan kontraksi otot maksimal levator ani tidak mengalami peningkatan dengan nilai P<0,829.Kesimpulan: Suplementasi vitamin D3 meningkatkan kekuatan tonus basalKata kunci: kontraksi maksimal levator ani, perimetri, primipara defi sisensi vitamin D3, tonus basal, vitamin D.  

scholarly journals The Effect of Vitamin D3 Supplementation on Increases of Levator Ani Contraction Strength in Women with Uterine Prolapse

2020 ◽  
pp. 174-178
Author(s):  
Nenny Yoanitha ◽  
Benny H. Purwara ◽  
Irma Ruslina ◽  
Sonny Sasotya
Keyword(s):  
Vitamin D ◽  
Muscle Contraction ◽  
Soleus Muscle ◽  
Vitamin D3 ◽  
Uterine Prolapse ◽  
Serum Vitamin ◽  
Levator Ani ◽  
P Value ◽  
Levator Ani Muscle ◽  
Vitamin D3 Supplementation

Objective: To investigate the differences of levator muscle contraction strength after vitamin D3 supplementation, thus it is expected that the administration of vitamin D3 can reduce the incidence of uterine prolapse recurrence after reconstructive surgery.Methods: This study is a quasi-experimental study with pre-and-post vitamin D3 supplementation on uterine prolapse patient. Participants in this study were patient with uterine prolapse and fulfilled inclusion criteria (n=19). Serum vitamin D3 levels, levator ani muscle contraction strength (perineometer peritron TM), gastrocnemius soleus muscle contraction strength (hand held dynamometer) were measured prior to and after vitamin D3 1000 IU supplementation. This study was conducted in Gynecology Clinic, Physical Medicine and Rehabilitation Clinic, and The Department of Clinical Pathology Dr. Hasan Sadikin General Hospital/ Faculty of Medicine Universitas Padjadjaran on January-April 2019Results: This study showed an increase in levator ani muscle contraction strength with a significant P value of <0.001 and an increase in gastrocnemius soleus muscle contraction strength with a significant P value of <0.001 after vitamin D3 supplementation.Conlusions:  Vitamin D3 supplementation can increase levator ani and gastrocnemius soleus muscle contraction strength in uterine prolapse patient.Keywords: gastrocnemius soleus muscle contraction strength, handheld dynamometer, vitamin D, levator ani muscle contraction strength, perineometer peritronTM, uterine prolapse.   Abstrak Tujuan: Melihat perbedaan kekuatan kontraksi otot levator ani setelah suplementasi vitamin D3, dengan demikian diharapkan pemberian vitamin ini dapat mengurangi insidensi rekurensi prolapsus uteri pasca operasi rekonstruksi.Metode: Penelitian ini merupakan penelitian eksperimental quasi dengan  rancangan  sebelum dan sesudah pemberian vitamin D3 pada pasien prolapsus uteri. Subjek penelitian adalah pasien prolapsus uteri yang memenuhi kriteria inklusi penelitian (n=19). Dilakukan pemeriksaan kadar vitamin D serum, pengukuran kekuatan otot levator ani (perineometer peritronTM)  dan otot lurik gastrocnemius soleus (hand held dynamometer) sebagai otot pembanding sebelum dan sesudah pemberian 3 bulan vitamin D3 1000 IU. Penelitian dilakukan di Poliklinik Ginekologi FKUP/RSHS, Poliklinik Kedokteran Fisik dan Rehabilitasi FKUP/RSHS dan Laboratorium serologi Klinik Patologi Klinik FKUP/RSHS pada bulan Januari – April 2019Hasil: Penelitian ini memperlihatkan peningkatan kekuatan kontraksi otot levator ani dengan nilai signifikan p<0,001, dan peningkatan kekuatan kontraksi otot gastrocnemius soleus dengan nilai signifikan p<0,001 setelah subjek mendapatkan suplemen vitamin D3.Kesimpulan: Penelitian ini menyimpulkan bahwa suplementasi vitamin D3 dapat meningkatkan kekuatan kontraksi otot levator ani dan otot gastrocnemius soleus pada penderita prolapsus uteri.Kata kunci: kekuatan kontraksi otot levator ani, kekuatan kontraksi otot gastrocnemius soleus, hand held dynamometer, perineometer peritronTM, prolapsus uteri , vitamin D

Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD

2021 ◽  
Author(s):  
Cora M Best ◽  
Leila R Zelnick ◽  
Kenneth E Thummel ◽  
Simon Hsu ◽  
Christine Limonte ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Parent Compound ◽  
Serum Vitamin ◽  
Vitamin D Supplementation ◽  
Total Serum ◽  
P Value ◽  
Hydroxyvitamin D ◽  
Serum Vitamin D ◽  
Vitamin D3 Supplementation

Abstract Context The effect of daily vitamin D supplementation on the serum concentration of vitamin D (the parent compound) may offer insight into vitamin D disposition. Objective To assess the total serum vitamin D response to vitamin D3 supplementation and whether it varies according to participant characteristics. To compare results with corresponding results for total serum 25-hydroxyvitamin D (25(OH)D), which is used clinically and measured in supplementation trials. Design Exploratory study within a randomized trial. Intervention 2,000 International Units of vitamin D3 per day (or matching placebo). Setting Community-based. Participants 161 adults (mean ± SD age 70 ± 6 years; 66% males) with type 2 diabetes. Main Outcome Measures Changes in total serum vitamin D and total serum 25(OH)D concentrations from baseline to year 2. Results At baseline, there was a positive, nonlinear relation between total serum vitamin D and total serum 25(OH)D concentrations. Adjusted effects of supplementation were a 29.2 (95% CI: 24.3, 34.1) nmol/L increase in serum vitamin D and a 33.4 (95% CI: 27.7, 39.2) nmol/L increase in serum 25(OH)D. Among those with baseline 25(OH)D &lt; 50 compared with ≥ 50 nmol/L, the serum vitamin D response to supplementation was attenuated (15.7 vs 31.2 nmol/L; interaction p-value = 0.02), whereas the serum 25(OH)D response was augmented (47.9 vs 30.7 nmol/L; interaction p-value = 0.05). Conclusions Vitamin D3 supplementation increases total serum vitamin D and 25(OH)D concentrations with variation according to baseline 25(OH)D, which suggests that 25-hydroxylation of vitamin D3 is more efficient when serum 25(OH)D concentration is low.

scholarly journals Assessment of Serum Vitamin D3 Level in One Year Old Children Using D3 Supplement

2020 ◽  
Author(s):  
Danial Alebouyeh ◽  
Nasrin Khalessi ◽  
Maryam Saboute ◽  
Maryam Alizadeh Chamkhaleh ◽  
Mandana Kashaki
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
P Value ◽  
Childhood And Adolescence ◽  
Serum Vitamin D ◽  
Vitamin D3 Supplementation ◽  
25 Hydroxy Vitamin D ◽  
The Mean ◽  
Sufficient Vitamin

Abstract Introduction. Vitamin D status is a key determinant of bone health and growth during childhood and adolescence. Therefore, we design a study to find out the association between the levels of serum vitamin D and need to consumption of vitamin D supplement.Method and materials. In this cross sectional study infants under 20 months referred to Ali Asghar Children's Hospital were included. Infants with maternal diseases and congenital malformations were excluded. All infants used vitamin D3 supplementation 400 IU per day from day fifth of birth. The level of 25-hydroxy vitamin D at the age of 1 years (month 12) were measured. Level of 25-hydroxy vitamin D in mothers were checked, too. Furthermore, we defined sufficient level of 25-hydroxy vitamin D ≥30ng/ml.Results. In this study, 68 infants under 20 months were examined. Half of them were boy. Mean age of infants was 16±3 months and mothers was 33±3 years old. In addition, the mean level of serum 25-hydroxy vitamin D in the infants were 40.99±13.86 ng/ml and in mothers were 31.39±13.14 ng/ml. 62.1% of mothers were in sufficient group and also 83% of infants had sufficient vitamin D level (25-hydroxy vitamin D ≥ 30ng/ml). There was not any significant correlation between vitamin D level in infants and mothers (P value=0.965). The mean level of serum vitamin D3 in boys was 39.55±3.79 ng/ml (12-51) and girls was 35.32±3.67 ng/ml (13.4-50). Similarly, significant relationship was not shown between gender and vitamin D of infants (P value = 0.437). Level of vitamin D in second children was significantly higher than first children (P value=0.011). The correlation between gestational age and vitamin D3 deficiency was also insignificant (P value=0.087). Head circumference (r= -0.404, P value=0.014) and age of mothers (r= 0.344, P value=0.04) correlated with vitamin D.Conclusion. In summary, we demonstrated most of the infants had sufficient vitamin D level at the age of 1 year. So it is recommended to continue vitamin D3 supplementation consumption.

scholarly journals Effects of Vitamin D3 Supplementation on Epigenetic Aging in Overweight and Obese African Americans With Suboptimal Vitamin D Status: A Randomized Clinical Trial

2018 ◽  
Vol 74 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Li Chen ◽  
Yanbin Dong ◽  
Jigar Bhagatwala ◽  
Anas Raed ◽  
Ying Huang ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Dna Methylation ◽  
Vitamin D ◽  
African Americans ◽  
Randomized Clinical Trial ◽  
Vitamin D3 ◽  
Vitamin D Supplementation ◽  
P Value ◽  
Epigenetic Aging ◽  
Vitamin D3 Supplementation

Abstract Background We have previously shown that vitamin D supplementation increases telomerase activity, suggesting an anti-aging effect. In this study, we aim to test the hypothesis that vitamin D supplementation would slow down epigenetic aging, a new marker of biological aging. Methods A randomized clinical trial was previously conducted among 70 overweight/obese African Americans with serum 25-hydroxyvitamin D [25(OH)D] < 50 nmol/L, who were randomly assigned into four groups of 600 IU/d, 2,000 IU/d, 4,000 IU/d of vitamin D3 supplements or placebo followed by 16-week interventions. Whole genome-wide DNA methylation analysis was conducted in 51 participants. DNA methylation ages were calculated according to the Horvath and the Hannum methods. Methylation-based age acceleration index (∆Age) is defined as the difference between DNA methylation age and chronological age in years. Mixed-effects models were used to evaluate the treatment effects. Results Fifty-one participants (aged 26.1 ± 9.3 years, 16% are male) were included in the study. After the adjustment of multi-covariates, vitamin D3 supplementation of 4,000 IU/d was associated with 1.85 years decrease in Horvath epigenetic aging compared with placebo (p value = .046), and 2,000 IU/d was associated with 1.90 years decrease in Hannum epigenetic aging (p value = .044). Serum 25(OH)D concentrations were significantly associated with decreased Horvath ∆Age only (p values = .002), regardless of treatments. Conclusions Our results suggest that vitamin D supplementation may slow down Horvath epigenetic aging. But the effect on Hannum epigenetic aging is not conclusive. Large-scale and longer duration clinical trials are needed to replicate the findings.

scholarly journals Role of Vitamin D3 in fracture union in adults

2021 ◽  
Vol 7 (1) ◽  
pp. 38-41
Author(s):  
Arunabh Arora ◽  
Amrit Kumar Singh
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Healing ◽  
Vitamin D3 ◽  
Serum Alkaline Phosphatase ◽  
Serum Vitamin ◽  
The Elderly ◽  
Fracture Union ◽  
Advantages And Disadvantages ◽  
Vitamin D3 Supplementation

Fractures play an important role in morbidity and often premature mobility among the elderly population. Because inactivity as a result of a fracture is harmful both to bone healing and health, it appears early or rapid fracture healing would be highly recommendable for returning fracture patients to come back to normal as soon as possible with minimal side effects. The literature remains unclear regarding supplementation required for promoting bone healing in fracture cases. Hereby we evaluated the advantages and disadvantages of vitamin D3 supplementation in fracture cases along with the quantitative analysis of vitamin D3 at the time of fracture and after fracture union.: A total of 200 patients were assessed clinically, biochemically (serum alkaline phosphatase, serum vitamin D3, and serum parathormone), and radiologically. All patients who satisfy inclusion criteria are followed up and vitamin D3 levels were measured up within 1 day of fracture and at the interval of 6 months after the orthopaedic intervention. The outcomes were monitored by the 5 points radiographic scoring system by Warden et al. With the majority of patients falling under the vitamin insufficiency group i.e. 53% of all patients were found to be vitamin insufficient at the time of fracture. 33% of patients found to be vitamin D deficient while 14% found to be insufficient stage. No patient was found to be in a toxicity state. According to Warden’s scoring., 50% of patients were in grade 3, 15% in grade 4, 33% in grade 2, and only 2% in grade 1. Regarding the prevalence of vitamin D deficiency or insufficiency in the general population, this study shows an alarming rate of vitamin D insufficient patients in a group of 200 patients, which indicates the need for attention towards vitamin D status not only for bone-related issues but for other issues related to vitamin D deficiency.

scholarly journals Effects of Vitamin D3 Supplementation and Resistance Training on 25-Hydroxyvitamin D Status and Functional Performance of Older Adults: A Randomized Placebo-Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 86
Author(s):  
Rudolf Aschauer ◽  
Sandra Unterberger ◽  
Patrick A. Zöhrer ◽  
Agnes Draxler ◽  
Bernhard Franzke ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Resistance Training ◽  
Muscle Strength ◽  
Vitamin D3 ◽  
Functional Mobility ◽  
Timed Up And Go ◽  
Chair Stand ◽  
Hydroxyvitamin D ◽  
Vitamin D3 Supplementation

Vitamin D status is associated with muscle strength and performance in older adults. To examine the additive effects of vitamin D3 supplementation during resistance training, 100 seniors (65–85 years) participated in a 16-week intervention. Besides a daily dose of 400 mg of calcium, participants received either 800 IU vitamin D3 per day (VDD), 50,000 IU vitamin D3 per month (VDM) or nothing (CON). After the initial loading phase of four weeks, all groups started a 10-week resistance training program. Assessments of 25-hydroxyvitamin D (25(OH)D) status, muscle strength endurance (30-s chair stand and arm curl tests), aerobic capacity (6-min walk test) and functional mobility (gait speed and timed up and go test) were undertaken at baseline, after four weeks and at the end of the study. 25(OH)D status significantly improved in VDD and VDM, but not in CON (time x group: p = 0.021), as 15.2% of CON, 40.0% of VDD and 61.1% of VDM reached vitamin D sufficiency (>30 ng/mL; p = 0.004). Chair stand test, arm curl test, 6-min walk test, gait speed and timed up and go test improved over the whole intervention period (p < 0.05), however only chair stand and arm curl test were selectively affected by resistance training (p < 0.001). Neither muscle strength endurance, nor functional mobility or aerobic capacity were modulated by vitamin D supplementation. Therefore, the mere amelioration of 25(OH)D status of older adults does not lead to an additive effect on muscular performance during RT.

scholarly journals Study of association between hypovitminosis D and fibroid uterus

2021 ◽  
Vol 10 (6) ◽  
pp. 2432
Author(s):  
Sangeeta Chowdhary ◽  
Mala Shukla ◽  
Ruchi Joshi
Keyword(s):  
Vitamin D ◽  
Vitamin D3 ◽  
Financial Burden ◽  
Critical Role ◽  
Serum Vitamin ◽  
P Value ◽  
Vitamin D Receptors ◽  
Fibroid Uterus ◽  
Vitamin D Levels ◽  
Prospective Longitudinal

Background: Fibroid uterus or leiomyoma is a benign tumour composed mainly of unicellular smooth muscle cells with varying amounts of fibrous connective tissue. UF are associated with significant morbidity as it presents in form of abnormal uterine bleeding, anaemia, pelvic pain, subfertility, and obstetric complications and causes financial burden on the patient. Recent studies have shown the critical role that vitamin D plays in fibroid formation, with individual fibroids expressing lower levels of vitamin D receptors than adjacent healthy tissue, making vitamin D deficiency a crucial, yet preventable risk factor.Methods: This was cross-sectional observational study. It was conducted on 140 female patients aged (18 to 50 years) presenting to the OPD of department of obstetrics and gynecology at NDMC & Hindu Rao Hospital during July 2019 to June 2020. 70 women had uterine fibroids on ultrasound and treated as cases and rest healthy women without fibroids served as controls. All women were subjected to ultrasound examination of uterus followed by serum vitamin D3 levels.Results: The mean value of vitamin D levels in cases was 12.81±8.56 ng/ml and in controls it was 19.83±9.21 ng/ml with p value<0.0001. Thus, it was statistically significant lower in cases of fibroid uterus as compared to controls. Secondary incidental outcomes were found between vitamin D3 level and BMI as fibroids occur statistically significantly more often in patient having of BMI ≥25 kg/m2. Also, menorrhagia and dysmenorrhea were the major complaints in 62.5% of cases followed by lowers abdominal pain and dyspareunia.Conclusions: Our study reached significance in the inverse correlation between fibroids and vitamin D levels at the primary outcome level. Larger prospective longitudinal studies drawing on more number and eliminating confounding variables are needed.

scholarly journals Correlation between serum vitamin D3 levels and blood pressure in patients with essential hypertension and normotensive individuals

2020 ◽  
Vol 7 (6) ◽  
pp. 971
Author(s):  
Divya V. Patil ◽  
Tarun Kumar Dutta
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Essential Hypertension ◽  
Vitamin D3 ◽  
Serum Vitamin ◽  
Sunlight Exposure ◽  
P Value ◽  
Lower Serum ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Background: Vitamin D, a fat-soluble vitamin is produced when ultraviolet rays from sunlight strike the skin. Literature data supports, there is a relationship between low vitamin D and pathogenesis of cardiovascular diseases and arterial hypertension. It had been seen that lower circulating 25(OH)D levels were associated with higher blood pressures. Aim was to study the correlation between serum vitamin D3 levels and blood pressure in patients with essential hypertension and normotensive individuals.Methods: An observational study was conducted on 60 individuals in the OPD at MGMCRI between January 2018 and December 2018. Based on history and blood pressure values (JNC 7), the population was divided into cases and controls in accordance with the age and sex. Serum Vitamin D levels were measured by chemiluminescence assay and classified into deficiency (<20ng/ml), insufficiency (20-30ng/ml) and sufficiency (30-100ng/ml). Statistical analysis was done using independent t test, one way ANOVA and correlation.Results: Among the hypertensive individuals, 90% were Vitamin D deficient and 10% had insufficiency. The mean Serum Vitamin D level in essential hypertension was 14.6±4.401 (p value <0.001). Serum Vitamin D levels were affected significantly by increasing BMI (p value <0.001) and less sunlight exposure (p value <0.001) among both cases and controls. There was also a significant negative correlation between serum vitamin D levels and systolic blood pressure (p <0.001).Conclusions: Isolated systolic hypertension was associated with lower serum Vitamin D levels. Obesity and reduced sunlight exposure are factors associated with lower serum Vitamin D levels.

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