scholarly journals Simultaneous near infrared spectroscopy and electroencephalography: a prospective screening tool for brain trauma / disease

2021 ◽  
Author(s):  
Joshua Lee
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Screening Tool ◽  
Brain Trauma ◽  
Alpha Power ◽  
Eyes Closed ◽  
Beta Power ◽  
Eyes Open ◽  
Trail Making

This thesis reports the development of a novel screening tool for brain trauma and disease using a headset capable of taking simultaneous measurements of electroencephalography (EEG) and functional near infrared spectroscopy (fNIRS) with a focus on developing the EEG side of the headset. Procedures for removing artifacts were developed for both modalities. The headset’s measurements were validated using a breath-holding task for fNIRS and an eyes open/eyes closed and trail making tasks for EEG. The eyes open/eyes closed (n=7) and trail making tasks (n=11) were further analyzed as potential tasks for use in screening. Integrated alpha power of EEG signals were found to provide robust differences between the eyes open/eyes closed states of the brain. Alpha power was also found to provide robust differences between rest and early trail making states in the trail making task, whereas, high beta power did not for either task.

scholarly journals Simultaneous near infrared spectroscopy and electroencephalography: a prospective screening tool for brain trauma / disease

2021 ◽  
Author(s):  
Joshua Lee
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Screening Tool ◽  
Brain Trauma ◽  
Alpha Power ◽  
Eyes Closed ◽  
Beta Power ◽  
Eyes Open ◽  
Trail Making

This thesis reports the development of a novel screening tool for brain trauma and disease using a headset capable of taking simultaneous measurements of electroencephalography (EEG) and functional near infrared spectroscopy (fNIRS) with a focus on developing the EEG side of the headset. Procedures for removing artifacts were developed for both modalities. The headset’s measurements were validated using a breath-holding task for fNIRS and an eyes open/eyes closed and trail making tasks for EEG. The eyes open/eyes closed (n=7) and trail making tasks (n=11) were further analyzed as potential tasks for use in screening. Integrated alpha power of EEG signals were found to provide robust differences between the eyes open/eyes closed states of the brain. Alpha power was also found to provide robust differences between rest and early trail making states in the trail making task, whereas, high beta power did not for either task.

scholarly journals Mismatch between Tissue Partial Oxygen Pressure and Near-Infrared Spectroscopy Neuromonitoring of Tissue Respiration in Acute Brain Trauma: The Rationale for Implementing a Multimodal Monitoring Strategy

2021 ◽  
Vol 22 (3) ◽  
pp. 1122
Author(s):  
Mario Forcione ◽  
Mario Ganau ◽  
Lara Prisco ◽  
Antonio Maria Chiarelli ◽  
Andrea Bellelli ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Oxygen Pressure ◽  
Near Infrared ◽  
Optical Signal ◽  
Brain Trauma ◽  
Partial Oxygen Pressure ◽  
Tissue Respiration ◽  
The Brain ◽  
Partial Oxygen

The brain tissue partial oxygen pressure (PbtO2) and near-infrared spectroscopy (NIRS) neuromonitoring are frequently compared in the management of acute moderate and severe traumatic brain injury patients; however, the relationship between their respective output parameters flows from the complex pathogenesis of tissue respiration after brain trauma. NIRS neuromonitoring overcomes certain limitations related to the heterogeneity of the pathology across the brain that cannot be adequately addressed by local-sample invasive neuromonitoring (e.g., PbtO2 neuromonitoring, microdialysis), and it allows clinicians to assess parameters that cannot otherwise be scanned. The anatomical co-registration of an NIRS signal with axial imaging (e.g., computerized tomography scan) enhances the optical signal, which can be changed by the anatomy of the lesions and the significance of the radiological assessment. These arguments led us to conclude that rather than aiming to substitute PbtO2 with tissue saturation, multiple types of NIRS should be included via multimodal systemic- and neuro-monitoring, whose values then are incorporated into biosignatures linked to patient status and prognosis. Discussion on the abnormalities in tissue respiration due to brain trauma and how they affect the PbtO2 and NIRS neuromonitoring is given.

scholarly journals Cerebral perfusion and blood–brain barrier assessment in brain trauma using contrast-enhanced near-infrared spectroscopy with indocyanine green: A review

2020 ◽  
Vol 40 (8) ◽  
pp. 1586-1598 ◽  
Author(s):  
Mario Forcione ◽  
Antonio M Chiarelli ◽  
David J Davies ◽  
David Perpetuini ◽  
Piotr Sawosz ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Indocyanine Green ◽  
Blood Brain Barrier ◽  
Near Infrared Spectroscopy ◽  
Trauma Care ◽  
Near Infrared ◽  
Clinical Status ◽  
Brain Trauma ◽  
Future Studies ◽  
Contrast Enhanced

Contrast-enhanced near-infrared spectroscopy (NIRS) with indocyanine green (ICG) can be a valid non-invasive, continuous, bedside neuromonitoring tool. However, its usage in moderate and severe traumatic brain injury (TBI) patients can be unprecise due to their clinical status. This review is targeted at researchers and clinicians involved in the development and application of contrast-enhanced NIRS for the care of TBI patients and can be used to design future studies. This review describes the methods developed to monitor the brain perfusion and the blood–brain barrier integrity using the changes of diffuse reflectance during the ICG passage and the results on studies in animals and humans. The limitations in accuracy of these methods when applied on TBI patients and the proposed solutions to overcome them are discussed. Finally, the analysis of relative parameters is proposed as a valid alternative over absolute values to address some current clinical needs in brain trauma care. In conclusion, care should be taken in the translation of the optical signal into absolute physiological parameters of TBI patients, as their clinical status must be taken into consideration. Discussion on where and how future studies should be directed to effectively incorporate contrast-enhanced NIRS into brain trauma care is given.

scholarly journals Near-infrared spectroscopy in evaluating psychogenic pseudosyncope—a novel diagnostic approach

QJM ◽  
2019 ◽  
Vol 113 (4) ◽  
pp. 239-244
Author(s):  
P Claffey ◽  
L Pérez-Denia ◽  
G Rivasi ◽  
C Finucane ◽  
R A Kenny
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Cerebral Perfusion ◽  
Near Infrared ◽  
Saturation Index ◽  
Diagnostic Algorithm ◽  
Cerebral Hypoperfusion ◽  
P Value ◽  
Non Invasive ◽  
Eyes Closed

Abstract Background Psychogenic pseudosyncope (PPS), a conversion disorder and syncope mimic, accounts for a large proportion of ‘unexplained syncope’. PPS is diagnosed by reproduction of patients’ symptoms during head-up tilt (HUT). Electroencephalogram (EEG), a time consuming and resource intensive technology, is used during HUT to demonstrate absence of cerebral hypoperfusion during transient loss of consciousness (TLOC). Near-infrared spectroscopy (NIRS) is a simple, non-invasive technology for continuous monitoring of cerebral perfusion. We present a series of patients for whom PPS diagnosis was supported by NIRS during HUT. Methods Eight consecutive patients with suspected PPS referred to a syncope unit underwent evaluation. During HUT, continuous beat-to-beat blood pressure (BP), heart rate (HR) and NIRS-derived tissue saturation index (TSI) were measured. BP, HR and TSI at baseline, time of first symptom, presyncope and apparent TLOC were measured. Patients were given feedback and followed for symptom recurrence. Results Eight predominantly female patients (6/8, 75%) aged 31 years (16–54) were studied with (5/8, 63%) having comorbid psychiatric diagnoses, and (5/8, 63%) presenting with frequent episodes of prolonged TLOC with eyes closed (6/8, 75%). All patients experienced reproduction of typical events during HUT. Systolic BP (mmHg) increased from baseline (129.7 (interquartile range [IQR] 124.9–133.4)) at TLOC (153.0 (IQR 146.7–159.0)) (P-value = 0.012). HR (bpm) increased from baseline 78 (IQR 68.6–90.0) to 115.7 (IQR 93.5–127.9) (P-value = 0.012). TSI (%) remained stable throughout, 71.4 (IQR 67.5–72.9) at baseline vs. 71.0 (IQR 68.2–73.0) at TLOC (P-value = 0.484). Conclusions NIRS provides a non-invasive surrogate of cerebral perfusion during HUT. We propose HUT incorporating NIRS monitoring in the diagnostic algorithm for patients with suspected PPS.

Activation during the Trail Making Test measured with functional near-infrared spectroscopy in healthy elderly subjects

NeuroImage ◽  
2014 ◽  
Vol 85 ◽  
pp. 583-591 ◽  
Author(s):  
Katja Hagen ◽  
Ann-Christine Ehlis ◽  
Florian B. Haeussinger ◽  
Sebastian Heinzel ◽  
Thomas Dresler ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Elderly Subjects ◽  
Trail Making Test ◽  
Functional Near Infrared Spectroscopy ◽  
Healthy Elderly ◽  
Trail Making ◽  
Healthy Elderly Subjects

Eeg Spectral Analysis in Schizophrenia

1980 ◽  
Vol 136 (5) ◽  
pp. 445-455 ◽  
Author(s):  
G. W. Fenton ◽  
P. B. C. Fenwick ◽  
J. Dollimore ◽  
T. L. Dunn ◽  
S. R. Hirsch
Keyword(s):  
Power Spectra ◽  
Alpha Power ◽  
Eeg Spectral Analysis ◽  
Eyes Closed ◽  
Beta Power ◽  
Eyes Open ◽  
Schizophrenic Patients ◽  
Patient Groups ◽  
Schizophrenic Group ◽  
Normal Controls

SummaryFour channels of EEG (T4-T6, P4-02, T3-T5, P3-01) were recorded from several groups of control subjects and schizophrenia patients on analogue tape. They were later digitized and analysed by computer; power spectra were computed for 30 second epochs of EEG per channel; eyes closed, eyes open. No difference between normal controls and neurotic in-patients was apparent. An acute schizophrenic group had less alpha power, this change being confined largely to the temporal areas. A chronic outpatient sample showed less alpha and beta power, while chronic long-stay schizophrenic patients had an excess of delta power. The changes in both chronic patient groups were diffuse rather than local.

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