scholarly journals Identification of clusters of asthma control: A preliminary analysis of the Inspirers studies

2020 ◽  
Vol 28 (4) ◽  
Author(s):  
Cristina Jácome ◽  
◽  
Rita Amaral ◽  
Rute Almeida ◽  
Ana Pereira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Hospital Admissions ◽  
Smoking Status ◽  
Severe Disease ◽  
Persistent Asthma ◽  
Good Control ◽  
Anxiety And Depression ◽  
Inhaled Medication

Aims: To identify distinct asthma control clusters based on Control of Allergic Rhinitis and Asthma Test (CARAT) and to compare patients’ characteristics among these clusters. Methods: Adults and adolescents (≥13 years) with persistent asthma were recruited at 29 Portuguese hospital outpatient clinics, in the context of two observational studies of the INSPIRERS project. Demographic and clinical characteristics, adherence to inhaled medication, beliefs about inhaled medication, anxiety and depression, quality of life, and asthma control (CARAT, >24 good control) were collected. Hierarchical cluster analysis was performed using CARAT total score (CARAT -T). Results: 410 patients (68% adults), with a median (percentile 25–percentile 75) age of 28 (16­‑46) years, were analysed. Three clusters were identified [mean CARAT -T (min -max)]: cluster 1 [27(24 -30)], cluster 2 [19(14 -23)] and cluster 3 [10(2 -13)]. Patients in cluster 1 (34%) were characterised by better asthma control, better quality of life, higher inhaler adherence and use of a single inhaler. Patients in clusters 2 (50%) and 3 (16%) had uncontrolled asthma, lower inhaler adherence, more symptoms of anxiety and depression and more than half had at least one exacerbation in the previous year. Furthermore, patients in cluster 3 were predominantly female, had more unscheduled medical visits and more anxiety symptoms, perceived a higher necessity of their prescribed inhalers but also higher levels of concern about taking these inhalers. There were no differences in age, body mass index, lung function, smoking status, hospital admissions or specialist physician follow -up time among the three clusters. Conclusion: An unsupervised method based on CARAT- -T, identified 3 clusters of patients with distinct, clinically meaningful characteristics. The cluster with better asthma control had a cut -off similar to the established in the validation study of CARAT and an additional cut -off seems to distinguish more severe disease. Further research is necessary to validate the asthma control clusters identified.

scholarly journals Bronchial asthma control, quality of life, and psychiatric disorders vicious cycle: Asyut society point of view

2022 ◽  
Vol 16 (1) ◽  
Author(s):  
Samiaa Hamdy Sadek ◽  
Maha Mohamed El-kholy ◽  
Fareda Ahmed Mohammed ◽  
Reham Mohammed El-Morshedy
Keyword(s):  
Quality Of Life ◽  
Psychiatric Disorders ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Hospital Admissions ◽  
Symptom Control ◽  
Anxiety And Depression ◽  
Asthma Patients ◽  
Healthy Control

Abstract Background Poorly controlled bronchial asthma limits patients’ quality of life (QOL), the condition which may potentiate the development of psychiatric disorders. The aim of this study was the assessment of anxiety and depression in bronchial asthma patients, and their interrelation with both level of asthma control and quality of life in our society. Results This study included 102 bronchial asthma patients, and 50 healthy control individuals. Patients had poorer QOL, and higher anxiety and depression scores compared to healthy control, moreover these scores were higher in uncontrolled asthma patients compared to controlled group. Poor QOL, frequent hospital admissions, and poor asthma control were the predictors for psychiatric disorders. Conclusion Depression and anxiety are frequently encountered in patients with bronchial asthma in our society; poor symptom control, poor QOL, and frequent hospital admissions are the main predictors for these psychiatric disorders.

scholarly journals Assessment of quality of life in asthma patients in 5 to 18 years of children

2020 ◽  
Vol 7 (11) ◽  
pp. 2214
Author(s):  
Nikhil Jain ◽  
Karan Joshi
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Persistent Asthma ◽  
Tertiary Hospital ◽  
P Value ◽  
Cross Sectional ◽  
Asthmatic Patients ◽  
Asthma Patients ◽  
Severity Of The Disease

Background: Asthma is a common cause of morbidity and mortality with prevalence of 300 million in world. The QOL of asthmatic patients cannot be determined only on the basis the severity of the disease, but requires a measurement of personal perception. This study was conducted with the aim to assess and compare the QOL using PedsQl scale in asthma patients between 5 to 18 years of age with different demographic and clinical variables.Methods: This was a cross-sectional observational study conducted at respiratory clinic in tertiary hospital, Rewa from October 2017 to June 2019. A total number of 150 asthmatic patients and their parents participated. Asthmatic patients (N=150) and their parents, presenting to asthma clinic of Gandhi Memorial Hospital, Rewa (after applying inclusion-exclusion criteria) were assessed for QOL using PedsQl scale 3.0. Statistical analysis was performed by SPSS version 20. Test of significance by student T-test and one way ANOVA.Results: The QOL is severely hampered by asthma with mean of 59 in intermittent asthma, 51 in mild, 44.74 in moderate and 40 in severe persistent asthma, significant p value of <0.05. Younger age, level of asthma control and severity were significantly related to QOL with p value of <0.05. Sex, socioeconomic status, were insignificantly related.Conclusions: QOL is impaired as the grading of asthma increases. Impairment of Quality of life are mostly associated with low level of asthma control, poly-therapy and frequent night attacks.

Dupilumab improves asthma control and quality of life in children with uncontrolled persistent asthma

2021 ◽  
Author(s):  
Alessandro Fiocchi ◽  
Wanda Phipatanakul ◽  
Sandy R. Durrani ◽  
Jeremy Cole ◽  
Xuezhou Mao ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Persistent Asthma

scholarly journals Long-term change in health-related quality of life in patients with asthma

2019 ◽  
Vol 28 (6) ◽  
pp. 708-714
Author(s):  
N. L. Perel’man ◽  
V. P. Kolosov
Keyword(s):  
Quality Of Life ◽  
Emotional Disorders ◽  
Asthma Control ◽  
Social Activity ◽  
Anxiety And Depression ◽  
Cold Air ◽  
The Social ◽  
Activity Domain

The aim of this study was to investigate long-term change in health-related quality of life (HRQL) in patients with asthma in real clinical practice and in relation to emotional disorders, cooperativeness (cooperation between the patient and the physician, and adherence to treatment), and cold air-provoked bronchial hyperresponsiveness (BHR).Methods. This observational study involved 32 patients with mild to moderate asthma. The study duration was 7.5 to 10 years. HRQL was assessed using SF-36 questionnaire and Asthma Quality of Life Questionnaire (AQLQ); emotional disorders were diagnosed using Hospital Anxiety and Depression Scale (HADS). Patients’ cooperativeness assessment was based on number of a patient’s scheduled visits to a physician during the study. The asthma control level was evaluated using the Asthma Control Test (ACT).Results. A significant worsening was found in the social activity domain of HRQL in the total group of the patients. According to AQLQ, a significant improvement was seen in the activity and symptoms domains and in the total score of quality of life (QoL). Long-term pharmacological treatment of asthma decreased anxiety and depression levels. The asthma control (ACT score) increased from 13.2 ± 1.0 to 19.7 ± 1.1 (р = 0.00003). Anxiety and depression decreased in patients with high cooperativeness during the long-term follow-up, while the total QoL and the specific QoL were unchanged excluding the social activity domain. A significant worsening in the activity scale and in the emotional scale of specific QoL together with growing depression and decreasing control of asthma were found in patients with lower cooperativeness. The cold air-provoked BNR slowed down the long-term improvement in the social activity domain. The cold air-provoked BNR also decreased patient-reported evaluation of daily activity.Conclusion. The long-term basic therapy of asthma provides a positive trend in HRQL in the real clinical practice independently on worsening of the disease. Lower cooperativeness of a patient could decrease specific QoL, which, in turn, worsens the control of asthma and contributes to negative emotional background and destructive behavior.

Dupilumab Improves Asthma Control and Asthma-Related Quality of Life in Uncontrolled Persistent Asthma Patients Across All Baseline Exacerbation Rates

CHEST Journal ◽  
2017 ◽  
Vol 152 (4) ◽  
pp. A26 ◽  
Author(s):  
Jonathan Corren ◽  
Mario Castro ◽  
Shyamalie Jayawardena ◽  
Vijay Joish ◽  
Nikhil Amin ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Persistent Asthma ◽  
Asthma Patients ◽  
Related Quality

Impact on quality of life by improving asthma control medication in patients with persistent asthma in a paediatric emergency department

2013 ◽  
Vol 20 (5) ◽  
pp. 350-355 ◽  
Author(s):  
Javier Benito-Fernández ◽  
Elisa Mojica-Muñoz ◽  
Amagoia Andrés-Olaizola ◽  
María González-Balenciaga ◽  
Mireya Urrutia-Adan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Emergency Department ◽  
Asthma Control ◽  
Persistent Asthma ◽  
Paediatric Emergency Department ◽  
Paediatric Emergency ◽  
Control Medication

scholarly journals Quality of life and asthma control in pregnant women with asthma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Nasrin Fazel ◽  
Michael Kundi ◽  
Erika Jensen-Jarolim ◽  
Isabella Maria Pali-Schöll ◽  
Asghar Kazemzadeh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pregnant Women ◽  
Asthma Control ◽  
Persistent Asthma ◽  
Respiratory Illness ◽  
Asthma Severity ◽  
Life Questionnaire ◽  
Asthma Control Questionnaire ◽  
Adverse Pregnancy

Abstract Background Asthma is the most commonly occurring respiratory illness during pregnancy. Associations with complications of pregnancy and adverse perinatal outcome have been established. However, little is known about quality of life (QoL) in pregnant women with asthma and how it relates to asthma control particularly for Iran. Objective To determine the relationship between asthma related QoL and asthma control and severity. Methods We conducted a prospective study in pregnant women with asthma. We used the Asthma Control Questionnaire and the Asthma Quality of Life Questionnaire (AQLQ) and the guidelines of the Global Initiative for Asthma for assessment of asthma severity. Results Among 1603 pregnant women, 34 were diagnosed with asthma. Of these 13 had intermittent, 10 mild, 8 moderate and 3 severe persistent asthma. There was a significant decrease of QoL with poorer asthma control (p = 0.014). This decline could be due to limitations of activity in those with poorer asthma control, which is underlined by the significant decline of QoL with increasing asthma severity (p = 0.024). Conclusion Although the majority of pregnant women with asthma had a favorable score in AQLQ, reduced QoL was related to increased asthma severity and poor asthma control. This underlines the importance of controlling asthma during pregnancy not only for the prevention of adverse pregnancy outcomes but also for the preservation of QoL.

Effects of poor asthma control, insomnia, anxiety and depression on quality of life in young asthmatics

2016 ◽  
Vol 53 (4) ◽  
pp. 398-403 ◽  
Author(s):  
Fredrik Sundbom ◽  
Andrei Malinovschi ◽  
Eva Lindberg ◽  
Kjell Alving ◽  
Christer Janson
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Anxiety And Depression

scholarly journals Effectiveness and Quality of Life with Montelukast in Asthma – A double-blind randomized control trial

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Mirza Saif Ullah Baig ◽  
Rashid Ahmed Khan ◽  
Kamran Khan ◽  
Nadeem Rizvi
Keyword(s):  
Quality Of Life ◽  
Placebo Group ◽  
Asthma Control ◽  
Persistent Asthma ◽  
Double Blind ◽  
Once Daily ◽  
The Mean ◽  
Moderate Persistent Asthma

Objective: To determine the role of montelukast – a leukotriene receptor antagonist (LTRA) – in improving the quality of life (QOL) and asthma control of adult patients with mild to moderate persistent asthma. Methods: Randomized, double-blind, placebo-controlled, non-crossover trial was conducted from March 2017 till November 2018 in three hospitals of Karachi and Hyderabad. Adults of age 15 years or more with mild to moderate persistent asthma. Treatment group was administered tablet montelukast 10mg once daily; the other group was given a similar looking placebo; as an adjuvant to the current medication. QOL was assessed with Asthma Quality of Life Questionnaire – Standard (AQLQ-S) before and after the treatment. Asthma control was monitored via Asthma Control Test (ACT). Results: After 4 weeks, the mean ± SD of overall QOL on AQLQ-S improved from 3.74±0.88 to 5.06±0.89 for montelukast group and from 3.58±0.92 to 4.71±0.97 for placebo group (p=0.02). The improvement in sub-domains of symptoms, activity, and emotional functions was not significant; however, the sub-domain “environmental stimuli” significantly improved with 5.06±0.89 for montelukast group and 4.71±0.97 for placebo group (p=0.02). The mean ± SD of ACT, after four weeks, for montelukast group was 18.19±2.91 and for placebo group 17.28±3.36. Only on ACT, Montelukast did not show any statistically insignificant results. Conclusion: The role of montelukast in improving QOL of adult patients with mild to moderate persistent asthma is quite beneficial. It improves patient quality of life. It has the ease of once daily oral administration and also eradicates side effects associated with long-term adherence to steroids. doi: https://doi.org/10.12669/pjms.35.3.42 How to cite this:Baig S, Khan RA, Khan K, Rizvi N. Effectiveness and Quality of Life with Montelukast in Asthma – A double-blind randomized control trial. Pak J Med Sci. 2019;35(3):---------. doi: https://doi.org/10.12669/pjms.35.3.42 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

A Randomized Trial of User-Controlled Text Messaging to Improve Asthma Outcomes: A Pilot Study

2017 ◽  
Vol 56 (14) ◽  
pp. 1336-1344 ◽  
Author(s):  
Maria T. Britto ◽  
Jennifer M. Rohan ◽  
Cassandra M. Dodds ◽  
Terri L. Byczkowski
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Text Messaging ◽  
Persistent Asthma ◽  
Text Messages ◽  
Control Group ◽  
Life Outcomes ◽  
Modest Improvement ◽  
Asthma Outcomes

We enrolled 64 patients age 12 to 22 years with a diagnosis of poorly controlled persistent asthma in a 6-month longitudinal crossover study. During the 3 intervention months, participants created personalized text messages to be sent to their phones. Adherence was objectively monitored in 22 of the participants. The adolescent participants gave high ratings on the acceptability of the text messaging system. Asthma control improved from baseline to month 1 regardless of whether teens were in the texting or control group. While participants were in the texting group, their quality of life improved and worry about their asthma decreased. Receiving the text intervention resulted in an increase in adherence of 2.75% each month relative to no intervention, but the improvements were not sustained. There was modest improvement in asthma control and quality of life outcomes, as well as improved adherence during the texting intervention.

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