scholarly journals Milk and cow’s meat allergy in a child: A clinical case

2021 ◽  
Vol 29 (4) ◽  
Author(s):  
Maria Marques ◽  
◽  
Inês Falcão ◽  
Moisés Labrador-Horrillo ◽  
Helena Falcão ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Milk Proteins ◽  
Food Challenge ◽  
Specific Ige ◽  
Oral Food Challenge ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

Allergy to bovine serum albumin is the main predictor of beef allergy associated with cow’s milk proteins allergy. We report a case of a 3-year-old child with cow’s milk proteins allergy since the age of 6 months who, after some ingestions of beef, developed episodes of irritability, urticaria and syncope. Specific IgE to beef, oral food challenge with medium rare cooked beef and specific IgE to bovine serum albumin were all positive, but an oral food challenge with well cooked beef was tolerated. Allergy to bovine serum albumin is not usually associated with severe reactions, since it is a thermolabile protein, however, the process of cooking meat may be insufficient to have an effect on the complex matrix of meat and associated serum albumins. The irregular pattern of the episodes and the previous diagnosis of cow’s milk proteins allergy may act as confounding factors leading to a delayed diagnosis.

scholarly journals The significance of cow’s milk proteins in the development of IgE-mediated food allergy among children

2019 ◽  
Vol 16 (2) ◽  
pp. 38-44
Author(s):  
S Yu Petrova ◽  
S V Khlgatian ◽  
V M Berzhets ◽  
L A Pishchulina ◽  
A V Vasilyeva
Keyword(s):  
Food Allergy ◽  
Whey Proteins ◽  
Milk Proteins ◽  
Specific Ige ◽  
Moscow Region ◽  
Food Allergies ◽  
Cow’S Milk ◽  
Food Allergens ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

Identification of offending allergens in patients with food allergy is a very important part of an allergist’s activity. Objective. To study the structure оf sensitization to food allergens among children in Moscow and Moscow region and to determine the significance of sensitization to milk proteins . Methods. The level and class of specific IgE in blood serum of children with IgEmediated allergic diseases were examined with RIDA AllergyScreen method. Serum of children with high level of specific IgE to milk allergenic proteins was studied. The level and ratio of specific IgE to individual milk allergens were revealed. Results. The structure of sensitization to food allergens was determined. It was revealed that cow’s milk allergens are the leading triggers of food allergy, especially in early childhood in Moscow and the Moscow region. The features of sensitization to cow’s milk proteins among children were analyzed. Conclusions. According to the study, about half of children with IgEmediated food allergies in Moscow and the Moscow region have sensitization to cow’s milk proteins. The leading role in the frequency of sensitization belongs to whey proteins of milk. Among them sensitization to а-lactalbumin was detected more often. The questions about the selection of hypoallergenic milk formulas for feeding of children with allergy to cow’s milk proteins were discussed.

scholarly journals High-titer IgG4 to cow’s milk proteins and relationship to specific IgE in Pediatric Eosinophilic Esophagitis

2019 ◽  
Vol 143 (2) ◽  
pp. AB135
Author(s):  
Lisa Workman ◽  
Jeffrey M. Wilson ◽  
Alexander J. Schuyler ◽  
Emily C. McGowan ◽  
Jonas Lidholm ◽  
...  
Keyword(s):  
Eosinophilic Esophagitis ◽  
High Titer ◽  
Milk Proteins ◽  
Specific Ige ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

Cow's Milk, Bovine Serum Albumin, and IDDM: Can We Settle the Controversies?

Diabetes Care ◽  
1997 ◽  
Vol 20 (5) ◽  
pp. 897-901 ◽  
Author(s):  
D. Hammond-McKibben ◽  
H.-M. Dosch
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Cow’S Milk ◽  
Cow's Milk

Selective Hydrolysis of Milk Proteins To Facilitate the Elimination of the ABBOS Epitope of Bovine Serum Albumin and Other Immunoreactive Epitopes†

1998 ◽  
Vol 61 (8) ◽  
pp. 1007-1012 ◽  
Author(s):  
ARNO C. ALTING ◽  
RON J. G. M. MEIJER ◽  
EMERENTIA C. H. van BERESTEIJN
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Whey Protein ◽  
Binding Sites ◽  
Bovine Serum ◽  
Whey Proteins ◽  
Milk Proteins ◽  
Specific Ige ◽  
Antibody Binding ◽  
Hydrolysis Of

Milk proteins are hydrolyzed to prevent immunological reactions, but immunoreactive epitopes, including the ABBOS epitope of bovine serum albumin (BSA), can still be detected in commercially available milk protein hydrolysates. We used lactococcal cell-envelope proteinase (CEP) for the hydrolysis of the individual milk proteins and of mixtures thereof, or for the hydrolysis of sodium caseinate (contaminated with whey proteins). CEP exclusively degraded casein, leaving the four major whey proteins intact. This property facilitated the removal of the intact whey proteins from the casein fragments by ultrafiltration. Depending on the molecular mass of the whey protein to be removed, membranes with cutoff values between 3 and 30 kDa were used, resulting in casein hydrolysates free of protein fragments with cross-reactive whey-protein-specific IgE (immunoglobulin E) or ABBOS antibody-binding sites. Even the casein itself was degraded in such a way by CEP that cross-reactive casein-specific IgE antibody-binding sites could be eliminated. The product could find application in infant formulas for therapeutic and preventive treatment of children with cow's milk allergy; in addition, the preventive use of such formulas in children genetically susceptible to the development of insulin-dependent diabetes mellitus (IDDM) should be considered if a relationship between the consumption of BSA and IDDM were to become more apparent. The method is also applicable for preparing casein-free whey protein preparations.

Sign in / Sign up

Export Citation Format

Share Document