scholarly journals Diagnostic strategies using DNA testing for hereditary haemochromatosis in at-risk populations: a systematic review and economic evaluation

2009 ◽  
Vol 13 (23) ◽  
Author(s):  
J Bryant ◽  
K Cooper ◽  
J Picot ◽  
A Clegg ◽  
P Roderick ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Economic Evaluation ◽  
Dna Testing ◽  
Hereditary Haemochromatosis ◽  
Diagnostic Strategies ◽  
At Risk Populations

scholarly journals A decision analysis model for diagnostic strategies using DNA testing for hereditary haemochromatosis in at risk populations

QJM ◽  
2008 ◽  
Vol 101 (8) ◽  
pp. 631-641 ◽  
Author(s):  
K. Cooper ◽  
J. Bryant ◽  
J. Picot ◽  
A. Clegg ◽  
P.R. Roderick ◽  
...  
Keyword(s):  
At Risk ◽  
Decision Analysis ◽  
Decision Analysis Model ◽  
Dna Testing ◽  
Analysis Model ◽  
Hereditary Haemochromatosis ◽  
Diagnostic Strategies ◽  
At Risk Populations

Psychosocial Aspects of DNA Testing for Hereditary Hemochromatosis in At-Risk Individuals: A Systematic Review

2009 ◽  
Vol 0 (0) ◽  
pp. 090108090224061
Author(s):  
Joanna Picot ◽  
Jackie Bryant ◽  
Keith Cooper ◽  
Andy Clegg ◽  
Paul Roderick ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Hereditary Hemochromatosis ◽  
Psychosocial Aspects ◽  
Dna Testing

scholarly journals Rapid immunochromatographic tests for the diagnosis of chronic Chagas disease in at-risk populations: A systematic review and meta-analysis

2019 ◽  
Vol 13 (5) ◽  
pp. e0007271 ◽  
Author(s):  
Andrea Angheben ◽  
Dora Buonfrate ◽  
Mario Cruciani ◽  
Yves Jackson ◽  
Julio Alonso-Padilla ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Chagas Disease ◽  
Meta Analysis ◽  
At Risk Populations ◽  
Chronic Chagas Disease

scholarly journals A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2232 ◽  
Author(s):  
Lauren M Young ◽  
Andrew Pipingas ◽  
David J White ◽  
Sarah Gauci ◽  
Andrew Scholey
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Depressive Symptoms ◽  
Meta Analysis ◽  
Nutrient Status ◽  
Vitamin Supplementation ◽  
Random Effects Models ◽  
At Risk Populations ◽  
Randomised Controlled ◽  
B Vitamin

A systematic review and meta-analysis was undertaken to examine and quantify the effects of B vitamin supplementation on mood in both healthy and ‘at-risk’ populations. A systematic search identified all available randomised controlled trials (RCTs) of daily supplementation with ≥3 B group vitamins with an intervention period of at least four weeks. Random effects models for a standardized mean difference were used to test for overall effect. Heterogeneity was tested using the I2 statistic. Eighteen articles (16 trials, 2015 participants) were included, of which 12 were eligible for meta-analysis. Eleven of the 18 articles reported a positive effect for B vitamins over a placebo for overall mood or a facet of mood. Of the eight studies in ‘at-risk’ cohorts, five found a significant benefit to mood. Regarding individual facets of mood, B vitamin supplementation benefited stress (n = 958, SMD = 0.23, 95% CI = 0.02, 0.45, p = 0.03). A benefit to depressive symptoms did not reach significance (n = 568, SMD = 0.15, 95% CI = −0.01, 0.32, p = 0.07), and there was no effect on anxiety (n = 562, SMD = 0.03, 95% CI = −0.13, 0.20, p = 0.71). The review provides evidence for the benefit of B vitamin supplementation in healthy and at-risk populations for stress, but not for depressive symptoms or anxiety. B vitamin supplementation may particularly benefit populations who are at risk due to (1) poor nutrient status or (2) poor mood status.

scholarly journals Efficiency of Diagnostic Testing for Helicobacter pylori Infections—A Systematic Review

Antibiotics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 55
Author(s):  
Paula Rojas García ◽  
Simon van der Pol ◽  
Antoinette D. I. van Asselt ◽  
Maarten Postma ◽  
Roberto Rodríguez-Ibeas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Helicobacter Pylori ◽  
Economic Evaluation ◽  
Evaluation Studies ◽  
Diagnostic Testing ◽  
Health Economic Evaluation ◽  
Cost Effective ◽  
Economic Evaluations ◽  
Diagnostic Strategies ◽  
H Pylori

Background: The most recommended treatment for a Helicobacter pylori infection is high doses of combined antibiotics. The objective of this article is to perform a systematic review of the economic evaluation studies applied to assess the efficiency of diagnostic testing for H. pylori infections, so that their main characteristics can be identified and to learn from the literature how the antimicrobial resistance (AMR) issue is incorporated into these economic evaluations. Methods: We conducted a systematic review to compare the costs and clinical effectiveness of diagnostic strategies for H. pylori infections. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and extracted the items from the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Results: We found thirteen articles that were of good quality according to CHEERS: six studies focused on diagnostics of Helicobacter pylori infections associated with dyspepsia and four on duodenal ulcers. Testing was found to be the most cost-effective strategy in eight articles. Four studies considered AMR. Conclusions: Testing was more cost-effective than empirical treatment, except in cases of high prevalence (as with developing countries) or when patients could be stratified according to their comorbidities. The introduction of AMR into the model may change the efficiency of the testing strategy.

Psychosocial Aspects of DNA Testing for Hereditary Hemochromatosis in At-Risk Individuals: A Systematic Review

2009 ◽  
Vol 13 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Joanna Picot ◽  
Jackie Bryant ◽  
Keith Cooper ◽  
Andy Clegg ◽  
Paul Roderick ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Hereditary Hemochromatosis ◽  
Psychosocial Aspects ◽  
Dna Testing

Dental Implant Placement in Patients with a History of Medications Related to Osteonecrosis of the Jaws: A Systematic Review

2020 ◽  
Author(s):  
Judd Sher ◽  
Kate Kirkham-Ali ◽  
Denny Luo ◽  
Catherine Miller ◽  
Dileep Sharma
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Drug Therapy ◽  
Dental Implant ◽  
Case Series ◽  
Cochrane Central Register ◽  
Bisphosphonate Treatment ◽  
Implant Placement ◽  
Increased Risk ◽  
History Of

The present systematic review evaluates the safety of placing dental implants in patients with a history of antiresorptive or antiangiogenic drug therapy. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. PubMed, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, and OpenGrey databases were used to search for clinical studies (English only) to July 16, 2019. Study quality was assessed regarding randomization, allocation sequence concealment, blinding, incomplete outcome data, selective outcome reporting, and other biases using a modified Newcastle-Ottawa scale and the Joanna Briggs Institute critical appraisal checklist for case series. A broad search strategy resulted in the identification of 7542 studies. There were 28 studies reporting on bisphosphonates (5 cohort, 6 case control, and 17 case series) and one study reporting on denosumab (case series) that met the inclusion criteria and were included in the qualitative synthesis. The quality assessment revealed an overall moderate quality of evidence among the studies. Results demonstrated that patients with a history of bisphosphonate treatment for osteoporosis are not at increased risk of implant failure in terms of osseointegration. However, all patients with a history of bisphosphonate treatment, whether taken orally for osteoporosis or intravenously for malignancy, appear to be at risk of ‘implant surgery-triggered’ MRONJ. In contrast, the risk of MRONJ in patients treated with denosumab for osteoporosis was found to be negligible. In conclusion, general and specialist dentists should exercise caution when planning dental implant therapy in patients with a history of bisphosphonate and denosumab drug therapy. Importantly, all patients with a history of bisphosphonates are at risk of MRONJ, necessitating this to be included in the informed consent obtained prior to implant placement. The James Cook University College of Medicine and Dentistry Honours program and the Australian Dental Research Foundation Colin Cormie Grant were the primary sources of funding for this systematic review.

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