Systemic Sarcoidosis: Sociodemographic and Genetic Characteristics in a Tunisian Population

2021 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Pulmonary Involvement ◽  
Tunisian Population ◽  
Military Hospital ◽  
Neurological Involvement ◽  
Genetic Characteristics ◽  
Ace Gene ◽  
Gene Treatment ◽  
Tunisian Patients ◽  
The Military ◽  
Epidemiological Characteristics

Background: Sarcoidosis is a multi-systemic granulomatosis of unknown cause, characterized by a clinical polymorphism. It results from interplay of environmental and genetic factors. Objective: The aim of our study was to describe sociodemographic and genetic characteristics in Tunisian patients with sarcoidosis. Methods: We conducted a retrospective study of patients with sarcoidosis followed in the internal medicine and neurology departments at the Military Hospital of Tunis. We collected epidemiological characteristics. Genetic study concerned only patients who accepted to participate. DNA extraction was performed from whole blood. HLA class II typing and gene mutation testing of the ACE gene were also performed. Results: Our study concerned 50 patients. The mediastino-pulmonary involvement was the most frequent (72.3%), followed by neurological involvement (58.5%), cutaneous involvement (50.8%) and ophthalmological involvement (40%). Genetic analysis showed a high frequency of the HLA DRB1 * 1501 allele (38%), DD genotype (30%) and D allele (54%) of the ACE gene. Treatment with corticosteroids was most often used 73.85%. The evolution was favorable in 13 cases (26.15%), and stable in 63% of cases. Conclusion: sociodemographic and genetic characteristic are variable from one ethnic to another. Advances in genotyping and statistical analysis are helping to elucidate the genetics of sarcoidosis.

scholarly journals Systemic Sarcoidosis: Sociodemographic and Genetic Characteristics in a Tunisian Population

2021 ◽  
Author(s):  
Bissene Douma ◽  
Hajer Derbali ◽  
linda Mrissa ◽  
Emna Ben Haj Ali ◽  
Sameh Sayahi ◽  
...  
Keyword(s):  
Pulmonary Involvement ◽  
Tunisian Population ◽  
Military Hospital ◽  
Neurological Involvement ◽  
Genetic Characteristics ◽  
Ace Gene ◽  
Gene Treatment ◽  
Tunisian Patients ◽  
The Military ◽  
Epidemiological Characteristics

Abstract Sarcoidosis is a multi-systemic granulomatosis of unknown cause, characterized by a clinical polymorphism. It results from interplay of environmental and genetic factors. The aim of our study was to describe sociodemographic and genetic characteristics in Tunisian patients with sarcoidosis. We conducted a retrorospective study of patients with sarcoidosis followed in the internal medicine and neurology departments at the Military Hospital of Tunis. We collected epidemiological characteristics. Genetic study concerned only patients who accepted to participate. DNA extraction was performed from whole blood. HLA class II typing and gene mutation testing of the ACE gene were also performed. Our study concerned 50 patients. The mediastino-pulmonary involvement was the most frequent (72.3%), followed by neurological involvement (58.5%), cutaneous involvement (50.8%) and ophthalmological involvement (40%). Genetic analysis showed a high frequency of the HLA DRB1 * 1501 allele (38%), DD genotype (30%) and D allele (54%) of the ACE gene. Treatment with corticosteroids was most often used 73.85%. The evolution was favorable in 13 cases (26.15%), and stable in 63% of cases. In conclusion, sociodemographic and genetic characteristic are variable from one ethnic to another. Advances in genotyping and statistical analysis are helping to elucidate the genetics of sarcoidosis.

scholarly journals Molecular epidemiological characteristics of echovirus 6 in mainland China: extensive circulation of genotype F from 2007 to 2018

2021 ◽  
Author(s):  
Wenjun Cheng ◽  
Tianjiao Ji ◽  
Shuaifeng Zhou ◽  
Yong Shi ◽  
Lili Jiang ◽  
...  
Keyword(s):  
Common Ancestor ◽  
Mainland China ◽  
Recent Common Ancestor ◽  
Genetic Characteristics ◽  
Most Recent Common Ancestor ◽  
Significant Difference ◽  
Echovirus 6 ◽  
Epidemiological Characteristics ◽  
Highest Posterior Density ◽  
Genotype F

AbstractEchovirus 6 (E6) is associated with various clinical diseases and is frequently detected in environmental sewage. Despite its high prevalence in humans and the environment, little is known about its molecular phylogeography in mainland China. In this study, 114 of 21,539 (0.53%) clinical specimens from hand, foot, and mouth disease (HFMD) cases collected between 2007 and 2018 were positive for E6. The complete VP1 sequences of 87 representative E6 strains, including 24 strains from this study, were used to investigate the evolutionary genetic characteristics and geographical spread of E6 strains. Phylogenetic analysis based on VP1 nucleotide sequence divergence showed that, globally, E6 strains can be grouped into six genotypes, designated A to F. Chinese E6 strains collected between 1988 and 2018 were found to belong to genotypes C, E, and F, with genotype F being predominant from 2007 to 2018. There was no significant difference in the geographical distribution of each genotype. The evolutionary rate of E6 was estimated to be 3.631 × 10-3 substitutions site-1 year-1 (95% highest posterior density [HPD]: 3.2406 × 10-3-4.031 × 10-3 substitutions site-1 year-1) by Bayesian MCMC analysis. The most recent common ancestor of the E6 genotypes was traced back to 1863, whereas their common ancestor in China was traced back to around 1962. A small genetic shift was detected in the Chinese E6 population size in 2009 according to Bayesian skyline analysis, which indicated that there might have been an epidemic around that year.

Simulation of an Aircraft Accident at Brussels Airport

1986 ◽  
Vol 2 (1-4) ◽  
pp. 207-208
Author(s):  
Fr Labeeu ◽  
M de Backer ◽  
C Bellanger
Keyword(s):  
Military Hospital ◽  
University Hospitals ◽  
Disaster Plan ◽  
Code Number ◽  
Landing Point ◽  
Call Number ◽  
Aircraft Accident ◽  
The Military

The exercise held at Brussels Airport was carried out by inexperienced personnel to highlight the most common errors and shortcomings of an existing disaster plan.INCIDENT COMMUNICATIONOnce an aircraft is known to be in trouble, all the nearby fire brigades are alerted by means of the unique call number 900 and move to take up their stand-by position close to the landing point. The Military Hospital is also alerted and sends out a liaison car, with a doctor among its occupants. This car joins the stand-by position. Once the aircraft has crashed, the fire engines rush to the site and all the major university hospitals and the Military Hospital are notified by the same 900-code number. Disaster teams arrive by road.This report is almost exclusively limited to aspects of rescue, triage, on-site stabilization, and evacuation of the casualties.

scholarly journals (P1-67) Collaboration of Military and Civil EMS during Russian Georgian War 2008

2011 ◽  
Vol 26 (S1) ◽  
pp. s120-s120
Author(s):  
K. Chikhradze ◽  
T. Kereselidze ◽  
T. Zhorzholiani ◽  
D. Oshkhereli ◽  
Z. Utiashvili ◽  
...  
Keyword(s):  
Emergency Care ◽  
Medical Personnel ◽  
Disaster Medicine ◽  
Military Hospital ◽  
Emergency Medical Care ◽  
Field Hospital ◽  
Occupied Territory ◽  
Long Time ◽  
The Military ◽  
The Village

IntroductionDuring 2008 Russian Federation realized major aggression against its direct neighbor, the sovereign republic of Georgia. It was Russia's attempt to crown its long time aggressive politics by force, using military forces. EMS physicians from Tbilisi went to the Gori district on August 8 at first light, 14 brigades were sent. At noontime of August 8, their number was increased up to 40. 6 brigades of disaster medicine experts joined them as well.ResultsDestination site for the beginning was the village Tkviavi, where a military field hospital was assembled and a Military Hospital in Gori. Later 6 brigades were withdrawn towards the village Avnevi. During fighting, wounded victims were evacuated from the battlefield, where initial triage was done. Evacuated victims were brought to the military hospital where the medical triage, emergency medical care and transportation to Gori military hospital or to Tbilisi hospitals was done. A portion of the wounded was directly taken to Gori military hospital and later to different civil hospitals in Tbilisi. Corpses were transported to Gori morgue as well. On August 9, the emergency care brigades and field hospital left Tkviavi and moved to the village Karaleti, then to Gori. On August 12, the occupied territory was totally evacuated by civil and military medical personnel. Although withdrawal of wounded was done on following days. Up to 2232 military and civil persons were assisted by EMS brigades during war period (8–12 August), from them 721 patients were transported among which 120 were severely injured.ConclusionClose collaboration between military and civil EMS gave the system opportunity to work in an organized manner. On the battlefield prepared military rescuers were active taking out wounded victims to the field or front-line hospitals from which civil emergency care brigades transported them to Tbilisi hospitals. Only 3 fatalities occurred during transportation.

scholarly journals Myelodysplastic Syndromes Experience of the Laboratory of the Military Hospital Avicenna Marrakech

2019 ◽  
Vol 4 (6) ◽  
pp. 115
Author(s):  
Mouhib Hanane ◽  
Karrati Ilham ◽  
Hanane Zahir ◽  
Yahyaoui Hicham ◽  
Ait Ameur Mustapha ◽  
...  
Keyword(s):  
Myelodysplastic Syndromes ◽  
Military Hospital ◽  
The Military

scholarly journals Sacral Tuberculosis: Never Ignore Buttock Pain

2021 ◽  
Vol 5 (1) ◽  
pp. 41-44
Author(s):  
Mohd Hazwan Bin Maznon ◽  
Khairul Abdillah Bin Mohamad ◽  
Siti Zulaifah Binti Che Saidi ◽  
Lim Han Sim ◽  
Ahmad Sabri Bin Omar
Keyword(s):  
Back Pain ◽  
Pulmonary Infection ◽  
Signs And Symptoms ◽  
Neurological Impairment ◽  
Pulmonary Involvement ◽  
Neurological Involvement ◽  
Rare Entity ◽  
Lumbosacral Junction ◽  
Buttock Pain ◽  
Lower Back

A last few decade, case of infection with Mycobacterium tuberculosis (TB) is increasing.  TB infection of other than pulmonary is quite challenging to diagnose due to non-specific signs and symptoms (Wellons III et al., 2004). Spine being the commonest site of skeletal TB which account approximately 50% from reported cases (Tuli, 2002). Spinal TB can be associated with pulmonary infection, however in less than 1% of cases, it occurs in the absence of pulmonary involvement (Davidson & Horowitz, 1970; Gorse, Pais, Kusske, & Cesario, 1983; Omari, Robertson, Nelson, & Chiu, 1989; Rezai, Lee, Cooper, Errico, & Koslow, 1995). TB infection involving the lumbosacral junction is uncommon, only 2 to 3% from all cases of spinal TB (Ahmadi, Bajaj, Destian, Segall, & Zee, 1993; Dayras, Lorilloux, Hugonet, & Benichou, 1985; MANSBERG, ROWE, & WALKER, 1991; Pun et al., 1990; Rajasekaran et al., 1998). Isolated sacral TB is rare entity, The patient usually presented with lower back pain with or without neurological involvement (Patankar et al., 2000). Here we presented a case of sacral TB which not associated with neurological impairment.

Sisters of Mercy

2019 ◽  
pp. 251-257
Author(s):  
Philip Gerard
Keyword(s):  
Military Hospital ◽  
Religious Orders ◽  
Black And White ◽  
Medical Supplies ◽  
Small Band ◽  
Sisters Of Mercy ◽  
Excellent Care ◽  
The Military

In July 1862, small band of Sisters of Mercy, led by Mother Mary Madeline Tobin, arrive at Beaufort and take charge of the military hospital at the Atlantic Hotel-once a fine report, now half-derelict and spoiled by looting. They find patients badly fed, suffering with little care and no sanitation. They demand food, clothing, cleaning and medical supplies. Quickly they transform the squalid place into a clean hospital that provides excellent care for wounded and ill men of both armies. They are among some 600 women from 21 religious orders who labor among the battlefield wounded. Four of the sisters die in service. All exhibit extraordinary commitment and perseverance and earn the undying loyalty of the soldiers to whom they minister-many of whom have never before encountered a nun and are at first confounded by their black and white habits, but quickly are won over by the sisters’ gentleness and competence.

The Life of a Combat Social Worker

2020 ◽  
pp. 15-27
Author(s):  
Jeffrey S. Yarvis
Keyword(s):  
Social Work ◽  
Social Workers ◽  
Social Worker ◽  
Mental Health Treatment ◽  
Health Clinic ◽  
Military Hospital ◽  
Base Camp ◽  
The Social ◽  
The Military

Chapter 1 gives the reader a tour—a kind of ride-a-long or a kind of “see-what-I-see” experience. Much of the chapter is about the combat part of combat social work: What does social work look like outside the wire, downrange, or in combat or other hostile and dangerous battles or threats. This chapter will enable the reader to appreciate the role and experiences of combat social workers, as captured in later autobiographical chapters. However, deployments are time-limited (7–15 months, as a rule), and most of the time spent as a military social worker is in garrison (i.e., base camp with offices, often a behavioral health clinic or the social work department at a military hospital). This is where and how most members of the military receive their mental health treatment—conducted by military social workers. This is discussed in Chapter 2.

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