scholarly journals Vitamin B12 is Found Sufficient in Newly Diagnosed Type 2 Diabetes in a Hospital Based Study

2016 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Vitamin B12 ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Diabetes Group ◽  
Cross Sectional

Background: Vitamin B12 deficiency may be related to peripheral neuropathy in people with type 2 diabetes mellitus (T2DM). Level of B12 in T2DM observed by many investigators showed variable results. Studies on vitamin B12 in T2DM are very limited in Bangladesh. Objectives: To observe serum vitamin B12 level in newly diagnosed T2DM patients. Methods: Observational cross-sectional study encompassing 50 newly diagnosed T2DM and 50 controls as per American Diabetes Association (ADA) criteria. Vitamin B12 and Hemoglobin A1c (HbA1c) were measured for all. Results: Both mean (492.46±28.82 vs. 346.48±19.65 pg/mL, mean±SEM; p=<0.001) and median (435.50 vs. 334.50 pg/mL) values of serum vitamin B12 were found to be higher in T2DM than those of controls. None of the diabetic subjects were found to be B12 deficient whereas 6 were borderline deficient; these frequencies were 7 and 11 respectively among the controls. Vitamin B12 level was statistically similar in patients with or without clinically evident peripheral neuropathy (mean±SEM; 523.48±39.39 vs. 441.84±38.76 pg/mL, p=0.172). B12 level showed positive correlation with fasting plasma glucose (FPG, r=0.285, p=0.061) and HbA1c (r=0.287, p= 0.043) in diabetes group but there was no correlation with body mass index (BMI). Conclusion: Vitamin B12 is found sufficient in newly diagnosed Bangladeshi T2DM patients.

scholarly journals The Prevalence of Vitamin B12 Deficiency in Patients with Type 2 Diabetes: A Cross-Sectional Study

2009 ◽  
Vol 22 (5) ◽  
pp. 528-534 ◽  
Author(s):  
M. C. Pflipsen ◽  
R. C. Oh ◽  
A. Saguil ◽  
D. A. Seehusen ◽  
D. Seaquist ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
B12 Deficiency

scholarly journals A cross sectional study to estimate the prevalence of vitamin B12 deficiency among type 2 diabetes cases on metformin therapy: a one year study

2021 ◽  
Vol 8 (5) ◽  
pp. 657
Author(s):  
Veeranarayana Gundu ◽  
Venkata Subrahmanyam Chintha
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Metformin Therapy ◽  
B12 Deficiency ◽  
One Year

Background: Type 2 diabetes mellitus is associated with long term neurological complications. Metformin usage as first line drug for longer duration is associated with Vitamin B12 deficiency. Metformin on longer usage is associated with B12 deficiency in various studies and prevalence is variable. The study aims to estimate the prevalence of Vitamin B12 deficiency and its associated risk factors among T2DM on metformin therapy.Methods: A cross sectional study for one year was conducted at Narayana Medical college a tertiary care hospital. All T2DM cases attending the department and on Metformin usage were enrolled and data of age, sex, duration of T2DM, dosage of Metformin were noted as variables. Levels of Hb1Ac and complete blood picture were noted. Statistical analysis was conducted by Statistical package for social sciences (SPSS) version 21 v and p<0.05 was considered statistically significant.Results: A total of 258 participants were enrolled of which 68 (26.36%) were B12 deficient, 46 cases (17.83%) moderately deficient and 144 (55.81%) were normal. Prevalence of Vitamin B12 in the study was 26.36%. There was a statistically significant association between Vitamin B12 levels and daily dose of metformin usage. (p>0.005)Conclusions: Our study clearly highlighted the association of Vitamin B12 deficiency among T2DM on metformin therapy. Prevalence of Vitamin B12 deficiency among T2DM patients on metformin is quite considerable and cannot be neglected. Physicians prescribing the drug should plan inclusion Vitamin B12 supplementation as regular drug in T2DM cases.

scholarly journals Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: a cross-sectional study

2016 ◽  
Vol 134 (6) ◽  
pp. 473-479 ◽  
Author(s):  
Charbel Pereira Damião ◽  
Amannda Oliveira Rodrigues ◽  
Maria Fernanda Miguens Castellar Pinheiro ◽  
Rubens Antunes da Cruz Filho ◽  
Gilberto Peres Cardoso ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional ◽  
H2 Antagonists ◽  
H2 Antagonist ◽  
B12 Deficiency

ABSTRACT: CONTEXT AND OBJECTIVE: The prevalence of vitamin B12 deficiency varies from 5.8% to 30% among patients undergoing long-term treatment with metformin. Because of the paucity of data on Brazilian patients, this study aimed to determine the frequency of B12 deficiency and related factors among Brazilian patients with type 2 diabetes mellitus (T2DM) using metformin. DESIGN AND SETTING: Cross-sectional study at a public university hospital. METHODS: Patients with T2DM and a control group of non-diabetics were included. Serum B12 levels were measured and biochemical B12 deficiency was defined as serum levels < 180 pg/ml. Associations between B12 deficiency and age, duration of T2DM, duration of use and dosage of metformin, and use of proton pump inhibitors (PPIs) or histamine H2 antagonists were determined. RESULTS: 231 T2DM patients using metformin (T2DM-met) and 231 controls were included. No difference in the frequency of PPI or H2-antagonist use was seen between the groups. B12 deficiency was more frequent in the T2DM-met group (22.5% versus 7.4%) and this difference persisted after excluding PPI/H2-antagonist users (17.9% versus 5.6%). The factors that interfered with serum B12 levels were PPI/H2-antagonist use and duration of metformin use ≥ 10 years. Use of PPI/H2-antagonists was associated with B12 deficiency, with an odds ratio of 2.60 (95% confidence interval, 1.34-5.04). CONCLUSIONS: Among T2DM patients, treatment with metformin and concomitant use of PPI/H2-antagonists are associated with a higher chance of developing B12 deficiency than among non-diabetics.

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