scholarly journals Sinonasal Inverted Papilloma: Epidemiological and Pathological Profile from 15 Cases

2020 ◽  
Vol 3 (1) ◽  
Keyword(s):  
Clinical Symptoms ◽  
Inverted Papilloma ◽  
High Rate ◽  
Low Grade ◽  
Nasal Blockage ◽  
Sinonasal Inverted Papilloma ◽  
Nasal Tumor ◽  
Important Means ◽  
Low Grade Dysplasia ◽  
Operating Method

Inverted papilloma is a rare benign Sino nasal tumor marked by strong local aggressiveness, a high rate of recurrence after surgery and an unpredictable risk of association with squamous cell carcinoma. We retrospectively investigated 15 cases of inverted papilloma that were treated between January 2004 and December 2018, diagnosed at the pathological anatomy department, CHU MOHAMMED VI of Marrakech. The objective of this work was to study the epidemiological and anatomopathological profile of these polyps. The sex ratio of 2.75 was clearly predominate in males with an average age of 40 years. Its main clinical symptoms was manifested by nasal blockage. The radiological assessment using CT and nasosinus MRI couple constituted a very important means of the positive diagnosis of the inverted papilloma and of the choice of the operating method. Histological examination showed a papillomata’s polypoid respiratory mucosa, at the level of the chorion, with signs of low grade dysplasia in only one case. Their high potential for local aggressiveness, the fear of a recurrence and the possibility of the occurrence of a malignant tumor require radical management.

Epiphora as a sign of unexpected underlying squamous cell carcinoma within sinonasal inverted papilloma

2020 ◽  
Vol 4 (5) ◽  
pp. 01-04
Author(s):  
Filippo Confalonieri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Nasal Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Drainage System ◽  
Nasolacrimal Duct ◽  
Inverted Papilloma ◽  
High Rate ◽  
Sinonasal Inverted Papilloma ◽  
The Right

Backgorund: Sinonasal inverted papilloma (SIP) is a benign tumor of the nasal cavity and sinus. It is characterized by aggressive malignant transformation and a high rate of recurrence. Inadequate removal of the tumor during surgery is one of the most significant contributors to recurrence. SIP has been reported to rarely occur in conjunction with Squamous Cell Carcinoma (SCC) invading the lacrimal drainage system and the orbit. The mechanism of this secondary SCC transformation has yet to be explained. Case presentation: Herein, the authors present the case of a 66-year-old woman with a rapidly enlarging sinonasal inverted papilloma with secondary squamous cell carcinoma of the right nasal cavity presenting with epiphora. Conclusions: Nasolacrimal duct obstructions require a thorough examination as it may hide a malignant pathology.

scholarly journals The comparison of endoscopic and external surgical approaches for sinonasal inverted papilloma and their impact on tumour recurrence

2019 ◽  
Vol 8 (4) ◽  
pp. 90-95
Author(s):  
Zuzanna Nowinka ◽  
Shadaba Ahmed
Keyword(s):  
Recurrence Rate ◽  
Endoscopic Surgery ◽  
Surgical Complications ◽  
Inverted Papilloma ◽  
Endoscopic Approach ◽  
High Rate ◽  
Surgical Approaches ◽  
Tumour Resection ◽  
External Approach ◽  
Sinonasal Inverted Papilloma

Introduction: Sinonasal inverted papilloma (SNIP) is a rare, benign tumour originating from the mucosal lining of the sinonasal cavity. The treatment is aimed at complete tumour resection. Current resection methods include external excision, endoscopic surgery and a combined approach. The high rate of SNIP recurrence poses a challenge for the ear nose and throat (ENT) specialist. There is a debate about which method provides the best outcomes. In this study, the most recent literature is analysed to evaluate the effectiveness of each surgical approach in terms of recurrence rate and surgical complications. Results: The literature search yielded data for 941 patients from ten studies. The analysis showed a recurrence rate of 13.5% for the endoscopic approach, 34% for combined and 36.7% for the external. The lowest recurrence rate (0%-3.6%) was reported when novel endoscopic approaches, such as prelacrimal recess or ‘TuNa’ saving, were used. However, the comparison of surgical complications was challenging due to inconsistent reporting. Discussion: The external approach previously considered a ‘gold standard’ is now becoming replaced by endoscopic surgery. The advantages of an endoscopic approach are a lower recurrence rate, better visualisation of the tumour and a more precise excision. Moreover, this approach preserves the surrounding tissues, reducing the amount of complications and recovery time. However, the external approach should still be employed when SNIP is widespread or in proximity with vital structures. Careful pre-operative planning is needed as the primary surgery has the best chances of eliminating the disease. Each revision surgery subsequently increases the risk of SNIP recurrence. Furthermore, there is a need for agreement on minimal surveillance time after SNIP resection. Conclusion: The endoscopic approach should be a mainstay of SNIP treatment due to low recurrence rate and better patient outcomes. Nevertheless, ENT specialists should keep in mind that for more advanced disease, external an combined methods may be more appropriate.

FDG PET for the routine follow-up in NHL: First prospective evaluation

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 7569-7569
Author(s):  
G. Jerusalem ◽  
R. Silvestre ◽  
Y. Beguin ◽  
R. Hustinx ◽  
M. Fassotte ◽  
...  
Keyword(s):  
Predictive Value ◽  
Fdg Pet ◽  
Clinical Symptoms ◽  
False Negative ◽  
B Cell Lymphoma ◽  
High Rate ◽  
Time Interval ◽  
Low Grade ◽  
Clinical Relapse

7569 Background: We have shown that FDG PET is able to detect preclinical relapses in patients with Hodgkin’s disease but the high rate of false-positivity (55%) was a problem (Jerusalem et al, Ann Oncol, 2003; 14 : 123–130). The aim of this study was to determine the accuracy of PET during follow-up after treatment in non-Hodgkin’s lymphoma (NHL). Methods: Patients were eligible if they had a positive baseline FDG PET and a negative end of treatment work-up including a negative PET study. They underwent FDG PET every 4–6 months until 3 years after diagnosis. Forty-five aggressive NHL (diffuse large B-cell lymphoma : 34, other : 11) and eighteen low grade NHL (follicular lymphoma : 16, other : 2) were recruited prospectively between 5/94 and 12/01. Results: A total of 197 FDG PET studies were realized. Six patients relapsed (aggressive NHL : 4, low grade NHL : 2) and 3 patients died (aggressive NHL : 2, pancreatic cancer : 1) during the time interval of the study protocol. Four asymptomatic relapses (aggressive NHL : 2, low grade NHL : 2) and one symptomatic relapse (aggressive NHL) was detected by FDG PET. Disease recurrence became symptomatic or clinically detectable a week, 3 months (both aggressive NHL), 12 and 17 months (both low grade NHL) after the first positive PET study. The latter had 4 positive FDG PET studies before biopsy-proven relapse. The time interval between the only false-negative PET and clinical relapse was 5 months in a patient with aggressive NHL. We observed for the whole study population a sensitivity of 89% (8/9), a specificity of 93% (174/188), a positive predictive value of 36% (8/22), a negative predictive value (NPV) of 99% (174/175) and an accuracy of 92% (182/197). In low grade NHL PET had a sensitivity of 100% (5/5), a specificity of 93% (50/54), a PPV of 56% (5/9), a NPV of 100% (50/50) and an accuracy of 93% (55/59). In aggressive NHL, PET had a sensitivity of 75% (3/4), a specificity of 93% (124/134), a PPV 23% (3/13), a NPV of 99% (124/125) and an accuracy of 92% (127/138). Conclusions: In aggressive NHL, routine follow-up by FDG PET is not very useful and we stopped it now in unselected aggressive NHL. In contrast, FDG PET can detect a relapse several months before the development of clinical symptoms in low grade NHL suggesting further evaluation of the role of PET in the routine follow-up of these patients. No significant financial relationships to disclose.

OC-056 High Rate of Missed Visible Lesions in Patients Referred with Low Grade Dysplasia with Subsequent Upstaging of Pathology by EMR in Majority

Gut ◽  
2016 ◽  
Vol 65 (Suppl 1) ◽  
pp. A32.1-A32 ◽  
Author(s):  
I Koumoutsos ◽  
P Wilson ◽  
S DeMartino ◽  
J Dunn
Keyword(s):  
High Rate ◽  
Low Grade ◽  
Low Grade Dysplasia

Is the diagnosis of low-grade dysplasia in ulcerative colitis consistent?

2001 ◽  
Vol 120 (5) ◽  
pp. A733-A733
Author(s):  
C LIM ◽  
A AXON ◽  
A VAIL ◽  
D FORMAN ◽  
M DIXON
Keyword(s):  
Ulcerative Colitis ◽  
Low Grade ◽  
Low Grade Dysplasia

Sinonasal Inverted Papilloma with Skull Base Involvement

2014 ◽  
Vol 75 (S 01) ◽  
Author(s):  
R. Manes ◽  
William Scott ◽  
Samuel Barnett ◽  
Pete Batra
Keyword(s):  
Skull Base ◽  
Inverted Papilloma ◽  
Sinonasal Inverted Papilloma

ENDOSCOPIC RESECTION OF LOW GRADE DYSPLASIA IN BARRETT’S OESOPHAGUS: A RETROSPECTIVE STUDY ABOUT 61 PATIENTS

2020 ◽  
Author(s):  
Fabrice Caillol ◽  
Arthur Falque ◽  
Margherita Pizzicannella ◽  
Christian Pesenti ◽  
Jean Philippe Ratone ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Endoscopic Resection ◽  
Barrett’S Oesophagus ◽  
Low Grade ◽  
Barrett's Oesophagus ◽  
Low Grade Dysplasia
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