Substantiation of using the ursodeoxycholic acid in the treatment of non-alcoholic steatohepatitis
Keyword(s):
The article provides brief epidemiological data on non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, emphasizing the danger of steatohepatitis, progression of which may cause the development of hepatocellular carcinoma. The properties of ursodeoxycholic acid, which are the basis for its use in a treatment of non-alcoholic steatohepatitis, are analyzed in detail, such as cytoprotective, antioxidant, antifibrotic ones, effects on apoptosis, etc. The authors presented the results of the main evidence-based studies demonstrating the effectiveness of ursodeoxycholic acid and its combinations with other drugs in the treatment of non-alcoholic steatohepatitis.
2014 ◽
Vol 23
(4)
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pp. 425-429
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2018 ◽
Vol 7
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pp. 130-133
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2004 ◽
Vol 18
(6)
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pp. 1105-1116
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