Long-term risk of cancer development in adult patients with idiopathic aplastic anemia after treatment with anti-thymocyte globulin

Background: Pancytopenia is diagnosed when there is a reduction in all three hematopoietic cell lines. Till date there is limited number of studies on the frequency of various causes of pancytopenia. Of these some have been reported from the Indian subcontinent. There appears to be a changing spectrum of pancytopenia over the past two decades. The objective was to study the etiopathological spectrum of adult patients with pancytopenia over a period of one and half year. Methods: The Prospective and retrospective observational study was conducted in the Department of Family Medicine, Batra Hospital and Medical Research Centre, New Delhi. A total of 120 Patients were included in the study. All patients gave their consent to take part in the study and were subjected to a questionnaire regarding symptoms, past relevant history, lifestyle and detailed clinical examination and investigations as mentioned in materials and methods. Results: Six broad diagnostic groups could be identified in adults with pancytopenia. Megaloblastic anemia (D1) was the largest group comprising 57.5% of all patients. 11.7% of patients with pancytopenia were diagnosed as Aplastic anemia (D2).11.7% of patients with pancytopenia were diagnosed as leukemia/lymphoma (D3) such as lymphoma (1), metastatic anaplastic carcinoma (1), acute leukemia (11), and metastatic gastric carcinoma (1). 15% of patients with pancytopenia were diagnosed with infections (D4) such as complicated malaria cases (7), HIV (5), disseminated tuberculosis (4), viral (2). We also encountered (D5) 0.8% was Myelophthisis/Storage disorder as myelodysplastic syndrome (1) and 3.3% were other (D6) as reactive marrow (4). Conclusion: Pancytopenia is not a disease itself. It is a hematological feature of varying etiology with slight male preponderance. Megaloblastic anemia along with mixed nutritional anemia is leading cause of pancytopenia in India followed by infections being second and aplastic anemia and acute leukemia being third common causes. Keyword: Pancytopenia, Megaloblastic anemia, Nutritional anemia.

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Long-term Efficacy of Tacrolimus Ointment for Recalcitrant Facial Erythema Resistant to Topical Corticosteroids in Adult Patients With Atopic Dermatitis

Archives of Dermatology ◽

10.1001/archderm.136.8.1062 ◽

2000 ◽

Vol 136 (8) ◽

pp. 1062-1063 ◽

Cited By ~ 19

Author(s):

H. Sugiura

Keyword(s):

Atopic Dermatitis ◽

Adult Patients ◽

Tacrolimus Ointment ◽

Topical Corticosteroids ◽

Term Efficacy ◽

Facial Erythema

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Effects of long-term growth hormone replacemente therapy on body composition in adult patients with growth hormone deficiency

Endocrine Abstracts ◽

10.1530/endoabs.70.aep681 ◽

2020 ◽

Author(s):

García Moreno Rosa María ◽

Ramírez Paola Parra ◽

Saiz Gonzalo Baonza ◽

Rojas-Marcos Patricia Martin ◽

Beatriz Lecumberri ◽

...

Keyword(s):

Growth Hormone ◽

Body Composition ◽

Growth Hormone Deficiency ◽

Adult Patients ◽

Hormone Deficiency

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A Long-term Study to Assess the Safety and Efficacy of Efgartigimod in Adult Patients With Primary Immune Thrombocytopenia (ITP).

Case Medical Research ◽

10.31525/ct1-nct04225156 ◽

2020 ◽

Author(s):

Keyword(s):

Immune Thrombocytopenia ◽

Adult Patients ◽

Term Study ◽

Safety And Efficacy ◽

Long Term Study ◽

Primary Immune Thrombocytopenia

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Faculty Opinions recommendation of HLA-matched sibling transplantation with BM and CD34(+)-purified PBSCs in adult patients with high-risk severe aplastic anemia to overcome graft rejection without an increase in GVHD.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5650958.5621057 ◽

2010 ◽

Author(s):

Albert N Békássy

Keyword(s):

High Risk ◽

Aplastic Anemia ◽

Graft Rejection ◽

Adult Patients ◽

Severe Aplastic Anemia ◽

Matched Sibling

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RESULTS OF SURGICAL TREATMENT OF PATIENTS WITH CHRONIC PANCREATITIS AND THE RISK OF CANCER AFTER SURGICAL TREATMENT

Problems in oncology ◽

10.37469/0507-3758-2018-64-2-228-233 ◽

2018 ◽

Vol 64 (2) ◽

pp. 228-233

Author(s):

Vladimir Lubyanskiy ◽

Vasiliy Seroshtanov ◽

Ye. Semenova

Keyword(s):

Pancreatic Cancer ◽

Chronic Pancreatitis ◽

Surgical Treatment ◽

Fibrous Tissue ◽

Pancreatic Head ◽

Head Region ◽

Intestinal Anastomoses ◽

Resection Of The Pancreas ◽

Risk Of Cancer

The aim: To analyze results of surgical treatment of patients with chronic pancreatitis (CP) and to assess the causes of pancreatic cancer after surgical treatment. Materials and methods: 137 patients had duodenum-preserving resections of the pancreas. Results: In the histological examination of the pancreas it was established that the growth of fibrous tissue was registered in patients with CP., which in 19 (13.8%) almost completely replaced the acinar tissue. In the long term after the operation from 6 months to 2 years in 8 patients (5.8%) pancreatic cancer was detected. Possible causes of tumor origin were analyzed, the value of preservation of ductal hypertension, which affects the state of the duct’s epithelium, was established. The most commonly used for treatment of chronic pancreatitis the Frey surgery removed pancreatic hypertension but in two patients during the operation an insufficient volume of the pancreatic head was reconstructed. In the case of the abandonment of a large array of fibrous tissue, local hypertension was retained in the region of the ductal structures of the head, which led to the transformation of the duct epithelium. An essential factor in the problem of the preservation of pancreatic hypertension were the stenosis of pancreatic intestinal anastomoses, they arose in the long term in 4 operated patients. With stenosis of anastomosis after duodenum-preserving resection both the hypertension factor and the regeneration factor could be realized, which under certain circumstances might be significant. Conclusion: After resection of the pancreas for CP cancer was diagnosed in 5.8% of patients. The main method of preventing the risk of cancer was performing the Frey surgery for CP eliminating pancreatic hypertension in the head region of the pancreas. Diagnosis of stenosis in the late period after resection of the pancreas was an important element in the prevention of recurrence of cancer since a timely reconstructive operation could improve the drainage of duct structures.

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Biomarkers for Early Detection of Colitis-associated Colorectal Cancer - Current Concepts, Future Trends

Current Drug Targets ◽

10.2174/1389450121666200220123844 ◽

2020 ◽

Vol 22 (1) ◽

pp. 137-145

Author(s):

Tomasz Mackiewicz ◽

Aleksander Sowa ◽

Jakub Fichna

Keyword(s):

Colorectal Cancer ◽

Early Detection ◽

Cancer Development ◽

Sporadic Colorectal Cancer ◽

Future Trends ◽

Significant Progress ◽

Current Standard ◽

Risk Of Cancer ◽

Histological Testing ◽

Made In

: Colitis-associated colorectal cancer (CAC) remains a critical complication of ulcerative colitis (UC) with mortality of approximately 15%, which makes early CAC diagnosis crucial. The current standard of surveillance, with repetitive colonoscopies and histological testing of biopsied mucosa samples is burdensome and expensive, and therefore less invasive methods and reliable biomarkers are needed. Significant progress has been made thanks to continuous extensive research in this field, however no clinically relevant biomarker has been established so far. This review of the current literature presents the genetic and molecular differences between CAC and sporadic colorectal cancer and covers progress made in the early detection of CAC carcinogenesis. It focuses on biomarkers under development, which can be easily tested in samples of body fluids or breath and, once made clinically available, will help to differentiate between progressors (UC patients who will develop dysplasia) from non-progressors and enable early intervention to decrease the risk of cancer development.

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