scholarly journals Modern condition of the problem of Lime Burreliosis of animals (systematic review)

2021 ◽  
pp. 64-78
Author(s):  
O. Panteleenko ◽  
B. Yarchuk ◽  
T. Tsarenko
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Clinical Manifestations ◽  
Ecological Factors ◽  
Scientific Data ◽  
Temperate Climate ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Considerable Uncertainty ◽  
Reservoir Hosts

Lyme borreliosis (LB) is the most common tick-borne disease in the temperate climate of the Northern Hemisphere. LB is caused by spirochetes, which are grouped in the complex Borrelia burgdorferi sensu lato, vectors – Ixodidae mites, dozens of species of small mammals and birds actas reservoir hosts, and the role of reservoirs of domestic animals, such as dogs and cats, is not excluded. Although the ecology and epidemiology of the disease have been extensively studied in Europe and North America, there is considerable uncertainty regarding the study of Lyme borreliosis in veterinary medicine. Search, selection andanalysis of scientific data on the research topic were carried out according to acceptable rules for systematic reviews of the literature. The scientometric database Web of Science Core Collection, the database of scientific articles Pub Med and the database Scientific Periodicals of Ukraine were used. Seventy-four scientific articles were used for the article, which contained the necessary set of data and met the set goal. The article highlights the main issues of the etiology of the disease, which describes the characteristics of the pathogen, its properties, genotypic composition of Borrelia, which cause Lyme disease, the spread of pathogenic genotypes of Borrelia in Europe and Ukraine. The connection of Lyme borreliosis spread with ecological factors, climatic changes and anthropogenic impact on biocenoses and biotopes, the role of vectors and reservoir hosts in the spread of LB is described. Data on the prevalence and degree of infection of Ixodes mites with Borrelia, as well as the spread of LB among the population of Europe and Ukraine are presented. The seroprevalence of each of the animal species (dogs, cats, horses, ruminants), clinical manifestations of LB, if documented and indicators of LB prevalence among animals in Europe and Ukraine, as well as currently known treatments, prevention and diagnosis of LB animals are considered. Key words: Borrelia Burgdorferi Sensu Lato, Lyme Diseases Etiology, Ixodidae.

scholarly journals Adaptive and Innate Immune Responsiveness toBorrelia burgdorferi sensu latoin Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Barbro H. Skogman ◽  
Sandra Hellberg ◽  
Christina Ekerfelt ◽  
Maria C. Jenmalm ◽  
Pia Forsberg ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Clinical Manifestations ◽  
Innate Immune ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Immune Responsiveness ◽  
Asymptomatic Children ◽  
Immunological Mechanisms ◽  
Spontaneous Secretion ◽  
Necrosis Factor

Why some individuals develop clinical manifestations in Lyme borreliosis (LB) while others remain asymptomatic is largely unknown. Therefore, we wanted to investigate adaptive and innate immune responsiveness toBorrelia burgdorferi sensu latoin exposedBorrelia-antibody-positive asymptomatic children (n=20), children with previous clinical LB (n=24), and controls (n=20). Blood samples were analyzed forBorrelia-specific interferon (IFN)-γ, interleukin (IL)-4, and IL-17 secretion by ELISPOT andBorrelia-induced IL-1β, IL-6, IL-10, IL-12(p70), and tumor necrosis factor (TNF) secretion by Luminex. We found no significant differences in cytokine secretion between groups, but a tendency towards an increased spontaneous secretion of IL-6 was found among children with previous clinical LB. In conclusion, the adaptive or innate immune responsiveness toBorrelia burgdorferi sensu latowas similar inBorrelia-exposed asymptomatic children and children with previous clinical LB. Thus, the immunological mechanisms of importance for eradicating the spirochete effectively without developing clinical manifestations of LB remain unknown.

scholarly journals Seroprevalence of antibodies against Borrelia burgdorferi sensu lato in healthy blood donors in Romania: an update

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Zsuzsa Kalmár ◽  
Violeta Briciu ◽  
Mircea Coroian ◽  
Mirela Flonta ◽  
Amanda-Lelia Rădulescu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Borrelia Burgdorferi ◽  
Western Blot ◽  
Lyme Borreliosis ◽  
Blood Donors ◽  
Clinical Manifestations ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Serum Samples ◽  
Igm Antibodies ◽  
Associated Risk Factors

Abstract Background The Borrelia burgdorferi sensu lato (s.l.) genogroup is the causative agent responsible for Lyme borreliosis, a common tick-borne infectious disease in some temperate regions of the Northern Hemisphere. In humans, the clinical manifestations of Lyme borreliosis vary from dermatological infection to severe systemic manifestations. In Romania, data on the seroprevalence of Lyme borreliosis and associated risk factors are scarce and outdated, as the only seroprevalence study with a large dataset was published more than 20 years ago. Therefore, the aim of the present study was to evaluate the seroprevalence for Borrelia burgdorferi s.l. in healthy blood donors from six Romanian counties and identify the associated risk factors. Methods The study was conducted among 1200 healthy blood donors aged between 18 and 65 years during November 2019 and September 2020 from six counties in the northwestern and central parts of Romania. A two-tiered testing strategy was applied. Positive and equivocal immunoenzymatic test results for IgG and IgM antibodies were further confirmed by Western blot. Results Serum samples from 20% of the blood donors had positive or equivocal IgG and IgM ELISA index values. In total, 2.3% of the serum samples for IgG and 1.8% for IgM were positive by Western blot. The seroprevalence for both antibodies varied between 1.5% (Satu-Mare) and 6.5% (Bistrița-Năsăud) in the six counties investigated. The highest seroprevalence was observed in men (4.7%), in blood donors performing their professional activities outdoors (4.2%), and in those aged  ≥ 56 years (8%). Conclusions These findings confirm the presence of specific IgG and IgM antibodies to B. burgdorferi s.l. among healthy blood donors from Romania. Furthermore, potential risk factors, such as gender, age, and behavior, associated with the presence of positive B. burgdorferi s.l. antibodies among healthy blood donors were identified. Graphical Abstract

scholarly journals Imbalanced presence of Borrelia burgdorferi s.l. multilocus sequence types in clinical manifestations of Lyme borreliosis

2016 ◽  
Vol 42 ◽  
pp. 66-76 ◽  
Author(s):  
E. Claudia Coipan ◽  
Setareh Jahfari ◽  
Manoj Fonville ◽  
G. Anneke Oei ◽  
Lodewijk Spanjaard ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Clinical Manifestations ◽  
Borrelia Burgdorferi S.L ◽  
Sequence Types

scholarly journals Borrelia burgdorferi Sensu Lato Spirochetes in Wild Birds in Northwestern California: Associations with Ecological Factors, Bird Behavior and Tick Infestation

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0118146 ◽  
Author(s):  
Erica A. Newman ◽  
Lars Eisen ◽  
Rebecca J. Eisen ◽  
Natalia Fedorova ◽  
Jeomhee M. Hasty ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Tick Infestation ◽  
Ecological Factors ◽  
Wild Birds ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Bird Behavior

scholarly journals Infection of Interleukin 17 Receptor A-Deficient C3H Mice with Borrelia burgdorferi Does Not Affect Their Development of Lyme Arthritis and Carditis

2015 ◽  
Vol 83 (7) ◽  
pp. 2882-2888 ◽  
Author(s):  
Carrie E. Lasky ◽  
Kara E. Jamison ◽  
Darcie R. Sidelinger ◽  
Carmela L. Pratt ◽  
Guoquan Zhang ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Heart Tissue ◽  
Lyme Arthritis ◽  
Mouse Strains ◽  
Interleukin 17 ◽  
Content Type ◽  
C3h Mice ◽  
A Subunit

Recently, a number of studies have reported the presence of interleukin 17 (IL-17) in patients with Lyme disease, and several murine studies have suggested a role for this cytokine in the development of Lyme arthritis. However, the role of IL-17 has not been studied using the experimental Lyme borreliosis model of infection of C3H mice withBorrelia burgdorferi. In the current study, we investigated the role of IL-17 in the development of experimental Lyme borreliosis by infecting C3H mice devoid of the common IL-17 receptor A subunit (IL-17RA) and thus deficient in most IL-17 signaling. Infection of both C3H and C3H IL-17RA−/−mice led to the production of high levels of IL-17 in the serum, low levels in the heart tissue, and no detectable IL-17 in the joint tissue. The development and severity of arthritis and carditis in the C3H IL-17RA−/−mice were similar to what was seen in wild-type C3H mice. In addition, development of antiborrelia antibodies and clearance of spirochetes from tissues were similar for the two mouse strains. These results demonstrate a limited role for IL-17 signaling through IL-17RA in the development of disease following infection of C3H mice withB. burgdorferi.

European Reservoir Hosts of Borrelia burgdorferi sensu lato

1998 ◽  
Vol 287 (3) ◽  
pp. 196-204 ◽  
Author(s):  
L. Gern ◽  
A. Estrada-Peña ◽  
F. Frandsen ◽  
J.S. Gray ◽  
T.G.T. Jaenson ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Reservoir Hosts

scholarly journals Co-feeding transmission in Lyme disease pathogens

Parasitology ◽  
2014 ◽  
Vol 142 (2) ◽  
pp. 290-302 ◽  
Author(s):  
MAARTEN J. VOORDOUW
Keyword(s):  
Lyme Borreliosis ◽  
Molecular Mechanisms ◽  
Ecological Factors ◽  
Borrelia Burgdorferi Sensu Lato ◽  
Fitness Advantage ◽  
Modest Contribution ◽  
Causative Agents ◽  
Tick Ecology ◽  
Mode Of Transmission ◽  
Recent Experimental Work

SUMMARYThis review examines the phenomenon of co-feeding transmission in tick-borne pathogens. This mode of transmission is critical for the epidemiology of several tick-borne viruses but its importance forBorrelia burgdorferi sensu lato, the causative agents of Lyme borreliosis, is still controversial. The molecular mechanisms and ecological factors that facilitate co-feeding transmission are therefore examined with particular emphasis onBorreliapathogens. Comparison of climate, tick ecology and experimental infection work suggests that co-feeding transmission is more important in European than North American systems of Lyme borreliosis, which potentially explains why this topic has gained more traction in the former continent than the latter. While new theory shows that co-feeding transmission makes a modest contribution toBorreliafitness, recent experimental work has revealed new ecological contexts where natural selection might favour co-feeding transmission. In particular, co-feeding transmission might confer a fitness advantage in the Darwinian competition among strains in mixed infections. Future studies should investigate the ecological conditions that favour the evolution of this fascinating mode of transmission in tick-borne pathogens.

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