scholarly journals Anticancer Properties of some Novel 2-Hetaryl-3-(5-Arylfuran-2-yl)-Acrylonitriles

2020 ◽  
Vol 11 (2) ◽  
pp. 8844-8853
Keyword(s):  
Nmr Spectroscopy ◽  
Anticancer Activity ◽  
1H Nmr Spectroscopy ◽  
Human Cancer ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Anticancer Properties ◽  
Activity Assessment ◽  
Effective Synthesis

In our present work, we displayed an effective synthesis and anticancer activity assessment of some novel 2-hetaryl-3-(5-arylfuran-2-yl)-acrylonitriles. The structures of synthesized substances were determined by 1H NMR spectroscopy and elemental analysis. In vitro anticancer activity assessment on the full panel of about 60 human cancer cell lines showed that received compounds displayed a weak and moderate kind of activity.

scholarly journals Purification and Characterization of a Lectin from Arisaema tortuosum Schott Having in-vitro Anticancer Activity against Human Cancer Cell Lines

BMB Reports ◽  
2005 ◽  
Vol 38 (5) ◽  
pp. 526-532 ◽  
Author(s):  
Vikram Dhuna ◽  
Jagmohan Singh Bains ◽  
Sukhdev Singh Kamboj ◽  
Jatinder Singh ◽  
Shanmugavel ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Purification And Characterization ◽  
Human Cancer Cell Lines

Quantitative two-dimensional HRMAS 1H-NMR spectroscopy-based metabolite profiling of human cancer cell lines and response to chemotherapy

2010 ◽  
Vol 63 (5) ◽  
pp. 1172-1183 ◽  
Author(s):  
Mathilde Bayet-Robert ◽  
Dominique Loiseau ◽  
Pascale Rio ◽  
Aicha Demidem ◽  
Chantal Barthomeuf ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Cell Lines ◽  
Cancer Cell ◽  
Metabolite Profiling ◽  
1H Nmr Spectroscopy ◽  
Human Cancer ◽  
Two Dimensional ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Response To Chemotherapy

Coordination-driven self-assembly of ruthenium(ii) architectures: synthesis, characterization and cytotoxicity studies

2018 ◽  
Vol 47 (25) ◽  
pp. 8466-8475 ◽  
Author(s):  
Aderonke Ajibola Adeyemo ◽  
Abhijith Shettar ◽  
Imtiyaz Ahmad Bhat ◽  
Paturu Kondaiah ◽  
Partha Sarathi Mukherjee
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Anticancer Activity ◽  
Self Assembly ◽  
Human Cancer ◽  
Oxygen Species ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Cytotoxicity Studies

Four organometallic η6-arene Ru(ii) architectures (MA1–MA4) have been reported. In vitro anticancer activity of the architectures against human cancer cell lines showed good cytotoxicity where the generation of reactive oxygen species (ROS) is responsible for the cell death.

scholarly journals Synthesis and Cytotoxic Evaluation of Novel Ester Derivatives of Betulin with AZT, d4T, and 3TC

2017 ◽  
Vol 12 (6) ◽  
pp. 1934578X1701200
Author(s):  
Dang Thi Tuyet Anh ◽  
Le Nhat Thuy Giang ◽  
Nguyen Thi Hien ◽  
Dinh Thi Cuc ◽  
Nguyen Ha Thanh ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Antitumor Activities ◽  
Human Cancer Cell Lines ◽  
Anticancer Properties ◽  
Derivatives Of

Novel ester derivatives of betulin with AZT, d4T, and 3TC were synthesized and assessed for antitumor activities against the KB and HepG2 human cancer cell lines in vitro by MTT assay. Some derivatives displayed high anticancer properties, with IC50 values between 1 and 21 μM on the two cancer cell lines.

scholarly journals In vitro anticancer activity of N-benzyl 1,10-phenanthroline derivatives on human cancer cell lines and their selectivity

2018 ◽  
Vol 23 (2) ◽  
pp. 68
Author(s):  
Eti Nurwening Sholikhah ◽  
Jumina Jumina ◽  
Sitarina Widyarini ◽  
Ruslin Hadanu ◽  
Mustofa Mustofa
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Vero Cell Line ◽  
Mcf 7

This research was conducted to evaluate the anticancer activity of new compounds of benzyl-1,10- phenanthroline derivatives and their selectivity. In vitro anticancer activity of 11 benzyl-1,10-phenanthroline derivatives were conducted on three human cancer cell lines, cervical cancer (HeLa), myeloma (NS-1), and breast cancer (MCF-7) using MTT-based cytotoxicity assay. The cytotoxicity of each compound was assessed to normal Vero cell line by the same method. The in vitro anticancer activity and cytotoxicity was expressed by the concentration inhibiting 50% of the cell growth (IC50), and the selectivity index (SI) was determined by calculating ratio of the IC50 on Vero cell line and the human cancer cell lines. The results showed that among the 11 compounds tested, the (1)-N-(4-butoxybenzyl)-1,10-phenanthrolinium bromide exhibited the best in vitro anticancer activity with an IC50 27.60 ± 2.76 µM on HeLa, 6.42 ± 5.53 µM on NS-1 and 9.44 ± 2.17 µM on MCF-7 cell lines. Its SI were 377.65 ± 39.97 on HeLa, 6158.72 ± 5306.34 on NS-1 and 1140.11 ± 261.85 on MCF-7 cell lines. This study demonstrated that (1)-N-(4-butoxybenzyl)-1,10-phenanthrolinium bromide possessed a potential in vitro anticancer activity on cancer cell lines with high selectivity

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