scholarly journals Genetic Polymorphism of NAT2 Gene and its Association with Prostate Cancer

2014 ◽  
Vol 5 (2) ◽  
pp. 39-42
Author(s):  
A Nesa ◽  
MT Rahman ◽  
Y Kabir ◽  
FA Rupam
Keyword(s):  
Prostate Cancer ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Slow Acetylator ◽  
Medical College ◽  
Acetylator Genotype ◽  
Nat2 Gene ◽  
Metabolizing Enzyme ◽  
Control Study

A N acetyltransferases 2 (NAT2) is one of the phase II metabolizing enzyme that participate in the bioconversion of heterocyclic arylamines into electrophilic nitrenium ions, which are important ultimate carcinogens that are directly implicated in tumor initiation process. Prostate epithelial cell express N acetyltransferases (NAT) enzymes and recent molecular epidemiological studies have analyzed the relationship between NAT2 in etiology of prostate cancer. A review by chen (2001) in prostate cancer (PCa) suggests that the frequencies of some polymorphisms in certain genes differ among different racial and ethnic groups. In a case control study in India by Srivastava and Mittal (2005), observed significant association between rapid acetylator genotype NAT2 and PCa in tobacco users (OR = 3.43, 95% CI: 1.68-7.02, p< 0.001) when compared with controls. Hamasaki et al (2003) in Japanese men, observed the frequency of the NAT slow acetylator genotype was statistically higher among prostate cancer patients (17.1%) compared with controls (8.6%). Another case control study in Turkey by Kosova et al. (2009), concluded that Nat2* 6A and NAT2 *7A/B gene polymorphism were significantly associated with prostate cancer. DOI: http://dx.doi.org/10.3329/akmmcj.v5i2.21131 Anwer Khan Modern Medical College Journal Vol. 5, No. 2: July 2014, Pages 39-42

scholarly journals Association of Ankle Brachial Pressure Index (ABPI) in Patients with Ischemic Stroke: A Case-Control Study

2013 ◽  
Vol 29 (1) ◽  
pp. 31-42
Author(s):  
Mohammad Selim Shahi ◽  
Aminur Rahman ◽  
Md Shaheen Wadud ◽  
Ak Takib Uddin Ahmed ◽  
Uttam Kumar Saha ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
The Difference ◽  
Relationship Of ◽  
Control Study

Background: Several epidemiological studies have identified the association of abnormal ABPI with ischemic stroke. So the goal of this study was to determine the actual relationship of ABPI with ischemic stroke in the context of our country. Materials and Methods: This case control study was carried out in the Department of Neurology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh. ABPI was measured by Doppler ultrasound machine of 100 patients who were admitted to the Mitford Hospital during the study period. Among them 50 patients with Ischemic stroke, confirmed by CT/MRI scan of brain were considered as ‘case’ and 50 age- sex matched individuals with one or more vascular risk factors (VRF) but without stroke were considered as ‘control’. Then the results of ABPI were compared between the two groups. Results: Among the 50 patients with ischemic stroke (case group) , 74% had normal ABPI and 26% had ABPI< 0.9; on the other hand among 50 age and sex matched individuals (control group) 90% had normal ABPI and 10% had ABPI <0.9. The difference was statistically significant between two groups (p=<0.05).This association remained significant even after adjustment for potential confounders (age, gender, high BMI, hypertension, diabetes mellitus, hyperlipidemia, smoking, ischemic heart disease and family history) in a multiple logistic regression model. Conclusion: The incidence of low ABPI is significantly higher in ischemic stroke patients than the age- sex matched control. Bangladesh Journal of Neuroscience 2013; Vol. 29 (1) : 31-42

scholarly journals Association of Ankle Brachial Pressure Index (ABPI) in Patients with Ischemic Stroke : A Case Control Study

2013 ◽  
Vol 12 (3) ◽  
pp. 27-33
Author(s):  
Mohammad Selim Shahi ◽  
Aminur Rahman ◽  
Md Shaheen Wadud ◽  
Uttam Kumar Saha ◽  
AK Takib Uddin Ahmed ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Case Control Study ◽  
Epidemiological Studies ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Medical College ◽  
The Difference ◽  
Relationship Of ◽  
Control Study

Background: Several epidemiological studies have identified the association of abnormal ABPI with ischemic stroke. So the goal of this study was to determine the actual relationship of ABPI with ischemic stroke in the context of our country. Methods: This case control study was carried out in the Department of Neurology, Sir Salimullah Medical College and Mitford Hospital, Dhaka, Bangladesh. ABPI was measured by Doppler ultrasound machine of 100 patients who were admitted to the Mitford Hospital during the study period. Among them 50 patients with Ischemic stroke, confirmed by CT/MRI scan of brain were considered as ‘case’ and 50 age-sex matched individuals with one or more vascular risk factors (VRF) but without stroke were considered as ‘control’. Then the results of ABPI were compared between the two groups. Results: Among the 50 patients with ischemic stroke (case group), 74% had normal ABPI and 26% had ABPI< 0.9; on the other hand among 50 age and sex matched individuals (control group) 90% had normal ABPI and 10% had ABPI <0.9. The difference was statistically significant between two groups. (p=<0.05).This association remained significant even after adjustment for potential confounders (age, gender, high BMI, hypertension, diabetes mellitus, hyperlipidemia, smoking, ischemic heart disease and family history) in a multiple logistic regression model. Conclusion: The incidence of low ABPI is significantly higher in ischemic stroke patients than the age- sex matched control. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 27-33

535: Population-Based Case-Control Study of PSA and DRE Screening on Prostate Cancer Mortality

2005 ◽  
Vol 173 (4S) ◽  
pp. 146-146
Author(s):  
Eric J. Bergstralh ◽  
Rosebud O. Roberts ◽  
Michael M. Lieber ◽  
Sara A. Farmer ◽  
Jeffrey M. Slezak ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Mortality ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Prostate Cancer Mortality ◽  
Control Study

Perinatal and childhood factors and risk of prostate cancer in adulthood: MCC-Spain case-control study

2016 ◽  
Vol 43 ◽  
pp. 49-55 ◽  
Author(s):  
Virginia Lope ◽  
Esther García-Esquinas ◽  
José Manuel Ruiz-Dominguez ◽  
Javier LLorca ◽  
José Juan Jiménez-Moleón ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Childhood Factors

scholarly journals A case–control study of selenium in nails and prostate cancer risk in British men

2004 ◽  
Vol 90 (7) ◽  
pp. 1392-1396 ◽  
Author(s):  
N E Allen ◽  
J S Morris ◽  
R A Ngwenyama ◽  
T J Key
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Prostate Cancer Risk ◽  
Case Control ◽  
Control Study

scholarly journals Bayesian inference for the stereotype regression model: Application to a case-control study of prostate cancer

2009 ◽  
Vol 28 (25) ◽  
pp. 3139-3157 ◽  
Author(s):  
Jaeil Ahn ◽  
Bhramar Mukherjee ◽  
Mousumi Banerjee ◽  
Kathleen A. Cooney
Keyword(s):  
Prostate Cancer ◽  
Bayesian Inference ◽  
Regression Model ◽  
Case Control Study ◽  
Case Control ◽  
Model Application ◽  
Control Study

Adherence to Mediterranean diet and prostate cancer risk in Sicily: population-based case–control study

2018 ◽  
Vol 31 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Giorgio Ivan Russo ◽  
Tatiana Solinas ◽  
Daniele Urzì ◽  
Salvatore Privitera ◽  
Daniele Campisi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Mediterranean Diet ◽  
Case Control Study ◽  
Prostate Cancer Risk ◽  
Population Based ◽  
Case Control ◽  
Control Study
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