scholarly journals Evaluation of Thyroid Function Status in Sonographically Suggested Fatty Liver Subjects

2018 ◽  
Vol 18 (2) ◽  
pp. 125-130
Author(s):  
Farhana Rahman ◽  
Sanowar Hossain ◽  
Shankar Kumar Biswas ◽  
Fatema Sultana Haque ◽  
Rubina Begum ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Thyroid Function ◽  
Fatty Liver Disease ◽  
The Other ◽  
Alcoholic Fatty Liver ◽  
The Mean ◽  
Thyroid Hormone Levels ◽  
Grade 3 ◽  
Alcoholic Fatty Liver Disease

Objectives: The liver metabolizes thyroid hormones and thereby influences the regulation of their systematic endocrine effects. On the other hand, thyroid hormones play an important role in hepatic lipid homeostasis. Several studies addressed the association between thyroid function tests and non alcoholic fatty liver disease. The results of those studies indicate that hypothyroidism might be related to non alcoholic fatty liver disease. The recognized link between hypothyroidism and elements of metabolic syndrome may explain this relation. The present study was performed to evaluate the thyroid function status with the severity of sonographically suggested fatty liver subjects.Materials and Methods: This cross sectional study was carried out at the Institute of Nuclear Medicine and Allied Sciences (INMAS) of Dhaka Medical College Hospital Campus, Dhaka during the period of January 2014 to December 2014. A total number of 155 consecutive patients having sonographically detected fatty liver from the above mentioned hospitals were included in this study and they were divided into three grades depending on the sonographic criteria. Data were analyzed between these three grades in respect of age, sex, BMI, thyroid hormone levels (FT3, FT4 and TSH), fasting lipid profile and serum liver enzyme levels.Results: 82 (52.9%) patients had grade 1, 50 (32.3%) had grade 2 and 23 (14.8%) had grade 3 fatty liver. The mean age was found 39±10.9 years in Grade 1, 39.5±10.4 years in Grade 2 and 41.4±7.1 years in Grade 3. The difference was not statistically significant (p>0.05) among three groups. Male to female ratio was almost 2:3 in the whole study subjects. The mean BMI was significantly higher in grade 3 (p<0.05) followed by grade 2 and grade 1. 128 (82.6%) patients were euthyroid, 23 (14.8%) were subclinical hypothyroid and 4 (2.6%) were hypothyroid. In Anova test, the mean FT3 and FT4 were significantly declined (p<0.05) with increased grade but the mean TSH level was significantly increased (p=0.001) with increased grade of fatty liver. The Spearman’s rank correlation test shows that no significant but a negative correlation (r= -0.101; p=0.175) was found between FT3 and fatty liver of the study patients, but a significant negative correlation (r=-0.277; p=0.001) was observed between FT4 and fatty liver of the study patients. On the other hand a significant positive correlation (r=0.325; p=0.001) was observed between TSH and fatty liver of the study patients.Conclusion: In this study it has been found that thyroid hormone levels are significantly decreased with increasing grades of fatty liver detected by ultrasound. The underlying pathophysiology for this association is still not clear, however several mechanisms have been proposed. So the findings of this study will inspire other researchers to evaluate the thyroid function status with the severity of sonographically suggested fatty liver in larger scale.Bangladesh J. Nuclear Med. 18(2): 125-130, July 2015

scholarly journals EVALUATION OF THYROID FUNCTION STATUS IN SONOGRAPHICALLY SUGGESTED FATTY LIVER SUBJECTS

2020 ◽  
pp. 1-3
Author(s):  
Amrendra Kumar Singh ◽  
Gagan Gunjan ◽  
Rajkamal Choudhary ◽  
Debarshi Jana
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Thyroid Function ◽  
Fatty Liver Disease ◽  
The Other ◽  
Alcoholic Fatty Liver ◽  
The Mean ◽  
Thyroid Hormone Levels ◽  
Grade 3 ◽  
Alcoholic Fatty Liver Disease

Objectives: The liver metabolizes thyroid hormones and thereby influences the regulation of their systematic endocrine effects. On the other hand, thyroid hormones play an important role in hepatic lipid homeostasis. Several studies addressed the association between thyroid function tests and non alcoholic fatty liver disease. The results of those studies indicate that hypothyroidism might be related to non alcoholic fatty liver disease. The recognized link between hypothyroidism and elements of metabolic syndrome may explain this relation. The present study was performed to evaluate the thyroid function status with the severity of sonographically suggested fatty liver subjects. Materials and Methods: This cross sectional study was carried out at the Department of Medicine of Jawaharlal Nehru Medical College & Hospital, Bhagalpur, Bihar during the period of June 2019 to May 2020. A total number of 155 consecutive patients having sonographically detected fatty liver from the above mentioned hospitals were included in this study and they were divided into three grades depending on the sonographic criteria. Data were analyzed between these three grades in respect of age, sex, BMI, thyroid hormone levels (FT3, FT4 and TSH), fasting lipid profile and serum liver enzyme levels. Results: 82 (52.9%) patients had grade 1, 50 (32.3%) had grade 2 and 23 (14.8%) had grade 3 fatty liver. The mean age was found 39±10.9 years in Grade 1, 39.5±10.4 years in Grade 2 and 41.4±7.1 years in Grade 3. The difference was not statistically significant (p>0.05) among three groups. Male to female ratio was almost 2:3 in the whole study subjects. The mean BMI was significantly higher in grade 3 (p<0.05) followed by grade 2 and grade 1. 128 (82.6%) patients were euthyroid, 23 (14.8%) were subclinical hypothyroid and 4 (2.6%) were hypothyroid. In Anova test, the mean FT3 and FT4 were significantly declined (p<0.05) with increased grade but the mean TSH level was significantly increased (p=0.001) with increased grade of fatty liver. The Spearman’s rank correlation test shows that no significant but a negative correlation (r= -0.101; p=0.175) was found between FT3 and fatty liver of the study patients, but a significant negative correlation (r=-0.277; p=0.001) was observed between FT4 and fatty liver of the study patients. On the other hand a significant positive correlation (r=0.325; p=0.001) was observed between TSH and fatty liver of the study patients. Conclusion: In this study it has been found that thyroid hormone levels are significantly decreased with increasing grades of fatty liver detected by ultrasound. The underlying pathophysiology for this association is still not clear, however several mechanisms have been proposed. So the findings of this study will inspire other researchers to evaluate the thyroid function status with the severity of sonographically suggested fatty liver in larger scale.

scholarly journals EVALUATION OF THYROID FUNCTION STATUS IN SONOGRAPHICALLY SUGGESTED FATTY LIVER SUBJECTS

2020 ◽  
pp. 55-57
Author(s):  
Shiv Kumar ◽  
Rajeev Ranjan Kumar ◽  
Ravikirti Ravikirti ◽  
Debarshi Jana
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Thyroid Function ◽  
Fatty Liver Disease ◽  
The Other ◽  
Alcoholic Fatty Liver ◽  
The Mean ◽  
Thyroid Hormone Levels ◽  
Grade 3 ◽  
Alcoholic Fatty Liver Disease

Objectives: The liver metabolizes thyroid hormones and thereby influences the regulation of their systematic endocrine effects. On the other hand, thyroid hormones play an important role in hepatic lipid homeostasis. Several studies addressed the association between thyroid function tests and non alcoholic fatty liver disease. The results of those studies indicate that hypothyroidism might be related to non alcoholic fatty liver disease. The recognized link between hypothyroidism and elements of metabolic syndrome may explain this relation. The present study was performed to evaluate the thyroid function status with the severity of sonographically suggested fatty liver subjects. Materials and Methods: This cross sectional study was carried out at the Department of Medicine, All India Institute of Medical Sciences (AIIMS), Patna, Bihar. A total number of 155 consecutive patients having sonographically detected fatty liver from the above mentioned hospitals were included in this study and they were divided into three grades depending on the sonographic criteria. Data were analyzed between these three grades in respect of age, sex, BMI, thyroid hormone levels (FT3, FT4 and TSH), fasting lipid profile and serum liver enzyme levels. Results: 82 (52.9%) patients had grade 1, 50 (32.3%) had grade 2 and 23 (14.8%) had grade 3 fatty liver. The mean age was found 39±10.9 years in Grade 1, 39.5±10.4 years in Grade 2 and 41.4±7.1 years in Grade 3. The difference was not statistically significant (p>0.05) among three groups. Male to female ratio was almost 2:3 in the whole study subjects. The mean BMI was significantly higher in grade 3 (p<0.05) followed by grade 2 and grade 1. 128 (82.6%) patients were euthyroid, 23 (14.8%) were subclinical hypothyroid and 4 (2.6%) were hypothyroid. In Anova test, the mean FT3 and FT4 were significantly declined (p<0.05) with increased grade but the mean TSH level was significantly increased (p=0.001) with increased grade of fatty liver. The Spearman’s rank correlation test shows that no significant but a negative correlation (r= -0.101; p=0.175) was found between FT3 and fatty liver of the study patients, but a significant negative correlation (r=-0.277; p=0.001) was observed between FT4 and fatty liver of the study patients. On the other hand a significant positive correlation (r=0.325; p=0.001) was observed between TSH and fatty liver of the study patients. Conclusion: In this study it has been found that thyroid hormone levels are significantly decreased with increasing grades of fatty liver detected by ultrasound. The underlying pathophysiology for this association is still not clear, however several mechanisms have been proposed. So the findings of this study will inspire other researchers to evaluate the thyroid function status with the severity of sonographically suggested fatty liver in larger scale.

scholarly journals A Study on Association between Neutrophil to Lymphocyte Ratio and Steatohepatitis and Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

2021 ◽  
Vol 10 (25) ◽  
pp. 1876-1882
Author(s):  
Jayachandra Jayachandra ◽  
Sree Raksha K.N ◽  
Rakshit R. Desai ◽  
Chetan V ◽  
Arjun P. Chandrashekar
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
The Mean ◽  
Grade 3 ◽  
Alcoholic Fatty Liver Disease

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is seen worldwide and is the most common liver disorder in industrialized countries. Non-alcoholic steatohepatitis (NASH) is the severest form of NAFLD and is associated with inflammation and oxidative stress. Human neutrophil peptides have the ability to enhance hepatic fibrosis. We wanted to study the association between neutrophil to lymphocyte ratio and steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease. METHODS This is an analytical cross-sectional study conducted among 50 cases and 50 controls attending the hospital attached to BMCRI. The neutrophil lymphocyte ratio was calculated and compared between cases and controls. RESULTS Our study results showed that 7 patients had grade 1, 19 had grade 2, 24 had grade 3 hepatic steatosis and 13 patients had fibrosis. The mean neutrophil lymphocyte ratio (NLR) was significantly higher in cases than controls (3.6 +/- 1.83 and 1.72 +/- 0.57, P - 0.00). However, there was no statistical significance (F: 2.06, P value: 0.14) in the utility of NLR in detecting higher grades of steatosis (grade 1:2.41 +/- 0.76, grade 2:4.01 +/- 2.46, grade 3:3.62 +/- 1.3). The mean NLR was significantly higher (P - 0.001) in patients with fibrosis (3.72 +/- 2.1) compared with controls (1.46 +/- 051). CONCLUSIONS The neutrophil lymphocyte ratio can be used to detect the presence of steatohepatitis and fibrosis in patients with NAFLD but cannot be used to predict the presence of higher grades of hepatic steatosis. KEY WORDS Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis, Fibrosis, Neutrophil-Lymphocyte Ratio

Vitamin D levels are not associated with non-alcoholic fatty liver disease severity in a Brazilian population

2020 ◽  
pp. 1-8
Author(s):  
Jeniffer Danielle M. Dutra ◽  
Quelson Coelho Lisboa ◽  
Silvia Marinho Ferolla ◽  
Carolina Martinelli M. L. Carvalho ◽  
Camila Costa M. Mendes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Fatty Liver ◽  
Disease Severity ◽  
Fatty Liver Disease ◽  
Hypovitaminosis D ◽  
Alcoholic Fatty Liver ◽  
Vitamin D Levels ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

Resistance exercise improves autonomic regulation at rest and haemodynamic response to exercise in non-alcoholic fatty liver disease

2013 ◽  
Vol 125 (3) ◽  
pp. 143-149 ◽  
Author(s):  
Djordje G. Jakovljevic ◽  
Kate Hallsworth ◽  
Pawel Zalewski ◽  
Christian Thoma ◽  
Jacek J. Klawe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Liver Disease ◽  
Fatty Liver ◽  
Resistance Exercise ◽  
Fatty Liver Disease ◽  
Submaximal Exercise ◽  
Sympathovagal Balance ◽  
Alcoholic Fatty Liver ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Autonomic dysfunction has been reported in patients with NAFLD (non-alcoholic fatty liver disease) and is associated with clinical presentations. To date, there are no therapies to improve autonomic regulation in people with NAFLD. The present study defines the impact of a short-term exercise programme on cardiac autonomic and haemodynamic regulation in patients with NAFLD. A total of 17 patients with clinically defined NAFLD [age, 55±12 years; BMI (body mass index), 33±5 kg/m2; liver fat, 17±9%] were randomized to 8 weeks of resistance exercise or a control group to continue standard care. Resting and submaximal exercise (50% of peak oxygen consumption) autonomic and cardiac haemodynamic measures were assessed before and after the intervention. Resistance exercise resulted in a 14% reduction in HR (heart rate) and 7% lower SBP (systolic blood pressure) during submaximal exercise (16 beats/min, P=0.03 and 16 mmHg, P=0.22). Sympathovagal balance, expressed as LF/HF (low-frequency/high-frequency) ratio of the mean HR beat-to-beat (R–R) interval, was reduced by 37% (P=0.26). Similarly sympathovagal balance of DBP (diastolic blood pressure) and SBP variability decreased by 29% (P=0.33) and 19% (P=0.55), respectively in the exercise group only. BRS (baroreflex sensitivity) increased by 31% (P=0.08) following exercise. The mean R–R interval increased by 23% (159 ms, P=0.09). Parasympathetic regulation was decreased by 17% (P=0.05) and overall sympathovagal balance in BP regulation (LF/HF ratio) increased by 26% (P=0.02) following resistance exercise. Resting haemodynamic measures remained similar between groups. Resistance exercise therapy seems to improve autonomic and submaximal exercise haemodynamic regulation in NAFLD. Further studies are required to define its role in clinical management of the condition.

scholarly journals Thyroid function and non-alcoholic fatty liver disease in hyperthyroidism patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bairong Wang ◽  
Baomin Wang ◽  
Yumei Yang ◽  
Jing Xu ◽  
Mengyang Hong ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Thyroid Function ◽  
Fatty Liver Disease ◽  
Color Doppler ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Abstract Background Although thyroid function has been demonstrated to be associated with non-alcoholic fatty liver disease (NAFLD) in different population, the prevalence and features of NAFLD in hyperthyroidism have not been reported. The present study aims to investigate the prevalence of NAFLD and association of thyroid function and NAFLD in hyperthyroidism patients. Methods This cross-sectional study was performed in Zhongshan Hospital, Fudan University, China. A total 117 patients with hyperthyroidism were consecutively recruited from 2014 to 2015. Thyroid function and other clinical features were measured, liver fat content was measured by color Doppler ultrasonically, NAFLD was defined in patients with liver fat content more than 9.15%. Statistical analyses were performed with SPSS software package version 13.0. Results The prevalence of NAFLD was 11.97% in hyperthyroidism. Patient with NAFLD had lower free triiodothyronine (FT3) and free thyroxine (FT4) levels than patients without NAFLD (P < 0.05). After adjusting for age, gender, metabolic parameters and inflammation factors, higher FT3 were associated with lower liver fat content (β = − 0.072, P = 0.009) and decreased odds ratio of NAFLD (OR = 0.267, 95%CI 0.087–0.817, P = 0.021). Conclusions FT3 level was negatively associated with the liver fat content in this population. These results may provide new evidence in the role of thyroid hormone on the regulation of liver fat content and NAFLD.

scholarly journals Prevalence of non-alcoholic fatty liver disease and its risk factors in patients referred to Ardabil city hospital during 2015-2016

2018 ◽  
Vol 5 (3) ◽  
pp. 917
Author(s):  
Anahita Zakeri ◽  
Sepideh Karamat-Panah
Keyword(s):  
Risk Factors ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
City Hospital ◽  
Normal Range ◽  
Cross Sectional ◽  
Alcoholic Fatty Liver ◽  
The Mean ◽  
Alcoholic Fatty Liver Disease

Background: Fatty liver is the most common liver disease worldwide, and the number of people with this disease is increasing in the world and in Iran. The aim of this study was to determine the prevalence of non-alcoholic fatty liver disease and its risk factors in patients referred to Ardabil city hospital during 2015-2016.Methods: This is a cross-sectional descriptive study which was done on 80 patients with fatty liver Referred to Ardabil city Hospital dueing 2015-2016. Required information including age, gender, degree of fatty liver, body mass index, serum lipids, liver aminotransferases, serum uric acid, and diabetes mellitus were collected by a cheklist and then analyzed by statistical methods in SPSS.19.Results: 40% of the patients were males and 60% were females. The mean age of the patients was 49.22 ± 14.58 years. 81.2% of the patients were overweight or had some degree of obesity. ALT in 38.5%, AST in 32.5%, ALP in 13.75%, and bilirubin in 21.25% of patients were above their normal range. Total cholesterol in 35%, triglyceride in 50%, and LDL in 17.5% of patients were higher than normal range, and HDL was lower than normal range in 41.2% of patients. 21.25% of patients had hyperuricemia and 38.8% had diabetes.Conclusions: The results showed that non-alcoholic fatty liver is more prevalent in females and older ages. Doing multi-center studies was recommended in Ardabil province or other provinces in Iran in future.

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