scholarly journals Study on oxidative stress and antioxidant level in patients of acute myocardial infarction before and after regular treatment

2015 ◽  
Vol 40 (2) ◽  
pp. 79-84 ◽  
Author(s):  
T Bashar ◽  
N Akhter
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin E ◽  
Plasma Vitamin ◽  
Regular Treatment ◽  
Before And After ◽  
The Difference ◽  
Plasma Vitamin E

In acute myocardial infarction (AMI), lack of oxygen delivery to myocardium leads to generation of reactive oxygen species (ROS) which play an important role in the pathogenesis of AMI. Endogenous anti-oxidants protect the myocardial tissues from the deleterious effect of free radical mediate injury. The study evaluates the extent of oxidative stress and antioxidant status against ROS in AMI patients and amelioration of oxidative stress after regular treatment and also assesses the association between oxidative stress and risk factors for atherosclerosis like dyslipidemia and diabetes mellitus (DM).The study was conducted on 72 AMI patients and age and sex matched 18 healthy controls. Patients were assigned to four groups, AMI without dyslipidemia or DM, with dyslipidemia, with DM and with both dyslipidemia and DM. Plasma malondialdehyde (MDA) and GSH content and vitamin E levels were determined on admission into hospital and on the 5th day of treatment. Plasma MDA level increased significantly (p<0.001) and erythrocyte GSH and plasma vitamin E levels were decreased (p<0.001) in all the groups of patients as compared to control. On the 5th day of regular treatment MDA level reduced (p<0.001) and GSH and vitamin E levels increased (p<0.001) in patients. The plasma MDA level was significantly higher (p<0.001) in patients with both dyslipidemia and DM or with only DM in comparison to patients without dyslipidemia and DM. The difference in the GSH level between patients with risk factors and without risk factors was not significant. It may be conclude that an imbalance exists between oxidant and antioxidant molecules in AMI patients which shift towards oxidative side and regular treatment restores this balance. There may be some association between oxidative stress in AMI and risk factors like dyslipidemia and diabetes mellitus.Bangladesh Med Res Counc Bull 2014; 40 (2): 79-84

scholarly journals Oxidative Stress and Antioxidant Status in Patients of acute Myocardial Infarction before and after Regular Treatment

2015 ◽  
Vol 10 (2) ◽  
pp. 60-65 ◽  
Author(s):  
Tahmina Bashar ◽  
Nargis Akhter
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin E ◽  
Antioxidant Status ◽  
Plasma Vitamin ◽  
Regular Treatment ◽  
Before And After ◽  
Plasma Vitamin E

In acute myocardial infarction (AMI), generation of free radicals contribute to its pathogenesis. We evaluated the extent of oxidative stress and its amelioration in AMI patients after regular treatment and assessed its association with risk factors like dyslipidemia and diabetes mellitus (DM). Plasma MDA level increased (p<0.001) and erythrocyte GSH and plasma vitamin E levels decreased (p<0.001) in AMI patients. On the 5th day of regular treatment MDA level reduced (p<0.001) and erythrocyte GSH and vitamin E levels increased (p<0.001). The rise in MDA and fall in vitamin E levels were significant (p<0.001) in patients with both dyslipidemia and DM in comparison to patients without dyslipidemia or DM. It is concluded that an imbalance exists between oxidant and antioxidant molecules in AMI patients which shifts towards oxidative side and treatment restores this balance. There may be some association between oxidative stress in AMI and risk factors like dyslipidemia and diabetes mellitus.University Heart Journal Vol. 10, No. 2, July 2014; 60-65

scholarly journals Plasma Vitamin E and Coenzyme Q10 Are Not Associated with a Lower Risk of Acute Myocardial Infarction in Singapore Chinese Adults

2012 ◽  
Vol 142 (6) ◽  
pp. 1046-1052 ◽  
Author(s):  
Nasheen Naidoo ◽  
Rob M. van Dam ◽  
Woon-Puay Koh ◽  
Cynthia Chen ◽  
Yian-Ping Lee ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Vitamin E ◽  
Coenzyme Q10 ◽  
Lower Risk ◽  
Plasma Vitamin ◽  
Chinese Adults ◽  
Singapore Chinese ◽  
Plasma Vitamin E

Gender comparisons of exercise-induced oxidative stress: influence of antioxidant supplementation

2007 ◽  
Vol 32 (6) ◽  
pp. 1124-1131 ◽  
Author(s):  
Allan H. Goldfarb ◽  
Michael J. McKenzie ◽  
Richard J. Bloomer
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Reduced Glutathione ◽  
Protein Carbonyls ◽  
Plasma Vitamin ◽  
Oxidized Glutathione ◽  
Antioxidant Supplementation ◽  
Plasma Vitamin E ◽  
Exercise Induced ◽  
Response To Exercise

The purpose of this study was to determine the influence of gender and antioxidant supplementation on exercise-induced oxidative stress. Twenty-five men and 23 women ran for 30 min at 80% VO2 max, once before and once after 2 weeks of supplementation, and again after a 1-week wash-out period. Subjects were randomly assigned to either placebo (P), antioxidant (A: 400 IU vitamin E + 1 g vitamin C), or a fruit and vegetable powder (FV) treatment. Blood was obtained at rest and immediately after exercise. Before supplementation, women had higher resting reduced glutathione, total glutathione, and plasma vitamin E compared with men. With both A and FV supplementations, plasma vitamin E gender differences disappeared. Protein carbonyls, oxidized glutathione, and malondialdehyde all increased similarly for both genders in response to exercise. Both A and FV attenuated the reduced glutathione decrease and the oxidized glutathione and protein carbonyls increase compared with P, with no gender differences. 8-Hydroxydeoxyguanosine was lower with treatment A compared with FV and P only for men. Plasma vitamin C increased 39% (A) and 21% (FV) compared with P. These data indicate that women have higher resting antioxidant levels than men. Markers of oxidative stress increased similarly in both genders in response to exercise of similar intensity and duration. Two weeks of antioxidant supplementation can attenuate exercise-induced oxidative stress equally in both genders.

scholarly journals Vitamin E Supplementation and Markers of Oxidative Stress in Indian Acute Myocardial Infarction Patients

2013 ◽  
Vol 5 (2) ◽  
pp. 46-53 ◽  
Author(s):  
Ijen Bhattacharya ◽  
Rahul Saxena ◽  
Raj Saxena ◽  
Alok Milton Lal
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Uric Acid ◽  
Vitamin E ◽  
Vitamin C ◽  
Plasma Vitamin ◽  
Blood Samples ◽  
Markers Of Oxidative Stress ◽  
Vitamin E Supplementation

Background: Reactive oxygen species have been identified as mediators of cell injury in a variety of cardiovascular complications including Myocardial Infarction (MI). It is conceivable that vitamin E supplementation can be used therapeutically due to its role in ameliorating antioxidant status and free radicals scavenging activity. Aim: Therefore, the present study was undertaken to assess the markers of oxidative stress i.e. erythrocyte glutathione peroxidase (GSHPx) & malondialdehyde (MDA); plasma vitamin C, E, A and uric acid level in the blood samples of MI patients and to investigate the effect of in-vitro vitamin E supplementation in ameliorating the levels of these antioxidants in the blood sample of MI patients. Material & Method: 60 MI subjects (age group 30-60 years) were taken for the study and 60 healthy individuals served as controls. In-vitro vitamin E supplementation in the blood samples of MI subjects were performed and above mentioned parameters were estimated by using standard methods. Data was compared statistically by using student t-test. Result: Vitamin E supplementation brought about an improved antioxidants status with significantly raised vitamin C, E, A and GSHPx levels (p<0.05, p<0.001), and simultaneously depleted level of erythrocyte MDA (p<0.001) in blood samples of MI subjects. However, plasma uric acid levels remain unaltered (p<0.1). Conclusion: These findings further support the preventive and cardio protective role of vitamin E supplementation in reducing oxidative stress levels in the blood samples of MI patients. DOI: http://dx.doi.org/10.3126/ajms.v5i2.8430 Asian Journal of Medical Science, Volume-5(2) 2014: 46-53

scholarly journals Different Patterns in Ranking of Risk Factors for the Onset Age of Acute Myocardial Infarction between Urban and Rural Areas in Eastern Taiwan

2021 ◽  
Vol 18 (11) ◽  
pp. 5558
Author(s):  
Hsiu-Ju Huang ◽  
Chih-Wei Lee ◽  
Tse-Hsi Li ◽  
Tsung-Cheng Hsieh
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Rural Areas ◽  
Urban Areas ◽  
Cross Sectional Study ◽  
Onset Age ◽  
Cross Sectional ◽  
The Difference ◽  
Urban And Rural Areas

This cross-sectional study aimed to investigate the difference in ranking of risk factors of onset age of acute myocardial infarction (AMI) between urban and rural areas in Eastern Taiwan. Data from 2013 initial onset of AMI patients living in the urban areas (n = 1060) and rural areas (n = 953) from January 2000 to December 2015, including onset age, and conventional risk factors including sex, smoking, diabetes, hypertension, dyslipidemia, and body mass index (BMI). The results of multiple linear regressions analysis showed smoking, obesity, and dyslipidemia were early-onset reversible risk factors of AMI in both areas. The ranking of impacts of them on the age from high to low was obesity (β = −6.7), smoking (β = −6.1), and dyslipidemia (β = −4.8) in the urban areas, while it was smoking (β = −8.5), obesity (β= −7.8), and dyslipidemia (β = −5.1) in the rural areas. Furthermore, the average onset ages for the patients who smoke, are obese, and have dyslipidemia simultaneously was significantly earlier than for patients with none of these comorbidities in both urban (13.6 years) and rural (14.9 years) areas. The findings of this study suggest that the different prevention strategies for AMI should be implemented in urban and rural areas.

Management of Ventricular Fibrillation during Acute Myocardial Infarction

1984 ◽  
Vol 23 (04) ◽  
pp. 209-213
Author(s):  
B. J. Northover
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Ventricular Fibrillation ◽  
Coronary Care Unit ◽  
Patient Survival ◽  
Left Ventricular ◽  
Ventricular Failure ◽  
Before And After ◽  
Coronary Care ◽  
The Creation

SummaryAnalysis of electrocardiograms tape-recorded from patients admitted to hospital with acute myocardial infarction revealed that the pattern of ventricular extrasystolic activity was not significantly different among those who subsequently developed ventricular fibrillation and those who did not. Episodes of ventricular fibrillation occurred predominantly within 4 hours from the start of infarction. Patients were 3 times less likely to survive an episode of ventricular fibrillation if they also had left ventricular failure than if this feature was absent. Management of episodes of ventricular fibrillation was compared in patients before and after the creation of a specially staffed and equipped coronary care unit. The success of electric shock as a treatment for ventricular fibrillation was similar before and after the creation of the coronary care unit. An attempt was made to determine which features in the management of ventricular fibrillation in this and in previously published series were associated with patient survival.

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