scholarly journals Association of Creatinine Clearance Rate and Coronary Angiographic Severity in Patients with Coronary Artery Disease

2015 ◽  
Vol 7 (2) ◽  
pp. 108-113
Author(s):  
Mofazzal Hossain ◽  
HI Lutfur Rahman Khan ◽  
Abdul Wadud Chowdhury ◽  
Abu Sadique Abdullah ◽  
Md Gaffar Amin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Clearance Rate ◽  
Negative Relationship ◽  
Creatinine Clearance Rate ◽  
Vessel Disease ◽  
Artery Disease ◽  
Vessel Score

Background: In epidemiological studies and clinical trials renal function has been shown to be an independent predictor of coronary artery disease (CAD). We conducted this study to find out the association between creatinine clearance rate (CCr) and coronary angiographic severity in patients with (CAD). Method: It was a cross sectional study carried out in the department of Cardiology, Dhaka Medical College Hospital, Dhaka during the period of April, 2011 to March, 2012. All the patients with Ischaemic heart disease (IHD) admitted in the department of Cardiology who fulfill the inclusion and exclusion criteria and underwent coronary angiogram were taken as sampling population. Sampling technique was purposive and sample size was 118. By Cockcroft-Gault formula, CCr was estimated from serum creatinine. Coronary angiographic severity of coronary artery disease was assessed by vessel score and stenosis score. Statistical analysis was carried out by descriptive statistics, correlation coefficient test and one way ANOVA test. Level of significance was set at 0.05. Results: Mean CCr among study subjects was 72.57 ± 17.78 ml/min. Vessel score showed 18.6% had normal coronaries, 37.3% single vessel disease, 31.4% double vessel disease and 12.7% triple vessel disease. There was significant positive relationship between serum creatinine and vessel score, and also negative relationship between CCr and vessel score. The study also showed significant negative correlation between CCr and stenosis score. Conclusion: Angiographic severity of coronary artery disease is associated with degree of renal dysfunction. Decreased creatinine clearance is associated with more extensive CAD. DOI: http://dx.doi.org/10.3329/cardio.v7i2.22257 Cardiovasc. j. 2015; 7(2): 108-113

scholarly journals Association of Glycosylated Haemoglobin Level with the Severity of Coronary Artery Disease in NSTEMI Diabetic Patients

2015 ◽  
Vol 8 (1) ◽  
pp. 43-48
Author(s):  
Mahmod Mohammad Salim ◽  
Malik Fazila Tun Nesa ◽  
Rahman Mohammad Arif ◽  
Hossain Mohammad Delwar ◽  
Mandal Md Raihan Masum
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diabetic Patients ◽  
Gensini Score ◽  
Vessel Disease ◽  
Triple Vessel Disease ◽  
Group I ◽  
Group Ii ◽  
Artery Disease ◽  
Vessel Score

Background: Relation between diabetes mellitus and ischemic heart disease is well established. But the effect of HbA1C on severity of coronary artery disease remains uncertain in non-ST elevation myocardial infarction and diabetic patient. Objective of our study was to know the relationship of HbA1C with the severity of coronary artery disease.Methods: In this cross sectional analytical study a total of 104 NSTEMI diabetic patients were enrolled by purposive sampling. They were divided into two groups according to the level of HbA1C, Group-I patients having HbA1C<7% and Group-II patients having HbA1C >7%. Vessel score and Gensini score was calculated from coronary angiogram and compared between groups.Results: Single vessel disease were significantly higher in group-I compared to Group-II( 38.5% vs 7.7% in Group-I vs Group-II,p<0.05). Double vessel disease were higher in group-II compared to Group-I but the difference was statistically not significant (42.3% vs 48.1% in Group-I vs Group-II respectively (p>0.05). Triple vessel disease were significantly higher in group-II compared to Group- I (19.2% vs 44.4% in Group-I vs Group-II,p<0.05). Mean Vessel score was higher in Group-II compared to Group-I(1.73 ± 0.86 vs 2.50 ±0.70 in Group-I vs Group-II, p<0.05). Mean Gensini score was higher in Group-II compared to Group-I (44.6 ± 38.4 vs 76.9 ± 44.6 in Group-I vs Group-II, p<0.05). There were significant positive linear correlation between HbA1C and Vessels score and Gensini score (p<0.05).Conclusion: This study may be concluded that the presence of HbA1C >7% are associated with of severe coronary artery disease in NSTEMI with diabetes mellitus.Cardiovasc. j. 2015; 8(1): 43-48

P0142CONTRAST INDUCED NEPHROPATHY AFTER CORONARY ANGIOGRAPHY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Durdona Saipova ◽  
Shavkat Muminov ◽  
Baxodir Nigmanov ◽  
Kamila Olimxanova
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Serum Creatinine ◽  
Functional State ◽  
Negative Relationship ◽  
Serum Creatinine Concentration ◽  
Contrast Induced Nephropathy ◽  
Creatinine Concentration ◽  
Artery Disease

Abstract Background and Aims Determination of markers of kidney damage in patients with coronary artery disease after coronary angiography. HYPERLINK “https://www.healthline.com/health/coronary-angiography” Method The study included 303 patients with coronary artery disease who were planned coronary angiography. The initial examination of patients included an assessment of the structural and functional state of the kidneys, metabolic profile and the functional state of the cardiovascular system. Renal filtration function was assessed by the clearance of creatinine and cystatin C with the calculation of glomerular filtration rate (eGFRcr and eGFRcis) All coronary artery disease patients included in the study underwent coronary angiography using a contrast drug unigexole. If there is necessity, stenting of the coronary arteries was performed. On the 2nd day after coronary angiography, a serum creatinine concentration was determined to isolate patients in whom coronary angiography was complicated by CIN. Contrast induced nephropathy was defined as an increase in serum creatinine concentration by 25% 24 hours after coronarography. According to the study, patients were divided into 2 groups - 67.99% of patients with an uncomplicated postoperative period of caranoroangiography; CIN (-) group and CIN (+) group 32.01% of patients who developed contrast-induced nephropathy. Subsequently, the CIN + and CIN- groups were retrospectively compared according to the initial hemodynamic parameters, structural and functional state of the kidneys, and metabolic characteristics. Results The results of the study showed that eGFRcr did not significantly differ in the CIN(+) and CIN(-) groups, although it turned out to be lower in both groups. (p &lt;0.05). While eGFRcis in the CIN(+) group was significantly lower than in patients with uncomplicated coronary angiography. Correlation analysis showed a reliable positive average relationship between the values of eGFRcr and eGFRcis in the CIN(+) group (r = 0.32, p &lt;0.001). Correlation revealed a reliable average negative relationship between eGFRcis and the relative density of urine (r = -0.46, p &lt;0.001), indicating a combined violation of the glomerular and canalicular function of the kidneys, which indicates that in these patients, despite the preserved eGFRcr, pathogenetic markers of impaired renal function are detected. The Resistance Index (RI), which characterizes the resistance of the microvasculature of the kidneys in all patients with coronary artery disease significantly exceeded the control values. The selected groups according to the value of RI were arranged as follows: the minimum value of RI is in the CIN(–) without diabetes mellites group, and the maximum value is in patients with СIN(+) and diabetes mellitus. Conclusion In patients with coronary artery disease undergoing endovascular procedures, eGFRcis is a more accurate indicator of latent impaired renal filtration function than eGFRcr. Decrease in eGFRcis below 89ml / min in patients with coronary artery disease at risk of developing contrast-induced nephropathy during caranoroangiography. An increase in RI of segmental arteries of the kidneys is associated with a decrease in the filtration function of the kidneys and patients with maximum RI have the greatest risk of developing glomerular dysfunction under conditions of exposure to contrast.

scholarly journals Relationship between triglyceride HDL-cholesterol ratio and severity of coronary artery disease in patient with acute coronary syndrome

2016 ◽  
Vol 43 (3) ◽  
pp. 157-161 ◽  
Author(s):  
Md Rasul Amin ◽  
Md Afzalur Rahman ◽  
Nur Alam ◽  
Md Nazmul Hasan ◽  
GM Sadik Hasan
Keyword(s):  
Coronary Artery Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Lesion Score ◽  
Coronary Angiogram ◽  
Vessel Disease ◽  
Low Hdl ◽  
Artery Disease ◽  
Vessel Score ◽  
Cad Risk

Cardiovascular Disease (CVD) is the leading cause of death worldwide, responsible for one third of death. Coronary artery Disease (CAD) is the most common cause. Dyslipidaemia is one of the major contributors of increased CAD risk. High LDL-C, high TG and low HDL-C have all been as predictors for CAD risk. TG/HDL-C ratio could be a very important, easy, non-invasive means of predicting the presence and extent of coronary atherosclerosis. The aim of this study was to evaluate the association between TG/HDL-C ratio and the extent of CAD assessed by coronary angiogram in our setting. This cross sectional analytical study has been done in the Department of Cardiology, Sir Salimullah Medical College & Mitford Hospital. A total 118 patients with newly diagnosed ACS, undergoing coronary angiogram in were selected purposively. Previous history of PCI or CABG, patients getting lipid lowering drugs, patient with congenital heart disease or vulvular heart disease was excluded. Angiographic severity of coronary artery disease was assessed by 2 indices – vessels score’ and ‘Lesion score’. Smoking was found in highest percentage (65.3%) and half of the patient’s risk factor were hypertension (51.7%) and overweight (50.8%). The relationship between vessel score with TG/HDL-C ratio shows that among patients with triple vessel disease on coronary angiogram, 93% had high (?4) TG/HDL-C ratio whereas among double vessel disease patients, 82% patients had high (?4) TG/HDL-C ratio. The 157 association between atherosclerosis lesion score with TG/HDL-C ratio shows that with the increase level atherosclerosis TG/HDL-C ratio also increased. A subject with low HDL (<40 mg/dl for male and <50 mg/dl for female) had 4.75 times increase in odds of having coronary artery disease while a subject with high LDL (>100 mg/dl) had 2.60 (95% CI 1.55% to 14.26%) times increase in odds of having coronary artery disease. In this study high TG/HDL-C ratio (>4) was found with severity of CAD in relation to vessel score and atherosclerosis lesion score. High TG/HDL-C ratio indicates an atherogenic plaque and a significant risk for the development of coronary artery disease. In this study high TG/HDL-C ratio was found as the most powerful predictor of coronary heart disease among all the lipid variables examined. This finding can help us to find out high risk ACS patient and plan for treatment strategy of severe CAD in our population.Bangladesh Med J. 2014 Sep; 43 (3): 157-161

scholarly journals Comparison of estimated GFR equations based on serum cystatin C alone and in combination with serum creatinine in patients with coronary artery disease

2015 ◽  
Vol 15 (7) ◽  
pp. 571-576 ◽  
Author(s):  
Yusuf Cetin Doganer ◽  
Umit Aydogan ◽  
James Edwin Rohrer ◽  
Aydogan Aydogdu ◽  
Tuncer Cayci ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Creatinine ◽  
Cystatin C ◽  
Serum Cystatin C ◽  
Estimated Gfr ◽  
Serum Cystatin ◽  
Artery Disease

scholarly journals Prolonged QTc Dispersion Correlates with Coronary Artery Disease in Acute ST Elevated Myocardial Infarction (STEMI)

2013 ◽  
Vol 5 (2) ◽  
pp. 173-181 ◽  
Author(s):  
NI Sharafat ◽  
M Khalequzzaman ◽  
M Akhtaruzzaman ◽  
AK Choudhury ◽  
S Hasem ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Qt Dispersion ◽  
Qtc Dispersion ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Artery Disease ◽  
Vessel Score ◽  
Vessel Involvement

Background: It has been found that there is strong association of QT dispersion and QT dispersion ratio with extent and severity of coronary artery disease. Qualitative importance of QTc dispersion on the base line ECG in patients with MI is recognized clinically but quantification of this phenomenon is less commonly used in clinical practice, which might be a better independent risk predictor of this group of patients. Methods: A total of 100 patients were selected, Study populations sub-divided into two groups on the basis of QTc dispersion. In group I (comparison group): QTc dispersion is <60 milliseconds (msec) in group II (study group) : QTc dispersion e”60milliseconds(msec). 50 patients in each group. QT dispersion was calculated on standard resting 12 lead ECGs. QT interval was measured from the beginning of the inscription of the QRS complex to the point at which the T wave returned to the isoelectric line. Angiographic severity of coronary artery disease was assessed by- Vessel score, Friesinger score and Leaman score. Interpretation of coronary angiogram was reviewed by at least two cardiologists. . Results: The mean vessel score for group I patients was 1.16±0.68 and that of group II patients was 2.30±0.64 and the mean difference was statistically significant (p<0.05). Patients those had single vessel involvement had mean QTc dispersion 57.05, patients those had double vessel disease mean QTc dispersion was 102.00 and patients those had triple vessel involvement had mean QTc dispersion 177.60. There was a strong positive correlation with the QTc dispersion and increasing number of vessel involvement (Pearson’s correlation coefficient). The mean Friesinger score for group I patients was 4.84±2.56 and that of group II patients was 9.80±2.60. The mean difference was significantly (p<0.05) higher in group II patients. There was a strong positive correlation between the QTc dispersion and Leaman score (Pearson’s correlation coefficient). In group I patients 56% had insignificant coronary artery disease and 44% had significant coronary artery disease defined by Friesinger index (n=100). In group II patients 6% had Insignificant coronary artery disease & had 94% significant coronary artery disease. Conclusion: QTc dispersion>60 ms had independent predictive value for the severity of coronary artery disease. The greater the QTc dispersion the higher the number of coronary artery involvement. We observed that there is a positive correlation between prolonged QT dispersion and coronary artery disease severity in terms of Vessel score, Friesinger score, Leaman score. DOI: http://dx.doi.org/10.3329/cardio.v5i2.14322 Cardiovasc. j. 2013; 5(2): 173-181

Comparison of the GRACE and TIMI Risk Scores in Predicting the Angiographic Severity of Coronary Artery Disease in Patients with non STelevation Myocardial Infarction

2017 ◽  
Vol 10 (1) ◽  
pp. 45-51
Author(s):  
Sharadindu Shekhar Roy ◽  
STM Abu Azam ◽  
Md Khalequzzaman ◽  
Mohammad Ullah ◽  
Samir Kumar Kundu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Roc Curve ◽  
Risk Scores ◽  
Cross Sectional ◽  
Timi Score ◽  
Artery Disease ◽  
Vessel Score ◽  
Grace Score

Background: The superiority of the GRACE and TIMI risk scores in predicting the angiographic severity of coronary artery disease in patients with non ST-elevation myocardial infarction (NSTEMI) has not yet been established. This study was done to compare the GRACE and TIMI risk scores in predicting the angiographic severity of coronary artery disease in this group of patients.Method: The cross sectional study done in the Department of Cardiology, NICVD, Dhaka. The patients admitted with NSTEMI were evaluated to calculate the GRACE and TIMI risk score from April, 2015 to April, 2016.Coronary angiogram was done during index hospitalization and the severity of the coronary artery disease was assessed by vessel score and Gensini score.Results: Of 115 patients assessed, a positive correlation of the vessel score and Gensini score was observed with both the GRACE and TIMI risk scores (p=<0.001) and the GRACE score (r=0.59) correlated better than the TIMI score (r=0.52). The GRACE score presented area under the Receiver Operating Characteristic (ROC) curve of 0.844(95% CI = 0.774 – 0.914) significantly superior to the area under the ROC curve of 0.752(95% CI =0.658– 0.846) of the TIMI score for the difference between the two scores.Conclusion: Both the GRACE and TIMI scores had good predictive value in predicting the severity of coronary artery disease in the patients with NSTEMI but when both the scores were compared, the GRACE score was found to be superior and correlated better with the severity of coronary artery disease.Cardiovasc. j. 2017; 10(1): 45-51

scholarly journals Correlation between Peripheral Arterial Disease and Coronary Artery Disease in Bangladeshi Population- A Five Years Retrospective Study

2017 ◽  
Vol 11 (2) ◽  
pp. 79-84
Author(s):  
Syed Dawood Md Taimur ◽  
Mashhud Zia Chowdhury ◽  
Md Enamul Hakim
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Arterial Disease ◽  
Positive Family History ◽  
Arterial Disease ◽  
Coronary Angiogram ◽  
Vessel Disease ◽  
Artery Disease ◽  
Peripheral Arterial

Background: Peripheral arterial disease (PAD) is under diagnosed in primary care practices, yet the extent of unrecognized PAD in patients with coronary artery disease (CAD) is unknown.Objective: To assess the prevalence of previously unrecognized PAD in patients undergoing coronary angiogram and to determine the relationship between presence of PAD and severity of CAD. Material &Methods: This five years retrospective study was conducted at invasive lab of the department of Cardiology, Ibrahim Cardiac Hospital & Research Institute, Dhaka, Bangladesh from January 2010 to December 2014. Total 77 patients were included in this study. Study variables were age, sex, risk factors like hypertension, diabetes mellitus, dyslipidaemia, smoking habit and positive family history for ischemic heart disease, severity of coronary artery and peripheral artery disease.Results: Mean age was 56.83±13.64 years, Male mean age was 53.98±15.08 years and female mean age was 54.5±1.73years. Hypertension were detected in 55.8%, diabetes in 87%, dyslipidaemia in 81.8%, smoking habits in 88.3% and 58.4% had positive family history. After catheterization 88.3% had peripheral arterial disease and 71.4% had coronary artery disease. Out of 77 patients 52 had both coronary and peripheral arterial disease which was statistically significant (p<.014). Coronary angiogram revealed 28.6% (22) patients had triple vessel disease, 23.3% (18) had single vessel disease, 19.5% (15) had double vessel disease and 28.6% (22) were normal coronary arteries. Peripheral angiogram revealed 51.9% had superficial femoral artery disease, 24.7% had anterior tibial artery disease, 26% had posterior tibial artery disease, 15.6% had common iliac artery and common femoral artery disease and 2.6% had renal artery disease.Conclusion: There is a strong and definite correlation between coronary and peripheral arterial disease. We found that cardiovascular risk factors were in fact risk factors for both PAD and CAD.University Heart Journal Vol. 11, No. 2, July 2015; 79-84

scholarly journals Anemia as a risk factor of contrast-associated acute kidney injury

2020 ◽  
Vol 92 (12) ◽  
pp. 48-52
Author(s):  
O. Iu. Mironova ◽  
A. D. Deev ◽  
P. G. Lakotka ◽  
V. V. Fomin
Keyword(s):  
Coronary Artery Disease ◽  
Acute Kidney Injury ◽  
Risk Factor ◽  
Coronary Artery ◽  
Serum Creatinine ◽  
Statistical Significance ◽  
Kidney Injury ◽  
Chronic Coronary Artery Disease ◽  
Absolute Increase ◽  
Artery Disease

Aim.The aim of our study was to assess the role of anemia as a risk factor of contrast-associated acute kidney injury (CA-AKI) in patients with stable coronary artery disease. Materials and methods.1023 patients with chronic coronary artery disease were enrolled in a prospective, open, cohort study (ClinicalTrials.gov ID NCT04014153). 83 patients had anemia. CA-AKI was defined as an increase of 25% or more, or an absolute increase of 0.5 mg/dl or more in serum creatinine from baseline value, assessed at 48 hours following the administration of the contrast. The primary endpoint of the study was the development of CA-AKI according to KDIGO criteria. Results.CA-AKI developed in 12 (14.5%) patients with anemia according to the relative increase of the level of serum creatinine (25% and more from the baseline). With using the absolute increase of the level of serum creatinine the prevalence of CA-AKI was 2 (2.4%) patients. Patients with anemia had higher rate of CA-AKI than the overall population of the study (14.4% versus 12.7%). Although our results were not statistically significant (р=0.61, odds ratio 1.19, 95% confidence interval 0.632.24). Conclusion.The prevalence of CA-AKI was higher in the group of patients with anemia, but didnt meet statistical significance and needs further evaluation in larger studies.

scholarly journals Angiographic profile of young patients (≤ 40 years) in a tertiary care center of Nepal

2020 ◽  
Vol 11 (6) ◽  
pp. 68-71
Author(s):  
Binay Kumar Rauniyar ◽  
Arun Kadel ◽  
Kiran Prasad Acharya ◽  
Kartikesh Kumar Thakur ◽  
Rakesh Bahadur Adhikari ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Tertiary Care ◽  
Significant Coronary Artery Disease ◽  
Young Patients ◽  
Vessel Disease ◽  
Single Vessel ◽  
Triple Vessel Disease ◽  
Artery Disease ◽  
Single Vessel Disease

Background: With rise in prevalence of conventional risk factors like diabetes, hypertension, smoking, dyslipidemia and obesity the incidence of coronary artery disease in young patients have increased in the recent decades even in developing world. There have been multiple studies done in Nepal studying the angiographic profile of coronary disease in general population. However, only few studies has been done till date on the angiographic profile in the young population in our country. Aims and Objectives: In this study, we aim to determine the angiographic profile of young patient ≤ 40 years in a tertiary care centre of Nepal. Materials and Methods: A retrospective analytic study was done in Shahid Gangalal National Heart Centre from January 2019 to December 2019. Individuals of both genders with age ≤ 40 years who underwent coronary angiography were included. Results: Total 109 patients were included. Out of 109, 89 were male and 20 were female. The mean age for male was 35.55 ± 4.31 and for female was 38.55 ± 1.90 (P = 0.003). Among 61 (55.96%) patients who had significant coronary artery disease, 33 patients (30.27%) with single vessel disease, 15 patients (13.76%) had double vessel disease, and 13 patients (11.92%) had triple vessel disease. Left anterior descending (LAD) artery was found to be most frequently involved in all patterns of Coronary artery disease (CAD). Smoking was the most common coronary risk factor present in 29.3% of patients followed by hypertension, family history of premature CAD and diabetes in 14.6%, 7.5% and 5.5% of patients respectively. Overall, the prevalence of smoking was more in males (31.4%) than in females (20%). Conclusion: Single vessel disease (SVD) was most prevalent in young patients with significant CAD. LAD is the most commonly involved coronary artery followed by Right coronary artery (RCA) and Left Circumflex (LCX).

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