scholarly journals Study on Insulin Like Growth Factor-1 As a Marker of Severity of Liver Dysfunction in Patients with Liver Cirrhosis

2019 ◽  
Vol 18 (1) ◽  
pp. 3-7
Author(s):  
Aloke Kumar Raha ◽  
Mohammad Izazul Hoque ◽  
Mamun Al Mahtab ◽  
Nooruddin Ahmad ◽  
Salimar Rahman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatitis B ◽  
Patient Group ◽  
Liver Dysfunction ◽  
Healthy Subjects ◽  
Clinical Stage ◽  
Insulin Like Growth Factor ◽  
Healthy Individuals ◽  
Cirrhotic Patients ◽  
Cirrhosis Of Liver

Background: Insulin Like Growth Factor-1 (IGF-1) is a polypeptide hormone predominantly synthesized in liver. It has been reported that serum IGF-1 concentrations low in hypopitutuitarism, malnutrition and various diseases particularly in patients with chronic liver disease. The aim of the study was to see the level of IGF-1 in patients with cirrhosis and its relation with severity of liver dysfunction. Materials and Methods : This study was carried out in the Department of Hepatology, Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka, Bangladesh. 40 persons (30 patients of cirrhosis of liver and 10 healthy individuals) were selected and grouped as Group-1 : 10 Child grade A patient, Group - 2 : 10 Child grade B patient, Group - 3 : 10 Child grade C cirrhotic patients and Group - 4 : 10 healthy subjects. Patients with recent antiviral therapy, acute illness, hepatocellular carcinoma and spontaneous bacterial peritonitis were excluded from the study. IGF-1 was measured using IMMULITE, DPC, USA which employs automated chemiluminescent immunoassays. Results : Among 30 cirrhotic patients 26 were male and 4 were female. Mean age was 38.83 ± 14.08 years. Etiology of cirrhosis was hepatitis B virus in 23 patient, hepatitis C virus in 1 patient, Cryptogenic in 6 patients. Healthy subjects were hepatitis B and C virus negative with normal liver function test and mean age was 36.40 ± 7.76 years, Mean serum IGF-1 was 82 ± 10.85 ng/ml in Child grade A, 50.77 ± 7.47 ng/ml in Child grade B, 29.69 ± 3.17 ng/ml in Child grade C patients and 130.96 ± 2.43 ng/ml in healthy individuals. Conclusion : Serum level of IGF -1 is low in patients with cirrhosis of liver than healthy individuals and reflects the severity of liver dysfunction in different clinical stage. Chatt Maa Shi Hosp Med Coll J; Vol.18 (1); Jan 2019; Page 3-7

Serum insulin-like growth factor (IGF)-II is more closely associated with liver dysfunction than is IGF-I in patients with cirrhosis

2000 ◽  
Vol 294 (1-2) ◽  
pp. 169-177 ◽  
Author(s):  
J.Anna Nikolić ◽  
Vera Todorović ◽  
Milena Božić ◽  
Ljubinka Tošić ◽  
Mirko Bulajić ◽  
...  
Keyword(s):  
Growth Factor ◽  
Liver Dysfunction ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Igf I

Determinants of serum insulin-like growth factor I in growth hormone deficient adults as compared to healthy subjects

1998 ◽  
Vol 48 (4) ◽  
pp. 479-486 ◽  
Author(s):  
Jens O. L. Jørgensen ◽  
Nina Vahl ◽  
Tony B. Hansen ◽  
Christian Skjaerbaek ◽  
Sanne Fisker ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Healthy Subjects ◽  
Serum Insulin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals The Effect of Oral Glucose on Serum Free Insulin-Like Growth Factor-I and -II in Healthy Adults*

1997 ◽  
Vol 82 (9) ◽  
pp. 3124-3127 ◽  
Author(s):  
Jan Frystyk ◽  
Thorbjørn Grøfte ◽  
Christian Skjærbæk ◽  
Hans Ørskov
Keyword(s):  
Growth Factor ◽  
Healthy Subjects ◽  
Time Course ◽  
Oral Glucose ◽  
Insulin Like Growth Factor ◽  
Serum Samples ◽  
Cross Sectional ◽  
Igf System ◽  
Igf I ◽  
The Impact

Abstract Insulin-like growth factor (IGF) binding protein-I (IGFBP-1) has been suggested to regulate the availability of free IGF and the glucose lowering activity of the IGF-system in relation to fuel supply. Our recent observations of significant inverse correlations between free IGF-I and IGFBP-1 in cross-sectionally collected fasting serum samples support a possible physiological association between the peptides. To further study the impact of IGFBP-1 on free IGF levels and the possible participation of the IGF-system in glucose homeostasis, we studied the time course of changes in IGFBP-1 and free IGFs in 13 healthy subjects undergoing an oral glucose tolerance test (OGTT). Serum was collected every 30 min for 330 min. Glucose, insulin, and GH followed the expected patterns and had regained baseline levels at 270 min. Total IGF-I and free and total IGF-II remained unaltered. IGFBP-1 decreased significantly by 37–52% (P < 0.05) from 150 to 210 min, whereafter the concentration gradually increased by 75% to a level that tended to be above baseline (P = 0.052). Free IGF-I decreased by 29–38% (P < 0.05) at the end of the study (270–330 min). IGFBP-1 was inversely correlated to free IGF-I at baseline (r = −0.57; P < 0.05), as well as during the OGTT (r = 0.66; P < 0.0001). In contrast, free IGF-II was not correlated to IGFBP-1. Insulin, but not free IGF-I, correlated significantly with serum glucose (P < 0.05). These results extend our previous findings of an inverse correlation between free IGF-I and IGFBP-1 in cross-sectional studies to include longitudinal observations, and thus further substantiates the hypothesis that IGFBP-1 is an important determinant of free IGF-I in vivo. Significant changes in free IGF-I were observed only in the late postprandial phase, when glucose and insulin were fully normalized, demonstrating that free IGFs probably do not participate in glucoregulation to any significant degree during an oral glucose load in healthy subjects.

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