scholarly journals Outcome of Oligonodular Hepatocellular Carcinoma after Hepatectomy

2020 ◽  
Vol 15 (1) ◽  
pp. 55-57
Author(s):  
SM Shakhwat Hossain ◽  
Md Mahboob Hasan ◽  
Md Mahbubur Rahman
Keyword(s):  
Hepatocellular Carcinoma ◽  
Recurrence Rate ◽  
Armed Forces ◽  
Early Recurrence ◽  
Intrahepatic Metastasis ◽  
High Rate ◽  
Preoperative Imaging ◽  
Military Hospital ◽  
Multicentric Occurrence ◽  
Significant Difference

Introduction: Hepatocellular carcinoma (HCC) is a common cancer and is the third most common cause of cancer-related death worldwide. Frequent recurrence of HCC after resection is a major surgical limitation. Early recurrence is the most disappointing outcome after surgery for multinodular HCC. Several studies found good results after hepatectomy for oligonodular (2 or 3 nodules) HCC. Objectives: To observe the recurrence rate three months after hepatectomy for oligonodular HCC and study the possible risk factors. Materials and Methods: The study population consisted of 102 patients with oligonodular HCC and received hepatectomy in Combined Military Hospital (CMH) between July 2011 and July 2017 according to the following criteria: (1) numbers of tumour nodules determined by preoperative imaging (computed tomography or magnetic resonance imaging) and intraoperative exploration; (2) diagnosis of HCC confirmed by postoperative histopathology; (3) incision margins negative; (4) complete clinicopathologic data; (5) adjuvant chemotherapy advised one month after operation. Multicentric occurrence (MO) and intrahepatic metastasis (IM) were determined in each patient according to the histopathologic examination. Results: Among 102 patients, 43(42.2%) had small tumor stain three months after surgery, 22(21.6%) and 21(20.6%) were definded as single and multiple recurrence respectively. The recurrence rate of patients with microvascular involvement was higher (64.3%) than those without (33.8%), (p<0.05). IM or MO, complete tumor capsule or not, number of tumors (2 versus 3), liver condition (cirrhosis versus chronic hepatitis) showed no significant difference. Conclusion: There was a high rate of very early recurrence for patients with oligonodular HCC three months ater hepatectomy, and the hepatic resection seems no-account for these patients regardless of very early recurrence or not a curative resection. Microvascular involvement was a risk factor while IM or MO is not. Journal of Armed Forces Medical College Bangladesh Vol.15 (1) 2019: 55-57

Clinicopathological Risk Factors for Recurrence within One Year after Initial Hepatectomy for Hepatocellular Carcinoma

2011 ◽  
Vol 77 (5) ◽  
pp. 572-578 ◽  
Author(s):  
Michihiro Hayashi ◽  
Tetsunosuke Shimizu ◽  
Fumitoshi Hirokawa ◽  
Yoshihiro Inoue ◽  
Koji Komeda ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
High Risk ◽  
Early Recurrence ◽  
Intrahepatic Metastasis ◽  
High Rate ◽  
Preoperative Imaging ◽  
Curative Intent ◽  
Initial Hepatectomy ◽  
Cancer Spread

Hepatocellular carcinoma (HCC) shows a high rate of recurrence after hepatectomy; predictive factors for early recurrence would help determine optimal therapeutic and management strategies. Among 163 patients with HCC undergoing hepatectomy with curative intent, 46 patients developed recurrence within 1 year. Clinicopathological data were retrospectively analyzed to identify predictive parameters for early recurrence. Survival rates in cases of recurrence within 1 year were worse than those of no recurrence within 1 year or recurrence after 1 year. Protein induced by vitamin K absence/antagonist II (PIVKA-II) greater than 150, positive fucosylated alpha-fetoprotein (L3-AFP), and deviancy from Milan criteria (MC) on preoperative imaging were associated with high risk of early recurrence and total number of these three risk factors predicted the survival. With multivariate analysis, 1) preoperatively, positive factors of two or more among three items of PIVKA-II, L3-AFP, and deviancy from MC; 2) and postoperatively, pathological cancer spread (microscopic vascular invasion and/or intrahepatic metastasis) both represented risks for early recurrence. A combination of three preoperative factors, PIVKA-II, L3-AFP, and MC status, in conjunction with the postoperative factor of cancer spread status represents a significant indicator for recurrence within 1 year. Improving the prognosis of patients with HCC would depend on how to adequately treat those at high risk of early recurrence.

scholarly journals Incidence of Occult Intrahepatic Metastasis in Hepatocellular Carcinoma Treated With Transplantation Corresponds to Early Recurrence Rates After Partial Hepatectomy

2018 ◽  
Vol 267 (5) ◽  
pp. 922-928 ◽  
Author(s):  
David D. Aufhauser ◽  
Eran Sadot ◽  
Douglas R. Murken ◽  
Kevin Eddinger ◽  
Maarouf Hoteit ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Partial Hepatectomy ◽  
Early Recurrence ◽  
Intrahepatic Metastasis ◽  
Recurrence Rates

scholarly journals Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma

Cancer ◽  
2003 ◽  
Vol 98 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Hung-Wei Pan ◽  
Yueh-Hsing Ou ◽  
Shian-Yang Peng ◽  
Shu-Hsian Liu ◽  
Po-Lin Lai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Recurrence ◽  
Intrahepatic Metastasis

Adjuvant Chemolipiodolization Reduces Early Recurrence Derived from Intrahepatic Metastasis of Hepatocellular Carcinoma After Hepatectomy

2011 ◽  
Vol 18 (13) ◽  
pp. 3624-3631 ◽  
Author(s):  
Masaki Ueno ◽  
Kazuhisa Uchiyama ◽  
Satoru Ozawa ◽  
Shinya Hayami ◽  
Yoshinobu Shigekawa ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Recurrence ◽  
Intrahepatic Metastasis

scholarly journals Factors predicting long-term outcome of early stage hepatocellular carcinoma after primary curative treatment - the role of surgical or nonsurgical methods

2020 ◽  
Author(s):  
Ming-Jeng Kuo ◽  
Chi-Ling Chen ◽  
Lein-ray Mo
Keyword(s):  
Hepatocellular Carcinoma ◽  
Late Recurrence ◽  
Early Recurrence ◽  
Curative Treatment ◽  
Treatment Modalities ◽  
Long Term Outcome ◽  
Increased Risk ◽  
Significant Difference ◽  
Early Hcc ◽  
Time Varying Covariates

Abstract Background The effect of putative factors on the clinical course of early hepatocellular carcinoma (HCC) after primary surgical or nonsurgical curative treatment, which remains elusive, was quantified. Methods Patients with newly diagnosed early HCC who received surgical resection (SR) or percutaneous radiofrequency ablation (RFA) with or without transcatheter arterial chemoembolization (TACE) from January 2003 to December 2016 were enrolled. The cumulative overall survival (OS) and disease-free survival (DFS) were compared. A polytomous logistic regression was used to estimate factors regarding early and late recurrence. Independent predictors of OS were identified using Cox proportional hazard regression. Results One hundred twenty-five patients underwent SR, and 176 patients underwent RFA, of whom 72 were treated with TACE followed by RFA. Either match analysis based on propensity score or multiple adjustment regression showed no significant difference in DFS and OS between the two groups. Multivariate analysis showed high AFP (>= 20 ng/mL), and multinodularity significantly increased risk of early recurrence (<=1year). In contrast, hepatitis B virus, hepatitis C virus and multinodularity were significantly associated with late recurrence (>1year). Multivariate Cox regression with recurrent events as time-varying covariates identified older age (HR=1.55, 95% CI:1.01-2.36), clinically significant portal hypertension (CSPH) (HR=1.97, 95% CI:1.26-3.08), early recurrence (HR=6.62, 95% CI:3.79-11.6) and late recurrence (HR=3.75, 95% CI:1.99-7.08) as independent risk factors of mortality. A simple risk score showed fair calibration and discrimination in early HCC patients after primary curative treatment. In the Barcelona Clinic Liver Cancer (BCLC) stage A subgroup, SR significantly improved DFS comparing to those received RFA with or without TACE. Conclusion Host and tumor factors rather than the initial treatment modalities determine the outcomes of early HCC after primary curative treatment. Statistical models based on recurrence types can predict early HCC prognosis but further external validation is necessary.

scholarly journals A Comparison of Ultra Sound Therapy and Micro Wave Diathermy on Patients with Adhesive Capsulitis of Shoulder Joint

2019 ◽  
Vol 11 (2) ◽  
pp. 30-35
Author(s):  
SM Shahidul Haque ◽  
Md Fashiur Rahman ◽  
Mohammad Yousuf ◽  
Md Rezaul Karim ◽  
M Kamrul Hasan
Keyword(s):  
Physical Exercise ◽  
Shoulder Joint ◽  
Adhesive Capsulitis ◽  
Armed Forces ◽  
Pain Scale ◽  
Ultra Sound ◽  
Military Hospital ◽  
Medical College ◽  
Sound Therapy ◽  
Significant Difference

Introduction: Adhesive capsulitis is one of the most common causes of pain and disability of the shoulder joint. Most patients are managed conservatively in a primary care setting with the expectation of a good outcome. There are many alternative forms of treatment for this condition. Several interventions are also used in combination for its management but most of it remained unclear. Ultra Sound Therapy (UST) is commonly employed as a first line agent for the management of adhesive capsulitis. But whether the UST (Ultra Sound Therapy) and MWD (Micro Wave Diathermy) therapy would produce a significant difference in out come was not yet settled. Objective: To compare the efficacy of ultra sound therapy (UST) and micro wave diathermy (MWD) for the management of patients with adhesive capsulitis of shoulder joint. Materials and Methods: This observational study was carried out in the Department of Physical Medicine at Combined Military hospital, Dhaka from 01 May 2015 to 30 November 2015. A total of eighty patients were enrolled in this study and they were divided into two equal groups. One group received counseling plus UST (Ultra Sound Therapy) (1MHz @ 1.0 Watt/cm2 area for 10 minutes for two weeks) with physical exercise. Another group received counseling, MWD (Micro Wave Diathermy) and physical exercise for same period. Each group received the above mentioned modalities on the basis of five days a week for 06 weeks. Results: The result was observed by applying VAS (Visual analog scale) pain scale and SPADI (Shoulder Pain And Disability Index) pain score. The highest significant improvement (P<0.005) was observed in group “A” throughout the whole treatment period. Conclusion: In this study, most patients with adhesive capsulitis were benefited with counseling plus Ultrasound therapy and physical exercise rather than counseling plus Microwave Diathermy with physical exercise. Journal of Armed Forces Medical College Bangladesh Vol.11(2) 2015: 30-35

scholarly journals MicroRNA-125b expression and intrahepatic metastasis are predictors for early recurrence after hepatocellular carcinoma resection

2017 ◽  
Vol 48 (4) ◽  
pp. 313-321 ◽  
Author(s):  
Tomonari Shimagaki ◽  
Tomoharu Yoshizumi ◽  
Norifumi Harimoto ◽  
Sachiyo Yoshio ◽  
Yutaka Naito ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Early Recurrence ◽  
Intrahepatic Metastasis

Impact of spontaneous hepatocellular carcinoma rupture on surgical outcome after liver resection: a systemic review and meta-analysis

2020 ◽  
Author(s):  
Wei Zhang ◽  
Zhi-Yong Huang ◽  
Chang Shu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Recurrence Rate ◽  
Surgical Outcome ◽  
Meta Analysis ◽  
Systemic Review ◽  
Cochrane Library ◽  
Tumor Rupture ◽  
Significant Difference ◽  
The Impact

Abstract Background Spontaneous tumor rupture is a rare but life-threatening complication of hepatocellular carcinoma (HCC). The impact of spontaneous ruptured HCC on long-term survival after liver resection (LR) remains unclear. Our aim was to compare the surgical outcome in patients who underwent LR with ruptured and non-ruptured HCC . Methods A comprehensive search using PubMed, Embase, Cochrane Library and Science Citation Index Expanded databases was performed. The primary outcomes were the hazard ratio (HR) for overall survival ( OS) and disease free survival (DFS). The secondary outcomes included morbidity, hospital mortality and recurrence rate . Results Ten retrospective studies including 3222 patients met the inclusion criteria. Pooled analysis revealed a significantly poorer OS and DFS for patients with ruptured HCC compared to patients with non-ruptured HCC (HR, 2.02; 95% CI, 1.61-2.54; P< 0.00001 and HR, 1.92; 95% CI, 1.56-2.35; P<0.00001, respectively). In the subgroup analysis, both the propensity score matching (PSM) and non-PSM studies demonstrated a significantly poorer OS in the ruptured HCC group (P=0.02 and P<0.00001, respectively). However, meta-analysis of two PSM studies showed that there was not significant difference in the DFS between the two groups (P=0.50). Patients in the ruptured HCC group had a higher mortality and recurrence rate than the non-ruptured HCC group, but the difference was not significant (P = 0.05 and P = 0.06, respectively) Conclusions Surgical outcomes of the patients with the ruptured or non-ruptured HCC undergoing LR were not only affected by tumor rupture itself, but also by the tumor characteristics and liver functional status. Therefore, classifying all ruptured but resectable HCC as T4 stage is unable to accurately represent their true prognosis.

Sign in / Sign up

Export Citation Format

Share Document