scholarly journals Hba1c Variability Has a Strong Relationship With Peripheral Sensory And Motor Neuropathy in Type-2 Diabetes Mellitus

2021 ◽  
pp. 93-100
Author(s):  
MA Hossain ◽  
MK Sarkar ◽  
I Mahbub ◽  
SMS Islam
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Microvascular Complications ◽  
Diabetic Patients ◽  
Motor Neuropathy ◽  
Type 2 Diabetic Patients ◽  
Hba1c Variability ◽  
Type 2 Diabetic

Diabetic peripheral neuropathy (DPN) is one of the most common long-term microvascular complications of diabetes. This study was undertaken to investigate the association of HbA1c variability with diabetic peripheral neuropathy (sensory and motor) in patients with type-2 diabetes. In this cross-sectional study, a total of 150 type-2 diabetic patients were screened for DPN and undergone quarterly HbA1c measurements during the year preceding enrolment were recruited. DPN was confirmed in patients displaying both clinical manifestations of neuropathy and neurological abnormalities assessment. Among the recruited patients, 24% (n = 36) were found to have DPN, and these patients also presented with a higher HbA1c as compared to the patients without DPN (p<0.05). In addition, the advanced age and longer duration of diabetes were important and significant (p<0.05) risk factors for peripheral neuropathy. Overall study suggests that increased HbA1c level is strongly associated with DPN (sensory and motor) in type-2 diabetic patients and could be considered as a potent indicator for DPN in the recruited patients. J. Bio-Sci. 29(1): 93-100, 2021 (June)

scholarly journals HbA1c variability and diabetic peripheral neuropathy in type 2 diabetic patients

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Jian-bin Su ◽  
Li-hua Zhao ◽  
Xiu-lin Zhang ◽  
Hong-li Cai ◽  
Hai-yan Huang ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Hba1c Variability ◽  
Type 2 Diabetic

scholarly journals Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Lin Xu ◽  
Bo Zhou ◽  
Huixia Li ◽  
Jiali Liu ◽  
Junhui Du ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Microvascular Complications ◽  
Linear Regression Analysis ◽  
Serum Levels ◽  
Diabetic Microangiopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Objective. Progranulin (PGRN) was recently introduced as a novel marker of chronic inflammatory response in obesity and type 2 diabetes capable of directly affecting the insulin signaling pathway. This study aimed to investigate the correlation between PGRN and type 2 diabetics with microvascular complications.Methods. PGRN serum levels and glucose metabolism related substance were measured in 84 type 2 diabetic patients with or without microangiopathies and 12 health persons. Further analyses of serum PGRN in different stages of diabetic microangiopathies were conducted.Results. Serum levels of PGRN were markedly higher in type 2 diabetic patients with microangiopathies. PGRN serum levels increased with the progress of diabetic microangiopathies with significantly highest values detectable in clinical diabetic nephropathy (CDN) and proliferative diabetic retinopathy (PDR) groups. Serum PGRN concentrations in all individuals positively and markedly correlated with systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), triglyceride (TG), urinary albumin excretion rate (UAER), blood urea nitrogen (BUN), creatinine (CRE), white blood cell (WBC), disease duration, IL-6, and TNF-α, while correlating negatively and significantly with eGFR. Multiple linear regression analysis showed that only UAER and CRE were independently associated with serum PGRN.Conclusion. PGRN might be considered as a marker for diabetic microangiopathy and its severity.

Anemia: an independent risk factor of diabetic peripheral neuropathy in type 2 diabetic patients

2017 ◽  
Vol 54 (10) ◽  
pp. 925-931 ◽  
Author(s):  
Fan Wu ◽  
Yuanyuan Jing ◽  
Xiaojun Tang ◽  
Dai Li ◽  
Lilin Gong ◽  
...  
Keyword(s):  
Risk Factor ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Independent Risk Factor ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Platelet-Derived NO in Subjects Affected by Type 2 Diabetes with and without Complications: Is there any Relationship with their Offspring?

2017 ◽  
Vol 125 (05) ◽  
pp. 290-296 ◽  
Author(s):  
Jacopo Sabbatinelli ◽  
Arianna Vignini ◽  
Eleonora Salvolini ◽  
Laura Nanetti ◽  
Laura Mazzanti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Type 2 Diabetes ◽  
Microvascular Complications ◽  
Diabetic Patients ◽  
No Production ◽  
Type 2 Diabetic Patients ◽  
Adult Type ◽  
Male Adult ◽  
Type 2 Diabetic

Abstract Macro- and microvascular complications are currently the principal causes of morbidity and mortality in patients with diabetes mellitus. Aim of this study was to determine if type 2 diabetic patients with nephropathy and coronary artery disease showed altered platelet-derived nitric oxide (NO) production, compared with diabetic subjects without complications, and if this alteration is also present in their diabetic offspring. In this case-control observational study, platelet NO and peroxynitrite content was determined on plasma from 60 male adult type 2 diabetic patients and 60 male offspring type 2 diabetic patients. Plasmatic levels of homocysteine were also determined in the same individuals. Moreover, Western blot analysis of platelet lysates was performed with specific monoclonal antibody for endothelial (eNOS) and inducible (iNOS) nitric oxide synthase. Our study showed a lower piastrinic production of NO in the group of parents without complications (ADH), compared with the group of offspring without complications (YDH) and with the groups of parents with complications. Furthermore, we observed a lower synthesis of peroxynitrite in platelets from the ADH group than in the groups of patients with complications, and in the YDH group compared with all other groups. Subjects from YDH group also showed lower iNOS expression, compared with all other groups. Our data suggest that alterations in nitric oxide metabolism may represent potential risk factors in type 2 diabetes complications, such as nephropathy and cardiovascular diseases, leading to development of new therapeutic strategies in order to delay and prevent the onset of such complications.

scholarly journals A study of peripheral neuropathy in cases of type-II diabetes mellitus patients with or without hypothyroidism

2021 ◽  
Vol 9 (9) ◽  
pp. 2787
Author(s):  
Sonali Das Pradhan ◽  
Sumana Panja ◽  
Shiuli Roy ◽  
Saktipada Pradhan ◽  
Kaushik Samajdar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Nerve Conduction ◽  
Nerve Conduction Studies ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Background: Type 2 diabetic patients have a higher prevalence of thyroid disorders, particularly hypothyroidism.  Peripheral neuropathy is a common and disabling complication of diabetes mellitus. Peripheral nervous system involvement in hypothyroidism is also a well-documented fact. Nerve conduction studies are generally considered to be the most sensitive and reproducible in the assessment of peripheral neuropathies. This study helped to determine the prevalence of peripheral neuropathy in diabetic hypothyroid patients as well as to compare it in diabetic patients with or without hypothyroidism. It compared the onset latency, amplitude, conduction velocity and F- wave latency of some nerves in type 2 diabetes mellitus patients with or without hypothyroidism.Methods: With RMS, EMG, EP MARK-II, nerve conduction studies are done in 30 cases (type 2 diabetes mellitus patients with hypothyroidism) and 30 controls (type 2 diabetes mellitus patients of diabetes without hypothyroidism) respectively, attending the Diabetic Clinic and Biochemistry Laboratory of North Bengal Medical College.Results: Data were treated with Unpaired t-Test. The study reveals that type 2 diabetes mellitus patients with hypothyroidism have higher prevalence of peripheral neuropathy. There is statistically significant (p<0.00) decrease in motor nerve conduction study in both right and left median nerves in diabetic patients with hypothyroidism than in diabetic patients without hypothyroidism.Conclusions: All diabetic patients should be screened for early detection of hypothyroidism as type 2 diabetic patients with hypothyroidism have higher prevalence of peripheral neuropathy. The nerve conduction study remains the most reliable, accurate, and sensitive method to evaluate peripheral nerve function.

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