scholarly journals Non-Diabetic Renal Disease in Type 2 Diabetic Patients with Nephropathy

2021 ◽  
Vol 10 (2) ◽  
pp. 73-78
Author(s):  
Jubaida Khanam Chowdhury ◽  
AKM Rashed Ul Hasan ◽  
Rajee Mahmud Talukder ◽  
Md Nizamuddin Chowdhury ◽  
Md Nazrul Islam
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Renal Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Diabetic Renal Disease ◽  
Group A ◽  
Group B ◽  
Type 2 Diabetic

Background: In diabetic patients a good proportion of nephropathy is due to nephropathy other than diabetic renal disease. The detection of superimposed primary nondiabetic renal disease in diabetic patients has an obvious prognostic and therapeutic importance. Objectives: To find out the proportion of diabetic subjects suffering from nondiabetic renal disease (NDRD) and to describe histological varieties in appropriate group. Materials and Methods: This crosssectional study was done in Department of Nephrology, Dhaka Medical College & Hospital, Dhaka from August 2015 to October 2016. Total 37 type 2 diabetic patients were selected. Renal biopsy was done and four cases were excluded due to inadequate sample. Tissue was sent for histopathology and direct immunofluorescence (DIF) examination. On the basis of histological diagnosis of biopsy reports patients were divided into three groups. Group I: Isolated NDRD, Group II: NDRD superimposed on diabetic nephropathy (mixed lesion) and Group III: Isolated diabetic nephropathy (DN). Each patient was evaluated for retinopathy from Ophthalmology department. Based on the presence or absence of retinopathy 33 patients were again divided into two groups. Group A includes patients with diabetic retinopathy (DR) and Group B includes patients without diabetic retinopathy. Results: NDRD was found in 57.6% cases, NDRD plus diabetic nephropathy (DN) in 21.2% and isolated DN in 21.2% cases. In Group A (patients with DR) NDRD, DN and mixed lesion were present in 7 (41.2%), 5 (29.4%) and 5 (29.4%) cases. In Group B (patients without DR) NDRD, DN and mixed lesion were present in 12 (75%), 2 (12.5%) and 2 (12.5%) cases respectively. p value (0.189) was not significant. Conclusion: Kidney disease other than diabetic nephropathy can occur in type 2 diabetic patients. In this study NDRD was found in high frequency. Lack of retinopathy is a poor predictor of nondiabetic kidney disease. Therefore, renal biopsy should be recommended in type 2 diabetic patients with risk factors of NDRD for accurate diagnosis, prompt initiation of disease-specific treatment and ultimately better renal outcome. J Enam Med Col 2020; 10(2): 73-78

scholarly journals SP454NON-DIABETIC RENAL DISEASE IN TYPE 2 DIABETIC PATIENTS: PREVALENCE, CLINICAL PREDICTORS ANDOUTCOMES

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii275-iii276 ◽  
Author(s):  
Siyar Erdogmus ◽  
Zeynep Kendi Celebi ◽  
Serkan Akturk ◽  
Gizem Kumru ◽  
Sim Kutlay ◽  
...  
Keyword(s):  
Renal Disease ◽  
Diabetic Patients ◽  
Clinical Predictors ◽  
Type 2 Diabetic Patients ◽  
Diabetic Renal Disease ◽  
Type 2 Diabetic

scholarly journals A study in prevalence of diabetic nephropathy in recently detected cases of type 2 diabetes mellitus as evidenced by altered creatinine clearance, urinary albumin and serum creatinine, with special emphasis on hypertension, hypercholesterolemia and obesity

2018 ◽  
Vol 5 (2) ◽  
pp. 351 ◽  
Author(s):  
Vitan Patel ◽  
Minal Shastri ◽  
Nisha Gaur ◽  
Prutha Jinwala ◽  
Abhishek Y. Kadam
Keyword(s):  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Urinary Albumin ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group A ◽  
Group B ◽  
Associated Risk Factors

Background: Diabetic nephropathy is one of the commonest and most dreaded complications of Diabetes. The Aim was to evaluate the significance of microalbuminuria and creatinine clearance for detecting incipient diabetic nephropathy, and to find out the prevalence of nephropathy among freshly detected Type 2 diabetic patients with vs. those without hypertension, hypercholesterolemia and/or obesity.Methods: In this prospective study, 100 recently diagnosed diabetics were studied. Group A had 50 patients with at least one risk factor are hypertension, hypercholesterolemia and obesity. Group B had 50 patients without any of the aforementioned factors. Patients were investigated for presence of Diabetic nephropathy with abnormal serum Creatinine, creatinine clearance and urinary albumin levels.Results: As many as 43 out of 100 patients were found to have Diabetic nephropathy. The number was significantly higher in group A compared to group B (34/50 vs. 9/50). Incidence of nephropathy was higher with higher number of associated risk factors. Urinary microalbuminuria was the commonest abnormality, Serum creatinine was found in only 30.23% of total positive cases.Conclusions: Incidence of diabetic nephropathy is much larger than imagined in freshly diagnosed/new onset cases of DM type 2. Author also conclude that hypertension, obesity and hypercholesterolemia can contribute to development of nephropathy (68% vs. 18% in those who had the factors vs. those who didn’t). Also, urinary microalbuminuria appears to be much more sensitive than serum creatinine as screening tool.

scholarly journals HUBUNGAN KADAR FIBRINOGEN PLASMA DAN MIKROALBUMINURIA PADA PENDERITA DIABETES MELLITUS TIPE 2

2018 ◽  
Vol 14 (1) ◽  
pp. 11
Author(s):  
Rikarni . ◽  
Lillah . ◽  
Yoesri .
Keyword(s):  
Endothelial Dysfunction ◽  
Diabetic Patients ◽  
Fibrinogen Concentration ◽  
Creatinine Ratio ◽  
Type 2 Diabetic Patients ◽  
Albumin Creatinine Ratio ◽  
Group A ◽  
Group B ◽  
Type 2 Diabetic

Increase of fibrinogen concentration in type 2 diabetic patients is an indicator for vascular inflammation, endothelial dysfunction. Hyperfibrinogenemia is a strong marker and independently for atherosclerosis. Beside that, hyperfibrino -genemia can precede macroand microvascular complication. In type 2 diabetic, microalbuminuria is early marker for diabetic nephropathy and show that there isendothelial dysfunction. Microalbuminuria not only useful to predict renal damage, but also useful to predict cardiovascular damage.Microalbuminuria is a marker for endothelial dysfunction. To know the correlation between increase of fibrinogen concentration andmicroalbuminuria in type 2 diabetic patients. The study was performed in Dr. M. Djamil central Hospital by using cross sectionalmethod and consecutive random sampling. Sample were type 2 diabetic patients included criteria were measured albumin/ creatinineratio and the patients was divided in 2 group, that is group A (normoalbuminuria) and group B (microalbuminuria) with totalsample were 90 patients. Each group were performed measurement of albumin/ creatinine ratio, random glucose concentration, andfibrinogen concentration in plasma. In group A, we found the average of albumin/ creatinine ratio is 6.6 μg/mg and in group B is107.5 μg/mg. The average of random glucose concentration in group A is 181.3 mg/dl, and in group B is 204 mg/dl and the difference of concentration is not significantly (p > 0.05). The average of fibrinogen concentration in group A is 383.5 ± 104.6 mg/dl, and in group B is 467 ± 79 mg/dl. Increasing fibrinogen concentration in group B is higher than group A and the increasing is significantlystatistical difference (p <0.05). In this study we also founded the positive correlation between concentration of fibrinogen plasma andalbuminuria ( r = 0.036, p =0.0004). In type 2 diabetic patients with normoalbuminuria has been increased fibrinogen concentration,and the increasing of fibrinogen concentration in type 2 diabetic patients with microalbuminuria is higher than type 2 diabetic patientswith normoalbuminuria. There are positive correlation between fibrinogen plasma concentration and albumin/creatinine ratio

Evaluation of the Vasoprotective Effects of Metformin versus Glibenclamide in Type 2 Diabetic Patients

2021 ◽  
pp. 6409-6412
Author(s):  
Zainab H. Fathi ◽  
Jehan A. Mohammad ◽  
Marwah H. Mohammed
Keyword(s):  
Endothelial Function ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Metformin Monotherapy ◽  
Group A ◽  
Glucose Lowering Effect ◽  
Group B ◽  
Oral Hypoglycemic Drugs ◽  
Type 2 Diabetic

Adiponectin (APN) is an adipokine with anti-inflammatory and anti-atherogenic properties decreased in type 2 diabetes mellitus (T2DM) that may influence endothelial function by regulating serum nitric oxide (NO) levels. The current study aimed to investigate the effect of two oral hypoglycemic drugs, Metformin and Glibenclamide (GLC), on circulating APN and NO levels and to find a correlation between APN and NO levels in type 2 diabetic patients. Fifty males and females previously diagnosed with T2DM were conducted in this trial and classified into groups: Group A involved 18 untreated patients with T2DM, group B involved 16 patients receiving Metformin monotherapy (1000 mg/day) for up to 1 year and group C involved 16 patients receiving GLC (5 mg/day) for up to 1 year. Circulating APN and NO were measured. Compared to GLC, Metformin therapy showed a significant increase in APN and NO levels in type 2 diabetic patients. Our findings established that Metformin has a protective effect on endothelial function, including increased APN and NO bioavailability, beyond its glucose-lowering effect.

scholarly journals Renal disease in relatives of Indo-Asian Type 2 diabetic patients with end-stage diabetic nephropathy

Diabetologia ◽  
2003 ◽  
Vol 46 (5) ◽  
pp. 618-624 ◽  
Author(s):  
P. K. Chandie Shaw ◽  
L. A. van Es ◽  
L. C. Paul ◽  
F. R. Rosendaal ◽  
J. H. M. Souverijn ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
End Stage ◽  
Type 2 Diabetic

scholarly journals Correlation of Serum Magnesium Level and Blood Glucose status among Type 2 Diabetic Patients

2021 ◽  
Vol 8 (2) ◽  
pp. 106-109
Author(s):  
KAM Mahbub Hasan ◽  
Asraful Hoque ◽  
Naheed Fatema ◽  
Mohammed Rashed Anwar ◽  
AKM Mohiuddin Bhuiyan ◽  
...  
Keyword(s):  
Blood Sugar ◽  
Serum Magnesium ◽  
Magnesium Level ◽  
Diabetic Patients ◽  
Serum Magnesium Level ◽  
Type 2 Diabetic Patients ◽  
Group A ◽  
Group B ◽  
Type 2 Diabetic

Background: Serum magnesium level is an important electrolytes for the maintenance of haemodynamic of the body. Objective: The purpose of the present study was to correlate the serum magnesium level and blood sugar status. Methodology: This cross sectional study was carried out in the Department of Medicine at Shaheed Suhrawardy Medical College Hospital, Dhaka, Bangladesh from July 2012 to December 2012. All the type 2 diabetic patients admitted in the Department of Medicine in-patient department of ShSMCH who were 18 years and above age with both sexes were included as study population and were designated as group A and non-diabetic patients were included as group B. Blood samples were drawn after an overnight fast for the measurement of fasting blood sugar and serum magnesium. Result: In this present study a total number of 60 patients were enrolled for this study after fulfilling the inclusion and exclusion criteria of which 30 patients were in group A and the rest 30 patients were in group B. The correlation coefficient of FBS and HbA1C with Serum Magnesium level was recorded. The FBS and serum magnesium was negatively correlated to each other significantly which was -0.534. The HbA1C and serum magnesium was negatively correlated to each other significantly which was -0.556. Conclusion: In conclusion the blood sugar level is inversely correlate with the serum magnesium level in type 2 diabetic patients. Journal of Current and Advance Medical Research, July 2021;8(2):106-109

scholarly journals Clinical Observation of Retinal Vessel Density In Type 2 Diabetic Patients With High Mopyopia

2021 ◽  
Author(s):  
Ruifeng Su ◽  
Zhiyang Jia
Keyword(s):  
High Myopia ◽  
Retinal Vessel ◽  
Vessel Density ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group A ◽  
Group B ◽  
Retinal Vessel Density ◽  
Type 2 Diabetic

Abstract Purpose: To quantitatively analyze the difference of superficial and deep retinal vessel density between diabetic patients with high myopia , diabetic patients without high myopia and normal subjects.Methods: This cross-sectional study recruited type 2 diabetic patients with no history of ocular treatment in Shijiazhuang, China.Thirty type 2 diabetic patients with high myopia (30 eyes) were included in group A, 30 type 2 diabetic patients (30 eyes) without myopia were included in group B. Another 30 sex-,age-matched healthy volunteers (30 eyes)were included in group C. The superficial and deep retinal vessel density were measured and compared among the three groups to determine the effects of high myopia on diabetes.Results: No statistically significant differences in central superficial retinal vessel density(CSVD) was found in three groups（P＞0. 05).There were significant differences in the temporal superficial retinal vessel density（TSVD）,superior superficial retinal vessel density(SSVD), nasal superficial retinal vessel density(NSVD),inferior superficial retinal vessel density(ISVD) between the three groups, respectively (P＜0.05).TSVD,SSVD,NSVD,ISVD in group A were all lower than those in group B and group C(P ＜0.05).ISVD in group B was lower than that in group C and no statistically significant differences in TSVD,SSVD,NSVD were found between groups B and C(P＞0.05). There were significant differences in central deep retinal vessel density(CDVD),temporal deep retinal vessel density(TDVD),superior deep retinal vessel density(SDVD), nasal deep retinal vessel density(NDVD),inferior deep retinal vessel density(IDVD) between the three groups, respectively (P＜0.05).CDVD in group A was higher than that in group B , but there was no significant difference between group A and group C.TDVD,SDVD,NDVD,IDVD in group A were all lower than those in group B and C(P ＜0.05),and those in group B were lower than those in group C(P ＜0.05).Conclusion: Myopia and diabetes are important factors affecting vessel density. The parafoveal superficial and deep vessel density of type 2 diabetic patients with high myopia were lower than those of diabetics and normal persons. However,there was no difference in macular fovea superficial and deep retinal vessel density between diabetic patients with high myopia and normal persons.Myopia did not show a protective effect on retinal vessel density reduction in diabetic patients.

Sign in / Sign up

Export Citation Format

Share Document