scholarly journals Incidence of 1-lyponatraemia in Patients with lschemic Stroke: Our Experience at RMCH

2009 ◽  
Vol 22 (2) ◽  
pp. 212-215
Author(s):  
I Mahmood ◽  
MK Rahman ◽  
MMR Khan ◽  
MA Haque ◽  
MMH Chowdhury ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cohort Study ◽  
Ischemic Stroke ◽  
Clinical Evidence ◽  
Extracellular Fluid ◽  
Cerebral Salt Wasting ◽  
Salt Wasting ◽  
Electrolyte Disorder ◽  
Inappropriate Secretion

Hyponatraemia is a common electrolyte disorder in central nervous system (CNS) disease and is often attributed to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). By contrast, there are patients with intracranial disease who develop hyponatraemia with similar characteristics, but differ in that there is clinical evidence of a contracted extracellular fluid (ECF) volume. This form of hyponatraemia is caused by excessive renal Na excretion, resulting from a centrally mediated process, and is termed cerebral salt wasting (CSW). Hyponatraemia, if acute that is developed within hours or days may cause confusion, coma restlessness or seizures. 72 patients with ischemic stroke admitted at RMCH were selected for this prospective cohort study. Among the subjects 34 (47.22%) cases were found to have hyponatraemia. The number was quite large and screening patients with stroke for electrolytes may be extremely helpful to reduce mortality and morbidity.TAJ 2009; 22(1): 212-215

scholarly journals Central Nervous System Agents for Ischemic Stroke: Neuroprotection Mechanisms

2011 ◽  
Vol 11 (2) ◽  
pp. 81-97 ◽  
Author(s):  
Rachna S. Pandya ◽  
Lijuan Mao ◽  
Hua Zhou ◽  
Shuanhu Zhou ◽  
Jiang Zeng ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Central Nervous System Agents

Clinical evidence for dose tolerance of the central nervous system in hypofractionated radiotherapy

2018 ◽  
Vol 7 (4) ◽  
pp. 293-305 ◽  
Author(s):  
Jinyu Xue ◽  
Bahman Emami ◽  
Jimm Grimm ◽  
Gregory J. Kubicek ◽  
Sucha O. Asbell ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Evidence ◽  
Hypofractionated Radiotherapy ◽  
The Central Nervous System ◽  
Dose Tolerance

scholarly journals Progenitor Cell Therapy for the Treatment of Central Nervous System Injury: A Review of the State of Current Clinical Trials

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Peter A. Walker ◽  
Matthew T. Harting ◽  
Shinil K. Shah ◽  
Mary-Clare Day ◽  
Ramy El Khoury ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Clinical Trials ◽  
Nervous System ◽  
Ischemic Stroke ◽  
Cell Therapy ◽  
Progenitor Cell ◽  
Neurological Injury ◽  
Cell Therapies ◽  
Potential Efficacy ◽  
Cord Injury

Recent preclinical work investigating the role of progenitor cell therapies for central nervous system (CNS) injuries has shown potential neuroprotection in the setting of traumatic brain injury (TBI), spinal cord injury (SCI), and ischemic stroke. Mechanisms currently under investigation include engraftment and transdifferentiation, modulation of the locoregional inflammatory milieu, and modulation of the systemic immunologic/inflammatory response. While the exact mechanism of action remains controversial, the growing amount of preclinical data demonstrating the potential benefit associated with progenitor cell therapy for neurological injury warrants the development of well-controlled clinical trials to investigate therapeutic safety and efficacy. In this paper, we review the currently active or recently completed clinical trials investigating the safety and potential efficacy of bone marrow-derived progenitor cell therapies for the treatment of TBI, SCI, and ischemic stroke. Our review of the literature shows that while the preliminary clinical trials reviewed in this paper offer novel data supporting the potential efficacy of stem/progenitor cell therapies for CNS injury, a great deal of additional work is needed to ensure the safety, efficacy, and mechanisms of progenitor cell therapy prior to widespread clinical trials.

SYMPTOMATIC HYPONATREMIA IN ACUTE INFECTIONS OF THE CENTRAL NERVOUS SYSTEM

PEDIATRICS ◽  
1956 ◽  
Vol 18 (4) ◽  
pp. 604-613
Author(s):  
William L. Nyhan ◽  
Robert E. Cooke
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hypertonic Saline ◽  
Water Intake ◽  
Extracellular Fluid ◽  
Water Intoxication ◽  
Extracellular Fluid Volume ◽  
Acute Infections ◽  
The Central Nervous System ◽  
Acute Hyponatremia

Acute hyponatremia has been noted on seven occasions in five patients with acute infections of the central nervous system. Symptoms were those of water intoxication and the response to the administration of hypertonic saline was prompt and dramatic. The hyponatremia appears to be due to acute expansion of the extracellular fluid volume in association with antidiuresis. Frequent determinations of the concentrations of electrolytes in the serum and prophylactic limitation of water intake are recommended as possible means of reducing mortality in disease of the central nervous system.

Low risk of clinically important central nervous system dysraphism in a cohort study of 69 patients with isolated aplasia cutis congenita of the head

2020 ◽  
Vol 37 (3) ◽  
pp. 455-460
Author(s):  
Travis J. Kuemmet ◽  
James J. Miller ◽  
Daniel Michalik ◽  
Sean M. Lew ◽  
Mohit Maheshwari ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cohort Study ◽  
Low Risk ◽  
Aplasia Cutis Congenita ◽  
Aplasia Cutis
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